{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:37:05Z","timestamp":1790498225367,"version":"4.1.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    A scorpion peptide reported to exhibit both analgesic and antitumor activity in animal models may present as an alternative therapeutic agent for breast cancer. We aimed to investigate the effect of\n                    <jats:italic>Buthus martensii Karsch<\/jats:italic>\n                    antitumor-analgesic peptide (BmK AGAP) on breast cancer cell stemness and epithelial-mesenchymal transition (EMT). We treated MCF-7 and MDA-MB-231 cells with different concentrations of rBmK AGAP and observed that rBmK AGAP inhibited cancer cell stemness, epithelial-mesenchymal transition (EMT), migration, and invasion. Analysis by qPCR, ELISA, western blot, immunofluorescence staining, sphere formation, colony assay, transwell migration, and invasion assays demonstrated rBmK AGAP treatment decreased the expressions of Oct4, Sox2, N-cadherin, Snail, and increased the expression of E-cadherin. rBmK AGAP inhibited breast cancer cell stemness, EMT, migration, and invasion by down-regulating PTX3 through NF-\u03baB and Wnt\/\u03b2-catenin signaling Pathway\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Xenograft tumor model confirmed inhibition of tumor growth, stem-like features, and EMT by rBmK AGAP. Thus, rBmK AGAP is a potential therapeutic agent against breast cancer and related pain.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2019.00021","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T23:16:51Z","timestamp":1548371811000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":57,"title":["Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer"],"prefix":"10.3389","volume":"9","author":[{"given":"Sylvanus","family":"Kampo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulbul","family":"Ahmmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Owusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Winsum","family":"Anabah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha Raissa","family":"Doudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene Dogkotenge","family":"Kuugbee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1245\/s10434-014-4313-2","article-title":"FOXA1 expression significantly predict response to chemotherapy in estrogen receptor-positive breast cancer patients","volume":"22","author":"Xu","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1111\/j.1349-7006.2010.01493.x","article-title":"Up-regulation of proinflammatory genes as an adaptation to hypoxia in MCF-7 cells and human mammary invasive carcinoma microenvironment","volume":"101","author":"Tafani","year":"2010","journal-title":"Cancer Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/biof.21","article-title":"Pentraxin; multifunctional proteins at the interface of innate immunity and inflammation","volume":"35","author":"Deban","year":"2009","journal-title":"Biofactors"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.1007\/s13277-015-4361-7","article-title":"Emerging prognostic markers related to mesenchymal characteristics of poorly differentiated breast cancer","volume":"4","author":"Scimeca","year":"2015","journal-title":"Tumor Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.18632\/oncotarget.2894","article-title":"Morphine promote cancer stem cell properties, contributing to chemoresistance in breast cancer","volume":"6","author":"Niu","year":"2015","journal-title":"Oncotarget"},{"key":"B8","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3389\/fphys.2017.00510","article-title":"Fentanyl promote breast cancer cell stemness and epithelial-mesenchymal transition by upregulating \u03b11, 6-fucosylation via Wnt\/\u03b2-catenin signaling pathway","volume":"8","author":"Yang","year":"2017","journal-title":"Front Physiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1213\/ANE.0b013e31820568af","article-title":"The novel role of the mu opioid receptor in lung cancer progression; a laboratory investigation","volume":"112","author":"Mathew","year":"2011","journal-title":"Anesth Analg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e91577","DOI":"10.1371\/journal.pone.0091577","article-title":"The Mu opioid receptor promote opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer","volume":"9","author":"Lennon","year":"2014","journal-title":"PLoS ONE"},{"key":"B11","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/nrc2499","article-title":"Cancer stem cells in solid tumors: accumulating evidence and unresolved questions","volume":"8","author":"Visvader","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumor stem cells and drug resistance","volume":"5","author":"Dean","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"B13","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.semcancer.2012.04.001","article-title":"Cancer stem cells and epithelial-mesenchymal transition: concept and molecular links","volume":"22","author":"Sheel","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.1038\/onc.2010.215","article-title":"EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer","volume":"29","author":"Sing","year":"2010","journal-title":"Oncogene"},{"key":"B15","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.ceb.2005.08.001","article-title":"Molecular requirement for epithelial-mesenchymal transition during tumor progression","volume":"17","author":"Huber","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transition in tumor progression","volume":"2","author":"Thierry","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"34705","DOI":"10.1371\/journal.pone.0034705","article-title":"A multi-cancer mesenchymal transition gene expression signature is associated with prolonged time to recurrence in glioblastoma","volume":"7","author":"Cheng","year":"2012","journal-title":"PLoS ONE"},{"key":"B18","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/j.1365-2559.2005.02156.x","article-title":"E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance","volume":"46","author":"Rakha","year":"2005","journal-title":"Histopathology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1046\/j.1365-2168.2000.01513.x","article-title":"E-cadherin-catenin cell-cell adhesion complex and human cancer","volume":"87","author":"Wijnhoven","year":"2000","journal-title":"Br J Surg."},{"key":"B20","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.oraloncology.2012.02.024","article-title":"Is E-cadherin immunoexpression a prognostic factor for head and neck squamous cell carcinoma (HNSCC)? A systematic review and meta-analysis","volume":"48","author":"Zhao","year":"2012","journal-title":"Oral Oncol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/modpathol.3800041","article-title":"Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer:a study utilizing high-density tissue microarray and immunohistochemistry","volume":"17","author":"Deeb","year":"2004","journal-title":"Mod Pathol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1158\/0008-5472.CAN-06-1479","article-title":"Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel","volume":"67","author":"Cheng","year":"2007","journal-title":"Cancer Res."},{"key":"B23","first-page":"20","article-title":"The biochemical research on scorpion venoms and their application in therapy","volume":"56","author":"Zhou","year":"1984","journal-title":"Progr Biochem Biophys"},{"key":"B24","first-page":"273","article-title":"Isolation, purification and a study on the analgesic effect of the analgesic peptide from scorpion venom of Buthus martensii Karsch","volume":"11","author":"Wang","year":"1994","journal-title":"J Shenyang Coll Pharm."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1002\/bmc.882","article-title":"Purification and characterization of an analgesic peptide from Buthus martensii Karsch","volume":"21","author":"Shao","year":"2007","journal-title":"Biomed Chromatogr."},{"key":"B26","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1081\/PB-120015456","article-title":"Isolation purification, and N-terminal partial sequence of an anti-tumor-analgesic peptide from the venom of the Chinese scorpion Buthus martensii Karsch","volume":"32","author":"Liu","year":"2002","journal-title":"Prep Biochem Biotechnol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.bbrc.2010.02.179","article-title":"Location of the analgesic domain of scorpion toxin BmK AGAP by mutagenesis of disulfide bridges","volume":"394","author":"Ma","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1744806918761238","article-title":"Inhibition of spinal MARPKs by scorpion venom peptide BmK AGAP produces a sensory-specific analgesic effect","volume":"14","author":"Ruan","year":"2018","journal-title":"Mole Pain"},{"key":"B29","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1046-5928(02)00609-5","article-title":"Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii Karsch in Escherichia coli","volume":"27","author":"Liu","year":"2003","journal-title":"Prot Exp Purif"},{"key":"B30","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3389\/fphar.2016.00496","article-title":"Antinociceptive effects of AGAP, a recombinant neurotoxic polypeptide: possible involvement of the tetrodotoxin-resistant sodium channels in small dorsal root ganglia neurons","volume":"7","author":"Li","year":"2016","journal-title":"Front. Pharmacol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0146052","DOI":"10.1371\/journal.pone.0146052","article-title":"What do we learn from spheroid culture system? insights from tumor spheres derived from primary colon cancer tissue","volume":"11","author":"Qureshi-Baig","year":"2016","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s10911-012-9258-0","article-title":"Determining mammosphere-forming potential: application of limiting dilution analysis","volume":"17","author":"Rota","year":"2012","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"B33","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0167-5699(84)90137-3","article-title":"Limiting dilution analysis of cells of immune system I. The clonal basis of the immune response","volume":"5","author":"Lefkovits","year":"1984","journal-title":"Immunol Today"},{"key":"B34","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/ppul.23199","article-title":"Pentraxin 3 as a clinical marker in children with lower respiratory tract infection","volume":"51","author":"Kim","year":"2015","journal-title":"Pediatr Pulmonol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e4674","DOI":"10.1126\/scisignal.aah4674","article-title":"Pentraxin-3 is a P13K signaling target that promotes stem cell-like traits in basal-like breast cancers","volume":"10","author":"Thomas","year":"2017","journal-title":"Sci Signal"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3711","DOI":"10.4161\/cc.22048","article-title":"Functional roles of pluripotency transcription factors in mesenchymal stem cells","volume":"11","author":"Tsai","year":"2012","journal-title":"Cell Cycle"},{"key":"B37","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.1365-2443.2010.01400.x","article-title":"Role of SOX2 in maintaining pluripotency of human embryonic stem cells","volume":"15","author":"Adachi","year":"2010","journal-title":"Genes Cells"},{"key":"B38","doi-asserted-by":"publisher","first-page":"481","DOI":"10.18632\/oncotarget.1664","article-title":"Elevated Pentraxin 3 in bone metastatic breast cancer is correlated with osteolytic function","volume":"5","author":"Choi","year":"2014","journal-title":"Oncotarget"},{"key":"B39","doi-asserted-by":"publisher","first-page":"352","DOI":"10.4161\/chan.21910","article-title":"Voltage-gated sodium channels and metastatic disease","volume":"6","author":"Brackenbury","year":"2012","journal-title":"Channels"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1002\/jcb.23166","article-title":"Analgesic-antitumor peptide inhibits proliferation and migration of SHG-44 human malignant glioma cells","volume":"112","author":"Zhao","year":"2011","journal-title":"J Cell Biochem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S1535-6108(02)00154-X","article-title":"\u03b2-catenin interacts with and inhibits NF-kB in human colon and breast cancer","volume":"2","author":"Deng","year":"2002","journal-title":"Cancer Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1093\/annonc\/mdm056","article-title":"Prevalence of pain in patients with cancer: a systematic review of the past 40 years","volume":"18","author":"van den","year":"2007","journal-title":"Ann Oncol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1093\/annonc\/mdp001","article-title":"Cancer-related pain: a pan-European survey of prevalence, treatment, and patients attitudes","volume":"20","author":"Breivik","year":"2009","journal-title":"Ann Oncol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3892\/ol.2012.1049","article-title":"Analgesic \u2013 antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells","volume":"5","author":"Gu","year":"2013","journal-title":"Oncol Lett"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1007\/s13277-015-4067-x","article-title":"Analgesic-Antitumor peptide inhibits the migration and invasion of HepG2 cells by an unregulated VGSC \u03b21, subunit","volume":"37","author":"Guo","year":"2015","journal-title":"Tumor Biol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ccr.2005.02.013","article-title":"Smoldering and polarized inflammation in the initiation and promotion of malignant disease","volume":"7","author":"Balkwill","year":"2005","journal-title":"Cancer Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"B49","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/emmm.200900043","article-title":"Inflammation and EMT: an alliance towards organ fibrosis and cancer progression","volume":"1","author":"L\u00f3pez-Novoa","year":"2009","journal-title":"EMBO Mol Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.3748\/wjg.v12.i18.2884","article-title":"Non-steroidal anti-inflammation drugs in the prevention of gastric cancer","volume":"12","author":"Dai","year":"2006","journal-title":"World J Gastroenterol"},{"key":"B51","first-page":"1322","article-title":"Aspirin use and risk of fatal cancer","volume":"53","author":"Tun","year":"1993","journal-title":"Cancer Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1093\/jnci\/djg106","article-title":"Non-steroidal anti-inflammatory drugs use and the risk of gastric cancer: a systematic review and meta-analysis","volume":"95","author":"Wang","year":"2003","journal-title":"J Nat Cancer Inst"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1016\/j.jhep.2016.02.029","article-title":"The pentraxin PTX3 and SAP in innate immunity regulation of inflammation and tissue remodeling","volume":"64","author":"Bottazzi","year":"2016","journal-title":"J Hepatol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.imlet.2014.04.012","article-title":"The yin-yang of the long pentraxin PTX3 in inflammation and immunity","volume":"161","author":"Daigo","year":"2014","journal-title":"Immunol Lett"},{"key":"B55","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.cell.2015.01.004","article-title":"PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer","volume":"160","author":"Bonavita","year":"2015","journal-title":"Cell"},{"key":"B56","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1074\/jbc.272.13.8172","article-title":"Characterization of the promoter for the human long pentraxin PTX3: role of NF-\u03baB in tumor necrosis factor-\u03b1 and interleukin-1\u03b2 regulation","volume":"272","author":"Basile","year":"1997","journal-title":"J. Biol. Chem"},{"key":"B57","doi-asserted-by":"publisher","first-page":"41364","DOI":"10.18632\/oncotarget.17326","article-title":"Oleate-induced PTX3 promotes head and neck squamous cell carcinoma metastasis through the up-regulation of vimentin","volume":"8","author":"Chan","year":"2017","journal-title":"Oncotarget"},{"key":"B58","doi-asserted-by":"publisher","first-page":"23987","DOI":"10.18632\/oncotarget.4364","article-title":"Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistance cancers","volume":"6","author":"Chi","year":"2015","journal-title":"Oncotarget"},{"key":"B59","doi-asserted-by":"publisher","first-page":"7741","DOI":"10.18632\/oncotarget.3482","article-title":"PTX3 gene activation in EGF-induced head and neck cancer cell metastasis","volume":"6","author":"Chang","year":"2015"},{"key":"B60","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrc3204","article-title":"The diverse and complex roles of NF-kappaB subunits in cancer","volume":"12","author":"Perkins","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"B61","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-kB in cancer development and progression","volume":"441","author":"Karim","year":"2006","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e014442","DOI":"10.1371\/journal.pone.0144462","article-title":"Curcumin inhibits non-small cell lung cancer cells metastasis through the adiponectin\/NF-kB\/MMPs signaling pathway","volume":"10","author":"Tsai","year":"2015","journal-title":"PLoS ONE"},{"key":"B63","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00249-004-0389-0","article-title":"Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspect","volume":"33","author":"Diss","year":"2004","journal-title":"Eur Biophys J"},{"key":"B64","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.molmed.2010.01.005","article-title":"Ion channels and the hallmarks of Cancer","volume":"16","author":"Prevarskaya","year":"2010","journal-title":"Trends Mol Med"},{"key":"B65","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.1158\/1078-0432.CCR-05-0327","article-title":"Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis","volume":"11","author":"Fraser","year":"2005","journal-title":"Clin Cancer Res"},{"key":"B66","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s12974-015-0349-x","article-title":"Tumor necrosis factor-\u03b1 enhances voltage-gated Na+ currents in primary culture of mouse cortical neurons","volume":"12","author":"Chen","year":"2015","journal-title":"J Neuroinflamm"},{"key":"B67","first-page":"153","article-title":"Ion channel activity and cancer cells proliferation: a short review with particular reference to prostate cancer","volume-title":"Ion Channels and Physiopathology of Nerve Conduction and Cell Proliferation","author":"Fraser","year":"2002"},{"key":"B68","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.peptides.2010.03.017","article-title":"Structure and functional relationship of toxin from Chinese scorpion Buthus martensii Karsch (BmK AGAP): gaining insight into related sites of analgesic activity","volume":"31","author":"Cui","year":"2010","journal-title":"Peptide"},{"key":"B69","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/mc.10169","article-title":"Cross-regulation of NF-kB by the APC\/GSK-3beta-catenin pathway","volume":"39","author":"Deng","year":"2004","journal-title":"Mol Carcinog."},{"key":"B70","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10585-010-9367-3","article-title":"A system view of epithelial-mesenchymal transition signaling states","volume":"28","author":"Thomas","year":"2011","journal-title":"Clin Exp Metast"},{"key":"B71","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3389\/fimmu.2016.00378","article-title":"Crosstalk between Wnt\/\u03b2-catenin and NF-kB signaling pathway during inflammation","volume":"7","author":"Ma","year":"2016","journal-title":"Front Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nrc1694","article-title":"Migrating cancer stem cells: an integrated concept of malignant tumor progression","volume":"5","author":"Brabletz","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"B73","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1172\/JCI200421358","article-title":"NF-\u03baB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression","volume":"114","author":"Huber","year":"2004","journal-title":"J Clin Invest"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1126\/science.1094291","article-title":"Convergence of Wnt, beta-catenin, and cadherin pathways","volume":"303","author":"Nelson","year":"2004","journal-title":"Science"},{"key":"B75","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1349-7006.2011.02131.x","article-title":"Subtype-specific alterations of Wnt signaling pathway in breast cancer","volume":"103","author":"Mukherjee","year":"2012","journal-title":"Clin. Progn. Signif. Cancer Sci"},{"key":"B76","doi-asserted-by":"publisher","first-page":"E65","DOI":"10.3390\/jcm5070065","article-title":"EMT in breast carcinoma- a review","volume":"5","author":"Lima","year":"2016","journal-title":"J Clin Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"17083","DOI":"10.1371\/journal.pone.0017083","article-title":"An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer","volume":"6","author":"Katz","year":"2001","journal-title":"PLoS ONE"},{"key":"B78","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/modpathol.2010.205","article-title":"\u03b2-catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNBI mutation","volume":"24","author":"Geyer","year":"2011","journal-title":"Mod Pathol"}],"updated-by":[{"DOI":"10.3389\/fonc.2021.639813","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000}}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2019.00021\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T21:53:13Z","timestamp":1625003593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2019.00021\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":78,"alternative-id":["10.3389\/fonc.2019.00021"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2019.00021","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,25]]},"article-number":"21"}}