{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:33:54Z","timestamp":1780396434227,"version":"3.54.1"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (<jats:italic>p<\/jats:italic>=0.035), with hemoglobin level &amp;lt;10 g\/dl (<jats:italic>p<\/jats:italic>=0.014) and with white blood cells \u226510,000\/\u03bcl (<jats:italic>p<\/jats:italic>=0.008). Median SS was significantly higher in MF patients compared to ET and PV (<jats:italic>p<\/jats:italic>=0.015). SS also correlated with higher <jats:italic>JAK2<\/jats:italic> variant allele frequency (<jats:italic>p<\/jats:italic>=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.<\/jats:p>","DOI":"10.3389\/fonc.2021.777730","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T06:38:42Z","timestamp":1635230322000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms"],"prefix":"10.3389","volume":"11","author":[{"given":"Riccardo","family":"Moia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micol Giulia","family":"Cittone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Boggione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia 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