{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T13:13:49Z","timestamp":1770297229766,"version":"3.49.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2018.00168","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T07:52:10Z","timestamp":1526543530000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of a Human Leukocyte Antigen Score to Predict Progression-Free Survival in Head and Neck Squamous Cell Carcinoma Patients"],"prefix":"10.3389","volume":"8","author":[{"given":"Gunnar","family":"Wichmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Herchenhahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlen","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Wiegand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1002\/hed.20861","article-title":"DNA copy number variation and loss of heterozygosity in relation to recurrence of and survival from head and neck squamous cell carcinoma: a review","volume":"30","author":"Chen","year":"2008","journal-title":"Head Neck"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1126\/science.1206923","article-title":"Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1","volume":"333","author":"Agrawal","year":"2011","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1126\/science.1208130","article-title":"The mutational landscape of head and neck squamous cell carcinoma","volume":"333","author":"Stransky","year":"2011","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nature14129","article-title":"Comprehensive genomic characterization of head and neck squamous cell carcinomas","volume":"517","year":"2015","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1158\/1078-0432.CCR-14-2481","article-title":"Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes","volume":"21","author":"Keck","year":"2014","journal-title":"Clin Cancer Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1172\/JCI67010","article-title":"HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas","volume":"123","author":"Kostareli","year":"2013","journal-title":"J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/15592294.2015.1137414","article-title":"Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients","volume":"11","author":"Kostareli","year":"2016","journal-title":"Epigenetics"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1002\/ijc.29649","article-title":"Leipzig head and neck group (LHNG). The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer","volume":"137","author":"Wichmann","year":"2015","journal-title":"Int J Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/carcin\/22.3.433","article-title":"Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics","volume":"22","author":"Yokoyama","year":"2001","journal-title":"Carcinogenesis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1002\/ijc.10234","article-title":"Reduced poly(ADP-ribosyl)ation in lymphocytes of laryngeal cancer patients: results from a case-control study","volume":"98","author":"Rajaee-Behbahani","year":"2002","journal-title":"Int J Cancer"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/ijc.24442","article-title":"Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes","volume":"125","author":"Abbasi","year":"2009","journal-title":"Int J Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.oraloncology.2011.05.004","article-title":"Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer","volume":"47","author":"Anantharaman","year":"2011","journal-title":"Oral Oncol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s13167-011-0082-1","article-title":"Head and neck cancer: effective prevention in youth and predictive diagnostics for personalised treatment strategies according to biological differences","volume":"2","author":"Dietz","year":"2011","journal-title":"EPMA J"},{"key":"B14","article-title":"HPV Infection","volume-title":"Head and Neck Cancer","author":"Golusi\u0144ski","year":"2017"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1002\/ijc.28142","article-title":"Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway","volume":"133","author":"Holzinger","year":"2013","journal-title":"Int J Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrc.2018.11","article-title":"The molecular landscape of head and neck cancer","volume":"18","author":"Leemans","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1159\/000101542","article-title":"Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma","volume":"69","author":"Wreesmann","year":"2007","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"B18","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1159\/000292104","article-title":"Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers","volume":"72","author":"Smith","year":"2010","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"B19","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.oraloncology.2017.04.017","article-title":"HLA traits linked to development of head and neck squamous cell carcinoma affect the progression-free survival of patients","volume":"69","author":"Wichmann","year":"2017","journal-title":"Oral Oncol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ejca.2016.11.013","article-title":"Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and 18F-FDG-PET\/CT","volume":"72","author":"Wichmann","year":"2017","journal-title":"Eur J Cancer"},{"key":"B21","volume-title":"DeLOS-II. Randomised Phase II Screening Study To The Use Of A TPF-Chemotherapy (Short Induction) Before TPF Induction, Radiotherapy With Or Without Cetuximab In The Primary Therapy Of The Only By Laryngectomy Operable Carcinoma Of The Larynx\/Hypopharynx. EudraCT-Nr.: 2006-006091-38. Clinical Trials.Gov, NCT00508664","author":"Dietz","year":"2007"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer. The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/bjc.1990.437","article-title":"Lack of MHC class I antigens and tumour aggressiveness of the squamous cell carcinoma of the larynx","volume":"62","author":"Esteban","year":"1990","journal-title":"Br J Cancer"},{"key":"B25","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1034\/j.1399-0039.1999.540304.x","article-title":"HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomas","volume":"54","author":"Feenstra","year":"1999","journal-title":"Tissue Antigens"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2172-9-1","article-title":"HLA class I supertypes: a revised and updated classification","volume":"9","author":"Sidney","year":"2008","journal-title":"BMC Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.4161\/onci.21511","article-title":"In silico prediction of tumor antigens derived from functional missense mutations of the cancer gene census","volume":"1","author":"Khalili","year":"2012","journal-title":"Oncoimmunology"},{"key":"B28","first-page":"24","article-title":"Immune cell infiltration patterns and survival in head and neck squamous cell carcinoma","volume":"5","author":"Russell","year":"2013","journal-title":"Head Neck Oncol"},{"key":"B29","first-page":"37","article-title":"Evaluation: from precision, recall and F-measure to ROC, informedness, markedness and correlation","volume":"2","author":"Powers","year":"2011","journal-title":"J Mach Learn Tech"},{"key":"B30","article-title":"New approaches to the population genetic and segregation analysis of the HL-A system","volume-title":"Histocompatibility Testing 1970","author":"Mattiuz","year":"1970"},{"key":"B31","first-page":"1438","article-title":"Meningioma: is there an association with human leukocyte antigens?","volume":"12","author":"Machulla","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B32","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/S0198-8859(98)00054-8","article-title":"Validation of haplotype frequency estimation methods","volume":"59","author":"Schipper","year":"1998","journal-title":"Hum Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S1470-2045(13)70181-5","article-title":"SPECTRUM investigators. Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial","volume":"14","author":"Vermorken","year":"2013","journal-title":"Lancet Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2018.00168\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T07:52:17Z","timestamp":1526543537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2018.00168\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,17]]},"references-count":33,"alternative-id":["10.3389\/fonc.2018.00168"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2018.00168","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,17]]},"article-number":"168"}}