{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:14:23Z","timestamp":1781216063498,"version":"3.54.1"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014759","name":"Medical Scientific Research Foundation of Zhejiang Province, China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014759","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a fairly rare subtype of primary cutaneous lymphoma. This study aims to investigate the clinicopathologic features, <jats:sup>18<\/jats:sup>F-FDG PET\/CT findings, and outcome of patients with SPTCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single-center study enrolled 11 patients with SPTCL between August 2010 and March 2020.\u00a0A total of 26 <jats:sup>18<\/jats:sup>F-FDG PET\/CT scans were performed, and\u00a0the initial and follow-up PET\/CT imaging features, clinicopathologic and immunohistochemical characteristics, and outcome were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The male-to-female ratio was 1.2. The mean age at diagnosis was 24.2 years (age range: 13\u201348 years). Histopathological examinations revealed atypical T-lymphocyte rimming of individual subcutaneous adipocytes, mostly with CD2<jats:sup>+<\/jats:sup>, CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>\u2212<\/jats:sup>, CD5<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup>, CD56<jats:sup>\u2212<\/jats:sup>, T-cell intracellular antigen-1<jats:sup>+<\/jats:sup>, Granzyme B<jats:sup>+<\/jats:sup>, and high Ki-67 index. Multiple large skin ulcerations with a maximum diameter of 10\u00a0cm were observed in one of the 11 patients (9.1%, 1\/11), and hemophagocytic syndrome was found in another one. At initial PET\/CT scans, the lesions in all 11 patients showed increased uptake of <jats:sup>18<\/jats:sup>F-FDG with a wide range of maximum standard uptake value (SUVmax) from 2.0 to 14.9. The morphology of the lesions presented as multiple nodules and\/or disseminated plaques mainly involving the trunk and\/or limbs. Five patients had extracutaneous non-lymph node lesions with SUVmax of 5.6 \u00b1 2.8 on <jats:sup>18<\/jats:sup>F-FDG PET\/CT. No significant correlation between SUVmax and Ki-67 index was observed (r = 0.19, <jats:italic>P<\/jats:italic> &amp;gt; 0.05). Follow-up <jats:sup>18<\/jats:sup>F-FDG PET\/CT scans in six patients showed complete remission of the disease in two, partial remission in three, and progressive disease in one. During the follow-up period, there was no death except for the patient with multiple ulcerations who died 4 months after diagnosis of SPTCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SPTCL may be a group of heterogeneous diseases with varying degrees of <jats:sup>18<\/jats:sup>F-FDG uptake. <jats:sup>18<\/jats:sup>F-FDG PET\/CT demonstrates its usefulness in detecting disease extent, providing diagnostic work-up, staging, and evaluating treatment response of SPTCL. Multiple large skin ulcerations may be a factor of poor prognosis for patients with SPTCL.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2021.650822","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T18:18:43Z","timestamp":1625163523000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Report of Eleven Patients of Subcutaneous Panniculitis-Like T-Cell Lymphoma: Clinicopathologic Features, 18F-FDG PET\/CT Findings and Outcome"],"prefix":"10.3389","volume":"11","author":[{"given":"Maoqing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184168","article-title":"Cutaneous Lymphoma Incidence Patterns in the United States: A Population-Based Study of 3884 Cases","volume":"113","author":"Bradford","year":"2009","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/00000478-199101000-00002","article-title":"T-Cell Lymphoma Involving Subcutaneous Tissue. 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