{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:37:12Z","timestamp":1759228632223,"version":"3.41.2"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Clinical features and survival analysis of neuroblastoma (NB) are well explored. However, clinical research of NB patients with bone metastasis is rarely reported. Thus, the current study was performed to analyze the clinical features, survival outcome, and risk factors in those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We reviewed the Surveillance, Epidemiology, and End Results (SEER) database to select cases diagnosed with NB with bone metastasis from 2010 to 2016. Overall survival (OS) and cancer-specific survival (CSS) were analyzed through univariate Cox regression analysis. Subsequently, we performed multivariate analysis to determine independent predictors of survival. The Kaplan\u2013Meier method was applied to intuitively show differences in prognostic value between independent risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We finally identified 393 NB patients with bone metastasis who were selected for survival analysis. Nearly half of the patients (47.3%) were aged &amp;gt;3 years. The adrenal gland was the primary tumor site, accounting for approximately two thirds of cases (66.2%). The 5-year OS and CSS rates of all patients were 62.1% and 64.1%, respectively. The univariate analysis indicated that age, lung metastasis, and tumor size were significantly associated with OS and CSS. Based on the multivariable analysis, age at 2 and 3 years, lung metastasis, and tumor size &amp;gt;10\u00a0cm remained significant negative predictors of OS and CSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For NB patients with bone metastasis, three independent prognostic risk factors (age, lung metastasis, and tumor size) are helpful to clinicians for predicting prognosis and guiding treatment. Reasonable treatment modalities for these patients should be further investigated to prolong survival.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2021.677023","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T05:51:58Z","timestamp":1622526718000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Characteristics and Survival Outcomes in Neuroblastoma With Bone Metastasis Based on SEER Database Analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Bin","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianshui","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.hoc.2009.11.011","article-title":"Neuroblastoma: Biology, Prognosis, and Treatment","volume":"24","author":"Park","year":"2010","journal-title":"Hematol\/Oncol Clin North Am"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2017.1285230","article-title":"Overview and Recent Advances in the Treatment of Neuroblastoma","volume":"17","author":"Whittle","year":"2017","journal-title":"Expert Rev Anticancer Ther"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)60983-0","article-title":"Neuroblastoma","volume":"369","author":"Maris","year":"2007","journal-title":"Lancet (Lond Engl)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199905000-00005","article-title":"Metastatic Sites in Stage IV and IVS Neuroblastoma Correlate With Age, Tumor Biology, and Survival","volume":"21","author":"DuBois","year":"1999","journal-title":"J Pediatr Hematol\/Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1200\/jco.2008.16.6876","article-title":"The International Neuroblastoma Risk Group (INRG) Staging System: An INRG Task Force Report","volume":"27","author":"Monclair","year":"2009","journal-title":"J Clin Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.01410","article-title":"Targets and Antibody Formats for Immunotherapy of Neuroblastoma","volume":"38","author":"Park","year":"2020","journal-title":"J Clin Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.21037\/atm.2020.01.37","article-title":"Novel Prognostic Nomograms for Female Patients With Breast Cancer and Bone Metastasis At Presentation","volume":"8","author":"Wang","year":"2020","journal-title":"Ann Trans Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13018-019-1120-2","article-title":"Prognostic Factors of Patients With Extremity Myxoid Liposarcomas After Surgery","volume":"14","author":"Wu","year":"2019","journal-title":"J Orthopaedic Surg Res"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2017.1373315","article-title":"Treatment and Survival of Childhood Neuroblastoma: Evidence From a Population-Based Study in the United States","volume":"34","author":"Coughlan","year":"2017","journal-title":"Pediatr Hematol Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25987","article-title":"Childhood Neuroblastoma: Incidence and Survival in Argentina. 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