{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:25:14Z","timestamp":1784366714706,"version":"3.55.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Severity of liver cirrhosis is distinct from clinical portal hypertension because there exist different degrees of liver cirrhosis in hepatocellular carcinoma (HCC) patients without significant clinical portal hypertension. Whether severity of cirrhosis affects surgical outcomes for HCC patients in absence of portal hypertension or not remains unclear. This study aims to analyze the effect of cirrhotic severity on surgical outcomes for HCC patients with hepatitis B virus (HBV) infection in absence of portal hypertension. This retrospective study enrolled 166 patients who underwent curative resection for a single HCC \u22645 cm in absence of portal hypertension between February 2011 and December 2013. Liver cirrhosis was sub-classified into no\/mild (no\/F4A) and moderate\/severe (F4B\/F4C) according to the Laennec scoring system. The surgical outcomes and complications were analyzed. The surgical mortality was zero in this study. Major complications were apparently higher in the F4B\/F4C group than in the no\/F4A group (17.0% vs 7.4%, <jats:italic>p &amp;lt;<\/jats:italic>0.001). The 1-year, 3-year and 5-year overall survival (OS) rates were 98.5, 88.1 and 80%, respectively, in the no\/F4A group, which were significantly higher than those in the F4B\/F4C group (98.0, 69.2 and 54.7%, <jats:italic>p<\/jats:italic> = 0.001). Microscopic vascular invasion, absence of tumor capsule and severity of liver cirrhosis were independent risk factors of surgical outcomes for HCC patients without portal hypertension. In conclusion, severity of liver cirrhosis affected surgical outcomes for early-stage HCC patients independent of portal hypertension.<\/jats:p>","DOI":"10.3389\/fonc.2021.671313","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T06:13:01Z","timestamp":1621491181000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Sub-Classification of Cirrhosis Affects Surgical Outcomes for Early Hepatocellular Carcinoma Independent of Portal Hypertension"],"prefix":"10.3389","volume":"11","author":[{"given":"Er-lei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-017-9259-9","article-title":"42,573 Cases of Hepatectomy in China: A Multicenter Retrospective Investigation","volume":"61","author":"Zhang","year":"2018","journal-title":"Sci China Life Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e165059","DOI":"10.1001\/jamasurg.2016.5059","article-title":"Effect of Background Liver Cirrhosis on Outcomes of Hepatectomy for Hepatocellular Carcinoma","volume":"152","author":"Sasaki","year":"2017","journal-title":"JAMA Surg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.12.007","article-title":"Prognostic Factors for Survival After Hepatic Resection of Early Hepatocellular Carcinoma in HBV-related Cirrhotic Patients","volume":"40","author":"Zhu","year":"2016","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0232-4","article-title":"Comparison of Recurrence of Hepatocellular Carcinoma After Resection in Patients With Cirrhosis to its Occurrence in a Surveilled Cirrhotic Population","volume":"16","author":"Cucchetti","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12367","article-title":"Risk Factors and Management for Early and Late Intrahepatic Recurrence of Solitary Hepatocellular Carcinoma After Curative Resection","volume":"17","author":"Cheng","year":"2015","journal-title":"HPB (Oxford)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61285-9","article-title":"Hepatocellular Carcinoma","volume":"380","author":"Oliveri","year":"2012","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28832","article-title":"Risk Prediction of Hepatocellular Carcinoma in Patients With Cirrhosis: The ADRESS-HCC Risk Model","volume":"120","author":"Flemming","year":"2014","journal-title":"Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24121","article-title":"Risk Assessment of Hepatitis B Virus-Related Hepatocellular Carcinoma Development Using Liver Stiffness Measurement (Fibroscan)","volume":"53","author":"Jung","year":"2011","journal-title":"Hepatology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12923","article-title":"The Need for Histological Subclassification of Cirrhosis: A Systematic Review and Meta-Analysis","volume":"36","author":"Kim","year":"2016","journal-title":"Liver Int"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.05.009","article-title":"Influence of Coexisting Cirrhosis on Outcomes After Partial Hepatic Resection for Hepatocellular Carcinoma Fulfilling the Milan Criteria: An Analysis of 293 Patients","volume":"142","author":"Taura","year":"2007","journal-title":"Surgery"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14732","article-title":"Influence of Liver Fibrosis on Prognosis After Surgical Resection for Resectable Single Hepatocellular Carcinoma","volume":"89","author":"Suh","year":"2018","journal-title":"ANZ J Surg"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.009","article-title":"Evolving Consensus in Portal Hypertension. 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