{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:52Z","timestamp":1787026972480,"version":"build-2736575974"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The value of prophylactic central neck dissection (PCND) for papillary thyroid carcinoma (PTC) with clinically evident lateral cervical lymph node metastases (cN1b) remains unclear. Therefore, a systematic review and meta-analysis was conducted to assess the efficacy and safety of PCND.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive systematic search was conducted on PubMed, Web of Science, Cochrane library and Embase databases up to September 2021 to identify eligible studies. Controlled clinical trials assessing therapeutic effects and safety of PCND for cN1b PTC patients were included. The risk of bias for each cohort study was assessed using the Newcastle-Ottawa Scale (NOS). The primary outcomes were indexes related to the locoregional recurrence (LRR) and surgical complications. Review Manager software V5.4.0 was used for statistical analysis. A fixed effects model was adopted for the data without heterogeneity, otherwise a random effects model was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 4 retrospective cohort studies, which comprised 483 PTC patients. There was no statistically significant difference in the central neck recurrence (CNR) (10.2% vs. 3.8%, relative risk (RR) = 1.82; 95%CI 0.90\u20133.67; P = 0.09), lateral neck recurrence (LNR) (5.1% vs. 7.7%, RR = 0.47; 95% CI 0.13\u20131.74; P = 0.26), and overall recurrence (OR) (18.9% vs. 16.9%, RR = 0.77; 95%CI 0.34\u20131.76; P = 0.54), between LND + PCND group and LND group. Simultaneously, PCND increased the risk of permanent hypoparathyroidism (11.4% vs. 4.5%, RR = 2.70, 95%CI 1.05\u20136.94; P = 0.04) and overall complications (17.0% vs. 5.3%, RR = 3.28; 95%CI 1.37\u20137.86; P = 0.008).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis showed that PCND did not have any advantage in preventing LRR for cN1b PTC. Meanwhile, PCND may result in the increased rate of surgical complications. However, the current evidence is limited and more clinical trials are still needed to further clarify the true role of PCND.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:uri>\n                      , CRD42021281825.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2021.803986","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:43:26Z","timestamp":1642121006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Prophylactic Central Neck Dissection for cN1b Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Xing-qiang","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-sheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-jian","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0043","article-title":"The Prognostic Significance of Nodal Metastases From Papillary Thyroid Carcinoma can be Stratified Based on the Size and Number of Metastatic Lymph Nodes, as Well as the Presence of Extranodal Extension","volume":"22","author":"Randolph","year":"2012","journal-title":"Thyroid"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0224","article-title":"A Preoperative Nomogram for the Prediction of Ipsilateral Central Compartment Lymph Node Metastases in Papillary Thyroid Cancer","volume":"24","author":"Thompson","year":"2014","journal-title":"Thyroid"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.surg.2005.09.013","article-title":"Nodal Yield, Morbidity, and Recurrence After Central Neck Dissection for Papillary Thyroid Carcinoma","volume":"138","author":"Pereira","year":"2005","journal-title":"Surgery"},{"key":"B5","unstructured":"NCCN Clinicial Practice Guidelines in Oncology\u2014Thyroid Carcinoma"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23391","article-title":"Tumor Location-Dependent Skip Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Cancer","volume":"36","author":"Lee","year":"2014","journal-title":"Head Neck"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20606","article-title":"Is Central Neck Dissection Necessary for the Treatment of Lateral Cervical Nodal Recurrence of Papillary Thyroid Carcinoma","volume":"29","author":"Roh","year":"2007","journal-title":"Head Neck"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24568","article-title":"Central Compartment Management in Patients With Papillary Thyroid Cancer Presenting With Metastatic Disease to the Lateral Neck: Anatomic Pathways of Lymphatic Spread","volume":"39","author":"Likhterov","year":"2017","journal-title":"Head Neck"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23982","article-title":"Elective Central Compartment Neck Dissection in Patients With Papillary Thyroid Carcinoma Recurrence","volume":"123","author":"Trivizki","year":"2013","journal-title":"Laryngoscope"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2019-0532","article-title":"Role of Prophylactic Central Compartment Lymph Node Dissection on the Outcome Of Patients With Papillary Thyroid Carcinoma and Synchronous Ipsilateral Cervical Lymph Node Metastases","volume":"26","author":"De Napoli","year":"2020","journal-title":"Endocr Pract"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08861-4","article-title":"Is a Prophylactic Central Compartment Neck Dissection Required in Papillary Thyroid Carcinoma Patients With Clinically Involved Lateral Compartment Lymph Nodes","volume":"28","author":"Harries","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26299","article-title":"Prophylactic Central Neck Dissection has No Advantage in Patients With Metastatic Papillary Thyroid Cancer to the Lateral Neck","volume":"123","author":"Carmel-Neiderman","year":"2021","journal-title":"J Surg Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.09.003","article-title":"A Multicenter Cohort Study of Total Thyroidectomy and Routine Central Lymph Node Dissection for Cn0 Papillary Thyroid Cancer","volume":"150","author":"Popadich","year":"2011","journal-title":"Surgery"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8985","article-title":"Prophylactic Central Neck Dissection for Papillary Thyroid Cancer","volume":"100","author":"Barczy\u0144ski","year":"2013","journal-title":"Br J Surg"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2089-3","article-title":"Influence of Prophylactic Neck Dissection on Rate of Retreatment for Papillary Thyroid Carcinoma","volume":"37","author":"Hartl","year":"2013","journal-title":"World J Surg"},{"key":"B17","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00268-006-0907-6","article-title":"Central Lymph Node Dissection in Differentiated Thyroid Cancer","volume":"31","author":"White","year":"2007","journal-title":"World J Surg"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0608","article-title":"A Systematic Review and Meta-Analysis of Prophylactic Central Neck Dissection on Short-Term Locoregional Recurrence in Papillary Thyroid Carcinoma After Total Thyroidectomy","volume":"23","author":"Lang","year":"2013","journal-title":"Thyroid"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.02.004","article-title":"Prophylactic Central Lymph Node Dissection for Clinically Node-Negative Papillary Thyroid Microcarcinoma: Influence on Serum Thyroglobulin Level, Recurrence Rate, and Postoperative Complications","volume":"151","author":"So","year":"2012","journal-title":"Surgery"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0121","article-title":"In Papillary Thyroid Cancer, Preoperative Central Neck Ultrasound Detects Only Macroscopic Surgical Disease, But Negative Findings Predict Excellent Long-Term Regional Control and Survival","volume":"22","author":"Moreno","year":"2012","journal-title":"Thyroid"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000250451.59685.67","article-title":"Total Thyroidectomy Plus Neck Dissection in Differentiated Papillary Thyroid Carcinoma Patients: Pattern of Nodal Metastasis, Morbidity, Recurrence, and Postoperative Levels of Serum Parathyroid Hormone","volume":"245","author":"Roh","year":"2007","journal-title":"Ann Surg"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.09.019","article-title":"Influence of Prophylactic Central Lymph Node Dissection on Postoperative Thyroglobulin Levels and Radioiodine Treatment in Papillary Thyroid Cancer","volume":"148","author":"Hughes","year":"2010","journal-title":"Surgery"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5691-4","article-title":"The Effect of Prophylactic Central Neck Dissection on Locoregional Recurrence in Papillary Thyroid Cancer After Total Thyroidectomy: A Systematic Review and Meta-Analysis: pCND for the Locoregional Recurrence of Papillary Thyroid Cancer","volume":"24","author":"Zhao","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3825","article-title":"Prophylactic Central Compartment Lymph Node Dissection in Papillary Thyroid Carcinoma: Clinical Implications Derived From the First Prospective Randomized Controlled Single Institution Study","volume":"100","author":"Viola","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0317","article-title":"American Thyroid Association Design and Feasibility of a Prospective Randomized Controlled Trial of Prophylactic Central Lymph Node Dissection for Papillary Thyroid Carcinoma","volume":"22","author":"Carling","year":"2012","journal-title":"Thyroid"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1600-z","article-title":"Central Lymph Node Metastasis of Unilateral Papillary Thyroid Carcinoma: Patterns and Factors Predictive of Nodal Metastasis, Morbidity, and Recurrence","volume":"18","author":"Roh","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01320","article-title":"Local and Regional Control in Patients With Papillary Thyroid Carcinoma: Specific Indications of External Radiotherapy and Radioactive Iodine According to T and N Categories in AJCC 6th Edition","volume":"13","author":"Chow","year":"2006","journal-title":"Endocrine-Related Cancer"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4332","article-title":"Adjuvant Radioactive Iodine Therapy Is Associated With Improved Survival for Patients With Intermediate-Risk Papillary Thyroid Cancer","volume":"100","author":"Ruel","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.3.288","article-title":"Sentinel Lymphadenectomy in Thyroid Malignant Neoplasms","volume":"133","author":"Kelemen","year":"1998","journal-title":"Arch Surg (Chicago Ill 1960)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0011","article-title":"Complications of Central Neck Dissection in Patients With Papillary Thyroid Carcinoma: Results of a Study on 1087 Patients and Review of the Literature","volume":"22","author":"Giordano","year":"2012","journal-title":"Thyroid"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-018-4547-4","article-title":"Prophylactic Central Neck Dissection for Papillary Thyroid Carcinoma With Clinically Uninvolved Central Neck Lymph Nodes: A Systematic Review and Meta-Analysis","volume":"42","author":"Chen","year":"2018","journal-title":"World J Surg"},{"key":"B32","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00268-013-2260-x","article-title":"Intraoperative Nerve Monitoring can Reduce Prevalence of Recurrent Laryngeal Nerve Injury in Thyroid Reoperations: Results of a Retrospective Cohort Study","volume":"38","author":"Barczy\u0144ski","year":"2014","journal-title":"World J Surg"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2020.1831913","article-title":"Novel Techniques for Intraoperative Parathyroid Gland Identification: A Comprehensive Review","volume":"15","author":"Wong","year":"2020","journal-title":"Expert Rev Endocrinol Metab"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2021.803986\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:43:29Z","timestamp":1642121009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2021.803986\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,14]]},"references-count":33,"alternative-id":["10.3389\/fonc.2021.803986"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2021.803986","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,14]]},"article-number":"803986"}}