{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:26:19Z","timestamp":1776979579443,"version":"3.51.4"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Given the expanding clinical applications of laparoscopic surgery and neoadjuvant chemotherapy in advanced gastric cancer treatment, there is an emerging need to summarize the few evidences that evaluated the safety and efficacy of laparoscopic versus open gastrectomy in patients with advanced gastric cancer (AGC) following neoadjuvant chemotherapy (NAC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 1 to 2, 2021, we searched Ovid Embase, PubMed, Cochrane central register Trials (Ovid), and web of science to find relevant studies published in English, and two authors independently performed literature screening, quality assessment of the included studies, data extraction, and data analysis. This study was registered with PROSPERO (CRD42021228845).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial search retrieved 1567 articles, and 6 studies were finally included in the meta-analysis review, which comprised 2 randomized control trials and 4 observational studies involving 288 laparoscopic gastrectomy (LG) and 416 open gastrectomy (OG) AGC patients treated with NAC. For intraoperative conditions, R0 resection rate, blood transfusion, intraoperative blood loss, number of lymph nodes dissected, proximal margin, and distal margin were comparable between LG group and open OG group. For postoperative short-term clinical outcomes, LG has significantly less postoperative complications (OR = 0.65, 95%CI: 0.42\u20131.00, p = 0.05) and shorter postoperative time to first aerofluxus (WMD = -0.57d, 95%CI: -0.89\u20130.25, p = 0.0004) than OG, and anastomotic leakage, pulmonary infection, pleural effusion, surgical site infection, thrombosis, intestinal obstruction, peritoneal effusion or abscess formation, postoperative time to first defecation, postoperative time to first liquid diet, and postoperative length of stay were comparable between the two groups. For postoperative survival outcomes, there were no significant differences in disease-free survival (DFS) and overall survival (OS) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The available evidences indicated that LG is an effective and feasible technology for the treatment of AGC patients treated with NAC, and LG patients have much less postoperative complications and faster bowel function recovery than OG patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic Review Registration<\/jats:title><jats:p>PROSPERO database (identifier, CRD42021228845).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2021.704244","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T05:38:07Z","timestamp":1628228287000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Safety and Efficacy of Laparoscopic Versus Open Gastrectomy in Patients With Advanced Gastric Cancer Following Neoadjuvant Chemotherapy: A Meta-Analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Xu-Liang","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Wen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Yang","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Zu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Kun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9218-2","article-title":"Clinical Impact of Lymphadenectomy Extent in Resectable Gastric Cancer of Advanced Stage","volume":"14","author":"Schwarz","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70070-X","article-title":"Surgical Treatment of Gastric Cancer: 15-Year Follow-Up Results of the Randomised Nationwide Dutch D1D2 Trial","volume":"11","author":"Songun","year":"2010","journal-title":"Lancet Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2003.11.020","article-title":"Morbidity and Mortality After D1 and D2 Gastrectomy for Cancer: Interim Analysis of the Italian Gastric Cancer Study Group (IGCSG) Randomised Surgical Trial","volume":"30","author":"Degiuli","year":"2004","journal-title":"Eur J Surg Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601761","article-title":"Survival Results of a Multicentre Phase II Study to Evaluate D2 Gastrectomy for Gastric Cancer","volume":"90","author":"Degiuli","year":"2004","journal-title":"Br J Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3322\/caac.21657","article-title":"Current Treatment and Recent Progress in Gastric Cancer","author":"Joshi","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.01.008","article-title":"Neoadjuvant Chemotherapy in Advanced Gastric and Esophago-Gastric Cancer. Meta-Analysis of Randomized Trials","volume":"51","author":"Coccolini","year":"2018","journal-title":"Int J Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000011","article-title":"Laparoscopy-Assisted Billroth I Gastrectomy","volume":"4","author":"Kitano","year":"1994","journal-title":"Surg Laparosc Endosc"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3160-z","article-title":"A Multi-Institutional, Prospective, Phase II Feasibility Study of Laparoscopy-Assisted Distal Gastrectomy With D2 Lymph Node Dissection for Locally Advanced Gastric Cancer (Jlssg0901)","volume":"19","author":"Inaki","year":"2015","journal-title":"World J Surg"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.7215","article-title":"Morbidity and Mortality of Laparoscopic Versus Open D2 Distal Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial","volume":"34","author":"Hu","year":"2016","journal-title":"J Clin Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/01.sla.0000225364.03133.f8","article-title":"A Multicenter Study on Oncologic Outcome of Laparoscopic Gastrectomy for Early Cancer in Japan","volume":"245","author":"Kitano","year":"2007","journal-title":"Ann Surg"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001654","article-title":"Long-Term Outcomes of Laparoscopic Versus Open Surgery for Clinical Stage I Gastric Cancer: the LOC-1 Study","volume":"264","author":"Honda","year":"2016","journal-title":"Ann Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/SLA.0000000000001346","article-title":"Decreased Morbidity of Laparoscopic Distal Gastrectomy Compared With Open Distal Gastrectomy for Stage I Gastric Cancer: Short-Term Outcomes From a Multicenter Randomized Controlled Trial (KLASS-01)","volume":"263","author":"Kim","year":"2016","journal-title":"Ann Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s10120-016-0646-9","article-title":"Short-Term Surgical Outcomes From a Phase III Study of Laparoscopy-Assisted Versus Open Distal Gastrectomy With Nodal Dissection for Clinical Stage IA\/IB Gastric Cancer: Japan Clinical Oncology Group Study JCOG0912","volume":"20","author":"Katai","year":"2017","journal-title":"Gastric Cancer"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.6727","article-title":"Effect of Laparoscopic Distal Gastrectomy vs Open Distal Gastrectomy on Long-Term Survival Among Patients With Stage I Gastric Cancer: The KLASS-01 Randomized Clinical Trial","volume":"5","author":"Kim","year":"2019","journal-title":"JAMA Oncol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1016\/j.ejso.2020.06.046","article-title":"Laparoscopic Versus Open Distal Gastrectomy for Advanced Gastric Cancer: a Meta-Analysis of Randomized Controlled Trials and High-Quality Nonrandomized Comparative Studies","volume":"46","author":"Chen","year":"2020","journal-title":"Eur J Surg Oncol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/annonc\/mdl386","article-title":"Importance of Histological Tumor Response Assessment in Predicting the Outcome in Patients With Colorectal Liver Metastases Treated With Neo-Adjuvant Chemotherapy Followed by Liver Surgery","volume":"18","author":"Rubbia-Brandt","year":"2007","journal-title":"Ann Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020362","article-title":"Chemotherapeutic Induced Fascial Oedema","volume":"64","author":"Lim","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"B19","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1093\/neuonc\/not236","article-title":"Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Glioblastoma: A Literature-Based Meta-Analysis From 91 Trials","volume":"16","author":"Han","year":"2014","journal-title":"Neuro Oncol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41568-020-00308-y","article-title":"The Rediscovery of Platinum-Based Cancer Therapy","volume":"21","author":"Rottenberg","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/gad.1376506","article-title":"Necrotic Death as a Cell Fate","volume":"20","author":"Zong","year":"2006","journal-title":"Genes Dev"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, Inflammation, and Cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling Inflammation: Gasdermins in Physiology and Disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"B24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy Drugs Induce Pyroptosis Through Caspase-3 Cleavage of a Gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E Suppresses Tumour Growth by Activating Anti-Tumour Immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"eaaz7548","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A From Cytotoxic Lymphocytes Cleaves GSDMB to Trigger Pyroptosis in Target Cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.3473","article-title":"Assessment of Laparoscopic Distal Gastrectomy After Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer: A Randomized Clinical Trial","volume":"154","author":"Li","year":"2019","journal-title":"JAMA Surg"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4739-z","article-title":"Laparoscopic Versus Open Distal Gastrectomy for Locally Advanced Gastric Cancer After Neoadjuvant Chemotherapy: Safety and Short-Term Oncologic Results","volume":"30","author":"Li","year":"2016","journal-title":"Surg Endosc"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11626","article-title":"Open vs. Laparoscopic Surgery for Locally Advanced Gastric Cancer After Neoadjuvant Therapy: Short-Term and Long-Term Survival Outcomes","volume":"20","author":"Wang","year":"2020","journal-title":"Oncol Lett"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-07552-1","article-title":"Short- and Long-Term Outcomes of Laparoscopic Versus Open Gastrectomy for Locally Advanced Gastric Cancer Following Neoadjuvant Chemotherapy","volume":"35","author":"Fujisaki","year":"2021","journal-title":"Surg Endosc"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-019-01880-w","article-title":"Comparison of Perioperative and Survival Outcomes of Laparoscopic Versus Open Gastrectomy After Preoperative Chemotherapy: A Propensity Score\u2013Matched Analysis","volume":"82","author":"Xi","year":"2020","journal-title":"Indian J Surg"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-020-01109-w","article-title":"Open Versus Minimally Invasive Total Gastrectomy After Neoadjuvant Chemotherapy: Results of a European Randomized Trial","volume":"24","author":"van der Wielen","year":"2021","journal-title":"Gastric Cancer"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement","volume":"3","author":"Moher","year":"2009","journal-title":"Open Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the Quality of Reports of Randomized Clinical Trials: Is Blinding Necessary","volume":"17","author":"Jadad","year":"1996","journal-title":"Control Clin Trials"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical Evaluation of the Newcastle-Ottawa Scale for the Assessment of the Quality of Nonrandomized Studies in Meta-Analyses","volume":"25","author":"Stang","year":"2009","journal-title":"Eur J Epidemiol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New Response Evaluation Criteria In Solid Tumours: Revised Recist Guideline (Version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0041-5","article-title":"Japanese Classification of Gastric Carcinoma: 3rd English Edition","volume":"14","year":"2011","journal-title":"Gastric Cancer"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0516-x","article-title":"Comparison of Laparoscopic Versus Open Gastrectomy for Advanced Gastric Cancer: An Updated Meta-Analysis","volume":"19","author":"Quan","year":"2016","journal-title":"Gastric Cancer"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1462-9","article-title":"Laparoscopic Versus Open Total Gastrectomy With D2 Dissection for Gastric Cancer: A Meta-Analysis","volume":"139","author":"Wang","year":"2013","journal-title":"J Cancer Res Clin Oncol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12957-019-1600-1","article-title":"Laparoscopic Versus Open Gastrectomy for Locally Advanced Gastric Cancer: a Systematic Review and Meta-Analysis of Randomized Controlled Studies","volume":"17","author":"Beyer","year":"2019","journal-title":"World J Surg Onc"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31824682f4","article-title":"Laparoscopic Versus Open Distal Gastrectomy for Advanced Gastric Cancer: A Meta-Analysis of Randomized Controlled Trials and High-Quality Nonrandomized Comparative Studies","volume":"255","author":"Vi\u00f1uela","year":"2012","journal-title":"Ann Surg"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.10.019","article-title":"Preoperative Cisplatin, fluorouracil, and Docetaxel With or Without Radiotherapy After Poor Early Response to Cisplatin and fluorouracil for Resectable Oesophageal Adenocarcinoma (AGITG DOCTOR): Results From a Multicentre, Randomised Controlled Phase II Trial","volume":"31","author":"Barbour","year":"2020","journal-title":"Ann Oncol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3504-0","article-title":"Equipping the 8th Edition American Joint Committee on Cancer Staging for Gastric Cancer With the 15-Node Minimum: A Population-Based Study Using Recursive Partitioning Analysis","volume":"21","author":"Yuan","year":"2017","journal-title":"Gastrointest Surg"},{"key":"B44","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1634\/theoncologist.2016-0239","article-title":"Does a Higher Cutoff Value of Lymph Node Retrieval Substantially Improve Survival in Patients With Advanced Gastric Cancer?-Time to Embrace a New Digit","volume":"22","author":"Liu","year":"2017","journal-title":"Oncologist"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.12.015","article-title":"Lymphadenectomy With Optimum of 29 Lymph Nodes Retrieved Associated With Improved Survival in Advanced Gastric Cancer: a 25,000-Patient International Database Study","volume":"224","author":"Woo","year":"2017","journal-title":"J Am Coll Surg"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003217","article-title":"Korean Laparo-endoscopic Gastrointestinal Surgery Study (KLASS) Group. Short-Term Outcomes of a Multicenter Randomized Controlled Trial Comparing Laparoscopic Distal Gastrectomy With D2 Lymphadenectomy to Open Distal Gastrectomy for Locally Advanced Gastric Cancer (KLASS-02-RCT)","volume":"270","author":"Lee","year":"2019","journal-title":"Ann Surg"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2015.02.003","article-title":"Laparoscopy-Assisted Versus Open Distal Gastrectomy for Early Gastric Cancer: A Meta-Analysis Based on Seven Randomized Controlled Trials","volume":"24","author":"Deng","year":"2015","journal-title":"Surg Oncol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199908000-00006","article-title":"Subtotal Versus Total Gastrectomy for Gastric Cancer: Five-Year Survival Rates in a Multicenter Randomized Italian Trial. Italian Gastrointestinal Tumor Study Group","volume":"230","author":"Bozzetti","year":"1999","journal-title":"Ann Surg"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S275621","article-title":"Risk Factors and Clavien-Dindo Classification of Postoperative Complications After Laparoscopic and Open Gastrectomies for Gastric Cancer: A Single-Center, Large Sample, Retrospective Cohort Study","volume":"12","author":"Lian","year":"2020","journal-title":"Cancer Manag Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/SLA.0b013e3182583e2e","article-title":"Laparoscopy-Assisted Versus Open Distal Gastrectomy for Early Gastric Cancer: Evidence From Randomized and Nonrandomized Clinical Trials","volume":"256","author":"Zeng","year":"2012","journal-title":"Ann Surg"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw350","article-title":"Gastric Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up","volume":"27","author":"Smyth","year":"2016","journal-title":"Ann Oncol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10120-020-01042-y","article-title":"Japanese Gastric Cancer Treatment Guidelines 2018 (5th Edition)","volume":"24","year":"2021","journal-title":"Gastric Cancer"},{"key":"B53","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/bjs.8966","article-title":"Differences in Outcomes of Oesophageal and Gastric Cancer Surgery Across Europe","volume":"100","author":"Dikken","year":"2013","journal-title":"Br J Surg"},{"key":"B54","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1089\/sur.2013.9999","article-title":"Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery","volume":"14","author":"Bratzler","year":"2013","journal-title":"Surg Infect (Larchmt)"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2018.04.005","article-title":"Laparoscopic Versus Open Gastrectomy for Advanced Gastric Cancer: A Meta-Analysis Based on High-Quality Retrospective Studies and Clinical Randomized Trials","volume":"42","author":"Wei","year":"2018","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6283-0","article-title":"Long-Term Outcomes of Laparoscopy-Assisted Distal Gastrectomy Versus Open Distal Gastrectomy for Gastric Cancer: A 10-Year Single-Institution Experience","volume":"33","author":"Wang","year":"2019","journal-title":"Surg Endosc"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.08.015","article-title":"Adenocarcinoma of the Gastric Cardia: What Is the Optimal Surgical Approach","volume":"199","author":"Ito","year":"2004","journal-title":"J Am Coll Surg"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2021.704244\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T05:38:10Z","timestamp":1628228290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2021.704244\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":57,"alternative-id":["10.3389\/fonc.2021.704244"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2021.704244","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]},"article-number":"704244"}}