{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:55:31Z","timestamp":1793778931582,"version":"4.6.1"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Epstein\u2212Barr virus (EBV) contributes significantly to the development and occurrence of B-cell lymphomas. However, the association between EBV infection status and clinical outcomes in Hodgkin lymphoma (HL) patients has long been controversial. Therefore, we aimed to estimate the prognostic significance of EBV infection in HL survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, Web of Science, and the Cochrane Library for relevant cohort studies from the date of their inception to February 20, 2022. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), Failure-free survival (FFS), Progression-free survival (PFS), Event-free survival (EFS) and disease-specific survival (DSS) were extracted from the studies or calculated. Subgroup analyses were conducted independently on the five survival outcomes to investigate the source of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 42 qualified studies involving 9570 patients were identified in our meta-analysis. There was an association between EBV positivity and significantly poorer OS (HR=1.443, 95% CI: 1.250-1.666) and DSS (HR=2.312, 95% CI: 1.799-2.972). However, the presence of EBV in HL showed no effect on FFS, PFS or EFS. In subgroup analyses of OS, DSS and FFS stratified by age groups, EBV positivity was associated with poorer prognosis in elderly patients. Meanwhile, in children and adolescents with EBV-positive HL, we also observed a trend toward a better prognosis, though the results were not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EBV-positive status is associated with poor OS and DSS in HL patients. EBV infection should therefore be considered a valuable prognostic marker and risk-stratifying factor in HL, especially in older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:uri>\n                      , identifier CRD42022328708.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2022.1034398","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:49:01Z","timestamp":1666831741000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The prognostic value of Epstein\u2212Barr virus infection in Hodgkin lymphoma: A systematic review and meta-analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Jianyu","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu181","article-title":"Hodgkin\u2019s lymphoma: Esmo clinical practice guidelines for diagnosis, treatment and follow-up","volume":"25","author":"Eichenauer","year":"2014","journal-title":"Ann Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41572-020-0189-6","article-title":"Hodgkin Lymphoma","volume":"6","author":"Connors","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/s2352-3026(20)30357-4","article-title":"The role of pet in first-line treatment of Hodgkin lymphoma","volume":"8","author":"Trotman","year":"2021","journal-title":"Lancet Haematol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25856","article-title":"Hodgkin Lymphoma: A 2020 update on diagnosis, risk-stratification, and management","volume":"95","author":"Ansell","year":"2020","journal-title":"Am J Hematol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/bjh.15614","article-title":"Diagnosis of Hodgkin lymphoma in the modern era","volume":"184","author":"Wang","year":"2019","journal-title":"Br J Haematol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2016.05.003","article-title":"Prognostic factors in Hodgkin lymphoma","volume":"53","author":"Br\u00f6ckelmann","year":"2016","journal-title":"Semin Hematol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2021.153370","article-title":"Prognostic value of Bcl2 and P53 in Hodgkin lymphoma: A systematic review and meta-analysis","volume":"219","author":"Travaglino","year":"2021","journal-title":"Pathol Res Pract"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-772632","article-title":"Biology of classical Hodgkin lymphoma: Implications for prognosis and novel therapies","volume":"131","author":"Mottok","year":"2018","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/978-3-319-22822-8_12","article-title":"Contribution of the Epstein-Barr virus to the pathogenesis of Hodgkin lymphoma","volume":"390","author":"Murray","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.442.414a46_442_447","article-title":"Effect of Epstein-Barr virus infection on response to chemotherapy and survival in hodgkin\u2019s disease","volume":"94","author":"Murray","year":"1999","journal-title":"Blood"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1309\/mmau-0qyh-7bha-w8c2","article-title":"Guidelines for interpreting eber in situ hybridization and Lmp1 immunohistochemical tests for detecting Epstein-Barr virus in Hodgkin lymphoma","volume":"117","author":"Gulley","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3390\/cancers10060163","article-title":"Epstein Barr Virus-associated Hodgkin lymphoma","volume":"10","author":"Carbone","year":"2018","journal-title":"Cancers (Basel)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.6.2429","article-title":"Adverse clinical outcome in hodgkin\u2019s disease is associated with loss of retinoblastoma protein expression, high Ki67 proliferation index, and absence of Epstein-Barr virus-latent membrane protein 1 expression","volume":"90","author":"Morente","year":"1997","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1080\/028418699431942","article-title":"Epstein-Barr Virus distribution in hodgkin\u2019s disease in an unselected Swedish population","volume":"38","author":"Enblad","year":"1999","journal-title":"Acta Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.3.182","article-title":"Improved prognosis of Epstein-Barr virus associated childhood hodgkin\u2019s lymphoma: Study of 47 south African cases","volume":"53","author":"Engel","year":"2000","journal-title":"J Clin Pathol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008337100424","article-title":"Epstein-Barr Virus association in classical hodgkin\u2019s disease provides survival advantage to patients and correlates with higher expression of proliferation markers in reed-sternberg cells","volume":"11","author":"Naresh","year":"2000","journal-title":"Ann Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010415)91:8<1579::aid-cncr1169>3.0.co;2-l","article-title":"Epstein-Barr Virus and survival after Hodgkin disease in a population-based series of women","volume":"91","author":"Clarke","year":"2001","journal-title":"Cancer"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1774","article-title":"Assessment of the prognostic impact of the Epstein-Barr virus-encoded latent membrane protein-1 expression in hodgkin\u2019s disease","volume":"84","author":"Glavina-Durdov","year":"2001","journal-title":"Br J Cancer"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03815.x","article-title":"Hodgkin\u2019s disease in the elderly: A population-based study","volume":"119","author":"Stark","year":"2002","journal-title":"Br J Haematol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg065","article-title":"The effect of Epstein-Barr virus status on outcome in age- and sex-defined subgroups of patients with advanced hodgkin\u2019s disease","volume":"14","author":"Flavell","year":"2003","journal-title":"Ann Oncol"},{"key":"B22","article-title":"Expression of Epstein-Barr virus latent membrane protein-1 in Hodgkin and reed-sternberg cells of classical hodgkin\u2019s lymphoma: Associations with presenting features, serum interleukin 10 levels, and clinical outcome","volume":"9","author":"Herling","year":"2003","journal-title":"Clin Cancer Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/01.Mp.0000071843.09960.Bf","article-title":"Longer failure-free survival interval of Epstein-Barr virus-associated classical hodgkin\u2019s lymphoma: A single-institution study","volume":"16","author":"Krugmann","year":"2003","journal-title":"Mod Pathol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.01.701","article-title":"Impact of latent Epstein-Barr virus infection on outcome in children and adolescents with hodgkin\u2019s lymphoma","volume":"23","author":"Claviez","year":"2005","journal-title":"J Clin Oncol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.02.6310","article-title":"Epstein-Barr Virus as a marker of survival after hodgkin\u2019s lymphoma: A population-based study","volume":"23","author":"Keegan","year":"2005","journal-title":"J Clin Oncol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500286879","article-title":"Epstein-Barr Virus infection is not the sole cause of high prevalence for hodgkin\u2019s lymphoma in Saudi Arabia","volume":"47","author":"Al-Kuraya","year":"2006","journal-title":"Leuk Lymphoma"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.06.5342","article-title":"Prognostic significance of T-cell or cytotoxic molecules phenotype in classical hodgkin\u2019s lymphoma: A clinicopathologic study","volume":"24","author":"Asano","year":"2006","journal-title":"J Clin Oncol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1182\/blood-2004-09-3759","article-title":"Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: A population-based study","volume":"107","author":"Jarrett","year":"2006","journal-title":"Blood"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1159\/000093639","article-title":"Association between the Epstein-Barr virus and hodgkin\u2019s lymphoma in the north-Eastern part of Hungary: Effects on therapy and survival","volume":"116","author":"Keresztes","year":"2006","journal-title":"Acta Haematol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181647bc3","article-title":"Pediatric Hodgkin lymphoma in 2 south American series: A distinctive epidemiologic pattern and lack of association of Epstein-Barr virus with clinical outcome","volume":"30","author":"Chabay","year":"2008","journal-title":"J Pediatr Hematol Oncol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1182\/blood-2008-07-168096","article-title":"Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with ebv infection and outcome","volume":"113","author":"Chetaille","year":"2009","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.20.5138","article-title":"Latent Epstein-Barr virus infection of tumor cells in classical hodgkin\u2019s lymphoma predicts adverse outcome in older adult patients","volume":"27","author":"Diepstra","year":"2009","journal-title":"J Clin Oncol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.489243","article-title":"Cell cycle characteristics and Epstein-Barr virus are differentially associated with aggressive and non-aggressive subsets of Hodgkin lymphoma in pediatric patients","volume":"51","author":"Barros","year":"2010","journal-title":"Leuk Lymphoma"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/hon.933","article-title":"Impact of Epstein-Barr virus in the clinical evolution of patients with classical hodgkin\u2019s lymphoma in Brazil","volume":"28","author":"Souza","year":"2010","journal-title":"Hematol Oncol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.031542","article-title":"Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical hodgkin\u2019s lymphoma","volume":"96","author":"Kamper","year":"2011","journal-title":"Haematologica"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1464-8","article-title":"Impact of the Epstein-Barr virus positivity on hodgkin\u2019s lymphoma in a Large cohort from a single institute in Korea","volume":"91","author":"Koh","year":"2012","journal-title":"Ann Hematol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-454694","article-title":"Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: Correlative analysis from a Large north American cooperative group trial","volume":"121","author":"Kanakry","year":"2013","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828b6ad3","article-title":"Prognostic significance of cox-2 expression and correlation with bcl-2 and vegf expression, microvessel density, and clinical variables in classical Hodgkin lymphoma","volume":"37","author":"Koh","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12175","article-title":"Prognostic significance of Cd20 expression and Epstein-Barr virus (Ebv) association in classical Hodgkin lymphoma in Japan: A clinicopathologic study","volume":"64","author":"Elsayed","year":"2014","journal-title":"Pathol Int"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2403-2","article-title":"Programmed death-1 (Pd-1), programmed death-ligand 1 (Pd-L1), and ebv-encoded rna (Eber) expression in Hodgkin lymphoma","volume":"94","author":"Paydas","year":"2015","journal-title":"Ann Hematol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e2359","DOI":"10.5812\/ijp.2359","article-title":"The role of Epstein-Barr virus lmp-1 immunohistochemical staining in childhood Hodgkin lymphoma","volume":"25","author":"Tanyildiz","year":"2015","journal-title":"Iran J Pediatr"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2610-5","article-title":"Pretreatment whole blood Epstein-Barr virus-DNA is a significant prognostic marker in patients with Hodgkin lymphoma","volume":"95","author":"Park","year":"2016","journal-title":"Ann Hematol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/his.13085","article-title":"Epstein\u2013Barr Virus latent membrane protein-1 up-regulates cytokines and correlates with older age and poorer prognosis in Hodgkin lymphoma","volume":"70","author":"Chang","year":"2017","journal-title":"Histopathology"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2016.09.004","article-title":"Prognostic significance of Epstein-Barr virus (Ebv) infection in hodgkin lymphoma patients","volume":"23","author":"Myriam","year":"2017","journal-title":"J Infect Chemother"},{"key":"B45","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/ejh.12987","article-title":"An anergic immune signature in the tumor microenvironment of classical Hodgkin lymphoma is associated with inferior outcome","volume":"100","author":"Hollander","year":"2018","journal-title":"Eur J Haematol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2468","article-title":"Epstein-Barr Virus positivity is associated with angiogenesis in, and poorer survival of, patients receiving standard treatment for classical hodgkin\u2019s lymphoma","volume":"36","author":"Koh","year":"2018","journal-title":"Hematol Oncol"},{"key":"B47","article-title":"Pd-1, Foxp3, and csf-1r expression in patients with Hodgkin lymphoma and their prognostic value","volume":"11","author":"Wang","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1800005","article-title":"Assessment of tumor Epstein-Barr virus status and its impact on outcomes in intermediate and high-risk childhood classic Hodgkin lymphoma treated at a tertiary cancer center in India","volume":"61","author":"Cheriyalinkal Parambil","year":"2020","journal-title":"Leuk Lymphoma"},{"key":"B49","doi-asserted-by":"publisher","first-page":"9410","DOI":"10.1038\/s41598-020-66010-z","article-title":"Tumor-associated macrophages in classical Hodgkin lymphoma: Hormetic relationship to outcome","volume":"10","author":"Werner","year":"2020","journal-title":"Sci Rep"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.11.004","article-title":"Cd68-positive tumour associated macrophages, pd-L1 expression, and ebv latent infection in a high hiv-prevalent south African cohort of Hodgkin lymphoma patients","volume":"53","author":"Antel","year":"2021","journal-title":"Pathology"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2021.106607","article-title":"Pretreatment whole blood Epstein-Barr virus DNA predicts prognosis in Hodgkin lymphoma","volume":"107","author":"Qin","year":"2021","journal-title":"Leuk Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.3390\/v13122523","article-title":"Prognostic role of the expression of latent-membrane protein 1 of Epstein\u2013Barr virus in classical Hodgkin lymphoma","volume":"13","author":"Santisteban-Espejo","year":"2021","journal-title":"Viruses"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1971864","article-title":"Latent Epstein-Barr virus infection status and prognosis in patients with newly diagnosed Hodgkin lymphoma in southeast China: A single-center retrospective study","volume":"26","author":"Wang","year":"2021","journal-title":"Hematology"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.153781","article-title":"Expression and prognostic analysis of Stat6(Ye361) in Hodgkin lymphoma","volume":"231","author":"Yang","year":"2022","journal-title":"Pathol Res Pract"},{"key":"B55","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The prisma 2020 statement: An updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst Rev"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-16","article-title":"Practical methods for incorporating summary time-to-Event data into meta-analysis","volume":"8","author":"Tierney","year":"2007","journal-title":"Trials"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Contemp Clin Trials"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivy163","article-title":"Statistical primer: Heterogeneity, random- or fixed-effects model analyses","volume":"27","author":"Barili","year":"2018","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw691","article-title":"Statistical controversies in clinical research: Publication bias evaluations are not routinely conducted in clinical oncology systematic reviews","volume":"28","author":"Herrmann","year":"2017","journal-title":"Ann Oncol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2014.06.001","article-title":"Prevalence and prognostic significance of Epstein-Barr virus infection in classical hodgkin\u2019s lymphoma: A meta-analysis","volume":"45","author":"Lee","year":"2014","journal-title":"Arch Med Res"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4906","article-title":"Effect of latent membrane protein 1 expression on overall survival in Epstein-Barr virus-associated cancers: A literature-based meta-analysis","volume":"6","author":"Chen","year":"2015","journal-title":"Oncotarget"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2015.20","article-title":"Understanding the interplay between host immunity and Epstein-Barr virus in npc patients","volume":"4","author":"Shen","year":"2015","journal-title":"Emerg Microbes Infect"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00700-21","article-title":"Reevaluating the impact of Epstein-Barr virus noncoding rnas on the interferon response","volume":"12","author":"Murphy","year":"2021","journal-title":"mBio"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03440-20","article-title":"Multiple viral micrornas regulate interferon release and signaling early during infection with Epstein-Barr virus","volume":"12","author":"Bouvet","year":"2021","journal-title":"mBio"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.3390\/v14051017","article-title":"Immunosuppressive tumor microenvironment and immunotherapy of Epstein-Barr virus-associated malignancies","volume":"14","author":"Zheng","year":"2022","journal-title":"Viruses"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3759","article-title":"Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: A population-based study","volume":"106","author":"Jarrett","year":"2005","journal-title":"Blood"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30473","article-title":"The impact of ebv and hiv infection on the microenvironmental niche underlying Hodgkin lymphoma pathogenesis","volume":"140","author":"Carbone","year":"2017","journal-title":"Int J Cancer"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.011","article-title":"Human viral oncogenesis: A cancer hallmarks analysis","volume":"15","author":"Mesri","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.3390\/cancers14112647","article-title":"An update on the pathology and molecular features of Hodgkin lymphoma","volume":"14","author":"Satou","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.955603","article-title":"Strategies of Epstein-Barr virus to evade innate antiviral immunity of its human host","volume":"13","author":"Albanese","year":"2022","journal-title":"Front Microbiol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/path.4431","article-title":"Epstein-Barr Virus-encoded Ebna1 and zebra: Targets for therapeutic strategies against ebv-carrying cancers","volume":"235","author":"Daskalogianni","year":"2015","journal-title":"J Pathol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22834-1_4","article-title":"The latent membrane protein 1 (Lmp1)","volume":"391","author":"Kieser","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.01.008","article-title":"Prognostic significance of ebv-Lmp1 and vegf-a expressions in non-hodgkin\u2019s lymphomas","volume":"32","author":"Paydas","year":"2008","journal-title":"Leukemia Res"},{"key":"B76","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.3390\/cancers13215451","article-title":"New look of ebv Lmp1 signaling landscape","volume":"13","author":"Wang","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016002618","article-title":"Epstein-Barr Virus DNA in serum as an early prognostic marker in children and adolescents with Hodgkin lymphoma","volume":"1","author":"Welch","year":"2017","journal-title":"Blood Adv"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33802","article-title":"Disparity analysis and prognostic value of pretreatment whole blood Epstein-Barr virus DNA load and Epstein-Barr encoding region status in lymphomas: A retrospective multicenter study in huaihai lymphoma working group","volume":"150","author":"Shen","year":"2022","journal-title":"Int J Cancer"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.1034398\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:49:07Z","timestamp":1666831747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.1034398\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":78,"alternative-id":["10.3389\/fonc.2022.1034398"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2022.1034398","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"article-number":"1034398"}}