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Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate whether frontal lobe invasion (FLI) was an unfavorable prognostic factor in patients with olfactory neuroblastoma (ONB), and to explore the optimal treatment strategy for ONB patients with FLI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Some 37 patients with FLI were retrospectively studied, and 74 well-matched patients without FLI were enrolled as the control group. The long-term survivals were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were found between the two groups in overall survival (OS), progression-free survival (PFS), locoregional failure-free survival (LRFS), and distant metastasis-free survival (DMFS) (all p &amp;gt;0.05). Multivariate analyses showed that FLI wasn\u2019t an independent predictor for OS (HR = 1.100, 95% CI = 0.437\u20132.772, p = 0.840). Among the 37 patients with FLI, patients who received surgery combined with chemo-\/radiotherapy showed better OS (89.4% <jats:italic>vs.<\/jats:italic> 53.6%, p = 0.001) and PFS (87.8% <jats:italic>vs.<\/jats:italic> 53.6%, p = 0.001) compared with those who didn\u2019t undergo surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FLI wasn\u2019t a poor prognostic factor for ONB patients. Endoscopic resection combined with radiotherapy was an effective therapeutic method for ONB patients with FLI.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2021.640892","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T06:12:48Z","timestamp":1625465568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Treatment Outcomes of Olfactory Neuroblastoma Patients With Frontal Lobe 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