{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:19:02Z","timestamp":1785777542005,"version":"3.56.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2020.01154","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T06:05:01Z","timestamp":1594879501000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Risk of Second Primary Malignancies in Colon Cancer Patients Treated With Colectomy"],"prefix":"10.3389","volume":"10","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaibo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueer","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leitao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhe","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanming","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin."},{"key":"B4","doi-asserted-by":"publisher","first-page":"djx030","DOI":"10.1093\/jnci\/djx030","article-title":"Annual report to the nation on the status of cancer, 1975-2014, featuring survival","volume":"109","author":"Jemal","year":"2017","journal-title":"J Natl Cancer Inst."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1002\/cncr.30164","article-title":"Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008","volume":"122","author":"Donin","year":"2016","journal-title":"Cancer."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/S0140-6736(05)67887-7","article-title":"Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials","volume":"366","author":"Clarke","year":"2005","journal-title":"Lancet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.3389\/fonc.2019.01426","article-title":"Risk of second primary cancers among long-term survivors of breast cancer","volume":"9","author":"Li","year":"2019","journal-title":"Front Oncol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1136\/thoraxjnl-2018-212456","article-title":"Incidence of second and higher order smoking-related primary cancers following lung cancer: a population-based cohort study","volume":"74","author":"Barclay","year":"2019","journal-title":"Thorax."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0143067","DOI":"10.1371\/journal.pone.0143067","article-title":"The incidence characteristics of second primary malignancy after diagnosis of primary colon and rectal cancer: a population based study","volume":"10","author":"Guan","year":"2015","journal-title":"PloS ONE."},{"key":"B10","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1186\/s12885-018-4823-6","article-title":"Second primary colorectal cancer after the initial primary colorectal cancer","volume":"18","author":"Yang","year":"2018","journal-title":"BMC Cancer."},{"key":"B11","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1055\/a-1041-2945","article-title":"How to identify patients who are less likely to have metachronous neoplasms after a colon cancer: a predictive model","volume":"52","author":"Frazzoni","year":"2020","journal-title":"Endoscopy."},{"key":"B12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1177\/1457496918798212","article-title":"Risk of synchronous and metachronous colorectal cancer: population-based estimates in denmark with focus on non-hereditary cases diagnosed after age 50","volume":"108","author":"Lindberg","year":"2019","journal-title":"Scand J Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1002\/sim.7215","article-title":"Accounting for competing risks in randomized controlled trials: a review and recommendations for improvement","volume":"36","author":"Austin","year":"2017","journal-title":"Statist Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jclinepi.2020.03.004","article-title":"Ignoring competing events in the analysis of survival data may lead to biased results: a nonmathematical illustration of competing risk analysis","volume":"122","author":"Schuster","year":"2020","journal-title":"J Clin Epidemiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1016\/S1470-2045(14)71116-7","article-title":"Nomograms in oncology: more than meets the eye","volume":"16","author":"Balachandran","year":"2015","journal-title":"Lancet Oncol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.eururo.2018.08.038","article-title":"Reporting and interpreting decision curve analysis: a guide for investigators","volume":"74","author":"Van Calster","year":"2018","journal-title":"Eur Urol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ejcsup.2014.05.001","article-title":"Current knowledge and future research directions in treatment-related second primary malignancies","volume":"12","author":"Morton","year":"2014","journal-title":"EJC Suppl."},{"key":"B18","doi-asserted-by":"publisher","first-page":"728","DOI":"10.5009\/gnl16526","article-title":"Assessment of the risk of colorectal cancer survivors developing a second primary pancreatic cancer","volume":"11","author":"Chung","year":"2017","journal-title":"Gut Liver."},{"key":"B19","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/bjs.10327","article-title":"Risk of second primary cancer in patients treated with radiotherapy for rectal cancer","volume":"104","author":"Martling","year":"2017","journal-title":"Br J Surg."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e644","DOI":"10.1634\/theoncologist.2019-0266","article-title":"Second primary malignancies in patients with colorectal cancer: a population-based analysis","volume":"25","author":"Jia","year":"2020","journal-title":"Oncologist."},{"key":"B21","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s10522-017-9682-z","article-title":"Immunosenescence and cancer","volume":"18","author":"Pawelec","year":"2017","journal-title":"Biogerontology."},{"key":"B22","doi-asserted-by":"publisher","first-page":"478.e1","DOI":"10.1016\/j.ajog.2019.05.025","article-title":"Second primary anal and oropharyngeal cancers in cervical cancer survivors","volume":"221","author":"Papatla","year":"2019","journal-title":"Am J Obstetr Gynecol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s40257-015-0155-3","article-title":"Second primary malignancies in CTCL patients from 1992 to 2011: a SEER-based, population-based study evaluating time from CTCL diagnosis, age, sex, stage, and CD30+ subtype","volume":"17","author":"Amber","year":"2016","journal-title":"Am J Clin Dermatol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/cncr.31689","article-title":"Risk factors for metachronous bilateral renal cell carcinoma: a surveillance, epidemiology, and end results analysis","volume":"125","author":"Syed","year":"2019","journal-title":"Cancer."},{"key":"B25","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13058-019-1219-8","article-title":"Associations of race and ethnicity with risk of developing invasive breast cancer after lobular carcinoma in situ","volume":"21","author":"Dania","year":"2019","journal-title":"Breast Cancer Res."},{"key":"B26","first-page":"259","article-title":"Incidence of prostate cancer and marital status","volume":"79","author":"Newell","year":"1987","journal-title":"J Natl Cancer Inst."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.jsxm.2018.07.004","article-title":"Sexual activity and risk of prostate cancer: a dose-response meta-analysis","volume":"15","author":"Jian","year":"2018","journal-title":"J Sex Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1245\/s10434-019-07326-7","article-title":"Sidedness of colorectal cancer impacts risk of second primary gastrointestinal malignancy","volume":"26","author":"Broman","year":"2019","journal-title":"Ann Surg Oncol."}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2020.01154\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T06:05:05Z","timestamp":1594879505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2020.01154\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,16]]},"references-count":28,"alternative-id":["10.3389\/fonc.2020.01154"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2020.01154","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,16]]},"article-number":"1154"}}