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Oncol."],"abstract":"<jats:p>Osteolytic destruction is a hallmark of multiple myeloma and impairs myeloma patients\u2019 quality of life. However, the molecular mechanism underlying the pathogenesis of myeloma-associated bone disease remains unclear. In this study, we demonstrate the role of myeloma cell-expressed integrin \u03b16 in bone. Integrin \u03b16 binds to laminin 8 and epidermal growth factor receptor on mesenchymal stem cells (MSCs) to form a trimer complex and upregulates the secretion of osteolytic cytokines from both myeloma cells and MSCs, leading to enhanced bone resorption and reduced bone formation. Thus, this study elucidates an important mechanism for myeloma-induced bone lesions and implicates that targeting integrin \u03b16 may be a viable approach for bone healing in myeloma patients.<\/jats:p>","DOI":"10.3389\/fonc.2021.692190","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T20:40:39Z","timestamp":1622752839000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Promotion of Bone Lesions Through the Myeloma Integrin \u03b16-Mediated Osteolytic 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