{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:09:22Z","timestamp":1753891762446,"version":"3.41.2"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>The oncogenic Epstein\u2013Barr virus (EBV) persistently infects more than 95% of the human adult population. Even so it can readily transform human B cells after infection <jats:italic>in vitro<\/jats:italic>, it only rarely causes tumors in patients. A substantial proportion of the 1% of all human cancers that are associated with EBV occurs during coinfections, including those with the malaria parasite <jats:italic>Plasmodium falciparum<\/jats:italic>, the human immunodeficiency virus (HIV), and the also oncogenic and closely EBV-related Kaposi sarcoma-associated herpesvirus (KSHV). In this review, I will discuss how these infections interact with EBV, modify its immune control, and shape its tumorigenesis. The underlying mechanisms reveal new aspects of EBV-associated pathologies and point toward treatment possibilities for their prevention by the human immune system.<\/jats:p>","DOI":"10.3389\/fonc.2021.756480","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T06:28:46Z","timestamp":1635402526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Modification of EBV-Associated Pathologies and Immune Control by Coinfections"],"prefix":"10.3389","volume":"11","author":[{"given":"Christian","family":"M\u00fcnz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/s41579-019-0249-7","article-title":"Latency and Lytic Replication in the Oncogenesis of the Epstein Barr 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