{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:39:14Z","timestamp":1788406754979,"version":"build-2803163510"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2019.00915","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T14:29:21Z","timestamp":1568903361000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":84,"title":["Decision Making in Patients With Metastatic Spine. The Role of Minimally Invasive Treatment Modalities"],"prefix":"10.3389","volume":"9","author":[{"given":"Alfredo","family":"Conti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcliz","family":"Acker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kluge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Loebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kreimeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Budach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vajkoczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Ghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino F.","family":"Germano'","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Senger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.nec.2004.04.018","article-title":"Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients","volume":"15","author":"Perrin","year":"2004","journal-title":"Neurosurg Clin N Am."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.3171\/foc.2001.11.6.11","article-title":"Evaluation and treatment of spinal metastases: an overview","volume":"11","author":"Jacobs","year":"2001","journal-title":"Neurosurg Focus."},{"key":"B3","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1212\/WNL.49.2.452","article-title":"Spinal epidural metastasis as the initial manifestation of malignancy: clinical features and diagnostic approach","volume":"49","author":"Schiff","year":"1997","journal-title":"Neurology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1215\/S1152851704000262","article-title":"A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease","volume":"7","author":"Klimo","year":"2005","journal-title":"Neuro Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3171\/jns.1998.89.4.0599","article-title":"Transthoracic vertebrectomy for metastatic spinal tumors","volume":"89","author":"Gokaslan","year":"1998","journal-title":"J Neurosurg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/B978-0-444-53486-6.00033-8","article-title":"Neuroimaging of spine tumors","volume":"136","author":"Pinter","year":"2016","journal-title":"Handb Clin Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.ijrobp.2010.03.022","article-title":"Incidence and treatment patterns in hospitalizations for malignant spinal cord compression in the United States, 1998-2006","volume":"80","author":"Mak","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B8","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3171\/2017.1.SPINE16684","article-title":"Stereotactic body radiotherapy for de novo spinal metastases: systematic review","volume":"27","author":"Husain","year":"2017","journal-title":"J Neurosurg Spine."},{"key":"B9","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1474-4422(08)70089-9","article-title":"Metastatic epidural spinal cord compression","volume":"7","author":"Cole","year":"2008","journal-title":"Lancet Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1097\/00007632-199011010-00005","article-title":"Scoring system for the preoperative evaluation of metastatic spine tumor prognosis","volume":"15","author":"Tokuhashi","year":"1990","journal-title":"Spine."},{"key":"B11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12957-018-1439-x","article-title":"Prognostic factors in patients with metastatic spine tumors derived from lung cancer-a novel scoring system for predicting life expectancy","author":"Uei","year":"2018","journal-title":"World J Surg Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1097\/01.brs.0000180401.06919.a5","article-title":"A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis","volume":"30","author":"Tokuhashi","year":"2005","journal-title":"Spine."},{"key":"B13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/BRS.0b013e3181913f19","article-title":"Outcome of treatment for spinal metastases using scoring system for preoperative evaluation of prognosis","volume":"34","author":"Tokuhashi","year":"2009","journal-title":"Spine."},{"key":"B14","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S0360-3016(96)00619-0","article-title":"Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials","volume":"37","author":"Gaspar","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B15","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s11060-017-2716-1","article-title":"Recursive partitioning analysis is predictive of overall survival for patients undergoing spine stereotactic radiosurgery","volume":"137","author":"Balagamwala","year":"2018","journal-title":"J Neurooncol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1016\/j.ijrobp.2011.02.019","article-title":"Recursive partitioning analysis index is predictive for overall survival in patients undergoing spine stereotactic body radiation therapy for spinal metastases","volume":"82","author":"Chao","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B17","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/00007632-200102010-00016","article-title":"Surgical strategy for spinal metastases","volume":"26","author":"Tomita","year":"2001","journal-title":"Spine."},{"key":"B18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ocl.2008.09.004","article-title":"Total en bloc spondylectomy for spinal tumors: surgical techniques and related basic background","volume":"40","author":"Kawahara","year":"2009","journal-title":"Orthop Clin North Am."},{"key":"B19","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1089\/jpm.2015.28999.sml","article-title":"ACR appropriateness criteria(R) metastatic epidural spinal cord compression and recurrent spinal metastasis","volume":"18","author":"Lo","year":"2015","journal-title":"J Palliat Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"231","DOI":"10.2217\/cns-2016-0044","article-title":"Modern approaches to the management of metastatic epidural spinal cord compression","volume":"6","author":"Husain","year":"2017","journal-title":"CNS Oncol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/SPC.0b013e32835689cd","article-title":"Adjuvant bone-targeted therapy to prevent metastasis: lessons from the AZURE study","volume":"6","author":"Coleman","year":"2012","journal-title":"Curr Opin Support Palliat Care."},{"key":"B22","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13046-017-0578-1","article-title":"Current concepts in bone metastasis, contemporary therapeutic strategies and ongoing clinical trials","volume":"36","author":"Gdowski","year":"2017","journal-title":"J Exp Clin Cancer Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"E1221","DOI":"10.1097\/BRS.0b013e3181e16ae2","article-title":"A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group","volume":"35","author":"Fisher","year":"2010","journal-title":"Spine."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1200\/JCO.2010.34.3897","article-title":"Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group","volume":"29","author":"Fourney","year":"2011","journal-title":"J Clin Oncol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3171\/2010.3.SPINE09459","article-title":"Reliability analysis of the epidural spinal cord compression scale","volume":"13","author":"Bilsky","year":"2010","journal-title":"J Neurosurg Spine."},{"key":"B26","doi-asserted-by":"publisher","first-page":"E422","DOI":"10.1097\/BRS.0000000000001308","article-title":"New magnetic resonance imaging features predictive for post-treatment ambulatory function: imaging analysis of metastatic spinal cord compression","volume":"41","author":"Oshima","year":"2016","journal-title":"Spine."},{"key":"B27","doi-asserted-by":"publisher","first-page":"E448","DOI":"10.1097\/BRS.0000000000002378","article-title":"Analysis of the relationship between the Epidural Spinal Cord Compression (ESCC) scale and paralysis caused by metastatic spine tumors","volume":"43","author":"Uei","year":"2018","journal-title":"Spine."},{"key":"B28","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1002\/cncr.20756","article-title":"Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy","volume":"103","author":"van der Linden","year":"2005","journal-title":"Cancer."},{"key":"B29","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/0360-3016(95)00572-G","article-title":"Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial","volume":"32","author":"Maranzano","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0167-8140(97)00101-1","article-title":"Pain relief and quality of life following radiotherapy for bone metastases: a randomised trial of two fractionation schedules","volume":"45","author":"Gaze","year":"1997","journal-title":"Radiother Oncol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0167-8140(98)00011-5","article-title":"Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases","volume":"47","author":"Nielsen","year":"1998","journal-title":"Radiother Oncol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0167-8140(99)00097-3","article-title":"8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomised comparison with a multifraction schedule over 12 months of patient follow-up","volume":"52","author":"Yarnold","year":"1999","journal-title":"Bone Pain Trial Working Party Radiother Oncol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/jnci\/dji139","article-title":"Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases","volume":"97","author":"Hartsell","year":"2005","journal-title":"J Natl Cancer Inst."},{"key":"B34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.radonc.2008.05.018","article-title":"Randomized clinical trial with two palliative radiotherapy regimens in painful bone metastases: 30 Gy in 10 fractions compared with 8 Gy in single fraction","volume":"89","author":"Foro Arnalot","year":"2008","journal-title":"Radiother Oncol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"25691","DOI":"10.18632\/oncotarget.14823","article-title":"The role of radiation therapy in bone metastases management","volume":"8","author":"De Felice","year":"2017","journal-title":"Oncotarget."},{"key":"B36","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.clon.2011.11.004","article-title":"Update on the systematic review of palliative radiotherapy trials for bone metastases","volume":"24","author":"Chow","year":"2012","journal-title":"Clin Oncol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/cncr.27616","article-title":"Single-fraction radiotherapy versus multifraction radiotherapy for palliation of painful vertebral bone metastases-equivalent efficacy, less toxicity, more convenient: a subset analysis of Radiation Therapy Oncology Group trial 97-14","volume":"119","author":"Howell","year":"2013","journal-title":"Cancer."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1200\/JCO.1994.12.11.2345","article-title":"Impact of postoperative radiation therapy and other perioperative factors on outcome after orthopedic stabilization of impending or pathologic fractures due to metastatic disease","volume":"12","author":"Townsend","year":"1994","journal-title":"J Clin Oncol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0140-6736(05)66954-1","article-title":"Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial","volume":"366","author":"Patchell","year":"2005","journal-title":"Lancet."},{"key":"B40","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/ncpneuro0116","article-title":"Surgery insight: current management of epidural spinal cord compression from metastatic spine disease","volume":"2","author":"Witham","year":"2006","journal-title":"Nat Clin Pract Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/0002-9610(67)90402-3","article-title":"Complications after radical head and neck surgery performed through previously irradiated tissues","volume":"114","author":"Marchetta","year":"1967","journal-title":"Am J Surg."},{"key":"B42","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1001\/archotol.1973.00780010393005","article-title":"Risks of head and neck surgery in previously irradiated patients","volume":"97","author":"Joseph","year":"1973","journal-title":"Arch Otolaryngol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1055\/s-2007-1000187","article-title":"Reconstruction of complex radiation-induced injuries using free-tissue transfer","volume":"14","author":"Gurlek","year":"1998","journal-title":"J Reconstr Microsurg."},{"key":"B44","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1177\/000313480306901116","article-title":"Radiated groin wounds: pitfalls in reconstruction","volume":"69","author":"Payne","year":"2003","journal-title":"Am Surg."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/j.athoracsur.2004.04.082","article-title":"Sternal preservation: a better way to treat most sternal wound complications after cardiac surgery","volume":"78","author":"Douville","year":"2004","journal-title":"Ann Thorac Surg."},{"key":"B46","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3892\/ijo_00000527","article-title":"Timing of surgery and radiotherapy in the management of metastatic spine disease: a systematic review","volume":"36","author":"Itshayek","year":"2010","journal-title":"Int J Oncol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/00007632-200104010-00025","article-title":"Spinal radiation before surgical decompression adversely affects outcomes of surgery for symptomatic metastatic spinal cord compression","volume":"26","author":"Ghogawala","year":"2001","journal-title":"Spine."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1002\/1097-0142(19800601)45:11<2805::aid-cncr2820451115>3.0.co;2-#","article-title":"Time dependent effects of adriamycin and x-ray therapy on wound healing in the rat","volume":"45","author":"Devereux","year":"1980","journal-title":"Cancer."},{"key":"B49","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1200\/JCO.1987.5.3.480","article-title":"Wound complications in the multimodality treatment of extremity and superficial truncal sarcomas","volume":"5","author":"Arbeit","year":"1987","journal-title":"J Clin Oncol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/00000658-198907000-00014","article-title":"Wound complications of adjuvant radiation therapy in patients with soft-tissue sarcomas","volume":"210","author":"Ormsby","year":"1989","journal-title":"Ann Surg."},{"key":"B51","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s10029-006-0150-y","article-title":"Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome","volume":"10","author":"Wang","year":"2006","journal-title":"Hernia."},{"key":"B52","first-page":"e9","article-title":"Wound healing in patients with cancer","volume":"8","author":"Payne","year":"2008","journal-title":"Eplasty."},{"key":"B53","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3171\/2010.3.SPINE09202","article-title":"Diagnosis and management of metastatic spine disease. A review","volume":"13","author":"Sciubba","year":"2010","journal-title":"J Neurosurg Spine."},{"key":"B54","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3171\/SPI-07\/08\/151","article-title":"Phase I\/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure","volume":"7","author":"Chang","year":"2007","journal-title":"J Neurosurg Spine."},{"key":"B55","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/01.brs.0000251863.76595.a2","article-title":"Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution","volume":"32","author":"Gerszten","year":"2007","journal-title":"Spine."},{"key":"B56","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/153303460700600209","article-title":"Technical and clinical experience with spine radiosurgery: a new technology for management of localized spine metastases","volume":"6","author":"Jin","year":"2007","journal-title":"Technol Cancer Res Treat."},{"key":"B57","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/cncr.22442","article-title":"Partial volume tolerance of the spinal cord and complications of single-dose radiosurgery","volume":"109","author":"Ryu","year":"2007","journal-title":"Cancer."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1016\/j.ijrobp.2010.08.012","article-title":"Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases","volume":"81","author":"Mahadevan","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B59","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3171\/2016.8.SPINE16121","article-title":"Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey","volume":"26","author":"Redmond","year":"2017","journal-title":"J Neurosurg Spine."},{"key":"B60","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.ijrobp.2018.06.047","article-title":"Imaging-based outcomes for 24 Gy in 2 daily fractions for patients with de novo spinal metastases treated with Spine Stereotactic Body Radiation Therapy (SBRT)","volume":"102","author":"Tseng","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B61","doi-asserted-by":"publisher","first-page":"105","DOI":"10.7785\/tcrt.2012.500239","article-title":"Comparison of whole versus partial vertebral body stereotactic body radiation therapy for spinal metastases","volume":"11","author":"Patel","year":"2012","journal-title":"Technol Cancer Res Treat."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e597","DOI":"10.1016\/j.ijrobp.2012.03.009","article-title":"International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery","volume":"83","author":"Cox","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B63","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3171\/sup.2004.101.supplement3.0402","article-title":"Patterns of failure after single-dose radiosurgery for spinal metastasis","volume":"101","author":"Ryu","year":"2004","journal-title":"J Neurosurg."},{"key":"B64","doi-asserted-by":"publisher","first-page":"E6","DOI":"10.3171\/2016.9.FOCUS16369","article-title":"The impact of histology and delivered dose on local control of spinal metastases treated with stereotactic radiosurgery","volume":"42","author":"Yamada","year":"2017","journal-title":"Neurosurg Focus."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.1118\/1.3438081","article-title":"Stereotactic body radiation therapy: the report of AAPM Task Group 101","volume":"37","author":"Benedict","year":"2010","journal-title":"Med Phys."},{"key":"B66","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.ijrobp.2012.05.007","article-title":"Probabilities of radiation myelopathy specific to stereotactic body radiation therapy to guide safe practice","volume":"85","author":"Sahgal","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B67","doi-asserted-by":"publisher","first-page":"5075","DOI":"10.1200\/JCO.2008.19.3508","article-title":"Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases","volume":"27","author":"Rose","year":"2009","journal-title":"J Clin Oncol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3171\/2011.11.SPINE116","article-title":"Vertebral compression fracture risk after stereotactic body radiotherapy for spinal metastases","volume":"16","author":"Boehling","year":"2012","journal-title":"J Neurosurg Spine."},{"key":"B69","doi-asserted-by":"publisher","first-page":"e343","DOI":"10.1016\/j.ijrobp.2012.04.034","article-title":"Vertebral compression fracture (VCF) after spine stereotactic body radiation therapy (SBRT): analysis of predictive factors","volume":"84","author":"Cunha","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B70","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1200\/JCO.2013.50.1411","article-title":"Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score","volume":"31","author":"Sahgal","year":"2013","journal-title":"J Clin Oncol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3171\/2012.4.SPINE11902","article-title":"Single-session and multisession CyberKnife radiosurgery for spine metastases-University of Pittsburgh and Georgetown University experience","volume":"17","author":"Heron","year":"2012","journal-title":"J Neurosurg Spine."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.2217\/fon.15.160","article-title":"Single versus multiple session stereotactic body radiotherapy for spinal metastasis: the risk-benefit ratio","volume":"11","author":"Redmond","year":"2015","journal-title":"Future Oncol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"646","DOI":"10.3171\/2016.4.SPINE151523","article-title":"Re-irradiation stereotactic body radiotherapy for spinal metastases: a multi-institutional outcome analysis","volume":"25","author":"Hashmi","year":"2016","journal-title":"J Neurosurg Spine."},{"key":"B74","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S1470-2045(13)70556-4","article-title":"Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial","volume":"15","author":"Chow","year":"2014","journal-title":"Lancet Oncol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e409","DOI":"10.1016\/j.prro.2017.05.007","article-title":"Reirradiation of the spine with stereotactic radiosurgery: efficacy and toxicity","volume":"7","author":"Boyce-Fappiano","year":"2017","journal-title":"Pract Radiat Oncol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ijrobp.2010.08.021","article-title":"Reirradiation human spinal cord tolerance for stereotactic body radiotherapy","volume":"82","author":"Sahgal","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta17420","article-title":"A systematic review of evidence on malignant spinal metastases: natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression","volume":"17","author":"Sutcliffe","year":"2013","journal-title":"Health Technol Assess."},{"key":"B78","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3171\/SPI\/2008\/8\/3\/271","article-title":"Does spinal surgery improve the quality of life for those with extradural (spinal) osseous metastases? An international multicenter prospective observational study of 223 patients. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2007","volume":"8","author":"Ibrahim","year":"2008","journal-title":"J Neurosurg Spine."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1007\/s00586-011-1867-6","article-title":"Surgery improves pain, function and quality of life in patients with spinal metastases: a prospective study on 118 patients","volume":"20","author":"Quan","year":"2011","journal-title":"Eur Spine J."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1016\/j.ejso.2017.05.006","article-title":"Evolution in treatment strategy for metastatic spine disease: presently evolving modalities","volume":"43","author":"Kumar","year":"2017","journal-title":"Eur J Surg Oncol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s007010050199","article-title":"Surgical results for spinal metastases","volume":"140","author":"Klekamp","year":"1998","journal-title":"Acta Neurochir."},{"key":"B82","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1007\/s00586-016-4463-y","article-title":"Predictors for surgical complications of en bloc resections in the spine: review of 220 cases treated by the same team","volume":"25","author":"Boriani","year":"2016","journal-title":"Eur Spine J."},{"key":"B83","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3171\/2012.11.SPINE12111","article-title":"Local disease control for spinal metastases following \u201cseparation surgery\u201d and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients","volume":"18","author":"Laufer","year":"2013","journal-title":"J Neurosurg Spine."},{"key":"B84","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3171\/spi.2004.1.3.0287","article-title":"Single-stage posterolateral transpedicular approach for resection of epidural metastatic spine tumors involving the vertebral body with circumferential reconstruction: results in 140 patients. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004","volume":"1","author":"Wang","year":"2004","journal-title":"J Neurosurg Spine."},{"key":"B85","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.spinee.2007.05.002","article-title":"The use of an expandable cage for corpectomy reconstruction of vertebral body tumors through a posterior extracavitary approach: a multicenter consecutive case series of prospectively followed patients","volume":"8","author":"Shen","year":"2008","journal-title":"Spine J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00586-011-1738-1","article-title":"Comparison of polymethylmethacrylate versus expandable cage in anterior vertebral column reconstruction after posterior extracavitary corpectomy in lumbar and thoraco-lumbar metastatic spine tumors","volume":"20","author":"Eleraky","year":"2011","journal-title":"Eur Spine J."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1016\/j.spinee.2013.10.028","article-title":"The incidence and patterns of hardware failure after separation surgery in patients with spinal metastatic tumors","volume":"14","author":"Amankulor","year":"2014","journal-title":"Spine J."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.wneu.2015.06.018","article-title":"Minimally invasive muscle sparing posterior-only approach for lumbar circumferential decompression and stabilization to treat spine metastasis\u2013technical report","volume":"84","author":"Donnelly","year":"2015","journal-title":"World Neurosurg."},{"key":"B89","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.wneu.2017.09.067","article-title":"Minimally invasive separation surgery with intraoperative stereotactic guidance: a feasibility study","volume":"109","author":"Nasser","year":"2018","journal-title":"World Neurosurg."},{"key":"B90","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1590\/0004-282X20150099","article-title":"An update in the management of spinal metastases","volume":"73","author":"Joaquim","year":"2015","journal-title":"Arq Neuropsiquiatr."},{"key":"B91","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3171\/2010.3.SPINE09639","article-title":"Local disease control after decompressive surgery and adjuvant high-dose single-fraction radiosurgery for spine metastases","volume":"13","author":"Moulding","year":"2010","journal-title":"J Neurosurg Spine."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1093\/neuros\/nyy176","article-title":"Surgical resection with radiation treatment planning of spinal tumors","volume":"84","author":"Jakubovic","year":"2019","journal-title":"Neurosurgery."},{"key":"B93","doi-asserted-by":"publisher","first-page":"S101","DOI":"10.1097\/BRS.0b013e3181bac4b2","article-title":"Shifting paradigms in the treatment of metastatic spine disease","volume":"34","author":"Bilsky","year":"2009","journal-title":"Spine."},{"key":"B94","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/BRS.0000000000001824","article-title":"When less is more: the indications for MIS techniques and separation surgery in metastatic spine disease","volume":"41","author":"Zuckerman","year":"1976","journal-title":"Spine."},{"key":"B95","doi-asserted-by":"publisher","first-page":"E4","DOI":"10.3171\/2016.9.FOCUS16373","article-title":"Spinal stereotactic body radiotherapy following intralesional curettage with separation surgery for initial or salvage chordoma treatment","volume":"42","author":"Lockney","year":"2017","journal-title":"Neurosurg Focus."},{"key":"B96","doi-asserted-by":"publisher","first-page":"103","DOI":"10.21037\/atm.2018.01.28","article-title":"Minimally invasive versus conventional spine surgery for vertebral metastases: a systematic review of the evidence","volume":"6","author":"Pennington","year":"2018","journal-title":"Ann Transl Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3171\/2012.7.SPINE111086","article-title":"Comparison of mini-open anterior corpectomy and posterior total en bloc spondylectomy for solitary metastases of the thoracolumbar spine","volume":"17","author":"Fang","year":"2012","journal-title":"J Neurosurg Spine."},{"key":"B98","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3171\/2014.12.SPINE14543","article-title":"Posterior thoracic corpectomy with cage reconstruction for metastatic spinal tumors: comparing the mini-open approach to the open approach","volume":"23","author":"Lau","year":"2015","journal-title":"J Neurosurg Spine."},{"key":"B99","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3171\/2014.10.SPINE131201","article-title":"Comparison of minimally invasive surgery with standard open surgery for vertebral thoracic metastases causing acute myelopathy in patients with short- or mid-term life expectancy: surgical technique and early clinical results","volume":"22","author":"Miscusi","year":"2015","journal-title":"J Neurosurg Spine."},{"key":"B100","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1097\/BRS.0000000000001893","article-title":"Comparison between minimally invasive surgery and conventional open surgery for patients with spinal metastasis: a prospective propensity score-matched study","volume":"42","author":"Hansen-Algenstaedt","year":"2017","journal-title":"Spine."},{"key":"B101","doi-asserted-by":"publisher","first-page":"E1082","DOI":"10.1097\/BSD.0000000000000460","article-title":"A retrospective cohort study comparing the safety and efficacy of minimally invasive versus open surgical techniques in the treatment of spinal metastases","volume":"30","author":"Hikata","year":"2017","journal-title":"Clin Spine Surg."},{"key":"B102","doi-asserted-by":"publisher","first-page":"E1015","DOI":"10.1097\/BSD.0000000000000400","article-title":"Metastatic spine tumor surgery: a comparative study of minimally invasive approach using percutaneous pedicle screws fixation versus open approach","volume":"30","author":"Kumar","year":"2017","journal-title":"Clin Spine Surg."},{"key":"B103","doi-asserted-by":"publisher","first-page":"15","DOI":"10.7785\/tcrt.2012.500230","article-title":"Minimal access spine surgery (MASS) for decompression and stabilization performed as an out-patient procedure for metastatic spinal tumours followed by spine stereotactic body radiotherapy (SBRT): first report of technique and preliminary outcomes","volume":"11","author":"Massicotte","year":"2012","journal-title":"Technol Cancer Res Treat."},{"key":"B104","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1200\/JCO.2017.72.7362","article-title":"Integrating evidence-based medicine for treatment of spinal metastases into a decision framework: neurologic, oncologic, mechanicals stability, and systemic disease","volume":"35","author":"Barzilai","year":"2017","journal-title":"J Clin Oncol."}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2019.00915\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T14:01:11Z","timestamp":1695218471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2019.00915\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,19]]},"references-count":104,"alternative-id":["10.3389\/fonc.2019.00915"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2019.00915","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,19]]},"article-number":"915"}}