{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:56:33Z","timestamp":1777640193353,"version":"3.51.4"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background\/Aim<\/jats:title><jats:p>Most paratesticular liposarcomas (PLPSs) are well-differentiated liposarcomas (WDLPSs) with favourable prognoses. As such, the rare occurrence of PLPS often leads to its misdiagnosis as a hernia or hydrocele on physical examination. Curative resection of the tumour may not be possible in cases where PLPSs have transformed into dedifferentiated liposarcomas (DDLPSs) owing to a delay in diagnosis. Herein, we describe a case of unresectable paratesticular dedifferentiated liposarcoma (PDDLPS) with poor prognosis due to delayed diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 57-year-old man visited our hospital with a chief complaint of a right scrotal mass, which was diagnosed as scrotal hydrocele but without treatment or follow-up. Eight years later, the patient complained of abdominal distension, and a computed tomography scan revealed the presence of retroperitoneal and right scrotal masses. The right scrotal mass was removed, and histopathology revealed DDLPS. The patient was diagnosed with unresectable PDDLPS metastasising to the retroperitoneum, and the left pleura was treated with doxorubicin. After an initial response, pleural effusion and ascites increased during the sixth cycle of chemotherapy. The patient subsequently received eribulin but died 5 months after the initial DDLPS diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is difficult to distinguish PLPS from benign inguinal hernia and hydrocele testis on physical examination. PLPS generally has a considerably good prognosis. However, failure to diagnose WDLPS can be dangerous as it might lead to malignant transformation to DDLPS, which has a poor prognosis. Physicians should consider this malignancy when examining patients with hernias or hydroceles of the inguinal region and should perform ultrasonography or magnetic resonance imaging.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.1085794","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T17:54:37Z","timestamp":1669917277000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case report: Paratesticular dedifferentiated liposarcoma with poor prognosis"],"prefix":"10.3389","volume":"12","author":[{"given":"Hirotaka","family":"Suto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Inui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200301000-00005","article-title":"Paratesticular liposarcoma: A clinicopathologic study","volume":"27","author":"Montgomery","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2015.04.002","article-title":"Principles in management of soft tissue sarcoma","volume":"49","author":"Crago","year":"2015","journal-title":"Adv Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2013.08.009","article-title":"Primary spermatic cord tumors: disease characteristics, prognostic factors, and treatment outcomes","volume":"32","author":"Rodr\u00edguez","year":"2014","journal-title":"Urol Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960501)77:9<1873","article-title":"The management of spermatic cord sarcoma","volume":"77","author":"Fagundes","year":"1996","journal-title":"Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2003.11.014","article-title":"Adult spermatic cord sarcomas: management and results","volume":"10","author":"Coleman","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199501000-00055","article-title":"Liposarcoma of the spermatic cord: report of 6 cases and review of the literature","volume":"153","author":"Schwartz","year":"1995","journal-title":"J Urol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-27617-5_10","article-title":"Paratesticular soft tissue neoplasms","volume":"17","author":"Folpe","year":"2000","journal-title":"Semin Diagn Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.18926\/AMO\/32032","article-title":"Retroperitoneal liposarcoma presenting a indirect inguinal hernia","volume":"55","author":"Noguchi","year":"2001","journal-title":"Acta Med Okayama"},{"key":"B9","article-title":"Liposarcoma of the spermatic cord masquerading as an incarcerated inguinal hernia","volume":"69","author":"Hassan","year":"2003","journal-title":"Am Surg"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01753-3","article-title":"Optimal treatment strategy for paratesticular liposarcoma: retrospective analysis of 265 reported cases","volume":"25","author":"Kamitani","year":"2020","journal-title":"Int J Clin Oncol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000479364","article-title":"Dedifferentiated liposarcoma in the spermatic cord finally diagnosed at 7th resection of recurrence: A case report and bibliographic consideration","volume":"10","author":"Morozumi","year":"2017","journal-title":"Case Rep Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199211000-00003","article-title":"Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. a follow-up study of 92 cases with analysis of the incidence of \u201cdedifferentiation\u201d","volume":"16","author":"Weiss","year":"1992","journal-title":"Am J Surg Pathol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000426","article-title":"Dedifferentiated liposarcoma of the spermatic cord: A series of 42 cases","volume":"39","author":"Kryvenko","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199703000-00002","article-title":"Dedifferentiated liposarcoma: A clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation","volume":"21","author":"Henricks","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196310)16:10<1332","article-title":"Soft tissue sarcoma","volume":"16","author":"Hare","year":"1963","journal-title":"A Rev 200 cases. 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