{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:40:33Z","timestamp":1775713233100,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Paragangliomas of the gallbladder are exceptionally rare. To date, only a few cases of this disease have been reported globally, and the majority were found incidentally during surgery. Although complete resection can achieve a curative effect, specific targeted drugs may have survival benefits for patients with potential recurrence and metastasis risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 48-year-old woman was scheduled for anatomical central hepatectomy due to the discovery of a liver mass. Surprisingly, a gallbladder tumor accompanied by intrahepatic invasion was found rather than primary liver lesions during the operation. Postoperatively, the lesion was confirmed to be a paraganglioma originating from the gallbladder with intrahepatic invasion detectable on histopathology. After surgery, the patient was treated with a new targeted drug, surufatinib {200 mg, q.d. [<jats:italic>quaque die<\/jats:italic> (every day)]}, and no recurrence was observed during the regular follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Gallbladder paraganglioma is rare and occult, and surgeons do not know it well, so it is easily misdiagnosed before surgery. Postoperative pathological examination is the gold standard for diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given that the tumor contained abundant blood sinuses, the early and continuous enhancement of dynamic enhanced CT scanning was its characteristic manifestation. We presented a case in which a primary gallbladder paraganglioma was identified accidentally in a patient who was misdiagnosed with a liver lesion before surgery. Based on our experience in this work, the en bloc resection technique in combination with surufatinib might have a survival benefit to patients at risk of potential recurrence or metastasis; however, further follow-up observations are needed.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.1031112","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T09:18:29Z","timestamp":1674724709000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case Report: A rare case of primary paraganglioma of the gallbladder with a literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Yijun","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiya","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.humpath.2019.12.002","article-title":"Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: What can brown do for you","volume":"96","author":"Bellizzi","year":"2020","journal-title":"Hum Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0396","article-title":"Clinical management of paragangliomas","volume":"171","author":"Corssmit","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-018-4181-2","article-title":"Pheochromocytoma and paraganglioma-an update on diagnosis, evaluation, and management","volume":"35","author":"Jain","year":"2020","journal-title":"Pediatr Nephrol (Berlin Germany)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"101416","DOI":"10.1016\/j.beem.2020.101416","article-title":"An overview of 20 years of genetic studies in pheochromocytoma and paraganglioma","volume":"34","author":"Buffet","year":"2020","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-523-GPACRW","article-title":"Gallbladder paraganglioma: A case report with review of the literature","volume":"129","author":"Mehra","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.09.095","article-title":"Primary gallbladder paraganglioma: A case report and review of literature","volume":"75","author":"D'John","year":"2020","journal-title":"Int J Surg Case Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"300060520932114","DOI":"10.1177\/0300060520932114","article-title":"Primary hepatic neuroendocrine tumor with multiple liver metastases: A case report with literature review","volume":"48","author":"Xia","year":"2020","journal-title":"J Int Med Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.09.006","article-title":"Pheochromocytoma and paraganglioma: Genetics, diagnosis, and treatment","volume":"30","author":"Fishbein","year":"2016","journal-title":"Hematol\/Oncol Clinics North A"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1972.04180100080019","article-title":"Paraganglioma of the gallbladder","volume":"105","author":"Miller","year":"1972","journal-title":"Arch Surg (Chicago Ill 1960)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1001\/archsurg.1973.01350210117035","article-title":"Paraganglioma of the gallbladder","volume":"107","author":"Wolff","year":"1973","journal-title":"Arch Surg (Chicago Ill 1960)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(99)80121-6","article-title":"Paraganglia of the gallbladder: A report of two cases with an immunohistochemical study","volume":"195","author":"Kawabata","year":"1999","journal-title":"Pathol - 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