{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:28:08Z","timestamp":1785454088047,"version":"3.56.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2020.574552","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T13:46:17Z","timestamp":1603287977000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Isobaric Tags for Relative and Absolute Quantitation in Proteomic Analysis of Potential Biomarkers in Invasive Cancer, Ductal Carcinoma In Situ, and Mammary Fibroadenoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Da","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1055\/s-0033-1343991","article-title":"Management of pediatric and adolescent breast masses","volume":"27","author":"Kennedy","year":"2013","journal-title":"Semin Plast Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001225)90:6<342::AID-CNCR4>3.0.CO;2-I","article-title":"Distinction of phyllodes tumor from fibroadenoma: a reappraisal of an old problem","volume":"90","author":"Krishnamurthy","year":"2000","journal-title":"Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/000313480507100415","article-title":"Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature","volume":"71","author":"Valdes","year":"2005","journal-title":"Am Surg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0083","article-title":"Breast Cancer Screening and Diagnosis, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology","volume":"16","author":"Bevers","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30897-0","article-title":"Essential TNM: a registry tool to reduce gaps in cancer staging information","volume":"20","author":"Pineros","year":"2019","journal-title":"Lancet Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21565","article-title":"Cancer treatment and survivorship statistics, 2019","volume":"69","author":"Miller","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117009","article-title":"Heterogeneity of breast cancer: The importance of interaction between different tumor cell populations","volume":"239","author":"Januskeviciene","year":"2019","journal-title":"Life Sci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/path.5057","article-title":"The molecular pathology of cancer: from pan-genomics to post-genomics","volume":"244","author":"Huntsman","year":"2018","journal-title":"J Pathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0582-4","article-title":"Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study","volume":"25","author":"Staaf","year":"2019","journal-title":"Nat Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0507-7","article-title":"The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies","volume":"51","author":"Angus","year":"2019","journal-title":"Nat Genet"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0142-8","article-title":"Cancer overdiagnosis: a biological challenge and clinical dilemma","volume":"19","author":"Srivastava","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-016-9607-3","article-title":"Molecular pathology in real time","volume":"35","author":"Ryska","year":"2016","journal-title":"Cancer Metastasis Rev"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/path.5157","article-title":"Ethical considerations for modern molecular pathology","volume":"246","author":"Vos","year":"2018","journal-title":"J Pathol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2956","article-title":"Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing","volume":"5","author":"Lu","year":"2019","journal-title":"JAMA Oncol"},{"key":"B16","article-title":"[Advances in cancer proteomics study]","volume":"23","author":"Chen","year":"2004","journal-title":"Ai Zheng"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.7150\/jca.29354","article-title":"Quantitative Proteomic Analysis and Evaluation of the Potential Prognostic Biomarkers in Cholangiocarcinoma","volume":"10","author":"Tang","year":"2019","journal-title":"J Cancer"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1021\/ac100775s","article-title":"Impact of peptide modifications on the isobaric tags for relative and absolute quantitation method accuracy","volume":"83","author":"Tenga","year":"2011","journal-title":"Anal Chem"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.046417","article-title":"Integrated Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Quantitative Proteomic Analysis Identifies Galectin-1 as a Potential Biomarker for Predicting Sorafenib Resistance in Liver Cancer","volume":"14","author":"Yeh","year":"2015","journal-title":"Mol Cell Proteomics MCP"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0006-9","article-title":"Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry","volume":"13","author":"Mertins","year":"2018","journal-title":"Nat Protoc"},{"key":"B21","doi-asserted-by":"publisher","first-page":"9990","DOI":"10.1021\/acs.jmedchem.7b00275","article-title":"Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer","volume":"60","author":"Ouyang","year":"2017","journal-title":"J Med Chem"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M115.048967","article-title":"Prediction of Recurrence and Survival for Triple-Negative Breast Cancer (TNBC) by a Protein Signature in Tissue Samples","volume":"14","author":"Campone","year":"2015","journal-title":"Mol Cell Proteomics"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00161","article-title":"E2F2\/5\/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer","volume":"9","author":"Zhou","year":"2019","journal-title":"Front Oncol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00320","article-title":"Bioinformatics Analysis Identifies p53 as a Candidate Prognostic Biomarker for Neuropathic Pain","volume":"9","author":"Gao","year":"2018","journal-title":"Front Genet"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0309-y","article-title":"Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG","volume":"25","author":"Gu","year":"2019","journal-title":"Nat Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00021-13","article-title":"A mortalin\/HSPA9-mediated switch in tumor-suppressive signaling of Raf\/MEK\/extracellular signal-regulated kinase","volume":"33","author":"Wu","year":"2013","journal-title":"Mol Cell Biol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6131548","article-title":"PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer","volume":"2019","author":"Hou","year":"2019","journal-title":"Dis Markers"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e908","DOI":"10.1002\/mgg3.908","article-title":"High expression of PRKDC promotes breast cancer cell growth via p38 MAPK signaling and is associated with poor survival","volume":"7","author":"Zhang","year":"2019","journal-title":"Mol Genet Genomic Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s10549-017-4234-4","article-title":"MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer","volume":"164","author":"Han","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12666","article-title":"Expression of ribosome-binding protein 1 correlates with shorter survival in Her-2 positive breast cancer","volume":"106","author":"Liang","year":"2015","journal-title":"Cancer Sci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.114","article-title":"Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer","volume":"112","author":"Sun","year":"2015","journal-title":"Br J Cancer"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3131-x","article-title":"Elevated expression of HABP1 is a novel prognostic indicator in triple-negative breast cancers","volume":"36","author":"Wang","year":"2015","journal-title":"Tumour Biol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21329","article-title":"Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer","volume":"100","author":"Chen","year":"2009","journal-title":"J Surg Oncol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1186\/s13046-019-1318-5","article-title":"A positive feedback between IDO1 metabolite and COL12A1 via MAPK pathway to promote gastric cancer metastasis","volume":"38","author":"Xiang","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.5301\/ijbm.5000290","article-title":"The importance of hCG in human endometrial adenocarcinoma and breast cancer","volume":"33","author":"K\u00f6lbl","year":"2018","journal-title":"Int J Biol Markers"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20473","article-title":"FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression","volume":"8","author":"Vitali","year":"2017","journal-title":"Oncotarget"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmx135","article-title":"FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR","volume":"50","author":"Zhang","year":"2018","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.9473","article-title":"Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer","volume":"16","author":"Guo","year":"2018","journal-title":"Oncol Lett"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1113\/JP273309","article-title":"Hypoxia and cellular metabolism in tumour pathophysiology","volume":"595","author":"Parks","year":"2017","journal-title":"J Physiol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-018-9764-7","article-title":"Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases","volume":"37","author":"Sirover","year":"2018","journal-title":"Cancer Metastasis Rev"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax0249","article-title":"Single-cell transcriptional diversity is a hallmark of developmental potential","volume":"367","author":"Gulati","year":"2020","journal-title":"Sci (New York NY)"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/srep12120","article-title":"Large scale systematic proteomic quantification from non-metastatic to metastatic colorectal cancer","volume":"5","author":"Yin","year":"2015","journal-title":"Sci Rep"},{"key":"B43","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/15412555.2019.1711035","article-title":"Protein Network Analysis Identifies Changes in the Level of Proteins Involved in Platelet Degranulation, Proteolysis and Cholesterol Metabolism Pathways in AECOPD Patients","volume":"17","author":"Tan","year":"2020","journal-title":"COPD"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2020.574552\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T06:25:48Z","timestamp":1603347948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2020.574552\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":43,"alternative-id":["10.3389\/fonc.2020.574552"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2020.574552","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,21]]},"article-number":"574552"}}