{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:57:01Z","timestamp":1790834221233,"version":"4.1.0"},"reference-count":141,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","award":["U54CA224019, U01CA217862"],"award-info":[{"award-number":["U54CA224019, U01CA217862"]}],"id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2018.00213","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T04:36:46Z","timestamp":1528864606000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":110,"title":["Targeting the Immune Microenvironment in Acute Myeloid Leukemia: A Focus on T Cell Immunity"],"prefix":"10.3389","volume":"8","author":[{"given":"Adam J.","family":"Lamble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan F.","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1002\/cncr.22233","article-title":"Acute myeloid leukemia: epidemiology and etiology","volume":"107","author":"Deschler","year":"2006","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1182\/blood.V75.3.555.555","article-title":"Graft-versus-leukemia reactions after bone marrow transplantation","volume":"75","author":"Horowitz","year":"1990","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","article-title":"Accessories to the crime: functions of cells recruited to the tumor microenvironment","volume":"21","author":"Hanahan","year":"2012","journal-title":"Cancer Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.cell.2017.04.016","article-title":"An immune atlas of clear cell renal cell carcinoma","volume":"169","author":"Chevrier","year":"2017","journal-title":"Cell"},{"key":"B5","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cell.2017.07.025","article-title":"Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient","volume":"170","author":"Jim\u00e9nez-S\u00e1nchez","year":"2017","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1002\/ijc.23042","article-title":"Augmented expression of programmed death-1 in both neoplastic and non-neoplastic CD4+ T-cells in adult T-cell leukemia\/lymphoma","volume":"121","author":"Shimauchi","year":"2007","journal-title":"Int J Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/leu.2008.272","article-title":"PD-1\/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia\/lymphoma patients","volume":"23","author":"Kozako","year":"2009","journal-title":"Leukemia"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1182\/blood-2008-09-179697","article-title":"Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression","volume":"114","author":"Mumprecht","year":"2009","journal-title":"Blood"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e55818","DOI":"10.1371\/journal.pone.0055818","article-title":"Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1\/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia","volume":"8","author":"Christiansson","year":"2013","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1158\/1078-0432.CCR-11-2630","article-title":"Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression","volume":"18","author":"Nunes","year":"2012","journal-title":"Clin Cancer Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1182\/blood-2012-09-457531","article-title":"T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production","volume":"121","author":"Riches","year":"2013","journal-title":"Blood"},{"key":"B12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3324\/haematol.2013.098459","article-title":"Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia","volume":"99","author":"Gassner","year":"2014","journal-title":"Haematologica"},{"key":"B13","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1056\/NEJMoa020177","article-title":"Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer","volume":"348","author":"Zhang","year":"2003","journal-title":"N Engl J Med"},{"key":"B14","first-page":"3932","article-title":"Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas","volume":"61","author":"Schumacher","year":"2001","journal-title":"Cancer Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e76379","DOI":"10.1371\/journal.pone.0076379","article-title":"Tumor secretion of CCL22 activates intratumoral Treg infiltration and is independent prognostic predictor of breast cancer","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1016\/0959-8049(94)E0159-2","article-title":"Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma","author":"Vesalainen","year":"1994","journal-title":"Eur J Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1038\/bjc.2013.556","article-title":"The in situ local immune response, tumour senescence and proliferation in colorectal cancer","volume":"109","author":"Roxburgh","year":"2013","journal-title":"Br J Cancer"},{"key":"B18","first-page":"5132","article-title":"Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity","volume":"61","author":"Nakano","year":"2001","journal-title":"Cancer Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.1158\/1078-0432.CCR-16-2047","article-title":"The interplay between neutrophils and CD8(+) T cells improves survival in human colorectal cancer","volume":"23","author":"Governa","year":"2017","journal-title":"Clin Cancer Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s12185-016-2153-5","article-title":"Bone marrow T-cell percentage: a novel prognostic indicator in acute myeloid leukemia","volume":"105","author":"Ismail","year":"2017","journal-title":"Int J Hematol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1158\/2326-6066.CIR-16-0193","article-title":"Regulatory T cells: differentiation and function","volume":"4","author":"Plitas","year":"2016","journal-title":"Cancer Immunol Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1111\/febs.13656","article-title":"Targeting regulatory T cells in tumors","volume":"283","author":"Liu","year":"2016","journal-title":"FEBS J"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3909","DOI":"10.1182\/blood-2009-02-206946","article-title":"Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts","volume":"114","author":"Le Dieu","year":"2009","journal-title":"Blood"},{"key":"B24","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fimmu.2017.00064","article-title":"Kinetics of cytotoxic lymphocytes reconstitution after induction chemotherapy in elderly AML patients reveals progressive recovery of normal phenotypic and functional features in NK cells","volume":"8","author":"Rey","year":"2017","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0145-2126(97)00152-5","article-title":"Peripheral blood lymphocyte subset shifts in patients with untreated hematological tumors: evidence for systemic activation of the T cell compartment","volume":"22","author":"Van den Hove","year":"1998","journal-title":"Leuk Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1471-2172-11-38","article-title":"Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells","volume":"11","author":"Ersvaer","year":"2010","journal-title":"BMC Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1182\/blood-2010-04-277939","article-title":"Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells","volume":"117","author":"Kanakry","year":"2011","journal-title":"Blood"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1002\/ijc.25791","article-title":"Elevated frequencies of CD4(+) CD25(+) CD127lo regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia","volume":"129","author":"Shenghui","year":"2011","journal-title":"Int J Cancer"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1158\/1078-0432.CCR-08-3010","article-title":"Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia","volume":"15","author":"Szczepanski","year":"2009","journal-title":"Clin Cancer Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/j.1600-0609.2005.00537.x","article-title":"Increased population of CD4(+)CD25(high), regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients","volume":"75","author":"Wang","year":"2005","journal-title":"Eur J Haematol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/sj.leu.2402835","article-title":"Quantification and cytokine production of circulating lymphoid and myeloid cells in acute myelogenous leukaemia","volume":"17","author":"Panoskaltsis","year":"2003","journal-title":"Leukemia"},{"key":"B32","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/BF01715050","article-title":"Lymphoid subsets in acute myeloid leukemias: increased number of cells with NK phenotype and normal T-cell distribution","volume":"67","author":"Vidriales","year":"1993","journal-title":"Ann Hematol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature05115","article-title":"PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression","volume":"443","author":"Day","year":"2006","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1084\/jem.187.9.1383","article-title":"Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes","volume":"187","author":"Gallimore","year":"1998","journal-title":"J Exp Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/362758a0","article-title":"Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells","volume":"362","author":"Moskophidis","year":"1993","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e1002840","DOI":"10.1371\/journal.ppat.1002840","article-title":"CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction","volume":"8","author":"Peretz","year":"2012","journal-title":"PLoS Pathog"},{"key":"B37","doi-asserted-by":"publisher","first-page":"4805","DOI":"10.1182\/blood-2010-11-317297","article-title":"Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection","volume":"117","author":"Yamamoto","year":"2011","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"Zajac","year":"1998","journal-title":"J Exp Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13045-015-0189-2","article-title":"T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment","volume":"8","author":"Schnorfeil","year":"2015","journal-title":"J Hematol Oncol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1182\/blood-2010-01-262071","article-title":"Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia","volume":"116","author":"Kornblau","year":"2010","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","first-page":"4501","DOI":"10.1182\/blood-2010-10-310425","article-title":"Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia","volume":"117","author":"Zhou","year":"2011","journal-title":"Blood"},{"key":"B42","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.leukres.2014.05.014","article-title":"Impaired NK cells and increased T regulatory cell numbers during cytotoxic maintenance therapy in AML","volume":"38","author":"Lichtenegger","year":"2014","journal-title":"Leuk Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1007\/s00262-004-0505-0","article-title":"Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia","volume":"53","author":"Wendelbo","year":"2004","journal-title":"Cancer Immunol Immunother"},{"key":"B44","doi-asserted-by":"publisher","first-page":"5084","DOI":"10.1182\/blood-2011-07-365817","article-title":"Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?","volume":"118","author":"Ustun","year":"2011","journal-title":"Blood"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1182\/blood-2009-03-208181","article-title":"Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia","volume":"114","author":"Zhou","year":"2009","journal-title":"Blood"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14819","article-title":"Beneficial role of increased FOXP3(+) regulatory T-cells in acute myeloid leukaemia therapy response","author":"Menter","year":"2017","journal-title":"Br J Haematol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/bjh.14433","article-title":"Increased regulatory T cell graft content is associated with improved outcome in haematopoietic stem cell transplantation: a systematic review","volume":"176","author":"Fisher","year":"2017","journal-title":"Br J Haematol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1046\/j.1365-2249.2001.01692.x","article-title":"Acute myeloid leukaemia cells secrete a soluble factor that inhibits T and NK cell proliferation but not cytolytic function \u2013 implications for the adoptive immunotherapy of leukaemia","volume":"126","author":"Orleans-Lindsay","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.3324\/haematol.2016.143180","article-title":"Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a growth factor independence 1 dependent manner","volume":"101","author":"Al-Matary","year":"2016","journal-title":"Haematologica"},{"key":"B50","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nm1609","article-title":"Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer","volume":"13","author":"Nagaraj","year":"2007","journal-title":"Nat Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2017.10.001","article-title":"Expression of checkpoint molecules on myeloid-derived suppressor cells","volume":"192","author":"Ballbach","year":"2017","journal-title":"Immunol Lett"},{"key":"B52","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fonc.2015.00107","article-title":"Myeloid derived suppressor cells in chronic myeloid leukemia","volume":"5","author":"Giallongo","year":"2015","journal-title":"Front Oncol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"7339","DOI":"10.1007\/s13277-015-4004-z","article-title":"Myeloid-derived suppressor cells in B cell malignancies","volume":"36","author":"Yazdani","year":"2015","journal-title":"Tumour Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1182\/blood-2016-07-730614","article-title":"MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia","volume":"129","author":"Pyzer","year":"2017","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e1062208","DOI":"10.1080\/2162402X.2015.1062208","article-title":"Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome","volume":"5","author":"Kittang","year":"2016","journal-title":"Oncoimmunology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1182\/blood-2009-03-206672","article-title":"PD-1\/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model","volume":"114","author":"Zhang","year":"2009","journal-title":"Blood"},{"key":"B57","doi-asserted-by":"publisher","first-page":"6021","DOI":"10.4049\/jimmunol.167.10.6021","article-title":"Microenvironment produced by acute myeloid leukemia cells prevents T cell activation and proliferation by inhibition of NF-kappaB, c-Myc, and pRb pathways","volume":"167","author":"Buggins","year":"2001","journal-title":"J Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1182\/blood-2013-01-480129","article-title":"Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment","volume":"122","author":"Mussai","year":"2013","journal-title":"Blood"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e957994","DOI":"10.4161\/21624011.2014.957994","article-title":"Trial watch: IDO inhibitors in cancer therapy","volume":"3","author":"Vacchelli","year":"2014","journal-title":"Oncoimmunology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1172\/JCI31911","article-title":"Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase","volume":"117","author":"Sharma","year":"2007","journal-title":"J Clin Invest"},{"key":"B61","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.it.2016.01.002","article-title":"IDO in the tumor microenvironment: inflammation, counter-regulation, and tolerance","volume":"37","author":"Munn","year":"2016","journal-title":"Trends Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.leukres.2008.06.014","article-title":"Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients\u2019 sera by HPLC and is inducible by IFN-gamma","volume":"33","author":"Corm","year":"2009","journal-title":"Leuk Res"},{"key":"B63","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3109\/10428194.2015.1041388","article-title":"High serum concentration of L-kynurenine predicts unfavorable outcomes in patients with acute myeloid leukemia","volume":"57","author":"Mabuchi","year":"2016","journal-title":"Leuk Lymphoma"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.3109\/10428194.2014.953150","article-title":"Expression of indoleamine 2,3-dioxygenase in leukemic cells indicates an unfavorable prognosis in acute myeloid leukemia patients with intermediate-risk cytogenetics","volume":"56","author":"Fukuno","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.18632\/oncotarget.1504","article-title":"Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia","volume":"5","author":"Folgiero","year":"2014","journal-title":"Oncotarget"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1182\/blood-2006-07-036863","article-title":"Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells","volume":"109","author":"Curti","year":"2007","journal-title":"Blood"},{"key":"B67","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1080\/10245332.2015.1106814","article-title":"Indoleamine 2,3-dioxygenase and regulatory T cells in acute myeloid leukemia","volume":"21","author":"Mansour","year":"2016","journal-title":"Hematology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/MOH.0000000000000158","article-title":"Targeting immune checkpoints in lymphoma","volume":"22","author":"Ansell","year":"2015","journal-title":"Curr Opin Hematol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1182\/blood-2013-05-500801","article-title":"Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality","volume":"122","author":"Saha","year":"2013","journal-title":"Blood"},{"key":"B70","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1056\/NEJMoa1601202","article-title":"Ipilimumab for patients with relapse after allogeneic transplantation","volume":"375","author":"Davids","year":"2016","journal-title":"N Engl J Med"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1182\/blood-2017-10-752154","article-title":"Tyrosine kinase inhibitors and immune checkpoint blockade in allogeneic hematopoietic cell transplantation","volume":"131","author":"Soiffer","year":"2018","journal-title":"Blood"},{"key":"B72","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.4049\/jimmunol.171.7.3459","article-title":"Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes","volume":"171","author":"Maszyna","year":"2003","journal-title":"J Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/1074-7613(94)90071-X","article-title":"CTLA-4 can function as a negative regulator of T cell activation","volume":"1","author":"Walunas","year":"1994","journal-title":"Immunity"},{"key":"B74","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.immuni.2004.06.017","article-title":"B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse","volume":"21","author":"Pentcheva-Hoang","year":"2004","journal-title":"Immunity"},{"key":"B75","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1084\/jem.192.2.303","article-title":"Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4","volume":"192","author":"Takahashi","year":"2000","journal-title":"J Exp Med"},{"key":"B76","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<90::AID-IMMU90>3.0.CO;2-5","article-title":"Regulation of CD80\/B7-1 and CD86\/B7-2 molecule expression in human primary acute myeloid leukemia and their role in allogenic immune recognition","volume":"28","author":"Costello","year":"1998","journal-title":"Eur J Immunol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1182\/blood.V99.6.2146","article-title":"Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia","volume":"99","author":"LaBelle","year":"2002","journal-title":"Blood"},{"key":"B78","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.4049\/jimmunol.156.3.1126","article-title":"B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct","volume":"156","author":"Matulonis","year":"1996","journal-title":"J Immunol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0301-472X(01)00768-8","article-title":"Expression of CD86 in acute myelogenous leukemia is a marker of dendritic\/monocytic lineage","volume":"30","author":"Re","year":"2002","journal-title":"Exp Hematol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/14653240500499507","article-title":"CTLA-4 blockade by a human MAb enhances the capacity of AML-derived DC to induce T-cell responses against AML cells in an autologous culture system","volume":"8","author":"Zhong","year":"2006","journal-title":"Cytotherapy"},{"key":"B81","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.1365-2141.2006.06472.x","article-title":"CTLA-4 expressed by chemoresistant, as well as untreated, myeloid leukaemia cells can be targeted with ligands to induce apoptosis","volume":"136","author":"Laurent","year":"2007","journal-title":"Br J Haematol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1182\/blood-2002-06-1668","article-title":"CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells","volume":"101","author":"Pistillo","year":"2003","journal-title":"Blood"},{"key":"B83","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.coi.2007.04.012","article-title":"PD-1 and its ligands in T-cell immunity","volume":"19","author":"Keir","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"Freeman","year":"2000","journal-title":"J Exp Med"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s00262-011-1104-5","article-title":"Dual biological effects of the cytokines interleukin-10 and interferon-gamma","volume":"60","author":"Wilke","year":"2011","journal-title":"Cancer Immunol Immunother"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.celrep.2017.04.031","article-title":"Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression","volume":"19","author":"Garcia-Diaz","year":"2017","journal-title":"Cell Rep"},{"key":"B87","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1084\/jem.20090847","article-title":"PD-L1 regulates the development, maintenance, and function of induced regulatory T cells","volume":"206","author":"Francisco","year":"2009","journal-title":"J Exp Med"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1007\/s00262-010-0909-y","article-title":"In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors","volume":"59","author":"Berthon","year":"2010","journal-title":"Cancer Immunol Immunother"},{"key":"B89","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/ejh.12228","article-title":"Interferon-induced programmed death-ligand 1 (PD-L1\/B7-H1) expression increases on human acute myeloid leukemia blast cells during treatment","volume":"92","author":"Kr\u00f6nig","year":"2014","journal-title":"Eur J Haematol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1002\/eji.201242814","article-title":"Myeloid leukemia cells with a B7-2(+) subpopulation provoke Th-cell responses and become immuno-suppressive through the modulation of B7 ligands","volume":"43","author":"Dolen","year":"2013","journal-title":"Eur J Immunol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"622","DOI":"10.4161\/cbt.7.5.5689","article-title":"Clinical significance of B7-H1 (PD-L1) expression in human acute leukemia","volume":"7","author":"Chen","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"B92","doi-asserted-by":"publisher","first-page":"463","DOI":"10.21147\/j.issn.1000-9604.2017.05.11","article-title":"Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia","volume":"29","author":"Tan","year":"2017","journal-title":"Chin J Cancer Res"},{"key":"B93","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1182\/blood-2010-03-275446","article-title":"Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia","volume":"116","author":"Zhou","year":"2010","journal-title":"Blood"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1038\/leu.2013.355","article-title":"Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents","volume":"28","author":"Yang","year":"2014","journal-title":"Leukemia"},{"key":"B95","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.immuni.2016.05.001","article-title":"Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation","volume":"44","author":"Anderson","year":"2016","journal-title":"Immunity"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity","volume":"6","author":"Zhu","year":"2005","journal-title":"Nat Immunol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1084\/jem.20100643","article-title":"Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity","volume":"207","author":"Sakuishi","year":"2010","journal-title":"J Exp Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.stem.2010.11.014","article-title":"TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells","volume":"7","author":"Kikushige","year":"2010","journal-title":"Cell Stem Cell"},{"key":"B99","first-page":"6880","article-title":"Tim-3 is highly expressed in T cells in acute myeloid leukemia and associated with clinicopathological prognostic stratification","volume":"7","author":"Li","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"e330","DOI":"10.1038\/bcj.2015.58","article-title":"PD-1(hi)TIM-3(+) T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation","volume":"5","author":"Kong","year":"2015","journal-title":"Blood Cancer J"},{"key":"B101","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.4049\/jimmunol.1103627","article-title":"The TIGIT\/CD226 axis regulates human T cell function","volume":"188","author":"Lozano","year":"2012","journal-title":"J Immunol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1002\/eji.201041136","article-title":"Vstm3 is a member of the CD28 family and an important modulator of T-cell function","volume":"41","author":"Levin","year":"2011","journal-title":"Eur J Immunol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1158\/1078-0432.CCR-15-2626","article-title":"T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8+ T-cell exhaustion and poor clinical outcome in AML patients","volume":"22","author":"Kong","year":"2016","journal-title":"Clin Cancer Res"},{"key":"B104","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.clim.2017.08.021","article-title":"CD8(+) T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in acute myeloid leukemia (AML) patients","volume":"190","author":"Wang","year":"2018","journal-title":"Clin Immunol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1126\/science.aad0095","article-title":"Genomic correlates of response to CTLA-4 blockade in metastatic melanoma","volume":"350","author":"Van Allen","year":"2015","journal-title":"Science"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1126\/science.aaf1490","article-title":"Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade","volume":"351","author":"McGranahan","year":"2016","journal-title":"Science"},{"key":"B107","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1158\/2326-6066.CIR-16-0156","article-title":"Endogenous neoantigen-specific CD8 T cells identified in two glioblastoma models using a cancer immunogenomics approach","volume":"4","author":"Johanns","year":"2016","journal-title":"Cancer Immunol Res"},{"key":"B109","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nature10755","article-title":"Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting","volume":"482","author":"Matsushita","year":"2012","journal-title":"Nature"},{"key":"B110","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13073-016-0264-5","article-title":"pVAC-Seq: a genome-guided in silico approach to identifying tumor neoantigens","volume":"8","author":"Hundal","year":"2016","journal-title":"Genome Med"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1056\/NEJMoa1112304","article-title":"Prognostic relevance of integrated genetic profiling in acute myeloid leukemia","volume":"366","author":"Patel","year":"2012","journal-title":"N Engl J Med"},{"key":"B112","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Ley","year":"2013","journal-title":"N Engl J Med"},{"key":"B113","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"B114","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature10738","article-title":"Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"B115","doi-asserted-by":"publisher","first-page":"4109","DOI":"10.1182\/blood-2006-01-023127","article-title":"Expression of tumor-associated antigens in acute myeloid leukemia: implications for specific immunotherapeutic approaches","volume":"108","author":"Greiner","year":"2006","journal-title":"Blood"},{"key":"B116","doi-asserted-by":"publisher","first-page":"5496","DOI":"10.1038\/sj.onc.1205602","article-title":"Reactivating the expression of methylation silenced genes in human cancer","volume":"21","author":"Karpf","year":"2002","journal-title":"Oncogene"},{"key":"B117","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.leukres.2010.02.004","article-title":"The DNA demethylating agent 5-aza-2\u2019-deoxycytidine induces expression of NY-ESO-1 and other cancer\/testis antigens in myeloid leukemia cells","volume":"34","author":"Almstedt","year":"2010","journal-title":"Leuk Res"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1182\/blood-2009-11-249474","article-title":"Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia","volume":"116","author":"Goodyear","year":"2010","journal-title":"Blood"},{"key":"B119","doi-asserted-by":"publisher","first-page":"368ra171","DOI":"10.1126\/scitranslmed.aag1298","article-title":"Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions","volume":"8","author":"Rosenblatt","year":"2016","journal-title":"Sci Transl Med"},{"key":"B120","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1242\/dev.153163","article-title":"Wilms\u2019 tumour 1 (WT1) in development, homeostasis and disease","volume":"144","author":"Hastie","year":"2017","journal-title":"Development"},{"key":"B121","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1182\/blood.V96.4.1480","article-title":"Immunity to WT1 in the animal model and in patients with acute myeloid leukemia","volume":"96","author":"Gaiger","year":"2000","journal-title":"Blood"},{"key":"B122","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1182\/blood.V99.9.3272","article-title":"Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies","volume":"99","author":"Elisseeva","year":"2002","journal-title":"Blood"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1182\/blood-2002-01-0163","article-title":"CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia","volume":"100","author":"Scheibenbogen","year":"2002","journal-title":"Blood"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1182\/blood-2017-04-780155","article-title":"Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia","volume":"130","author":"Anguille","year":"2017","journal-title":"Blood"},{"key":"B125","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fimmu.2015.00036","article-title":"Review of the results of WT1 peptide vaccination strategies for myelodysplastic syndromes and acute myeloid leukemia from nine different studies","volume":"6","author":"Di Stasi","year":"2015","journal-title":"Front Immunol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.hoc.2010.02.007","article-title":"Epigenetic changes in the myelodysplastic syndrome","volume":"24","author":"Issa","year":"2010","journal-title":"Hematol Oncol Clin North Am"},{"key":"B127","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fimmu.2015.00029","article-title":"Augmenting antitumor immune responses with epigenetic modifying agents","volume":"6","author":"Heninger","year":"2015","journal-title":"Front Immunol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4049\/jimmunol.182.1.259","article-title":"Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation","volume":"182","author":"Lal","year":"2009","journal-title":"J Immunol"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1002\/eji.200838105","article-title":"DNA methylation controls Foxp3 gene expression","volume":"38","author":"Polansky","year":"2008","journal-title":"Eur J Immunol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.cell.2014.07.031","article-title":"Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus","volume":"158","author":"Feng","year":"2014","journal-title":"Cell"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1084\/jem.20070109","article-title":"CREB\/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation","volume":"204","author":"Kim","year":"2007","journal-title":"J Exp Med"},{"key":"B132","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1182\/blood-2009-03-210393","article-title":"Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting","volume":"115","author":"S\u00e1nchez-Abarca","year":"2010","journal-title":"Blood"},{"key":"B133","doi-asserted-by":"publisher","first-page":"3361","DOI":"10.1182\/blood-2011-09-377044","article-title":"Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)","volume":"119","author":"Goodyear","year":"2012","journal-title":"Blood"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3324\/haematol.2012.074823","article-title":"The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome","volume":"98","author":"Costantini","year":"2013","journal-title":"Haematologica"},{"key":"B135","doi-asserted-by":"publisher","first-page":"9612","DOI":"10.18632\/oncotarget.3324","article-title":"Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS\/AML patients: a rationale for combined targeting of PD-1 and DNA methylation","volume":"6","author":"\u00d8rskov","year":"2015","journal-title":"Oncotarget"},{"key":"B136","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cell.2017.03.036","article-title":"Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses","volume":"169","author":"Chiappinelli","year":"2017","journal-title":"Cell"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.cell.2017.10.022","article-title":"Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer","volume":"171","author":"Topper","year":"2017","journal-title":"Cell"},{"key":"B138","doi-asserted-by":"publisher","first-page":"e62924","DOI":"10.1371\/journal.pone.0062924","article-title":"Low dose decitabine treatment induces CD80 expression in cancer cells and stimulates tumor specific cytotoxic T lymphocyte responses","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"B139","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1038\/bcj.2014.14","article-title":"5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies","volume":"4","author":"Gang","year":"2014","journal-title":"Blood Cancer J"},{"key":"B140","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.leukres.2015.06.007","article-title":"Azacitidine improves the T-cell repertoire in patients with myelodysplastic syndromes and acute myeloid leukemia with multilineage dysplasia","volume":"39","author":"Fozza","year":"2015","journal-title":"Leuk Res"},{"key":"B141","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1080\/10428194.2017.1344905","article-title":"The emerging role of immune checkpoint based approaches in AML and MDS","volume":"59","author":"Boddu","year":"2018","journal-title":"Leuk Lymphoma"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2018.00213\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T12:44:10Z","timestamp":1720356250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2018.00213\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":141,"alternative-id":["10.3389\/fonc.2018.00213"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2018.00213","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,13]]},"article-number":"213"}}