{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:59Z","timestamp":1753891979028,"version":"3.41.2"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970196, 82073885"],"award-info":[{"award-number":["81970196, 82073885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20200097"],"award-info":[{"award-number":["BK20200097"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["Integration of Chinese and Western Medicine"],"award-info":[{"award-number":["Integration of Chinese and Western Medicine"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed\/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients are fraught with high recurrence rate and incurability. Acupuncture is known for alleviating patient symptoms and improving the quality of life, but it is not well investigated in MM, especially in combination with bortezomib. In this study, we employed LC-MS and UHPLC-MS together with bioinformatics methods to test serum samples from 5TMM3VT MM murine model mice with four different treatments [control (C) group, bortezomib (V) treatment group, acupuncture (A) group, and combined (VA) group]. MM mice in group VA had longer survival time than mice in group A or group V. Joint pathway analysis indicated the underlying arginine and proline metabolism pathway among the 32 significantly decreased metabolites in group VA. CCK-8 assay and <jats:italic>in vivo<\/jats:italic> experiments validated that ornithine, the metabolite of arginine, promoted MM cell proliferation. In addition, gene expression omnibus (GEO) database analysis suggested that MM patients with higher ornithine decarboxylase 1 (ODC1) expression were evidently associated with poor overall survival. In summary, this study demonstrates the synergistic effects of acupuncture and bortezomib on extending the survival of MM model mice and provides potential therapeutic targets in the treatment of MM.<\/jats:p>","DOI":"10.3389\/fonc.2021.779562","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T05:08:44Z","timestamp":1635829724000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Acupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine"],"prefix":"10.3389","volume":"11","author":[{"given":"Mengying","family":"Ke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x","article-title":"Criteria for the Classification of Monoclonal Gammopathies, Multiple Myeloma and Related Disorders: A Report of the International Myeloma Working Group","volume":"121","year":"2003","journal-title":"Br J Haematol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.8499","article-title":"Coexistent Multiple Myeloma or Increased Bone Marrow Plasma Cells Define Equally High-Risk Populations in Patients With Immunoglobulin Light Chain Amyloidosis","volume":"31","author":"Kourelis","year":"2013","journal-title":"J Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50129","article-title":"Biology and Therapy of Multiple Myeloma","volume":"210","author":"Joshua","year":"2019","journal-title":"Med J Aust"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129205","article-title":"Immunotherapy of Multiple Myeloma","volume":"130","author":"Minnie","year":"2020","journal-title":"J Clin Invest"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.178103","article-title":"Outcome and Survival of Myeloma Patients Diagnosed 2008-2015. Real-World Data on 4904 Patients From the Swedish Myeloma Registry","volume":"103","author":"Blimark","year":"2018","journal-title":"Haematologica"},{"key":"B6","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13045-021-01101-6","article-title":"CAR-T Therapy Alters Synthesis of Platelet-Activating Factor in Multiple Myeloma Patients","volume":"14","author":"Ke","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00767","article-title":"Dihydroartemisinin Induces Growth Arrest and Overcomes Dexamethasone Resistance in Multiple Myeloma","volume":"10","author":"Chen","year":"2020","journal-title":"Front Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S235944","article-title":"Bioactive Compounds From Abelmoschus Manihot L. Alleviate the Progression of Multiple Myeloma in Mouse Model and Improve Bone Marrow Microenvironment","volume":"13","author":"Hou","year":"2020","journal-title":"Onco Targets Ther"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X20500135","article-title":"Research Advances on Acupuncture Analgesia","volume":"48","author":"Qiao","year":"2020","journal-title":"Am J Chin Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.736373","article-title":"Corrigendum: Dihydroartemisinin Induces Growth Arrest and Overcomes Dexamethasone Resistance in Multiple Myeloma","volume":"11","author":"Chen","year":"2021","journal-title":"Front Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s41419-021-03510-4","article-title":"Suppression of Steroid 5alpha-Reductase Type I Promotes Cellular Apoptosis and Autophagy via PI3K\/Akt\/mTOR Pathway in Multiple Myeloma","volume":"12","author":"Dou","year":"2021","journal-title":"Cell Death Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01033-z","article-title":"RFWD2 Induces Cellular Proliferation and Selective Proteasome Inhibitor Resistance by Mediating P27 Ubiquitination in Multiple Myeloma","volume":"35","author":"Gu","year":"2021","journal-title":"Leukemia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12943-021-01380-0","article-title":"CHEK1 and Circchek1_246aa Evoke Chromosomal Instability and Induce Bone Lesion Formation in Multiple Myeloma","volume":"20","author":"Gu","year":"2021","journal-title":"Mol Cancer"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.675939","article-title":"Targeting RFWD2 as an Effective Strategy to Inhibit Cellular Proliferation and Overcome Drug Resistance to Proteasome Inhibitor in Multiple Myeloma","volume":"9","author":"Guo","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"977","DOI":"10.6004\/jnccn.2019.0038","article-title":"Adult Cancer Pain, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology","volume":"17","author":"Swarm","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.06.008","article-title":"A Phase IIA Trial of Acupuncture to Reduce Chemotherapy-Induced Peripheral Neuropathy Severity During Neoadjuvant or Adjuvant Weekly Paclitaxel Chemotherapy in Breast Cancer Patients","volume":"101","author":"Bao","year":"2018","journal-title":"Eur J Cancer"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.8907","article-title":"Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast Cancer: A Randomized Clinical Trial","volume":"320","author":"Hershman","year":"2018","journal-title":"JAMA"},{"key":"B18","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.brainresbull.2008.04.008","article-title":"Synergistic Anti-Hyperalgesia of Electroacupuncture and Low Dose of Celecoxib in Monoarthritic Rats: Involvement of the Cyclooxygenase Activity in the Spinal Cord","volume":"77","author":"Mi","year":"2008","journal-title":"Brain Res Bull"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e12457","DOI":"10.1111\/ecc.12457","article-title":"Systematic Review and Meta-Analysis of Acupuncture to Reduce Cancer-Related Pain","volume":"26","author":"Chiu","year":"2017","journal-title":"Eur J Cancer Care (Engl)"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X17500859","article-title":"Effectiveness of Acupuncture and Electroacupuncture for Chronic Neck Pain: A Systematic Review and Meta-Analysis","volume":"45","author":"Seo","year":"2017","journal-title":"Am J Chin Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00261-0","article-title":"The Effect of High and Low Frequency Electroacupuncture in Pain After Lower Abdominal Surgery","volume":"99","author":"Lin","year":"2002","journal-title":"Pain"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.05.005","article-title":"Acupuncture as an Adjunctive Therapy to Pharmacological Treatment in Patients With Chronic Pain Due to Osteoarthritis of the Knee: A 3-Armed, Randomized, Placebo-Controlled Trial","volume":"153","author":"Mavrommatis","year":"2012","journal-title":"Pain"},{"key":"B23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.tibs.2016.01.004","article-title":"Correction to: 'The Warburg Effect: How Does it Benefit Cancer Cells?': [Trends in Biochemical Sciences, 41 (2016) 211]","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"eaaw5473","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic Reprogramming and Cancer Progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32190","article-title":"(1) H NMR-Based Metabolomics Reveal Overlapping Discriminatory Metabolites and Metabolic Pathway Disturbances Between Colorectal Tumor Tissues and Fecal Samples","volume":"145","author":"Lin","year":"2019","journal-title":"Int J Cancer"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1920","article-title":"Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3","volume":"80","author":"Robinson","year":"2020","journal-title":"Cancer Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.3390\/ijms18122550","article-title":"Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics","volume":"18","author":"Li","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2020.02.014","article-title":"Cytochrome 450 Metabolites of Arachidonic Acid (20-HETE, 11,12-EET and 14,15-EET) Promote Pheochromocytoma Cell Growth and Tumor Associated Angiogenesis","author":"Colombero","year":"2020","journal-title":"Biochimie"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.24146","article-title":"Manual Acupuncture Relieves Bile Acid-Induced Itch in Mice: The Role of Microglia and TNF-Alpha","volume":"15","author":"Lee","year":"2018","journal-title":"Int J Med Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112045","article-title":"Inhibiting ATG5 Mediated Autophagy to Regulate Endoplasmic Reticulum Stress and CD4(+) T Lymphocyte Differentiation: Mechanisms of Acupuncture's Effects on Asthma","volume":"142","author":"Zhao","year":"2021","journal-title":"BioMed Pharmacother"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S312385","article-title":"Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture","volume":"14","author":"Zou","year":"2021","journal-title":"J Inflamm Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: Towards More Transparent and Integrative Metabolomics Analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3390\/jcm8010071","article-title":"Type 2 Diabetes Is Associated With a Different Pattern of Serum Polyamines: A Case(-)Control Study From the PREDIMED-Plus Trial","volume":"8","author":"Fernandez-Garcia","year":"2019","journal-title":"J Clin Med"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0697-7","article-title":"Autophagy Maintains Tumour Growth Through Circulating Arginine","volume":"563","author":"Poillet-Perez","year":"2018","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0533-8","article-title":"The Efficacy of Acupoint Stimulation for the Management of Therapy-Related Adverse Events in Patients With Breast Cancer: A Systematic Review","volume":"118","author":"Chao","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.79.2721","article-title":"Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline","volume":"36","author":"Lyman","year":"2018","journal-title":"J Clin Oncol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1177\/1534735419866919","article-title":"Moxibustion as a Therapy for Breast Cancer-Related Lymphedema in Female Adults: A Preliminary Randomized Controlled Trial","volume":"18","author":"Wang","year":"2019","journal-title":"Integr Cancer Ther"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e0151882","DOI":"10.1371\/journal.pone.0151882","article-title":"Anti-Inflammatory Effects of Acupuncture Stimulation via the Vagus Nerve","volume":"11","author":"Lim","year":"2016","journal-title":"PloS One"},{"key":"B39","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.autneu.2010.05.001","article-title":"Acupuncture and Cancer","volume":"157","author":"O'Regan","year":"2010","journal-title":"Auton Neurosci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1177\/1534735414534729","article-title":"A Pilot Study of Acupuncture in Treating Bortezomib-Induced Peripheral Neuropathy in Patients With Multiple Myeloma","volume":"13","author":"Bao","year":"2014","journal-title":"Integr Cancer Ther"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-7-41","article-title":"Electroacupuncture for Thalidomide\/Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma: A Feasibility Study","volume":"7","author":"Garcia","year":"2014","journal-title":"J Hematol Oncol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12885-016-3037-z","article-title":"Acupuncture Combined With Methylcobalamin for the Treatment of Chemotherapy-Induced Peripheral Neuropathy in Patients With Multiple Myeloma","volume":"17","author":"Han","year":"2017","journal-title":"BMC Cancer"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3390\/ijms17091514","article-title":"Cellular Metabolomics Revealed the Cytoprotection of Amentoflavone, a Natural Compound, in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells","volume":"17","author":"Yao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105709","article-title":"Untargeted Metabolomics Study and Pro-Apoptotic Properties of B-Norcholesteryl Benzimidazole Compounds in Ovarian Cancer SKOV3 Cells","volume":"202","author":"Gan","year":"2020","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s13058-018-1075-y","article-title":"Alterations in Arginine and Energy Metabolism, Structural and Signalling Lipids in Metastatic Breast Cancer in Mice Detected in Plasma by Targeted Metabolomics and Lipidomics","volume":"20","author":"Kus","year":"2018","journal-title":"Breast Cancer Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.658861","article-title":"Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer","volume":"9","author":"Du","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.3390\/biom11081086","article-title":"Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers","volume":"11","author":"Bednarz-Misa","year":"2021","journal-title":"Biomolecules"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0106-z","article-title":"Immune Control by Amino Acid Catabolism During Tumorigenesis and Therapy","volume":"19","author":"Lemos","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00938","article-title":"Myeloid Cell-Derived Arginase in Cancer Immune Response","volume":"11","author":"Grzywa","year":"2020","journal-title":"Front Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s40425-017-0308-4","article-title":"Inhibition of Arginase by CB-1158 Blocks Myeloid Cell-Mediated Immune Suppression in the Tumor Microenvironment","volume":"5","author":"Steggerda","year":"2017","journal-title":"J Immunother Cancer"},{"key":"B51","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40425-019-0504-5","article-title":"Suppression of Myeloid Cell Arginase Activity Leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity","volume":"7","author":"Miret","year":"2019","journal-title":"J Immunother Cancer"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1504","article-title":"SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes","volume":"79","author":"Song","year":"2019","journal-title":"Cancer Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/s41467-021-20896-z","article-title":"Dual Targeting of Polyamine Synthesis and Uptake in Diffuse Intrinsic Pontine Gliomas","volume":"12","author":"Khan","year":"2021","journal-title":"Nat Commun"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.3390\/cancers13081807","article-title":"A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma","volume":"13","author":"Gamble","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-73","article-title":"Identification of Unique Expression Signatures and Therapeutic Targets in Esophageal Squamous Cell Carcinoma","volume":"5","author":"Yan","year":"2012","journal-title":"BMC Res Notes"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00681","article-title":"Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling","volume":"9","author":"Zhang","year":"2019","journal-title":"Front Oncol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S198341","article-title":"ODC1 Promotes Proliferation and Mobility via the AKT\/GSK3beta\/beta-Catenin Pathway and Modulation of Acidotic Microenvironment in Human Hepatocellular Carcinoma","volume":"12","author":"Ye","year":"2019","journal-title":"Onco Targets Ther"},{"key":"B58","doi-asserted-by":"publisher","first-page":"eaau1099","DOI":"10.1126\/scitranslmed.aau1099","article-title":"Inhibition of Polyamine Synthesis and Uptake Reduces Tumor Progression and Prolongs Survival in Mouse Models of Neuroblastoma","volume":"11","author":"Gamble","year":"2019","journal-title":"Sci Transl Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2637","article-title":"PGC-1alpha Inhibits Polyamine Metabolism in Cyclin E1-Driven Ovarian Cancer","volume":"8","author":"Guo","year":"2019","journal-title":"Cancer Med"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70712","article-title":"Inhibition of the Aryl Hydrocarbon Receptor\/Polyamine Biosynthesis Axis Suppresses Multiple Myeloma","volume":"128","author":"Bianchi-Smiraglia","year":"2018","journal-title":"J Clin Invest"},{"key":"B61","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41698-017-0014-1","article-title":"Targeting Ornithine Decarboxylase (ODC) Inhibits Esophageal Squamous Cell Carcinoma Progression","volume":"1","author":"He","year":"2017","journal-title":"NPJ Precis Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2021.779562\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T05:08:47Z","timestamp":1635829727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2021.779562\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,2]]},"references-count":61,"alternative-id":["10.3389\/fonc.2021.779562"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2021.779562","relation":{},"ISSN":["2234-943X"],"issn-type":[{"type":"electronic","value":"2234-943X"}],"subject":[],"published":{"date-parts":[[2021,11,2]]},"article-number":"779562"}}