{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T23:38:26Z","timestamp":1789256306523,"version":"build-2803163510"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>The incidence of hematologic malignancies (HMs) is highest in the seventh decade of life and coincides with increasing occult, age-related vulnerabilities. Identification of frailty is useful in prognostication and treatment decision-making for older adults with HMs. This real-world analysis describes 311 older adults with HMs evaluated in a multidisciplinary oncogeriatric clinic. The accumulation of geriatric conditions [1-unit increase, hazards ratio (HR) = 1.13, 95% CI 1.00\u20131.27, p = 0.04] and frailty assessed by the Rockwood Clinical Frailty Scale (CFS, mild\/moderate\/severe frailty vs. very fit\/well, HR = 2.59, 95% CI 1.41\u20134.78, p = 0.002) were predictive of worse overall survival. In multivariate analysis, HM type [acute leukemia, HR = 3.84, 95% CI 1.60\u20139.22, p = 0.003; myelodysplastic syndrome (MDS)\/myeloproliferative neoplasm (MPN)\/bone marrow failure, HR = 2.65, 95% CI 1.10\u20136.35, p = 0.03], age (per 5-year increase, HR = 1.46, 95% CI 1.21\u20131.76, p &amp;lt; 0.001), hemoglobin (per 1 g\/dl decrease, HR = 1.21, 95% CI 1.05\u20131.40, p = 0.009), deficit in activities of daily living (HR = 2.20, 95% CI 1.11\u20134.34, p = 0.02), and Mini Nutrition Assessment score (at-risk of malnutrition vs. normal, HR = 2.00, 95% CI 1.07\u20133.73, p = 0.03) were independently associated with risk of death. The most commonly prescribed geriatric interventions were in the domains of audiology (56%) and pharmacy (54%). The Rockwood CFS correlated with prescribed interventions in nutrition (p = 0.01) and physical function (p &amp;lt; 0.001) domains. Geriatric assessment with geriatric intervention can be practically integrated into the routine care of older adults with HMs.<\/jats:p>","DOI":"10.3389\/fonc.2021.775050","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T04:59:17Z","timestamp":1638939557000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Integration of a Geriatric Assessment With Intervention in the Care of Older Adults With Hematologic Malignancies"],"prefix":"10.3389","volume":"11","author":[{"given":"Sarah 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