{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T07:57:14Z","timestamp":1782028634312,"version":"3.54.5"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800141, 81890994, 81770144, 81870110"],"award-info":[{"award-number":["81800141, 81890994, 81770144, 81870110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19DZ1910702"],"award-info":[{"award-number":["19DZ1910702"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Acute promyelocytic leukemia (APL) is characterized by the balanced translocation of chromosomes 15 and 17, resulting in the formation of <jats:italic>PML-RARA<\/jats:italic> fusion gene. More than 98% of APL have <jats:italic>PML-RARA<\/jats:italic> fusion, and less than 2% have other types of <jats:italic>RARA<\/jats:italic> gene partners, which named variant APL (vAPL). In the present study, we reported a vAPL with <jats:italic>BCOR-RARA<\/jats:italic>, which was the third case of <jats:italic>BCOR-RARA<\/jats:italic> APL published. The patient achieved complete remission (CR) with all-<jats:italic>trans<\/jats:italic> retinoic acid (ATRA) monotherapy, and molecular CR with ATRA plus standard chemotherapy. After that, he underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and ATRA maintenance and maintained a molecular CR status. This case provided valuable insights into the accurate identification of vAPL. Moreover, ATRA combined with chemotherapy followed by allo-HSCT was suggested as an optimal choice for those vAPL patients who had a high risk of relapse.<\/jats:p>","DOI":"10.3389\/fonc.2022.1013046","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T11:42:45Z","timestamp":1663933365000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Successful therapy with all-trans retinoic acid combined with chemotherapy followed by hematopoietic stem cell transplantation for acute promyelocytic leukemia carrying the BCOR-RARA fusion 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