{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:01:06Z","timestamp":1790344866930,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Invasive <jats:italic>Candida glabrata<\/jats:italic> infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient\u2019s treatment is rarely recognised. We described a case of development of echinocandin resistance in a patient with muscle-invasive bladder cancer (pT2b N0 M0, high grade) diagnosis, subjected to radical cystoprostatectomy and exposed to echinocandins. A male patient with a previous surgical history after a traffic accident, who was operated on due to bladder cancer, underwent an episode of candidemia and mixed postoperative wound and urinary tract infection caused by <jats:italic>C. glabrata<\/jats:italic> and extended spectrum \u03b2-lactamase (ESBL)-producing <jats:italic>Escherichia coli<\/jats:italic> during hospital treatment. The patient was started on caspofungin. Repeat blood cultures showed clearance of the bloodstream infection; however, infection persisted at the surgical site. Resistance to echinocandins developed within 2\u00a0months from the day of initiation of therapy with caspofungin in the <jats:italic>C. glabrata<\/jats:italic> strain obtained from the surgical site. The isolates sequentially obtained during the patient\u2019s treatment demonstrated resistance to echinocandins due to the mutation in hotspot 1 <jats:italic>FKS2<\/jats:italic>. Although resistance to echinocandins is relatively rare, it should be considered in oncological patients with increased complexity of treatment and intestinal surgery.<\/jats:p>","DOI":"10.3389\/fonc.2021.794235","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T05:34:57Z","timestamp":1639546497000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Case Report: Echinocandin-Resistance Candida glabrata FKS Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder 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