{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:41:37Z","timestamp":1791564097993,"version":"4.3.4"},"reference-count":239,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    The B-cell receptor (BCR) signaling pathway is a crucial pathway of B cells, both for their survival and for antigen-mediated activation, proliferation and differentiation. Its activation is also critical for the genesis of many lymphoma types. BCR-mediated lymphoma proliferation may be caused by activating BCR-pathway mutations and\/or by active or tonic stimulation of the BCR. BCRs of lymphomas have frequently been described as polyreactive. In this review, the role of specific target antigens of the BCRs of lymphomas is highlighted. These antigens have been found to be restricted to specific lymphoma entities. The antigens can be of infectious origin, such as\n                    <jats:italic>H. pylori<\/jats:italic>\n                    in gastric MALT lymphoma or RpoC of\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    in nodular lymphocyte predominant Hodgkin lymphoma, or they are autoantigens. Examples of such autoantigens are the BCR itself in chronic lymphocytic leukemia, LRPAP1 in mantle cell lymphoma, hyper-N-glycosylated SAMD14\/neurabin-I in primary central nervous system lymphoma, hypo-phosphorylated ARS2 in diffuse large B-cell lymphoma, and hyper-phosphorylated SLP2, sumoylated HSP90 or saposin C in plasma cell dyscrasia. Notably, atypical posttranslational modifications are often responsible for the immunogenicity of many autoantigens. Possible therapeutic approaches evolving from these specific antigens are discussed.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2020.604685","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T15:26:39Z","timestamp":1607527599000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Role of Specific B-Cell Receptor Antigens in Lymphomagenesis"],"prefix":"10.3389","volume":"10","author":[{"given":"Lorenz","family":"Thurner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Stilgenbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"K\u00fcppers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Dieter","family":"Preuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Bewarder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2360047","article-title":"RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination","volume":"248","author":"Oettinger","year":"1990","journal-title":"Sci (80)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00309-9","article-title":"Artemis, a novel DNA double-strand break repair\/V(D)J recombination protein, is mutated in human severe combined immune deficiency","volume":"105","author":"Moshous","year":"2001","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.10.3628","article-title":"Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions","volume":"73","author":"Hozumi","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.8356451","article-title":"Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes","volume":"261","author":"Komori","year":"1993","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.8356452","article-title":"Mice lacking TdT: mature animals with an immature lymphocyte repertoire","volume":"261","author":"Gilfillan","year":"1993","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.3929382","article-title":"The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining","volume":"229","author":"Tsujimoto","year":"1985","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B-cell lymphoma pathogenesis","volume":"5","author":"Kuppers","year":"2005","journal-title":"NatRevCancer"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001001","article-title":"Germinal Centers","volume":"12","author":"MacLennan","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nri1896","article-title":"Targeting of somatic hypermutation","volume":"6","author":"Odegard","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00079-9","article-title":"Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)","volume":"102","author":"Revy","year":"2000","journal-title":"Cell"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/ni1100","article-title":"Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5","volume":"5","author":"Allen","year":"2004","journal-title":"Nat Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0065-2776(10)05007-8","article-title":"BCL6. master regulator of the germinal center reaction and key oncogene in B Cell lymphomagenesis","volume":"105","author":"Basso","year":"2010","journal-title":"Adv Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00267-X","article-title":"Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells","volume":"19","author":"Shapiro-Shelef","year":"2003","journal-title":"Immunity"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0713-6","article-title":"The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development","volume":"21","author":"Laidlaw","year":"2020","journal-title":"Nat Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/381751a0","article-title":"Clonal selection and learning in the antibody system","volume":"381","author":"Rajewsky","year":"1996","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Sci (80)"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/337562a0","article-title":"Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes","volume":"337","author":"Nemazee","year":"1989","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/334676a0","article-title":"Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice","volume":"334","author":"Goodnow","year":"1988","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/349331a0","article-title":"Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice","volume":"349","author":"Erikson","year":"1991","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ni1076","article-title":"Receptor editing is the main mechanism of B cell tolerance toward membrane antigens","volume":"5","author":"Halverson","year":"2004","journal-title":"Nat Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.10.013","article-title":"Autoreactive B Cell Receptors Mimic Autonomous Pre-B Cell Receptor Signaling and Induce Proliferation of Early B Cells","volume":"29","author":"K\u00f6hler","year":"2008","journal-title":"Immunity"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041344","article-title":"Efficient generation of B lymphocytes by recognition of self-antigens","volume":"41","author":"Eschbach","year":"2011","journal-title":"Eur J Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.09.001","article-title":"B-cell tolerance checkpoints in health and autoimmunity","volume":"20","author":"Meffre","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042251","article-title":"Defective B cell tolerance checkpoints in systemic lupus erythematosus","volume":"201","author":"Yurasov","year":"2005","journal-title":"J Exp Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042321","article-title":"Impaired early B cell tolerance in patients with rheumatoid arthritis","volume":"201","author":"Samuels","year":"2005","journal-title":"J Exp Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/376181a0","article-title":"CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells","volume":"376","author":"Rathmell","year":"1995","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81349-5","article-title":"Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor","volume":"87","author":"Rathmell","year":"1996","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062287","article-title":"CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance","volume":"204","author":"Herv\u00e9","year":"2007","journal-title":"J Exp Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/374546a0","article-title":"CpG motifs in bacterial DNA trigger direct B-cell activation","volume":"374","author":"Krieg","year":"1995","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06339.x","article-title":"IL-10 and IL-10 receptor defects in humans","volume":"1246","author":"Glocker","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000024","article-title":"Defining the role of the MHC in autoimmunity: A review and pooled analysis","volume":"4","author":"Fernando","year":"2008","journal-title":"PloS Genet"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/ng1323","article-title":"A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes","volume":"36","author":"Bottini","year":"2004","journal-title":"Nat Genet"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.7.4704","article-title":"Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes","volume":"179","author":"Rieck","year":"2007","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.109","article-title":"PTPN22: the archetypal non-HLA autoimmunity gene","volume":"10","author":"Stanford","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nature01621","article-title":"Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease","volume":"423","author":"Ueda","year":"2003","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.07.017","article-title":"The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity","volume":"33","author":"Tavares","year":"2010","journal-title":"Immunity"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/416603a","article-title":"Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors","volume":"416","author":"Leadbetter","year":"2002","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.01.018","article-title":"B cells take the front seat: Dysregulated B cell signals orchestrate loss of tolerance and autoantibody production","volume":"33","author":"Jackson","year":"2015","journal-title":"Curr Opin Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511233332102","article-title":"Campylobacter jejuni Infection and Guillain\u2013Barr\u00e9 Syndrome","volume":"333","author":"Rees","year":"1995","journal-title":"NEJM"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500484674","article-title":"Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease","volume":"39","author":"Guilherme","year":"2006","journal-title":"Autoimmunity"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11810","article-title":"Human neoplasms elicit multiple specific immune responses in the autologous host","volume":"92","author":"Sahin","year":"1995","journal-title":"ProcNatlAcadSciUSA"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/science.1246886","article-title":"Association of the autoimmune disease scleroderma with an immunologic response to cancer","volume":"343","author":"Joseph","year":"2014","journal-title":"Sci (80)"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.12.003","article-title":"Autoantigenesis: The evolution of protein modifications in autoimmune disease","volume":"24","author":"Doyle","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.603","article-title":"The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase","volume":"191","author":"Arentz-Hansen","year":"2000","journal-title":"JExpMed"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/324258a0","article-title":"Rothbard JB. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis","volume":"324","author":"Zamvil","year":"1986","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"JClinInvest"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/ar95","article-title":"Citrullination: a small change for a protein with great consequences for rheumatoid arthritis","volume":"2","author":"van Venrooij","year":"2000","journal-title":"Arthritis Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200008)43:8<1768::AID-ANR13>3.0.CO;2-9","article-title":"SR proteins are autoantigens in patients with systemic lupus erythematosus. Importance of phosphoepitopes","volume":"43","author":"Neugebauer","year":"2000","journal-title":"Arthritis Rheum"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.5.843","article-title":"Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus","volume":"185","author":"Utz","year":"1997","journal-title":"JExpMed"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24355","article-title":"An integrated humoral and cellular response is elicited in pancreatic cancer by \u03b1-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen","volume":"125","author":"Cappello","year":"2009","journal-title":"Int J Cancer"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1021\/pr100213b","article-title":"Circulating autoantibodies to phosphorylated \u03b1-enolase are a hallmark of pancreatic cancer","volume":"10","author":"Tomaino","year":"2011","journal-title":"J Proteome Res"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1021\/pr901109w","article-title":"Mass spectrometry analysis of the post-translational modifications of alpha-enolase from pancreatic ductal adenocarcinoma cells","volume":"9","author":"Zhou","year":"2010","journal-title":"J Proteome Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/art.30138","article-title":"DEK in the synovium of patients with juvenile idiopathic arthritis: Characterization of DEK antibodies and posttranslational modification of the DEK autoantigen","volume":"63","author":"Mor-Vaknin","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636912","article-title":"Malondialdehyde modification of myelin oligodendrocyte glycoprotein leads to increased immunogenicity and encephalitogenicity","volume":"37","author":"W\u00e5llberg","year":"2007","journal-title":"Eur J Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803451200","article-title":"A role for collagen IV cross-links in conferring immune privilege to the goodpasture autoantigen: Structural basis for the crypticity of B cell epitopes","volume":"283","author":"Vanacore","year":"2008","journal-title":"J Biol Chem"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176811","article-title":"A Sulfilimine Bond Identified in Collagen IV","volume":"325","author":"Vanacore","year":"2009","journal-title":"Sci (80)"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38468","article-title":"Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity","volume":"119","author":"Suzuki","year":"2009","journal-title":"J Clin Invest"},{"key":"B59","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41467-017-02763-y","article-title":"T cells specific for post-translational modifications escape intrathymic tolerance induction","volume":"9","author":"Raposo","year":"2018","journal-title":"Nat Commun"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/35085588","article-title":"Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas","volume":"412","author":"Pasqualucci","year":"2001","journal-title":"Nature"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11816","article-title":"BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci","volume":"95","author":"Pasqualucci","year":"1998","journal-title":"Proc Natl Acad Sci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.35","article-title":"AID is required for germinal center-derived lymphomagenesis","volume":"40","author":"Pasqualucci","year":"2008","journal-title":"Nat Genet"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070884","article-title":"A role for AID in chromosome translocations between c-myc and the IgH variable region","volume":"204","author":"Dorsett","year":"2007","journal-title":"J Exp Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204640","article-title":"Mechanisms of chromosomal translocations in B cell lymphomas","volume":"20","author":"K\u00fcppers","year":"2001","journal-title":"Oncogene"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nature03147","article-title":"The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells","volume":"432","author":"Phan","year":"2004","journal-title":"Nature"},{"key":"B66","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature08638","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma","volume":"463","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200710","article-title":"MYD88 L265P Somatic Mutation in Waldenstr\u00f6m\u2019s Macroglobulinemia","volume":"367","author":"Treon","year":"2012","journal-title":"N Engl J Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5413","article-title":"p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia","volume":"88","author":"Gaidano","year":"1991","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090528","article-title":"TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma","volume":"206","author":"Schmitz","year":"2009","journal-title":"J Exp Med"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nature07969","article-title":"Frequent inactivation of A20 in B-cell lymphomas","volume":"459","author":"Kato","year":"2009","journal-title":"Nature"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/nature10113","article-title":"Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia","volume":"475","author":"Puente","year":"2011","journal-title":"Nature"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801445","article-title":"Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma","volume":"378","author":"Schmitz","year":"2018","journal-title":"N Engl J Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120904","article-title":"The coding genome of splenic marginal zone lymphoma: Activation of NOTCH2 and other pathways regulating marginal zone development","volume":"209","author":"Rossi","year":"2012","journal-title":"J Exp Med"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-814913","article-title":"Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma","volume":"131","author":"Tiacci","year":"2018","journal-title":"Blood"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3545","article-title":"Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma","volume":"104","author":"Guiter","year":"2004","journal-title":"Blood"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600363","article-title":"Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23","volume":"23","author":"MacPherson","year":"2004","journal-title":"EMBO J"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282780","article-title":"Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma","volume":"116","author":"Green","year":"2010","journal-title":"Blood"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.5414\/NP300698","article-title":"PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL)","volume":"33","author":"Berghoff","year":"2014","journal-title":"Clin Neuropathol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.11.006","article-title":"Combined Genetic Inactivation of \u03b22-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B Cell Lymphoma","volume":"20","author":"Challa-Malladi","year":"2011","journal-title":"Cancer Cell"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V14.10.1151.1151","article-title":"Leukemia and auto-immunization- some possible relationships","volume":"14","author":"Dameshek","year":"1959","journal-title":"Blood"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2469","article-title":"Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing","volume":"44","author":"Richter","year":"2012","journal-title":"Nat Genet"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601053113","article-title":"Elucidation of tonic and activated B-cell receptor signaling in Burkitt\u2019s lymphoma provides insights into regulation of cell survival","author":"Corso","year":"2016","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/nature04687","article-title":"A loss-of-function RNA interference screen for molecular targets in cancer","author":"Ngo","year":"2006","journal-title":"Nature"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153629","article-title":"Oncogenic CARD11 mutations in human diffuse large B cell lymphoma","volume":"319","author":"Lenz","year":"2008","journal-title":"Sci (80)"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/nature09671","article-title":"Oncogenically active MYD88 mutations in human lymphoma","volume":"470","author":"Ngo","year":"2011","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature08638","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma","volume":"463","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"B89","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/s41467-019-08677-1","article-title":"Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane","volume":"10","author":"Gomes de Castro","year":"2019","journal-title":"Nat Commun"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0290-0","article-title":"A multiprotein supercomplex controlling oncogenic signalling in lymphoma","volume":"560","author":"Phelan","year":"2018","journal-title":"Nature"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z","article-title":"Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma","volume":"338","author":"Wotherspoon","year":"1991","journal-title":"Lancet"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803","article-title":"Helicobacter pylori infection and gastric lymphoma","volume":"330","author":"Parsonnet","year":"1994","journal-title":"N Engl J Med"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91409-F","article-title":"Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori","volume":"342","author":"Wotherspoon","year":"1993","journal-title":"Lancet"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-228015","article-title":"Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins","volume":"115","author":"Craig","year":"2010","journal-title":"Blood"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050068","article-title":"Among B cell non-Hodgkin\u2019s lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity","volume":"201","author":"Bende","year":"2005","journal-title":"J Exp Med"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-274613","article-title":"MALT lymphoma-derived rheumatoid factors are nonpolyreactive high-affinity antibodies","volume":"116","author":"Hoogeboom","year":"2010","journal-title":"Blood"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031887","article-title":"Immunoproliferative Small Intestinal Disease Associated with Campylobacter jejuni","volume":"350","author":"Lecuit","year":"2004","journal-title":"N Engl J Med"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1002\/path.1984","article-title":"Chlamydia psittaci is variably associated with ocular adnexal MALT lymphoma in different geographical regions","volume":"209","author":"Chanudet","year":"2006","journal-title":"JPathol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.13.3745","article-title":"The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis","volume":"98","author":"Quinn","year":"2001","journal-title":"Blood"},{"key":"B101","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1056\/NEJMoa013376","article-title":"Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection","volume":"347","author":"Hermine","year":"2002","journal-title":"NEnglJMed"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-10-199505150-00006","article-title":"Eradication of Helicobacter pylori infection in primary low-grade gastric lymphoma of mucosa-associated lymphoid tissue","volume":"122","author":"Roggero","year":"1995","journal-title":"Ann Intern Med"},{"key":"B103","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.annonc.2019.10.010","article-title":"Marginal zone lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"31","author":"Zucca","year":"2020","journal-title":"Ann Oncol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.4466","article-title":"Chlamydophila Psittaci eradication with doxycycline as first-line targeted therapy for ocular adnexae lymphoma: Final results of an international phase II trial","volume":"30","author":"Ferreri","year":"2012","journal-title":"J Clin Oncol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv214","article-title":"High-dose clarithromycin is an active monotherapy for patients with relapsed\/refractory extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT): The HD-K phase II trial","volume":"26","author":"Ferreri","year":"2015","journal-title":"Ann Oncol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80233-6","article-title":"Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin","volume":"31","author":"Roggero","year":"2000","journal-title":"Hum Pathol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1038\/s41467-020-16375-6","article-title":"Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma","volume":"11","author":"Thurner","year":"2020","journal-title":"Nat Commun"},{"key":"B108","first-page":"322","article-title":"Moraxella catarrhalis-a bacterial involvement in the origin of nodular lymphocyte predominant hodgkin lymphoma of IGD type","volume":"10566","author":"Thurner","year":"2015","journal-title":"Haematologica"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(92)90039-P","article-title":"Analysis of HLA DP, DQ, and DR allesles in adult Italian rheumatoid arthritis patients","volume":"34","author":"Angelini","year":"1992","journal-title":"Hum Immunol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797980","article-title":"Continuous signaling of CD 79b and CD 19 is required for the fitness of Burkitt lymphoma B cells","volume":"37","author":"He","year":"2018","journal-title":"EMBO J"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1089","article-title":"Endemic Burkitt\u2019s lymphoma: a polymicrobial disease","volume":"3","author":"Rochford","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.019","article-title":"Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma","volume":"162","author":"Robbiani","year":"2015","journal-title":"Cell"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0271","article-title":"Epstein-barr virus-associated lymphomas","volume":"372","author":"Shannon-Lowe","year":"2017","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.6.1700","article-title":"Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor","volume":"17","author":"Kilger","year":"1998","journal-title":"EMBO J"},{"key":"B115","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/35095584","article-title":"Epstein-Barr virus: exploiting the immune system","volume":"1","author":"Thorley-Lawson","year":"2001","journal-title":"NatRevImmunol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.12.031","article-title":"Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model","volume":"148","author":"Zhang","year":"2012","journal-title":"Cell"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80623-8","article-title":"Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals","volume":"9","author":"Caldwell","year":"1998","journal-title":"Immunity"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/ni1036","article-title":"B cell receptor signal strength determines B cell fate","volume":"5","author":"Casola","year":"2004","journal-title":"NatImmunol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-090142","article-title":"Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival","volume":"110","author":"Mancao","year":"2007","journal-title":"Blood"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900442","article-title":"Roles of the TRAF2\/3 Binding Site in Differential B Cell Signaling by CD40 and Its Viral Oncogenic Mimic, LMP1","volume":"183","author":"Graham","year":"2009","journal-title":"J Immunol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","author":"Poiesz","year":"1980","journal-title":"Proc Natl Acad Sci"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.3.1186.1186_1186_1191","article-title":"Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi\u2019s sarcoma-associated herpesvirus\/human herpesvirus-8","author":"Horenstein","year":"1997","journal-title":"Blood"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-373738","article-title":"How I treat HIV-associated lymphoma","author":"Dunleavy","year":"2012","journal-title":"Blood"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-696757","article-title":"The genetics of nodal marginal zone lymphoma","volume":"128","author":"Spina","year":"2016","journal-title":"Blood"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200004)43:4<908::AID-ANR24>3.0.CO;2-K","article-title":"Salivary gland lymphomas in patients with Sjogren\u2019s syndrome may frequently develop from rheumatoid factor B cells","volume":"43","author":"Martin","year":"2000","journal-title":"Arthritis Rheum"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009388107","article-title":"Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins","volume":"107","author":"Coelho","year":"2010","journal-title":"ProcNatlAcadSciUSA"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040544","article-title":"Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia","volume":"200","author":"Messmer","year":"2004","journal-title":"J Exp Med"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015992","article-title":"Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells","volume":"5","author":"Binder","year":"2010","journal-title":"PloS One"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-244251","article-title":"Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: Implications for patient outcome and cell of origin","volume":"115","author":"Chu","year":"2010","journal-title":"Blood"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.2119\/2008-00102.Catera","article-title":"Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation","volume":"14","author":"Catera","year":"2008","journal-title":"Mol Med"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141018","article-title":"B cell chronic lymphocytic leukemia: Lessons learned from studies of the B cell antigen receptor","volume":"21","author":"Chiorazzi","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400376","article-title":"Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia","volume":"371","author":"Byrd","year":"2014","journal-title":"N Engl J Med"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-447904","article-title":"Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells","volume":"99","author":"Zwick","year":"2013","journal-title":"Blood"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v76.3.562.562","article-title":"Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies","volume":"76","author":"Borche","year":"1990","journal-title":"Blood"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24387","article-title":"Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity","volume":"115","author":"Herv\u00e9","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-374058","article-title":"Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen","volume":"119","author":"Steininger","year":"2012","journal-title":"Blood"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v94.6.1840","article-title":"Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"B139","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1084\/jem.20121801","article-title":"A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi","volume":"210","author":"Hoogeboom","year":"2013","journal-title":"J Exp Med"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.311","article-title":"Antigen receptor stereotypy across B-cell lymphoproliferations: The case of IGHV4-59\/IGKV3-20 receptors with rheumatoid factor activity","author":"Kostareli","year":"2012","journal-title":"Leukemia"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-454439","article-title":"CLL B-cell receptors can recognize themselves: Alternative epitopes and structural clues for autostimulatory mechanisms in CLL","volume":"121","author":"Binder","year":"2013","journal-title":"Blood"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/nature11309","article-title":"Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling","author":"Minden","year":"2012","journal-title":"Nature"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.11.021","article-title":"Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria","volume":"37","author":"Shao","year":"2013","journal-title":"Leuk Res"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014209","article-title":"BRAF mutations in hairy-cell leukemia","volume":"364","author":"Tiacci","year":"2011","journal-title":"N Engl J Med"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12282","article-title":"Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia","volume":"93","author":"Forconi","year":"2008","journal-title":"Haematologica"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1002\/hon.952","article-title":"Lack of allelic exclusion by secondary rearrangements of tumour B-cell receptor light chains in hairy cell leukaemia","volume":"29","author":"Sozzi","year":"2011","journal-title":"Hematol Oncol"},{"key":"B147","article-title":"Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse","volume":"113","author":"Swerdlow","year":"1983","journal-title":"AmJPathol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-2141.2005.05716.x","article-title":"Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): A clinicopathological study from the European MCL Network","volume":"131","author":"Tiemann","year":"2005","journal-title":"Br J Haematol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.7.1387.1387","article-title":"Genotypic characterization of centrocytic lymphoma: frequent rearrangement of the chromosome 11 bcl-1 locus","author":"Williams","year":"1990","journal-title":"Blood"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.09.014","article-title":"Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage","volume":"30","author":"Queir\u00f3s","year":"2016","journal-title":"Cancer Cell"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1383","article-title":"VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: Correlation with genomic aberrations, clinical characteristics, and outcome","volume":"102","author":"Kienle","year":"2003","journal-title":"Blood"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-343434","article-title":"Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases","volume":"118","author":"Hadzidimitriou","year":"2011","journal-title":"Blood"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3479","article-title":"Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma","volume":"101","author":"Walsh","year":"2003","journal-title":"Blood"},{"key":"B154","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1182\/blood-2015-11-681460","article-title":"Pathogenic role of B-cell receptor signaling and canonical NF-\u03baB activation in mantle cell lymphoma","volume":"128","author":"Saba","year":"2016","journal-title":"Blood"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-718494","article-title":"Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling","volume":"129","author":"Myklebust","year":"2017","journal-title":"Blood"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306220","article-title":"Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma","volume":"369","author":"Wang","year":"2013","journal-title":"N Engl J Med"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-537555","article-title":"A phase 1 study of the PI3K\u03b4 inhibitor idelalisib in patients with relapsed\/refractory mantle cell lymphoma (MCL)","volume":"123","author":"Kahl","year":"2014","journal-title":"Blood"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00667-4","article-title":"Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: An international, randomised, open-label, phase 3 study","volume":"387","author":"Dreyling","year":"2016","journal-title":"Lancet"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1715519","article-title":"Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma","volume":"378","author":"Tam","year":"2018","journal-title":"N Engl J Med"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0182-1","article-title":"LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting","volume":"33","author":"Thurner","year":"2019","journal-title":"Leukemia"},{"key":"B161","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)54845-6","article-title":"39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein\/alpha 2-macroglobulin receptor","volume":"266","author":"Herz","year":"1991","journal-title":"J Biol Chem"},{"key":"B162","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(19)50384-2","article-title":"A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor\/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein","volume":"267","author":"Williams","year":"1992","journal-title":"J Biol Chem"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200302069","article-title":"Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen","volume":"266","author":"Striekland","year":"1991","journal-title":"J Biol Chem"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.8.3161","article-title":"Functional domains of the receptor-associated protein (RAP)","volume":"91","author":"Orlando","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001623775","article-title":"Gene expression profiling of diffuse large B-cell lymphoma","author":"Rosenwald","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.027","article-title":"Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma","volume":"171","author":"Reddy","year":"2017","journal-title":"Cell"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal Gene Signatures in Large-B-Cell Lymphomas","volume":"359","author":"Lenz","year":"2008","journal-title":"N Engl J Med"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0016-8","article-title":"Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes","volume":"24","author":"Chapuy","year":"2018","journal-title":"Nat Med"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1514944112","article-title":"Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens","volume":"112","author":"Young","year":"2015","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523661","article-title":"Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis","volume":"115","author":"Cepok","year":"2005","journal-title":"J Clin Invest"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24427","article-title":"A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS","volume":"125","author":"Preuss","year":"2009","journal-title":"IntJCancer"},{"key":"B172","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jaut.2010.09.002","article-title":"Wegener\u2019s granuloma harbors B lymphocytes with specificities against a proinflammatory transmembrane protein and a tetraspanin","volume":"36","author":"Thurner","year":"2011","journal-title":"J Autoimmun"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-836932","article-title":"Hyper N-glycosylated SAMD14 and neurabin-I as driver CNS autoantigens of PCNSL","author":"Thurner","year":"2018","journal-title":"Blood"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.241653","article-title":"Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B cell-type diffuse large B-cell lymphoma","author":"Thurner","year":"2020","journal-title":"Haematologica"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76802","article-title":"Sumoylated HSP90 is a dominantly inherited plasma cell dyscrasias risk factor","volume":"125","author":"Preuss","year":"2015","journal-title":"JClinInvest"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-125450","article-title":"A new perspective: Molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies","volume":"111","author":"Myhrinder","year":"2008","journal-title":"Blood"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-306076","article-title":"Hyperphosphorylated paratarg-7: a new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenstrom macroglobulinemia","volume":"117","author":"Grass","year":"2011","journal-title":"Blood"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-351668","article-title":"Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A","volume":"118","author":"Preuss","year":"2011","journal-title":"Blood"},{"key":"B179","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S1470-2045(09)70331-6","article-title":"Autosomal-dominant inheritance of hyperphosphorylated paratarg-7","volume":"11","author":"Grass","year":"2010","journal-title":"Lancet Oncol"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1508808","article-title":"Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma","volume":"374","author":"Nair","year":"2016","journal-title":"N Engl J Med"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-012948","article-title":"Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations","volume":"109","author":"Stamatopoulos","year":"2007","journal-title":"Blood"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-162024","article-title":"Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA","volume":"112","author":"Chu","year":"2008","journal-title":"Blood"},{"key":"B183","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41375-018-0182-1","article-title":"LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting","volume":"33","author":"Thurner","year":"2018","journal-title":"Leukemia"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.141929","article-title":"Complementarity Determining Region-Independent Recognition Of A Superantigen By B-Cell Antigen Receptors Of Mantle Cell Lymphoma","volume":"101","author":"Fichtner","year":"2016","journal-title":"Haematologica"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0950","article-title":"Hairy cell leukemia: At the crossroad of somatic mutation and isotype switch","volume":"104","author":"Forconi","year":"2004","journal-title":"Blood"},{"key":"B186","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1182\/blood.V128.22.1213.1213","article-title":"Single-Agent Ibrutinib Demonstrates Efficacy and Safety in Patients with Relapsed\/Refractory Marginal Zone Lymphoma: A Multicenter, Open-Label, Phase 2 Study","volume":"128","author":"Noy","year":"2016","journal-title":"Blood"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.10962","article-title":"Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development","volume":"91","author":"Kuppers","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.4.1495","article-title":"Hodgkin and Reed-Sternberg cells in Hodgkin\u2019s disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells","volume":"184","author":"Kanzler","year":"1996","journal-title":"J Exp Med"},{"key":"B189","article-title":"L and H cells of nodular lymphocyte predominant Hodgkin\u2019s disease show immunoglobulin light-chain restriction","volume":"139","author":"Schmid","year":"1991","journal-title":"AmJPathol"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000194741.87798.45","article-title":"IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma","volume":"30","author":"Prakash","year":"2006","journal-title":"AmJSurgPathol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-114209","article-title":"Identification of Posttranvslationally Modified Neoantigens As Targets of B Cell Receptors of Burkitt Lymphoma","volume":"132","author":"Thurner","year":"2018","journal-title":"Blood"},{"key":"B192","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nm.3884","article-title":"Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma","volume":"21","author":"Wilson","year":"2015","journal-title":"Nat Med"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02403","article-title":"Randomized phase III trial of ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in non\u2013germinal center B-cell diffuse large B-cell lymphoma","volume":"37","author":"Younes","year":"2019","journal-title":"J Clin Oncol"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.5.1738.417k10_1738_1746","article-title":"V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity","volume":"94","author":"Thompsett","year":"1999","journal-title":"Blood"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1064-7","article-title":"Genes regulating the B cell receptor pathway are recurrently mutated in primary central nervous system lymphoma","volume":"124","author":"Montesinos-Rongen","year":"2012","journal-title":"Acta Neuropathol"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402341","article-title":"Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins","volume":"195","author":"Montesinos-Rongen","year":"2015","journal-title":"JImmunol"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0613","article-title":"Ibrutinib unmasks critical role of bruton tyrosine kinase in primary CNS lymphoma","volume":"7","author":"Grommes","year":"2017","journal-title":"Cancer Discovery"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0401","article-title":"Molecular analysis of immunoglobulin genes in primary intraocular lymphoma","volume":"46","author":"Coupland","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501548","article-title":"Ibrutinib in Previously Treated Waldenstr\u00f6m\u2019s Macroglobulinemia","volume":"372","author":"Treon","year":"2015","journal-title":"N Engl J Med"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802917","article-title":"Phase 3 trial of Ibrutinib plus rituximab in Waldenstrom\u2019s macroglobulinemia","volume":"378","author":"Dimopoulos","year":"2018","journal-title":"N Engl J Med"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0891-2","article-title":"Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma","volume":"122","author":"Montesinos-Rongen","year":"2011","journal-title":"Acta Neuropathol"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65526-5","article-title":"Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment","volume":"155","author":"Montesinos-Rongen","year":"1999","journal-title":"AmJPathol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa01133202","article-title":"A long-term study of prognosis in monoclonal gammopathy of undetermined significance","volume":"346","author":"Kyle","year":"2002","journal-title":"N Engl J Med"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01819.x","article-title":"Risk of Japanese carriers of hyperphosphorylated paratarg-7, the first autosomal-dominantly inherited risk factor for hematological neoplasms, to develop monoclonal gammopathy of undetermined significance and multiple myeloma","volume":"102","author":"Grass","year":"2011","journal-title":"Cancer Sci"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98259","article-title":"Antigen-mediated regulation in monoclonal gammopathies and myeloma","volume":"3","author":"Nair","year":"2018","journal-title":"JCI Insight"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15659","article-title":"Saposin C is a frequent target of paraproteins in Gaucher disease-associated MGUS\/multiple myeloma","volume":"184","author":"Preuss","year":"2018","journal-title":"Br J Haematol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-387324","article-title":"Familial monoclonal gammopathy of undetermined significance and multiple myeloma: Epidemiology, risk factors, and biological characteristics","volume":"119","author":"Greenberg","year":"2012","journal-title":"Blood"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29478","article-title":"CD4(+) T cells in chronic autoantigenic stimulation in MGUS, multiple myeloma and Waldenstrom\u2019s macroglobulinemia","volume":"137","author":"Neumann","year":"2015","journal-title":"Int J Cancer"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.03.002","article-title":"EBV transformation overrides gene expression patterns of B cell differentiation stages","volume":"45","author":"Siemer","year":"2008","journal-title":"Mol Immunol"},{"key":"B211","article-title":"The primary mediastinal clear cell lymphoma of B-cell type has variable defects in MHC antigen expression","volume":"59","author":"Moller","year":"1986","journal-title":"Immunology"},{"key":"B212","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF00705408","article-title":"Primary mediastinal clear cell lymphoma","volume":"409","author":"M\u00f6ller","year":"1986","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-236471","article-title":"Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia","volume":"115","author":"Friedberg","year":"2010","journal-title":"Blood"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000500","article-title":"An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis","volume":"363","author":"Weinblatt","year":"2010","journal-title":"N Engl J Med"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.96","article-title":"FDA approves first-in-class SYK inhibitor","author":"Mullard","year":"2018","journal-title":"Nat Rev Drug Discovery"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817073","article-title":"Ibrutinib\u2013rituximab or chemoimmunotherapy for chronic lymphocytic leukemia","volume":"381","author":"Shanafelt","year":"2019","journal-title":"N Engl J Med"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400029","article-title":"Resistance mechanisms for the Bruton\u2019s tyrosine kinase inhibitor ibrutinib","volume":"370","author":"Woyach","year":"2014","journal-title":"N Engl J Med"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-626846","article-title":"Hypermorphic mutation of phospholipase C, \u03b32 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation","volume":"126","author":"Liu","year":"2015","journal-title":"Blood"},{"key":"B219","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1182\/blood-2018-99-112184","article-title":"Dose-Adjusted Teddi-R Induces Durable Complete Remissions in Relapsed and Refractory Primary CNS Lymphoma","volume":"132","author":"Roschewski","year":"2018","journal-title":"Blood"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30262-2","article-title":"Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial","author":"Sharman","year":"2020","journal-title":"Lancet"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.03355","article-title":"Randomized Trial of Acalabrutinib Versus Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia","volume":"38","author":"Ghia","year":"2020","journal-title":"J\u00a0Clin Oncol"},{"key":"B222","doi-asserted-by":"publisher","first-page":"4318","DOI":"10.1182\/blood-2019-123057","article-title":"A Phase 3 Trial Comparing the Efficacy and Safety of Acalabrutinib in Combination with Venetoclax with or without Obinutuzumab, Compared with Investigator\u2019s Choice of Chemoimmunotherapy in Patients with Previously Untreated Chronic Lymphocytic Leukemia (CLL) without Del(17p) or TP53 Mutation","volume":"134","author":"Brown","year":"2019","journal-title":"Blood"},{"key":"B223","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1182\/blood-2019-124362","article-title":"LOXO-305: Targeting C481S Bruton Tyrosine Kinase in Patients with Ibrutinib-Resistant CLL","volume":"134","author":"Naeem","year":"2019","journal-title":"Blood"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.sabcs18-317","article-title":"Abstract 317: Vecabrutinib inhibits C481 mutated Bruton\u2019s tyrosine kinase and its downstream signaling in vitro","author":"Aslan","year":"","journal-title":"2019"},{"key":"B225","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1158\/2159-8290.CD-17-1409","article-title":"The btk inhibitor arq 531 targets ibrutinib-resistant cll and richter transformation","volume":"8","author":"Reiff","year":"2018","journal-title":"Cancer Discovery"},{"key":"B226","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1182\/blood-2019-122336","article-title":"Phase I\/II, open-label adaptive study of oral bruton tyrosine kinase inhibitor PRN1008 in patients with relapsed\/refractory primary or secondary immune thrombocytopenia","volume":"134","author":"Kuter","year":"2019","journal-title":"Blood"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519843084","article-title":"Primary analysis of a randomized phase II study to evaluate the efficacy and safety of evobrutinib, a BTK inhibitor, in patients with relapsing MS","author":"Montalban","year":"2019","journal-title":"Mult Scler J"},{"key":"B228","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.1182\/blood.v126.23.5474.5474","article-title":"Complete Resolution of Extensive Chronic Graft-Versus-Host Disease with Ibrutinib","volume":"126","author":"Scholoff","year":"2015","journal-title":"Blood"},{"key":"B229","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1056\/NEJMoa1315226","article-title":"Idelalisib and rituximab in relapsed chronic lymphocytic leukemia","volume":"370","author":"Furman","year":"2014","journal-title":"N Engl J Med"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1093\/ANNONC\/MDW282","article-title":"First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors and non-Hodgkin\u2019s lymphomas","volume":"27","author":"Patnaik","year":"2016","journal-title":"Ann Oncol"},{"key":"B231","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1182\/blood.v128.22.1218.1218","article-title":"Dynamo: A Phase 2 Study Demonstrating the Clinical Activity of Duvelisib in Patients with Relapsed Refractory Indolent Non-Hodgkin Lymphoma","volume":"128","author":"Flinn","year":"2016","journal-title":"Blood"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1022770","article-title":"Management of adverse events associated with idelalisib treatment: Expert panel opinion","author":"Coutr\u00e9","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1002\/hon.88_2629","article-title":"DISCOVERY OF A NOVEL, POTENTIAL FIRST-IN-CLASS MALT1 PROTEASE INHIBITOR FOR THE TREATMENT OF B CELL LYMPHOMAS","author":"Philippar","year":"2019","journal-title":"Hematol Oncol"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-804641","article-title":"Single-agent ibrutinib in relapsed or refractory follicular lymphoma: A phase 2 consortium trial","volume":"131","author":"Bartlett","year":"2018","journal-title":"Blood"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1603335113","article-title":"Targeting lymphoma with precision using semisynthetic anti-idiotype peptibodies","volume":"113","author":"Torchia","year":"2016","journal-title":"Proc Natl Acad Sci U. S. A."},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020991","article-title":"Design of targeted B cell killing agents","volume":"6","author":"Stepanov","year":"2011","journal-title":"PLoSOne"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg076","article-title":"Specific depletion of autoreactive B lymphocytes by a recombinant fusion protein in vitro and in vivo","volume":"15","author":"Zocher","year":"2003","journal-title":"IntImmunol"},{"key":"B238","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jneuroim.2008.01.001","article-title":"Depletion of autoreactive B-lymphocytes by a recombinant myelin oligodendrocyte glycoprotein-based immunotoxin","volume":"195","author":"Nachreiner","year":"2008","journal-title":"JNeuroimmunol"},{"key":"B239","first-page":"1","article-title":"Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease","volume":"6756","author":"Ellebrecht","year":"2016","journal-title":"Sci (80)"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2020.604685\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T11:24:28Z","timestamp":1610277868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2020.604685\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,9]]},"references-count":239,"alternative-id":["10.3389\/fonc.2020.604685"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2020.604685","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,9]]},"article-number":"604685"}}