{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:22Z","timestamp":1753891822403,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Ewing sarcoma (ES) is the second most common malignant bone tumor in children and has also been described in adults with highly aggressive behavior. ES belongs to the small round blue cell tumor family and presents the distinctive translocation of FET-ETS family genes (85% with <jats:italic>EWSR1<\/jats:italic>), generating gene fusions. Extraskeletal ES mainly occurs in soft tissues; the urogenital tract is rarely affected, and ureteral localization is an exceptional event with only 4 cases described in the literature. Here we report the first Italian case of primary ES of the ureter, a 24-year-old young man with lower back pain and a narrowed left ureteral lumen on CT scan. ES of the urogenital tract is an almost unique condition with a nonspecific clinical presentation and a challenging diagnosis for pathologists. We encourage awareness of these exceptional events in the differential diagnosis of ureteral lesions in young patients.<\/jats:p>","DOI":"10.3389\/fonc.2022.1070838","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T17:10:05Z","timestamp":1672938605000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Primary Ewing sarcoma of the ureter, an exceptional finding of unique manifestation of disease"],"prefix":"10.3389","volume":"12","author":[{"given":"Marina","family":"Valeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leocadia","family":"Dore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Rudini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Cieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia Maria","family":"Elefante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Saita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Bertuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piergiuseppe","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41572-018-0003-x","article-title":"Ewing Sarcoma","volume":"4","author":"Gr\u00fcnewald","year":"2018","journal-title":"Nat Rev Dis Prim"},{"volume-title":"Lyon (France): International agency for research on cancer","year":"2020","article-title":"Soft tissue and bone tumours","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/359162a0","article-title":"Gene fusion with ETS DNA-binding domain caused by chromosome translocation in human tumours","volume":"359","author":"Delattre","year":"1992","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00428-009-0842-7","article-title":"Histological heterogeneity of ewing\u2019s sarcoma\/PNET: An immunohistochemical analysis of 415 genetically confirmed cases with clinical support","volume":"455","author":"Llombart-Bosch","year":"2009","journal-title":"Virchows Arch"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.anndiagpath.2017.11.011","article-title":"Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, \u201cundifferentiated small round cell tumors\u201d. a clinicopathologic, immunophenotypic and molecular analysis","volume":"34","author":"Machado","year":"2018","journal-title":"Ann Diagn Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5256","article-title":"Ewing Sarcoma: Current management and future approaches through collaboration","volume":"33","author":"Gaspar","year":"2015","journal-title":"J Clin Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.21037\/tau-20-1122","article-title":"Renal ewing\u2019s sarcoma\/primitive neuroectodermal tumor (PNET): A case series of 7 patients and literature review","volume":"10","author":"Liang","year":"2021","journal-title":"Transl Androl Urol"},{"key":"B8","article-title":"Primary Ewing sarcoma of the kidney: A series of four cases","volume":"44","author":"Patra","year":"2022","journal-title":"Malays J Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.eucr.2022.102139","article-title":"Ewing-Like sarcoma bladder primary tumour: A case report and literature review","volume":"44","author":"Nakdali Kassab","year":"2022","journal-title":"Urol Case Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2015.11.007","article-title":"Prostatic sarcoma of the Ewing family in a 33-year-old male - 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