{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:43:41Z","timestamp":1790214221100,"version":"4.1.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2019.00949","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T13:08:46Z","timestamp":1569330526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress"],"prefix":"10.3389","volume":"9","author":[{"given":"Richa","family":"Garva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutamas","family":"Thepmalee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umpa","family":"Yasamut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangkab","family":"Sudsaward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Guazzelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramkumar","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopprarat","family":"Tongmuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasiprapa","family":"Khunchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Meysami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thawornchai","family":"Limjindaporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pa-thai","family":"Yenchitsomanus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Mutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Krstic-Demonacos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Demonacos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"368276","DOI":"10.1155\/2011\/368276","article-title":"Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription","volume":"2011","author":"Rajendran","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1158\/0008-5472.CAN-15-2733","article-title":"Mitochondrial sirtuins in cancer: emerging roles and therapeutic potential","volume":"76","author":"George","year":"2016","journal-title":"Cancer Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nature08197","article-title":"Recent progress in the biology and physiology of sirtuins","volume":"460","author":"Finkel","year":"2009","journal-title":"Nature."},{"key":"B4","doi-asserted-by":"publisher","first-page":"144","DOI":"10.18632\/aging.100544","article-title":"The sirtuins, oxidative stress and aging: an emerging link","volume":"5","author":"Merksamer","year":"2013","journal-title":"Aging."},{"key":"B5","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.freeradbiomed.2011.10.484","article-title":"The role of sirtuins in modulating redox stressors","volume":"52","author":"Webster","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20120030","article-title":"SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging","volume":"444","author":"Giralt","year":"2012","journal-title":"Biochem J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.cmet.2010.11.015","article-title":"Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation","volume":"12","author":"Qiu","year":"2010","journal-title":"Cell Metab."},{"key":"B8","doi-asserted-by":"publisher","first-page":"14447","DOI":"10.1073\/pnas.0803790105","article-title":"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis","volume":"105","author":"Ahn","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"Lee","year":"2012","journal-title":"Biochem J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1089\/ars.2008.2270","article-title":"Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment","volume":"11","author":"Azad","year":"2009","journal-title":"Antioxid Redox Signal."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1089\/ars.2010.3554","article-title":"Autophagy signaling through reactive oxygen species","volume":"14","author":"Huang","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/ars.2007.1957","article-title":"Redox regulation of cell survival","volume":"10","author":"Trachootham","year":"2008","journal-title":"Antioxid Redox Signal."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2012.08.038","article-title":"The influence of reactive oxygen species on cell cycle progression in mammalian cells","volume":"511","author":"Verbon","year":"2012","journal-title":"Gene"},{"key":"B14","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nrm.2016.14","article-title":"Nuclear DNA damage signalling to mitochondria in ageing","volume":"17","author":"Fang","year":"2016","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"6384","DOI":"10.1128\/MCB.00426-08","article-title":"SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70","volume":"28","author":"Sundaresan","year":"2008","journal-title":"Mol Cell Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/acel.12538","article-title":"Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease","volume":"16","author":"Ansari","year":"2017","journal-title":"Aging Cell."},{"key":"B17","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.molcel.2013.06.001","article-title":"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways","volume":"50","author":"Park","year":"2013","journal-title":"Mol Cell."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1007\/s13277-013-0726-y","article-title":"Altered expression of SIRT gene family in head and neck squamous cell carcinoma","volume":"34","author":"Lai","year":"2013","journal-title":"Tumour Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/15548627.2015.1009778","article-title":"SIRT5 regulation of ammonia-induced autophagy and mitophagy","volume":"11","author":"Polletta","year":"2015","journal-title":"Autophagy"},{"key":"B20","doi-asserted-by":"publisher","first-page":"10699","DOI":"10.1007\/s13277-014-2372-4","article-title":"SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer","volume":"35","author":"Lu","year":"2014","journal-title":"Tumour Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1002\/jcp.24399","article-title":"Sirtuins' modulation of autophagy","volume":"228","author":"Ng","year":"2013","journal-title":"J Cell Physiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/978-1-62703-637-5_17","article-title":"The emerging links between sirtuins and autophagy","volume":"1077","author":"Lee","year":"2013","journal-title":"Methods Mol Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/aps.2011.143","article-title":"Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1","volume":"33","author":"Zeng","year":"2012","journal-title":"Acta Pharmacol Sin"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1073\/pnas.0712145105","article-title":"A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy","volume":"105","author":"Lee","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"B25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ccr.2006.06.001","article-title":"Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis","volume":"10","author":"Degenhardt","year":"2006","journal-title":"Cancer Cell."},{"key":"B26","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.devcel.2008.08.012","article-title":"The role of autophagy in mammalian development: cell makeover rather than cell death","volume":"15","author":"Cecconi","year":"2008","journal-title":"Dev Cell."},{"key":"B27","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1093\/carcin\/bgr031","article-title":"The multiple roles of autophagy in cancer","volume":"32","author":"Rosenfeldt","year":"2011","journal-title":"Carcinogenesis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.prp.2016.02.002","article-title":"Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma","volume":"212","author":"Feng","year":"2016","journal-title":"Pathol Res Pract."},{"key":"B29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/jcmm.12000","article-title":"PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT\/mTOR axis via SIRT1","volume":"17","author":"Pinton","year":"2013","journal-title":"J Cell Mol Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"14366","DOI":"10.18632\/oncotarget.7321","article-title":"SIRT1 at the crossroads of AKT1 and ERbeta in malignant pleural mesothelioma cells","volume":"7","author":"Pinton","year":"2016","journal-title":"Oncotarget"},{"key":"B31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/mc.22757","article-title":"Inhibition of autophagy initiation potentiates chemosensitivity in mesothelioma","volume":"57","author":"Follo","year":"2018","journal-title":"Mol Carcinog"},{"key":"B32","doi-asserted-by":"publisher","first-page":"8516","DOI":"10.1074\/jbc.M210432200","article-title":"Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production","volume":"278","author":"Li","year":"2003","journal-title":"J Biol Chem"},{"key":"B33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.2174\/1568011054222364","article-title":"Etoposide, topoisomerase II and cancer","volume":"5","author":"Baldwin","year":"2005","journal-title":"Curr Med Chem Anticancer Agents"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s10495-009-0390-2","article-title":"Comprehensive analysis of expression pattern and promoter regulation of human autophagy-related genes","volume":"14","author":"Kusama","year":"2009","journal-title":"Apoptosis"},{"key":"B35","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s11010-007-9478-6","article-title":"Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin","volume":"303","author":"Nahhas","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"B36","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2008.10.052","article-title":"SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span","volume":"136","author":"Kawahara","year":"2009","journal-title":"Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1038\/onc.2008.192","article-title":"PCAF is an HIF-1[alpha] cofactor that regulates p53 transcriptional activity in hypoxia","volume":"27","author":"Xenaki","year":"2008","journal-title":"Oncogene."},{"key":"B38","doi-asserted-by":"publisher","first-page":"18384","DOI":"10.1074\/jbc.M313561200","article-title":"Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1","volume":"279","author":"Scarlatti","year":"2004","journal-title":"J Biol Chem"},{"key":"B39","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1242\/jcs.112.15.2473","article-title":"A human intracellular apyrase-like protein, LALP70, localizes to lysosomal\/autophagic vacuoles","volume":"112","author":"Biederbick","year":"1999","journal-title":"J Cell Sci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/sj.cdd.4402039","article-title":"Autophagy delays apoptotic death in breast cancer cells following DNA damage","volume":"14","author":"Abedin","year":"2007","journal-title":"Cell Death Diff"},{"key":"B41","doi-asserted-by":"publisher","first-page":"881","DOI":"10.7150\/ijms.5011","article-title":"Molecular mechanism of SAHA on regulation of autophagic cell death in tamoxifen-resistant MCF-7 breast cancer cells","volume":"9","author":"Lee","year":"2012","journal-title":"Int J Med Sci"},{"key":"B42","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1242\/jcs.114.20.3619","article-title":"A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation","volume":"114","author":"Munafo","year":"2001","journal-title":"J Cell Sci"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e49761","DOI":"10.1371\/journal.pone.0049761","article-title":"A molecular mechanism for direct sirtuin activation by resveratrol","volume":"7","author":"Gertz","year":"2012","journal-title":"PLoS ONE"},{"key":"B44","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12967-018-1650-0","article-title":"p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification","volume":"16","author":"Tian","year":"2018","journal-title":"J Transl Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"E429","DOI":"10.3390\/ijms20020429","article-title":"BAP1 status determines the sensitivity of malignant mesothelioma cells to gemcitabine treatment","volume":"20","author":"Guazzelli","year":"2019","journal-title":"Int J Mol Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1042\/BJ20130414","article-title":"Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts","volume":"454","author":"Liang","year":"2013","journal-title":"Biochem J"},{"key":"B48","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.freeradbiomed.2016.03.022","article-title":"A SIRT3\/AMPK\/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages","volume":"95","author":"Duan","year":"2016","journal-title":"Free Rad Biol Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/hep.29229","article-title":"Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity","volume":"66","author":"Li","year":"2017","journal-title":"Hepatology."},{"key":"B50","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.bbamcr.2016.10.015","article-title":"Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation","volume":"1864","author":"Guedouari","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41467-018-02951-4","article-title":"Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun."},{"key":"B52","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bbrc.2013.10.033","article-title":"SIRT5 desuccinylates and activates SOD1 to eliminate ROS","volume":"441","author":"Lin","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"B53","doi-asserted-by":"publisher","first-page":"42428","DOI":"10.1074\/jbc.R112.372300","article-title":"Structural basis for sirtuin activity and inhibition","volume":"287","author":"Yuan","year":"2012","journal-title":"J Biol Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.1207861","article-title":"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase","volume":"334","author":"Du","year":"2011","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","first-page":"79654","DOI":"10.18632\/oncotarget.12916","article-title":"SIRT1 promotes metastasis of human osteosarcoma cells","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"B56","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13395-018-0154-1","article-title":"A need for NAD+ in muscle development, homeostasis, and aging","volume":"8","author":"Goody","year":"2018","journal-title":"Skelet Muscle"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2019.00949\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T18:01:45Z","timestamp":1664474505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2019.00949\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,24]]},"references-count":56,"alternative-id":["10.3389\/fonc.2019.00949"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2019.00949","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,24]]},"article-number":"949"}}