{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:12:33Z","timestamp":1765807953266,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Histiocytic Sarcoma (HS) is a rare and aggressive malignancy, and patients can present with rapid tumor growth and invasion. The optimal diagnostic and therapeutic management is unknown since only a few cases have been published. Here we report a patient with histiocytic sarcoma of the right groin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 68 year-old male patient presented to our hospital with suspicion of a superinfected atheroma of the right groin. Computed tomography showed an abdominal tumor of unknown entity. Detailed assessment including immunohistochemically evaluation of biopsy material confirmed HS. The patient underwent radical tumor resection including compartment-resection of the right thigh. During five additional cycles of chemotherapy over a period of 1.5 years he remained relapse-free.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p>Diagnostic work up and treatment of HS is challenging, as there is a paucity of clinical reports and lack of standard guidelines for care. In the present case report, aggressive multidisciplinary treatment resulted in good clinical outcome, however, further studies evaluating this approach in similar patients are needed.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2021.633215","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T05:50:57Z","timestamp":1623045057000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Eighteen Month Relapse- Free\u00a0Survival Following Radical Multidisciplinary Oncological Treatment in a 68-Year-Old Male Patient With Histiocytic Sarcoma"],"prefix":"10.3389","volume":"11","author":[{"given":"Stefan","family":"Wehrmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagen","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominikus","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Siepmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Kaltofen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"H\u00e4nel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Mirow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1002\/9781118853771.ch51","article-title":"Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008)","volume-title":"Postgraduate Haematology","author":"Hoffbrand","year":"2015"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers6042275","article-title":"Clinicopathologic Characteristics and Outcomes of Histiocytic and Dendritic Cell Neoplasms: The Moffitt Cancer Center Experience Over the Last Twenty Five Years","volume":"6","author":"Dalia","year":"2014","journal-title":"Cancers (Basel)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-10-812495","article-title":"Histiocytic Sarcoma: A Population-Based Analysis of Incidence, Demographic Disparities, and Long-Term Outcomes","volume":"131","author":"Kommalapati","year":"2018","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3960\/jslrt.53.1","article-title":"Histiocytic Sarcoma an Updated Literature Review Based on the 2008 WHO Classification","volume":"53","author":"Takahashi","year":"2013","journal-title":"J Clin Exp Hematop"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2559.2002.01418.x","article-title":"Tumours of Histiocytes and Accessory Dendritic Cells: An Immunohistochemical Approach to Classification From the International Lymphoma Study Group Based on 61 Cases","volume":"41","author":"Pileri","year":"2002","journal-title":"Histopathology"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.06.109","article-title":"Impact of Surgery, Radiation and Systemic Therapy on the Outcomes of Patients With Dendritic Cell and Histiocytic Sarcomas","volume":"51","author":"Gounder","year":"2015","journal-title":"Eur J Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d5ddf8","article-title":"Development of Disseminated Histiocytic Sarcoma in a Patient With Autoimmune Lymphoproliferative Syndrome and Associated Rosai-Dorfman Disease","volume":"34","author":"Venkataraman","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2176-1","article-title":"Histiocytic and Dendritic Cell Neoplasms: What Have We Learnt by Studying 67 Cases","volume":"471","author":"Facchetti","year":"2017","journal-title":"Virchows Arch"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1159\/000340066","article-title":"Histiocytic Sarcoma - Targeted Therapy: Novel Therapeutic Options? 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