{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:24Z","timestamp":1753891944915,"version":"3.41.2"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2020.01414","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T06:10:56Z","timestamp":1597126256000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Supraclavicular Recurrence in Completely Resected (y)pN2 Non-Small Cell Lung Cancer: Implications for Postoperative Radiotherapy"],"prefix":"10.3389","volume":"10","author":[{"given":"Liang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjiao","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1093\/annonc\/mdv187","article-title":"2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer","volume":"26","author":"Eberhardt","year":"2015","journal-title":"Ann Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jtho.2019.10.022","article-title":"Asian thoracic oncology research group expert consensus statement on optimal management of stage III NSCLC","volume":"15","author":"Tan","year":"2020","journal-title":"J Thorac Oncol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.2139\/ssrn.3460654","article-title":"Randomized phase III study of pemetrexed plus cisplatin versus vinorelbine plus cisplatin for completely resected stage II to IIIA nonsquamous non-small-cell lung cancer","volume":"38","author":"Kenmotsu","year":"2020","journal-title":"J Clin Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s10147-005-0493-x","article-title":"Postoperative adjuvant therapy for completely resected early-stage non-small cell lung cancer","volume":"10","author":"Kato","year":"2005","journal-title":"Int J Clin Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jtho.2016.09.135","article-title":"Role of postoperative radiotherapy in pathologic stage IIIA (N2) non-small cell lung cancer in a prospective nationwide oncology outcomes database","volume":"12","author":"Herskovic","year":"2017","journal-title":"J Thorac Oncol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1016\/j.jtho.2018.08.2021","article-title":"Survival patterns for patients with resected N2 non-small cell lung cancer and postoperative radiotherapy: a prognostic scoring model and heat map approach","volume":"13","author":"Deng","year":"2018","journal-title":"J Thorac Oncol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.ijrobp.2013.12.048","article-title":"Patterns of local-regional failure in completely resected stage IIIA(N2) non-small cell lung cancer cases: implications for postoperative radiation therapy clinical target volume design","volume":"88","author":"Feng","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1634\/theoncologist.2010-0343","article-title":"Postoperative radiotherapy for resected pathological stage IIIA-N2 non-small cell lung cancer: a retrospective study of 221 cases from a single institution","volume":"16","author":"Dai","year":"2011","journal-title":"Oncologist."},{"key":"B9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ijrobp.2009.05.044","article-title":"A multicenter retrospective analysis of survival outcome following postoperative chemoradiotherapy in non-small-cell lung cancer patients with N2 nodal disease","volume":"77","author":"Zou","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B10","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1200\/JCO.2014.58.5380","article-title":"Postoperative radiotherapy for pathologic N2 non-small-cell lung cancer treated with adjuvant chemotherapy: a review of the National Cancer Data Base","volume":"33","author":"Robinson","year":"2015","journal-title":"J Clin Oncol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/JTO.0000000000000411","article-title":"Higgins: Postoperative radiotherapy is associated with better survival in non-small cell lung cancer with involved N2 lymph nodes: results of an analysis of the National Cancer Data Base","volume":"10","author":"Mikell","year":"2015","journal-title":"J Thorac Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ctrv.2016.10.001","article-title":"Postoperative radiotherapy for lung cancer: Is it worth the controversy?","volume":"51","author":"Billiet","year":"2016","journal-title":"Cancer Treat Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"CD002142","DOI":"10.1002\/14651858.CD002142.pub4","article-title":"Postoperative radiotherapy for non-small cell lung cancer","volume":"10","author":"Burdett","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.radonc.2013.08.011","article-title":"Modern post-operative radiotherapy for stage III non-small cell lung cancer may improve local control and survival: a meta-analysis","volume":"110","author":"Billiet","year":"2014","journal-title":"Radiother Oncol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"823","DOI":"10.2147\/OTT.S98765","article-title":"Delineation of clinical target volume for postoperative radiotherapy in stage IIIA-pN2 non-small-cell lung cancer","volume":"9","author":"Jing","year":"2016","journal-title":"Onco Targets Ther."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.1002\/cam4.2937","article-title":"Postoperative intensity-modulated radiation therapy reduces local recurrence and improves overall survival in III-N2 non-small-cell lung cancer: A single-center, retrospective study","volume":"9","author":"Wei","year":"2020","journal-title":"Cancer Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.athoracsur.2018.04.064","article-title":"Postoperative radiotherapy for surgically resected ypN2 non-small cell lung cancer","volume":"106","author":"Brandt","year":"2018","journal-title":"Ann Thorac Surg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"967","DOI":"10.21037\/tlcr.2019.12.02","article-title":"Patterns and risks of postoperative recurrence in completely resected EGFR-mutant non-small cell lung cancer: prognostic significance of routine immunohistochemical markers","volume":"8","author":"Ni","year":"2019","journal-title":"Transl Lung Cancer Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.lungcan.2005.01.001","article-title":"Complete resection in lung cancer surgery: proposed definition","volume":"49","author":"Rami-Porta","year":"2005","journal-title":"Lung Cancer."},{"key":"B20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.chest.2016.10.010","article-title":"The eighth edition lung cancer stage classification","volume":"151","author":"Detterbeck","year":"2017","journal-title":"Chest."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification","volume":"10","author":"Travis","year":"2015","journal-title":"J Thorac Oncol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.prro.2012.01.007","article-title":"Computed tomographic atlas for the new international lymph node map for lung cancer: a radiation oncologist perspective","volume":"3","author":"Lynch","year":"2013","journal-title":"Pract Radiat Oncol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1186\/s12885-019-5692-3","article-title":"Postoperative radiotherapy is effective in improving survival of patients with stage pIII-N2 non-small-cell lung cancer after pneumonectomy","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Cancer."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1016\/j.jtho.2016.05.037","article-title":"Patterns of locoregional relapses in patients with contemporarily staged stage III-N2 NSCLC treated with induction chemotherapy and resection: implications for postoperative radiotherapy target volumes","volume":"11","author":"Billiet","year":"2016","journal-title":"J Thorac Oncol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0169-5002(01)00207-0","article-title":"Overall survival and local recurrence of 406 completely resected stage IIIa-N2 non-small cell lung cancer patients: questionnaire survey of the Japan Clinical Oncology Group to plan for clinical trials","volume":"34","author":"Ichinose","year":"2001","journal-title":"Lung Cancer."},{"key":"B26","first-page":"417","article-title":"Survival of patients with resected pIIIa - N2 non small cell lung cancer: suggestion for subclassification","volume":"9","author":"Andjelic","year":"2004","journal-title":"J BUON."},{"key":"B27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.lungcan.2017.11.020","article-title":"Recurrence dynamics after trimodality therapy (Neoadjuvant concurrent chemoradiotherapy and surgery) in patients with stage IIIA (N2) lung cancer","volume":"115","author":"Lee","year":"2018","journal-title":"Lung Cancer."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e8662","DOI":"10.1097\/MD.0000000000008662","article-title":"Clinical analysis of the impact of sublobectomy on pulmonary function","volume":"96","author":"Yang","year":"2017","journal-title":"Medicine (Baltimore)."},{"key":"B29","doi-asserted-by":"publisher","first-page":"143","DOI":"10.6004\/jnccn.2019.7353","article-title":"Comparison of treatment strategies for patients with clinical stage T1-3\/N2 lung cancer","volume":"18","author":"Cheng","year":"2020","journal-title":"J Natl Compr Canc Netw."},{"key":"B30","first-page":"2294","article-title":"Cytokeratin 7 and thyroid transcription factor - 1 levels in patients with lung cancer complicated with superior vena cava syndrome and their correlation with clinicopathological characteristics","volume":"24","author":"Tong","year":"2019","journal-title":"J BUON."},{"key":"B31","doi-asserted-by":"publisher","first-page":"BSR20171086","DOI":"10.1042\/BSR20171086","article-title":"Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer","volume":"37","author":"Luo","year":"2017","journal-title":"Biosci Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0169-5002(98)00008-7","article-title":"Radiotherapy for locoregional recurrent tumors after resection of non-small cell lung cancer","volume":"20","author":"Kagami","year":"1998","journal-title":"Lung Cancer."},{"key":"B33","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ijrobp.2011.05.070","article-title":"The impact of extent and location of mediastinal lymph node involvement on survival in Stage III non-small cell lung cancer patients treated with definitive radiotherapy","volume":"83","author":"Fernandes","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B34","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S0360-3016(99)00120-0","article-title":"Is prolonged survival possible for patients with supraclavicular node metastases in non-small cell lung cancer treated with chemoradiotherapy?: analysis of the Radiation Therapy Oncology Group experience","volume":"44","author":"Machtay","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"B35","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0169-5002(03)00228-9","article-title":"The impact of regional nodal radiotherapy (dose\/volume) on regional progression and survival in unresectable non-small cell lung cancer: an analysis of RTOG data","volume":"41","author":"Emami","year":"2003","journal-title":"Lung Cancer."},{"key":"B36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.radonc.2013.05.023","article-title":"Target volume for postoperative radiotherapy in non-small cell lung cancer: results from a prospective trial","volume":"108","author":"Kepka","year":"2013","journal-title":"Radiother Oncol."}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2020.01414\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T06:11:00Z","timestamp":1597126260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2020.01414\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":36,"alternative-id":["10.3389\/fonc.2020.01414"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2020.01414","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"article-number":"1414"}}