{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:20:11Z","timestamp":1773750011831,"version":"3.50.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2019.00697","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T04:30:50Z","timestamp":1564547450000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Incorporation of Dosimetric Gradients and Parotid Gland Migration Into Xerostomia Prediction"],"prefix":"10.3389","volume":"9","author":[{"given":"Rosario","family":"Astaburuaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert S.","family":"Gabry\u015b","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"S\u00e1nchez-Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf O.","family":"Floca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Kl\u00fcter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hauswald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Bangert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B2","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.radonc.2012.02.006","article-title":"Novel approaches to improve the therapeutic index of head and neck radiotherapy: an analysis of data from the PARSPORT randomised phase III trial","volume":"103","author":"Buettner","year":"2012","journal-title":"Radiother. Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.radonc.2016.05.015","article-title":"Normal tissue complication probability (NTCP) modelling using spatial dose metrics and machine learning methods for severe acute oral mucositis resulting from head and neck radiotherapy","volume":"120","author":"Dean","year":"2016","journal-title":"Radiother Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fonc.2018.00035","article-title":"Design and selection of machine learning methods using radiomics and dosiomics features for NTCP modeling of xerostomia","volume":"8","author":"Gabry\u015b","year":"2018","journal-title":"Front Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.radonc.2018.06.012","article-title":"Parotid gland fat related Magnetic Resonance image biomarkers improve prediction of late radiation-induced xerostomia","volume":"128","author":"van Dijk","year":"2018","journal-title":"Radiother Oncol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ctro.2017.11.009","article-title":"Incorporating spatial dose metrics in machine learning-based normal tissue complication probability (NTCP) models of severe acute dysphagia resulting from head and neck radiotherapy","volume":"8","author":"Dean","year":"2018","journal-title":"Clin Transl Radiat Oncol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nrclinonc.2012.194","article-title":"Image-guided radiotherapy: from current concept to future perspectives","volume":"9","author":"Jaffray","year":"2012","journal-title":"Nat Rev Clin Oncol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.ijrobp.2012.03.034","article-title":"Normal tissue complication probability modeling of radiation-induced hypothyroidism after head-and-neck radiation therapy","volume":"85","author":"Bakhshandeh","year":"2013","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep26378","article-title":"LASSO-based NTCP model for radiation-induced temporal lobe injury developing after intensity- modulated radiotherapy of nasopharyngeal carcinoma","volume":"6","author":"Kong","year":"2016","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1186\/s12885-018-4348-z","article-title":"Development of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in nasopharyngeal carcinoma patients","volume":"18","author":"Luo","year":"2018","journal-title":"BMC Cancer."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13014-018-0961-x","article-title":"Fitting NTCP models to bladder doses and acute urinary symptoms during post-prostatectomy radiotherapy","volume":"13","author":"Mavroidis","year":"2018","journal-title":"Radiat Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0200192","DOI":"10.1371\/journal.pone.0200192","article-title":"Relationships among patient characteristics, irradiation treatment planning parameters, and treatment toxicity of acute radiation dermatitis after breast hybrid intensity modulation radiation therapy","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS ONE."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijrobp.2009.06.093","article-title":"Accurate accumulation of dose for improved understanding of radiation effects in normal tissue","volume":"1","author":"Jaffray","year":"2010","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B14","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1118\/1.4905050","article-title":"Towards adaptive radiotherapy for head and neck patients: uncertainties in dose warping due to the choice of deformable registration algorithm","volume":"42","author":"Veiga","year":"2015","journal-title":"Med Phys."},{"key":"B15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/sj.bdj.4807284","article-title":"Saliva and dental health. Clinical implications of saliva: report of a consensus meeting","volume":"169","author":"Edgar","year":"1990","journal-title":"Br Dent J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1067\/mpr.2001.113778","article-title":"A review of saliva: normal composition, flow, and function","volume":"85","author":"Humphrey","year":"2001","journal-title":"J Prosthet Dent."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1002\/cncr.22302","article-title":"Radiation-induced xerostomia in patients with head and neck cancer: a literature review","volume":"107","author":"Dirix","year":"2006","journal-title":"Cancer."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.ijrobp.2009.07.1685","article-title":"A Comparison of dose\u2013response models for the parotid gland in a large group of head\u2013and\u2013neck cancer patients","volume":"76","author":"Houweling","year":"2010","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B19","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.radonc.2012.03.004","article-title":"NTCP models for patient-rated xerostomia and sticky saliva after treatment with intensity modulated radiotherapy for head and neck cancer: the role of dosimetric and clinical factors","volume":"105","author":"Beetz","year":"2012","journal-title":"Radiat Oncol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.radonc.2012.11.013","article-title":"Quantitative analysis of normal tissue effects in the clinic (QUANTEC) guideline validation using quality of life questionnaire datasets for parotid gland constraints to avoid causing xerostomia during head-and-neck radiotherapy","volume":"106","author":"Lee","year":"2013","journal-title":"Radiother Oncol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.ijrobp.2011.04.020","article-title":"Treatment planning constraints to avoid xerostomia in head and neck radiotherapy: an independent test of QUANTEC criteria using a prospectively collected dataset","volume":"82","author":"Moiseenko","year":"2012","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B22","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ijrobp.2009.06.090","article-title":"Radiotherapy dose-volume effects on salivary gland function","volume":"76","author":"Deasy","year":"2010","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1080\/0284186X.2017.1324209","article-title":"Parotid gland mean dose as a xerostomia predictor in low-dose domains","volume":"56","author":"Gabry\u015b","year":"2017","journal-title":"Acta Oncol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1088\/0031-9155\/52\/5\/016","article-title":"The use of spatial dose gradients and probability density function to evaluate the effect of internal organ motion for prostate IMRT treatment planning","volume":"52","author":"Jiang","year":"2007","journal-title":"Phys Med Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.ijrobp.2003.12.024","article-title":"Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and- neck cancer using an integrated CT\/linear accelerator system","volume":"59","author":"Barker","year":"2004","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.ijrobp.2007.01.030","article-title":"Spatial and dosimetric variability of organs at risk in head-and-neck intensity-modulated radiotherapy","volume":"68","author":"Robar","year":"2007","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.radonc.2008.07.006","article-title":"Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration","volume":"89","author":"Lee","year":"2008","journal-title":"Radiother Oncol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.ijrobp.2010.10.072","article-title":"A clinical concept for interfractional adaptive radiation therapy in the treatment of head-and-neck cancer","volume":"82","author":"Jensen","year":"2012","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.3109\/0284186X.2015.1068951","article-title":"Volumetric and dosimetric changes to salivary glands during radiotherapy for head and neck cancer","volume":"54","author":"Najim","year":"2015","journal-title":"Acta Oncol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/jmrs.209","article-title":"A longitudinal evaluation of early anatomical changes of parotid gland in intensity modulated radiotherapy of nasopharyngeal carcinoma patients with parapharyngeal space involvement","volume":"64","author":"Zhang","year":"2017","journal-title":"J Med Radiat Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/j.ijrobp.2008.04.013","article-title":"Assessment of parotid gland dose changes during head and neck cancer radiotherapy using daily megavoltage computed tomographyand deformable image registration","volume":"71","author":"Lee","year":"2008","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B32","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE) Version 4.03","year":"2010"},{"key":"B33","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s11548-013-0840-8","article-title":"The medical imaging interaction toolkit: challenges and advances","volume":"8","author":"Nolden","year":"2013","journal-title":"Int J Comput Assist Radiol Surg."},{"key":"B34","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-03882-2_294","article-title":"MatchPoint: on bridging the innovation gap between algorithmic research and clinical use in image registration","volume-title":"World Congress on Medical Physics and Biomedical Engineering, September 7 - 12","author":"Floca","year":"2009"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1016\/j.csda.2010.11.018","article-title":"An experimental comparison of cross-validation techniques for estimating the area under the ROC curve","volume":"55","author":"Airola","year":"2011","journal-title":"Comput Stat Data Anal."},{"key":"B36","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1177\/0962280207087173","article-title":"Comparison of non-parametric confidence intervals for the area under the ROC curve of a continuous-scale diagnostic test","volume":"17","author":"Qin","year":"2008","journal-title":"Stat Methods Med Res"},{"key":"B37","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-84858-7","volume-title":"The Elements of Statistical Learning: Data Mining, Inference and Prediction","author":"Hastie","year":"2009"},{"key":"B38","unstructured":"MolnarC\n          Interpretable Machine Learning: A Guide for Making Black Box Models Explainable2019"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep13165","article-title":"Patient- and therapy-related factors associated with the incidence of xerostomia in nasopharyngeal carcinoma patients receiving parotid-sparing helical tomotherapy","volume":"5","author":"Lee","year":"2015","journal-title":"Sci Rep"},{"key":"B40","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B41","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S0360-3016(01)01717-5","article-title":"Quantitative dose-volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region","volume":"51","author":"Roesing","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.ijrobp.2003.09.021","article-title":"Scintigraphic assessment of early and late parotid gland function after radiotherapy for head-and-neck cancer: a prospective study of dose-volume response relationships","volume":"58","author":"Roesink","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.ijrobp.2004.12.076","article-title":"Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy","volume":"62","author":"Blanco","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B44","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.ijrobp.2006.06.045","article-title":"Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy","volume":"66","author":"Braam","year":"2006","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B45","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.ijrobp.2006.09.021","article-title":"The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy yun","volume":"67","author":"Li","year":"2007","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.ijrobp.2008.02.059","article-title":"Large cohort dose\u2013volume response analysis of parotid gland function after radiotherapy: intensity-modulated versus conventional radiotherapy","volume":"72","author":"Dijkema","year":"2008","journal-title":"Int J Rad Oncol Biol Phys."},{"key":"B47","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.meddos.2013.01.007","article-title":"A quantitative assessment of volumetric and anatomic changes of the parotid gland during intensity-modulated radiotherapy for head and neck cancer using serial computed tomography","volume":"38","author":"Ajani","year":"2013","journal-title":"Med Dosim."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1259\/bjr.20130363","article-title":"Pattern and predictors of volumetric change of parotid glands during intensity modulated radiotherapy","volume":"86","author":"Sanguineti","year":"2013","journal-title":"Br J Radiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1002\/lary.20601","article-title":"Radiation-induced volume changes in parotid and submandibular glands in patients with head and neck cancer receiving postoperative radiotherapy: a longitudinal study","volume":"119","author":"Wang","year":"2009","journal-title":"Laryngoscope."},{"key":"B50","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.clon.2010.09.003","article-title":"Tumour shrinkage and contour change during radiotherapy increase the dose to organs at risk but not the target volumes for head and neck cancer patients treated on the tomoTherapy HiArt system","volume":"23","author":"Loo","year":"2011","journal-title":"J Clin Oncol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1259\/bjr\/30678306","article-title":"Parotid gland volumetric changes during intensity-modulated radiotherapy in head and neck cancer","volume":"85","author":"Fiorentino","year":"2012","journal-title":"Br J Radiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1259\/bjr\/66754762","article-title":"Assessment of post-radiotherapy salivary glands","volume":"84","author":"Cheng","year":"2011","journal-title":"Br J Radiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1748-717X-8-107","article-title":"Treatment of nasopharyngeal carcinoma by tomotherapy: five-year experience","volume":"8","author":"Leung","year":"2013","journal-title":"Radiat Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2019.00697\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T05:46:53Z","timestamp":1569044813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2019.00697\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":53,"alternative-id":["10.3389\/fonc.2019.00697"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2019.00697","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,31]]},"article-number":"697"}}