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Oncol."],"abstract":"<jats:p>We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets with the non-affected triplet. The differences were observed in na\u00efve B-cells and marginal zone-like B-cells. DNA methylation differences were also detected when comparing each of the HL-affected triplets against each other. Even though we cannot determine whether treatment and\/or disease triggered the observed differences, we believe our data are important on behalf of forthcoming studies, and that it might provide important clues for a better understanding of HL pathogenesis.<\/jats:p>","DOI":"10.3389\/fonc.2020.598872","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T20:23:56Z","timestamp":1607545436000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures"],"prefix":"10.3389","volume":"10","author":[{"given":"Chuanyou","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thale Kristin","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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