{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:00:30Z","timestamp":1783119630542,"version":"3.54.6"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Malignancies, especially lymphoma, are a common cause of adult secondary HLH and an independent risk factor for the prognosis of HLH patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with lymphoma alone or concurrent lymphoma-associated phagocytic syndrome (LAHS) admitted to Beijing Friendship Hospital from January 2016 to December 2020 were enrolled in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>There were 348 lymphoma patients, 104 concurrent with LAHS. The pathological type of lymphoma without LAHS was dominated by B-cell lymphoma, while those with LAHS were T\/NK-cell lymphoma predominantly (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). Superficial lymph node enlargement was more significant in patients with B-LAHS (<jats:italic>p<\/jats:italic> = 0.006), while patients with T\/NK-LAHS had lower neutrophil counts (<jats:italic>p<\/jats:italic> = 0.005), lower fibrinogen levels (<jats:italic>p<\/jats:italic> &amp;lt; 0.001), higher transaminase levels, and more co-infection with EBV (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). B-LAHS had significantly higher IL-10 levels than with T\/NK-LAHS (<jats:italic>p<\/jats:italic> = 0.006), and NK\/T-LAHS had significantly higher IP-10 levels than other T-LAHS (<jats:italic>p<\/jats:italic> = 0.008). Age, platelet count, IPI, history of NK\/T lymphoma, and no remission of HLH were independent risk factors for prognosis in patients with non-Hodgkin lymphoma-associated phagocytic syndrome (NHL-LAHS), and a prognostic risk score model for NHL-LAHS was developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LAHS is a life-threatening disease with a poor prognosis. The prognostic risk\u00a0score model for NHL-LAHS with a good fit and validation for the test has value for clinical application.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2021.788056","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T04:58:48Z","timestamp":1638766728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical Features and Prognostic Risk Prediction of Non-Hodgkin Lymphoma-Associated Hemophagocytic 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