{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:09:16Z","timestamp":1790291356832,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2018.00446","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T07:14:26Z","timestamp":1540192466000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["miR-182 and miR-183 Promote Cell Proliferation and Invasion by Targeting FOXO1 in Mesothelioma"],"prefix":"10.3389","volume":"8","author":[{"given":"Rui","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwa Jeet","family":"Amatya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Kushitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Kai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kambara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Takeshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"716","DOI":"10.2471\/BLT.11.086678","article-title":"Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008","volume":"89","author":"Delgermaa","year":"2011","journal-title":"Bull World Health Organ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1183\/09031936.96.09091932","article-title":"The epidemiology of mesothelioma in historical context","volume":"9","author":"McDonald","year":"1996","journal-title":"Eur Respir J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1097\/JTO.0b013e3181f1cf2b","article-title":"Malignant pleural mesothelioma: a population-based study of survival","volume":"5","author":"Milano","year":"2010","journal-title":"J Thorac Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.lungcan.2008.02.013","article-title":"Frequent p16 inactivation by homozygous deletion or methylation is associated with a poor prognosis in Japanese patients with pleural mesothelioma","volume":"62","author":"Kobayashi","year":"2008","journal-title":"Lung Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/jjco\/hyq159","article-title":"Survival and prognostic factors in malignant pleural mesothelioma: a retrospective study of 314 patients in the west part of Japan","volume":"41","author":"Nojiri","year":"2011","journal-title":"Jpn J Clin Oncol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3892\/or.2012.2116","article-title":"CD9 expression as a favorable prognostic marker for patients with malignant mesothelioma","volume":"29","author":"Amatya","year":"2013","journal-title":"Oncol Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.cell.2009.02.005","article-title":"MicroRNAs and cancer: short RNAs go a long way","volume":"136","author":"Ventura","year":"2009","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2174\/15701611113119990012","article-title":"Therapeutic potential of modulating microRNAs in atherosclerotic vascular disease","volume":"13","author":"Araldi","year":"2015","journal-title":"Curr Vasc Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.atherosclerosis.2015.06.037","article-title":"The role of microRNAs in coronary artery disease: from pathophysiology to diagnosis and treatment","volume":"241","author":"Economou","year":"2015","journal-title":"Atherosclerosis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.3892\/ijo.2016.3358","article-title":"Differential microRNA expression profiling of mesothelioma and expression analysis of miR-1 and miR-214 in mesothelioma","volume":"48","author":"Amatya","year":"2016","journal-title":"Int J Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"25053","DOI":"10.1074\/jbc.M700501200","article-title":"MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster","volume":"282","author":"Xu","year":"2007","journal-title":"J Biol Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"6314","DOI":"10.3390\/ijms15046314","article-title":"GPC1 regulated by miR-96-5p, rather than miR-182-5p, in inhibition of pancreatic carcinoma cell proliferation","volume":"15","author":"Li","year":"2014","journal-title":"Int J Mol Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1101\/gad.257394.114","article-title":"miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma","volume":"29","author":"Kouri","year":"2015","journal-title":"Genes Dev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/mc.22741","article-title":"MiR-182 inhibits the epithelial to mesenchymal transition and metastasis of lung cancer cells by targeting the Met gene","volume":"57","author":"Li","year":"2018","journal-title":"Mol Carcinog."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.3892\/ijmm.2012.1111","article-title":"miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells","volume":"30","author":"Zhao","year":"2012","journal-title":"Int J Mol Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.3892\/or.2017.5411","article-title":"Interaction between transcription factors PAX6\/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines","volume":"37","author":"Pavlakis","year":"2017","journal-title":"Oncol Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.biopha.2015.01.016","article-title":"miR-183 induces cell proliferation, migration, and invasion by regulating PDCD4 expression in the SW1990 pancreatic cancer cell line","volume":"70","author":"Lu","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"B19","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/jmcb\/mjr013","article-title":"Applications of post-translational modifications of FoxO family proteins in biological functions","volume":"3","author":"Zhao","year":"2011","journal-title":"J Mol Cell Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.bbrc.2017.09.163","article-title":"FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells","volume":"493","author":"Choi","year":"2017","journal-title":"Biochem Biophys Res Commun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1007\/s13277-015-4425-8","article-title":"miR-411 contributes the cell proliferation of lung cancer by targeting FOXO1","volume":"37","author":"Zhao","year":"2016","journal-title":"Tumour Biol."},{"key":"B22","first-page":"3482","article-title":"MiR-374a promotes the proliferation of human osteosarcoma by downregulating FOXO1 expression","volume":"8","author":"He","year":"2015","journal-title":"Int J Clin Exp Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.1007\/s13277-015-3123-x","article-title":"Interplay of miR-21 and FoxO1 modulates growth of pancreatic ductal adenocarcinoma","volume":"36","author":"Song","year":"2015","journal-title":"Tumour Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"7195","DOI":"10.1007\/s13277-014-1913-1","article-title":"Inhibition of FoxO1 nuclear exclusion prevents metastasis of glioblastoma","volume":"35","author":"Chen","year":"2014","journal-title":"Tumour Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1158\/0008-5472.CAN-09-1891","article-title":"Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer","volume":"70","author":"Myatt","year":"2010","journal-title":"Cancer Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2144\/000112257","article-title":"CellProfiler: free, versatile software for automated biological image analysis","volume":"42","author":"Lamprecht","year":"2007","journal-title":"Biotechniques"},{"key":"B27","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2144\/000113083","article-title":"TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays","volume":"46","author":"Geb\u00e4ck","year":"2009","journal-title":"Biotechniques"},{"key":"B28","doi-asserted-by":"publisher","first-page":"23204","DOI":"10.1074\/jbc.M109.031427","article-title":"Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells","volume":"284","author":"Guttilla","year":"2009","journal-title":"J Biol Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/ijc.23874","article-title":"Survival of pleural malignant mesothelioma in Italy: a population-based study","volume":"124","author":"Montanaro","year":"2009","journal-title":"Int J Cancer"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/S0140-6736(15)01238-6","article-title":"Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial","volume":"387","author":"Zalcman","year":"2016","journal-title":"Lancet"},{"key":"B31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4103\/2229-3485.179431","article-title":"MicroRNA therapeutics: discovering novel targets and developing specific therapy","volume":"7","author":"Christopher","year":"2016","journal-title":"Perspect Clin Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"78193","DOI":"10.18632\/oncotarget.20409","article-title":"Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma","volume":"8","author":"Birnie","year":"2017","journal-title":"Oncotarget"},{"key":"B33","doi-asserted-by":"publisher","first-page":"8121","DOI":"10.1007\/s13277-015-3550-8","article-title":"MiR-183 promotes growth of non-small cell lung cancer cells through FoxO1 inhibition","volume":"36","author":"Zhang","year":"2015","journal-title":"Tumour Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.immuni.2016.05.015","article-title":"The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor foxo1 expression","volume":"44","author":"Ichiyama","year":"2016","journal-title":"Immunity"},{"key":"B35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0092-8674(90)90439-L","article-title":"The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?","volume":"63","author":"Weigel","year":"1990","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1038\/onc.2008.24","article-title":"FOXOs, cancer and regulation of apoptosis","volume":"27","author":"Fu","year":"2008","journal-title":"Oncogene"},{"key":"B37","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nrc839","article-title":"The phosphatidylinositol 3-Kinase AKT pathway in human cancer","volume":"2","author":"Vivanco","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.bbamcr.2011.03.013","article-title":"Interplay between FOXO, TOR, and Akt","volume":"1813","author":"Hay","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"B39","doi-asserted-by":"publisher","first-page":"6524","DOI":"10.1158\/0008-5472.CAN-17-0686","article-title":"Loss of FOXO1 Cooperates with TMPRSS2-ERG overexpression to promote prostate tumorigenesis and cell invasion","volume":"77","author":"Yang","year":"2017","journal-title":"Cancer Res."}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2018.00446\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T07:14:27Z","timestamp":1540192467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2018.00446\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,22]]},"references-count":39,"alternative-id":["10.3389\/fonc.2018.00446"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2018.00446","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,22]]},"article-number":"446"}}