{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:38:14Z","timestamp":1762868294737,"version":"3.41.2"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell'Istruzione, dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2010Z9FLM8_006","20178S4EK9"],"award-info":[{"award-number":["2010Z9FLM8_006","20178S4EK9"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2020.584022","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T05:44:40Z","timestamp":1601358280000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients"],"prefix":"10.3389","volume":"10","author":[{"given":"Eliana","family":"Bignotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Zanotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Todeschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Zizioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Romani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Capoferri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germana","family":"Tognon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Sartori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Calza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Odicino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Ravaggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin."},{"key":"B2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.maturitas.2014.04.018","article-title":"Cervical cancer in the older woman","volume":"78","author":"Elit","year":"2014","journal-title":"Maturitas."},{"key":"B3","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.semradonc.2018.11.002","article-title":"Management of nodal disease in advanced cervical cancer","volume":"29","author":"J\u00fcrgenliemk-Schulz","year":"2019","journal-title":"Semin Radiat Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","article-title":"Cervical cancer","volume":"393","author":"Cohen","year":"2019","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1258\/0004563041731529","article-title":"Evidence for the clinical use of tumour markers","volume":"41","author":"Duffy","year":"2004","journal-title":"Ann Clin Biochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.2147\/OTT.S250614","article-title":"Combined evaluation of preoperative serum CEA and CA125 as an independent prognostic biomarker in patients with early-stage cervical adenocarcinoma","volume":"13","author":"Huang","year":"2020","journal-title":"Onco Targets Ther."},{"key":"B7","doi-asserted-by":"publisher","first-page":"6710352","DOI":"10.1155\/2019\/6710352","article-title":"Prognostic role of squamous cell carcinoma antigen in cervical cancer: a meta-analysis","volume":"2019","author":"Liu","year":"2019","journal-title":"Dis Markers."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1038\/sj.onc.1205363","article-title":"The putative ovarian tumour marker gene HE4 (WFDC2) is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms","volume":"21","author":"Bingle","year":"2002","journal-title":"Oncogene."},{"key":"B9","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1095\/biolreprod45.2.350","article-title":"A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors","volume":"45","author":"Kirchhoff","year":"1991","journal-title":"Biol Reprod."},{"key":"B10","first-page":"548","article-title":"The emerging role of HE4 in the evaluation of epithelial ovarian and endometrial carcinomas","volume":"27","author":"Simmons","year":"2013","journal-title":"Oncology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1038\/bjc.2011.109","article-title":"Diagnostic and prognostic impact of serum HE4 detection in endometrial carcinoma patients","volume":"104","author":"Bignotti","year":"2011","journal-title":"Br J Cancer."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.cca.2011.04.028","article-title":"HE4 and epithelial ovarian cancer: comparison and clinical evaluation of two immunoassays and a combination algorithm","volume":"412","author":"Ruggeri","year":"2011","journal-title":"Clin Chim Acta."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1158\/1055-9965.EPI-11-0635","article-title":"Serum human epididymis protein 4 and risk for ovarian malignancy algorithm as new diagnostic and prognostic tools for epithelial ovarian cancer management","volume":"20","author":"Bandiera","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1515\/cclm-2011-0757","article-title":"Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome","volume":"50","author":"Zanotti","year":"2012","journal-title":"Clin Chem Lab Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"10528","DOI":"10.1038\/s41598-017-11104-4","article-title":"RERT: A novel regression tree approach to predict extrauterine disease in endometrial carcinoma patients","volume":"7","author":"Vezzoli","year":"2017","journal-title":"Sci Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1515\/cclm-2012-0097","article-title":"Human epididymis protein 4 (HE4) in benign and malignant diseases","volume":"50","author":"Hertlein","year":"2012","journal-title":"Clin Chem Lab Med."},{"key":"B17","doi-asserted-by":"crossref","DOI":"10.1002\/0471725250","volume-title":"Robust Statistics","author":"Huber","year":"1981"},{"key":"B18","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v039.i05","article-title":"Regularization paths for cox's proportional hazards model via coordinate descent","volume":"39","author":"Simon","year":"2011","journal-title":"J Stat Softw."},{"volume-title":"Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis","year":"2010","author":"Harrell","key":"B20"},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1201\/9780429492259","volume-title":"Flexible Imputation of Missing Data, 2nd edn","author":"Van Buuren","year":"2018"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1111\/j.1541-0420.2008.00995.x","article-title":"Generalized maximally selected statistics","volume":"64","author":"Hothorn","year":"2008","journal-title":"Biometrics."},{"key":"B23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ijgo.2015.07.024","article-title":"Systematic reviews and meta-analyses of the accuracy of HPV tests, visual inspection with acetic acid, cytology, and colposcopy","volume":"132","author":"Mustafa","year":"2016","journal-title":"Int J Gynaecol Obstet."},{"key":"B24","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/jcla.20340","article-title":"The utility of serum human epididymis protein 4 (HE4) in patients with a pelvic mass","volume":"23","author":"Montagnana","year":"2009","journal-title":"J Clin Lab Anal."},{"key":"B25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.5603\/GP.a2017.0011","article-title":"Tissue expression of human epididymal secretory protein 4 may be useful in the differential diagnosis of uterine cervical tumors","volume":"88","author":"Diniz","year":"2017","journal-title":"Ginekol Pol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.bbrc.2012.02.008","article-title":"Human epididymis protein 4 (HE4) plays a key role in ovarian cancer cell adhesion and motility","volume":"419","author":"Lu","year":"2012","journal-title":"Biochem Biophys Res Commun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1038\/srep03574","article-title":"HE4 (WFDC2) gene overexpression promotes ovarian tumor growth","volume":"4","author":"Moore","year":"2014","journal-title":"Sci Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"729","DOI":"10.18632\/oncotarget.6327","article-title":"Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer","volume":"7","author":"Zhu","year":"2016","journal-title":"Oncotarget."},{"key":"B29","doi-asserted-by":"publisher","first-page":"6026","DOI":"10.3390\/ijms14036026","article-title":"HE4 (WFDC2) promotes tumor growth in endometrial cancer cell lines","volume":"14","author":"Li","year":"2013","journal-title":"Int J Mol Sci."}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2020.584022\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T05:44:45Z","timestamp":1601358285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fonc.2020.584022\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":29,"alternative-id":["10.3389\/fonc.2020.584022"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2020.584022","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2020,9,29]]},"article-number":"584022"}}