{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:40:19Z","timestamp":1758894019253,"version":"3.41.2"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2020.00836","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T04:50:15Z","timestamp":1590123015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhi","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxing","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/sj.onc.1204178","article-title":"Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27","volume":"20","author":"Acquati","year":"2001","journal-title":"Oncogene."},{"key":"B2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.abb.2006.02.022","article-title":"Characterization of RNASET2, the first human member of the Rh\/T2\/S family of glycoproteins","volume":"449","author":"Campomenosi","year":"2006","journal-title":"Arch Biochem Biophys."},{"key":"B3","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/sj.onc.1205067","article-title":"Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer","volume":"21","author":"Liu","year":"2002","journal-title":"Oncogene."},{"key":"B4","doi-asserted-by":"publisher","first-page":"7851","DOI":"10.18632\/oncotarget.3490","article-title":"Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase","volume":"6","author":"Lualdi","year":"2015","journal-title":"Oncotarget."},{"key":"B5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.tibs.2010.02.002","article-title":"T2 Family ribonucleases: ancient enzymes with diverse roles","volume":"35","author":"Luhtala","year":"2010","journal-title":"Trends Biochem Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.2047-2927.2012.00022.x","article-title":"RNASET2 in human spermatozoa and seminal plasma: a novel relevant indicator for asthenozoospermia","volume":"1","author":"Liu","year":"2013","journal-title":"Andrology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/ng.398","article-title":"RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection","volume":"41","author":"Henneke","year":"2009","journal-title":"Nat Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jdermsci.2015.07.004","article-title":"Rnaset2 inhibits melanocyte outgrowth possibly through interacting with shootin1","volume":"80","author":"Wang","year":"2015","journal-title":"J Dermatol Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/jidsymp.2015.24","article-title":"Role and Mechanism of RNASET2 in the Pathogenesis of Vitiligo","volume":"17","author":"Wang","year":"2015","journal-title":"J Investig Dermatol Symp Proc."},{"key":"B10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.18632\/oncoscience.100","article-title":"Human RNASET2 derivatives as potential anti-angiogenic agents: actin binding sequence identification and characterization","volume":"2","author":"Nesiel-Nuttman","year":"2015","journal-title":"Oncoscience."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3892\/ijo.26.5.1159","article-title":"Tumor and metastasis suppression by the human RNASET2 gene","volume":"26","author":"Acquati","year":"2005","journal-title":"Int J Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"8140","DOI":"10.1073\/pnas.1222079110","article-title":"Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis","volume":"110","author":"Acquati","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3727\/096504008784523658","article-title":"RNASET2 as a tumor antagonizing gene in a melanoma cancer model","volume":"17","author":"Monti","year":"2008","journal-title":"Oncol Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/ng.3892","article-title":"Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes","volume":"49","author":"McKay","year":"2017","journal-title":"Nat Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1021\/jm1015507","article-title":"The 1","volume":"55","author":"de Leeuw","year":"2012","journal-title":"J Med Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3892\/or.2014.3175","article-title":"Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer","volume":"32","author":"Yin","year":"2014","journal-title":"Oncol Rep."},{"key":"B17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol Cell Proteomics."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.3389\/fimmu.2019.02587","article-title":"Innate immune response regulation by the human RNASET2 tumor suppressor gene","volume":"10","author":"Acquati","year":"2019","journal-title":"Front Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3390\/cancers12030717","article-title":"Overexpression of murine Rnaset2 in a colon syngeneic mouse carcinoma model leads to rebalance of intra-tumor M1\/M2 macrophage ratio, activation of T cells, delayed tumor growth, and rejection","volume":"12","author":"De Vito","year":"2020","journal-title":"Cancers (Basel)."},{"key":"B20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.18632\/oncoscience.295","article-title":"Human recombinant RNASET2: A potential anti-cancer drug","volume":"3","author":"Roiz","year":"2016","journal-title":"Oncoscience."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1002\/cncr.22327","article-title":"A recombinant human RNASET2 glycoprotein with antitumorigenic and antiangiogenic characteristics: expression, purification, and characterization","volume":"107","author":"Smirnoff","year":"2006","journal-title":"Cancer."},{"key":"B22","doi-asserted-by":"publisher","first-page":"22","DOI":"10.21037\/tgh.2019.03.09","article-title":"Comparison between 7th and 8th edition of AJCC TNM staging system for gastric cancer: old problems and new perspectives","volume":"4","author":"Marano","year":"2019","journal-title":"Transl Gastroenterol Hepatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1002\/cam4.1494","article-title":"Clinical significance of TM4SF1 as a tumor suppressor gene in gastric cancer","volume":"7","author":"Peng","year":"2018","journal-title":"Cancer Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"6551","DOI":"10.1007\/s13277-015-4460-5","article-title":"Expression and clinical implication of S100A12 in gastric carcinoma","volume":"37","author":"Li","year":"2016","journal-title":"Tumour Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s12032-010-9766-y","article-title":"Upregulated INHBA expression is associated with poor survival in gastric cancer","volume":"29","author":"Wang","year":"2012","journal-title":"Med Oncol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ejca.2008.10.032","article-title":"Genome-wide expression profile of sporadic gastric cancers with microsatellite instability","volume":"45","author":"D'Errico","year":"2009","journal-title":"Eur J Cancer."},{"key":"B27","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","year":"2014","journal-title":"Nature."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.cell.2015.11.015","article-title":"High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities","volume":"163","author":"Hart","year":"2015","journal-title":"Cell."},{"key":"B29","doi-asserted-by":"publisher","first-page":"733","DOI":"10.15252\/msb.20145216","article-title":"Measuring error rates in genomic perturbation screens: gold standards for human functional genomics","volume":"10","author":"Hart","year":"2014","journal-title":"Mol Syst Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a cancer dependency map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell."},{"key":"B31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin."},{"key":"B32","doi-asserted-by":"publisher","first-page":"4284","DOI":"10.1038\/sj.onc.1210208","article-title":"Gene expression analysis of early and advanced gastric cancers","volume":"26","author":"Vecchi","year":"2007","journal-title":"Oncogene."},{"key":"B33","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s00464-015-4184-z","article-title":"Redefining early gastric cancer","volume":"30","author":"Barreto","year":"2016","journal-title":"Surg Endosc."},{"key":"B34","first-page":"673","article-title":"[Morphological basis of gastric acid-forming function normally and in pathology]","volume":"68","author":"Birgele","year":"1982","journal-title":"Fiziol Zh SSSR Im I M Sechenova."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1073\/pnas.89.8.3503","article-title":"Cloning and expression of the tumor-associated antigen L6","volume":"89","author":"Marken","year":"1992","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B36","first-page":"89","article-title":"S100 protein family in human cancer","volume":"4","author":"Chen","year":"2014","journal-title":"Am J Cancer Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5349","DOI":"10.1158\/0008-5472.CAN-17-0061","article-title":"Oncogenic KRAS and p53 loss drive gastric tumorigenesis in mice that can be attenuated by E-cadherin expression","volume":"77","author":"Till","year":"2017","journal-title":"Cancer Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12943-016-0493-7","article-title":"miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-\u03baB signaling in gastric carcinogenesis","volume":"15","author":"Huang","year":"2016","journal-title":"Mol Cancer."},{"key":"B39","doi-asserted-by":"publisher","first-page":"23155","DOI":"10.18632\/oncotarget.19303","article-title":"Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer","volume":"8","author":"Pei","year":"2017","journal-title":"Oncotarget."},{"key":"B40","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000448945","article-title":"A high Ki67\/BCL2 index could predict lower disease-free and overall survival in intestinal-type gastric cancer","volume":"58","author":"Min","year":"2017","journal-title":"Eur Surg Res."}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2020.00836\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T04:50:19Z","timestamp":1590123019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2020.00836\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,22]]},"references-count":40,"alternative-id":["10.3389\/fonc.2020.00836"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2020.00836","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2020,5,22]]},"article-number":"836"}}