{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:28:12Z","timestamp":1789201692540,"version":"build-2803163510"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to estimate the extra risk of second primary cancer among breast cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and materials<\/jats:title>\n                    <jats:p>\n                      This is a systematic review. A comprehensive search of literature was performed in PubMed, Web of Science, Cochrane library, and Scopus. The search included all published studies up to October 2022. This systematic review included studies published in the English language that reported the risk of second primary non-breast cancer [\n                      <jats:italic>i.e.<\/jats:italic>\n                      , standardized incidence ratio (SIR)] among breast cancer patients older than 15 years. After evaluating the methodological quality of the selected studies, SIRs were pooled with consideration of heterogeneity among studies. The estimates were pooled by age and time since the diagnosis of primary breast cancer for both sexes (male and female). Age was categorized based on before 50 years and after 50 years, and time was categorized as duration of less than and more than 10 years, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2,484 articles, 30 articles were eligible for inclusion in the systematic review and meta-analysis. The studies varied in terms of population, number of cases, study design, setting, and year of implementation of the research. The estimated SIR for men and women was 1.28 (95% CI: 1.18, 1.38) and 1.27 (95% CI: 1.15, 1.39), respectively. Women diagnosed with breast cancer before menopause [SIR: 1.52 (95% CI: 1.34, 1.71)\n                      <jats:italic>vs<\/jats:italic>\n                      . 1.21 (95% CI: 1.08, 1.34)] as well as women after 10 years since their breast cancer diagnosis [1.33 (95% CI: 1.22, 1.431)\n                      <jats:italic>vs<\/jats:italic>\n                      . 1.24 (95% CI: 1.10, 1.37)] were at a higher risk of developing second primary cancer. Among men, while there were no differences in risk based on age, with the increase of time, the risk of second primary cancer was reduced [SIR: 1.22 (95% CI: 1.12, 1.33)\n                      <jats:italic>vs<\/jats:italic>\n                      . 1.00 (95% CI: 0.79, 1.22)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is an extra risk of second primary cancer among breast cancer patients. The extra risk should be considered for further screening and preventive measures among this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=336062<\/jats:uri>\n                      , identifier (CRD42022336062).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2022.1094136","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:33:00Z","timestamp":1673915580000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk of second primary cancer among breast cancer patients: A systematic review and meta-analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Parynaz","family":"Parhizgar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayad","family":"Bahadori Monfared","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Mohseny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliasghar","family":"Keramatinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Saeed","family":"Hashemi Nazari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Azizur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Al Marzouqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Al-Yateem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Mosavi Jarrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.3390\/cancers14102569","article-title":"Breast cancer\u2013epidemiology, classification, pathogenesis and treatment (Review of literature)","volume":"14","author":"Smolarz","year":"2022","journal-title":"Cancers."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.31557\/apjcc.2020.5.2.71-78","article-title":"Multiple primary tumours, how frequent we can offer curative therapy","volume":"5","author":"Elemam","year":"2020","journal-title":"Asian Pacific J Cancer Care"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: An overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int J cancer."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.31557\/apjcc.2020.5.4.251-258","article-title":"Improving the outcomes of breast cancer in China: Physicians\u2019 beliefs, recommendations, and practices for breast cancer screening","volume":"5","author":"Wu","year":"2020","journal-title":"Asian Pacific J Cancer Care"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.31557\/apjcc.2020.5.1.61-66","article-title":"Breast cancer awareness and detection of asymptomatic cases using breast palpation and fine-needle aspiration in bafoussam, Cameroon","volume":"5","author":"Richard","year":"2020","journal-title":"Asian Pacific J Cancer Care"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0437","article-title":"Global patterns of cancer incidence and mortality rates and TrendsGlobal patterns of cancer","volume":"19","author":"Jemal","year":"2010","journal-title":"Cancer epidemiology Biomarkers Prev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.10.029","article-title":"Risk of second cancers cancer after a first primary breast cancer: a systematic review and meta-analysis","volume":"136","author":"Molina-Montes","year":"2015","journal-title":"Gynecologic Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.31557\/apjcc.2021.6.4.477-492","article-title":"Demographic pattern, tumor size and stage of breast cancer in africa: A meta-analysis","volume":"6","author":"Olayide","year":"2021","journal-title":"Asian Pacific J Cancer Care"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.23.16_suppl.6511","article-title":"Long-term cause-specific mortality among 41,146 one-year survivors of Hodgkin lymphoma (HL)","volume":"23","author":"Dores","year":"2005","journal-title":"J Clin Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21651","article-title":"Risk of second cancer among women with breast cancer","volume":"118","author":"Mellemkj\u00e6r","year":"2006","journal-title":"Int J cancer."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33602","article-title":"Risks of subsequent primary cancers among breast cancer survivors according to hormone receptor status","volume":"127","author":"Sung","year":"2021","journal-title":"Cancer."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.04.057","article-title":"Risk of second primary cancer among women with breast cancer: A population-based study in Granada (Spain)","volume":"130","author":"Molina-Montes","year":"2013","journal-title":"Gynecologic Oncol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3322\/caac.21208","article-title":"Cancer statistics, 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA: Cancer J Clin"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41416-022-01940-1","article-title":"Italian Cancer figures, report 2013: Multiple tumours","volume":"37","author":"Group","year":"2013","journal-title":"Epidemiologia e prevenzione"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29462","article-title":"Risk of second primary malignancies in women with breast cancer: Results from the European prospective investigation into cancer and nutrition (EPIC)","volume":"137","author":"Ricceri","year":"2015","journal-title":"Int J cancer."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.2016.003699","article-title":"Second primary cancers after primary breast cancer diagnosis in Israeli women, 1992 to 2006","volume":"3","author":"Silverman","year":"2017","journal-title":"J Global Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30903-3","article-title":"Risk of subsequent primary neoplasms in survivors of adolescent and young adult cancer (Teenage and young adult cancer survivor study): a population-based, cohort study","volume":"20","author":"Bright","year":"2019","journal-title":"Lancet Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4351","article-title":"Nonmetastatic breast cancer patients subsequently developing second primary malignancy: A population-based study","volume":"10","author":"Bao","year":"2021","journal-title":"Cancer Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.05.032","article-title":"Long-term risks of secondary cancer for various whole and partial breast irradiation techniques","volume":"128","author":"Hoekstra","year":"2018","journal-title":"Radiotherapy Oncol J Eur Soc Ther Radiol Oncol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0556","article-title":"Bisphosphonate use and risk of recurrence, second primary breast cancer, and breast cancer mortality in a population-based cohort of breast cancer patients","volume":"27","author":"Korde","year":"2018","journal-title":"Cancer epidemiology Biomarkers Prev Publ Am Assoc Cancer Research cosponsored by Am Soc Prev Oncol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s10549-018-4729-7","article-title":"Long-term risk of second malignancies in women after breast conservation therapy for ductal carcinoma in situ or early-stage breast cancer","volume":"170","author":"Kushner","year":"2018","journal-title":"Breast Cancer Res Treat"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010593","article-title":"Second malignancy in young early-stage breast cancer patients with modern radiotherapy: A long-term population-based study (A STROBE-compliant study)","volume":"97","author":"Xie","year":"2018","journal-title":"Medicine."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33216","article-title":"Risk of secondary hematologic malignancies associated with breast cancer chemotherapy and G-CSF support: A nationwide population-based cohort","volume":"148","author":"Jabagi","year":"2021","journal-title":"Int J cancer."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01496-6","article-title":"Long-term risk of subsequent ipsilateral lesions after surgery with or without radiotherapy for ductal carcinoma in situ of the breast","volume":"125","author":"van Seijen","year":"2021","journal-title":"Br J cancer."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/BF01810741","article-title":"Racial and age differences in multiple primary cancers after breast cancer: A population-based analysis","volume":"14","author":"Schwartz","year":"1989","journal-title":"Breast Cancer Res Treat"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/BF01807033","article-title":"Age at diagnosis and multiple primary cancers of the breast and ovary","volume":"41","author":"Suris-Swartz","year":"1996","journal-title":"Breast Cancer Res Treat"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603404","article-title":"Family history of breast cancer and young age at diagnosis of breast cancer increase risk of second primary malignancies in women: A population-based cohort study","volume":"95","author":"Prochazka","year":"2006","journal-title":"Br J cancer."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23212","article-title":"Family history of breast or ovarian cancer modifies the risk of secondary leukemia after breast cancer: results from a population-based study","volume":"122","author":"Verkooijen","year":"2008","journal-title":"Int J Cancer."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1186\/s12885-021-08925-y","article-title":"Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study","volume":"21","author":"Zheng","year":"2021","journal-title":"BMC cancer."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0522","article-title":"MOOSE reporting guidelines for meta-analyses of observational studies","volume":"156","author":"Brooke","year":"2021","journal-title":"JAMA surgery."},{"key":"B31","article-title":"International association of cancer registries (IACR), European network of cancer registries (ENCR)","volume-title":"International rules for multiple primary cancers (ICD-O-Third edition)","year":"2000"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.05.010","article-title":"Night work and breast cancer risk: A systematic review and meta-analysis","volume":"41","author":"Megdal","year":"2005","journal-title":"Eur J cancer."},{"key":"B33","volume-title":"SIGN 50: A guideline developers\u2019 handbook 2015","year":"2017"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00204-8","article-title":"Misleading funnel plot for detection of bias in meta-analysis","volume":"53","author":"Tang","year":"2000","journal-title":"J Clin Epidemiol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"Bmj."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1080\/02841860801978921","article-title":"Risk of second primary cancer among patients with early operable breast cancer registered or randomised in Danish breast cancer cooperative group (DBCG) protocols of the 77, 82 and 89 programmes during 1977-2001","volume":"47","author":"Andersson","year":"2008","journal-title":"Acta Oncol (Stockholm Sweden)."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn530","article-title":"Acute myeloid leukemia after breast cancer: a population-based comparison with hematological malignancies and other cancers","volume":"20","author":"Beadle","year":"2009","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9509-8","article-title":"Risk of second non-hematological malignancies among 376,825 breast cancer survivors","volume":"106","author":"Brown","year":"2007","journal-title":"Breast Cancer Res Treat"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001333","article-title":"Other primary malignancies among women with adult-type ovarian granulosa cell tumors","volume":"28","author":"Bryk","year":"2018","journal-title":"Int J gynecological Cancer Off J Int Gynecological Cancer Society."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00173-1","article-title":"Incidence of second primary cancers in three Italian population-based cancer registries","volume":"33","author":"Buiatti","year":"1997","journal-title":"Eur J Cancer (Oxford Engl 1990)."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32832abd76","article-title":"Incidence of second cancer within 5 years of diagnosis of a breast, prostate or colorectal cancer: a population-based study","volume":"18","author":"Cluze","year":"2009","journal-title":"Eur J Cancer Prev Off J Eur Cancer Prev Organisation (ECP)."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2621-9","article-title":"Multiple primary non-breast tumors in breast cancer survivors","volume":"144","author":"Corso","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181b9f5d5","article-title":"Distribution of second primary malignancies suggests a bidirectional effect between breast and endometrial cancer a population-based study","volume":"19","author":"Cortesi","year":"2009","journal-title":"Int J Gynecological Cancer."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4193","article-title":"Risk of thyroid as a first or second primary cancer. a population-based study in Italy, 1998\u20132012","volume":"10","author":"Crocetti","year":"2021","journal-title":"Cancer Med"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1317","article-title":"Second primary neoplasms in 633,964 cancer patients in Sweden, 1958\u20131996","volume":"93","author":"Dong","year":"2001","journal-title":"Int J cancer."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980729)77:3<392::AID-IJC14>3.0.CO;2-A","article-title":"Second cancers following in situ carcinoma of the breast","volume":"77","author":"Franceschi","year":"1998","journal-title":"Int J cancer."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9460-0","article-title":"Leukemia following breast cancer: an international population-based study of 376,825 women","volume":"105","author":"Howard","year":"2007","journal-title":"Breast Cancer Res Treat"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1023\/a:1017159305119","article-title":"Second primary cancers in breast cancer patients in vaud, Switzerland","volume":"9","author":"Levi","year":"1998","journal-title":"Cancer causes control CCC."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005556","article-title":"Risk of secondary cancers in women with breast cancer and the influence of radiotherapy: A national cohort study in Taiwan","volume":"95","author":"Lin","year":"2016","journal-title":"Medicine."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12582","article-title":"Trend of incidence of second primary malignancies following breast cancer in Taiwan: A 12-year nationwide cohort study","volume":"22","author":"Lu","year":"2016","journal-title":"Breast J"},{"key":"B51","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/(SICI)1097-0215(20000101)85:1<78::AID-IJC14>3.0.CO;2-S","article-title":"Primary brain tumours as second primary: a novel association between meningioma and colorectal cancer","volume":"85","author":"Malmer","year":"2000","journal-title":"Int J cancer."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2015.18.4.378","article-title":"Risk of second primary malignancy in breast cancer survivors: A nested population-based case-control study","volume":"18","author":"Marcheselli","year":"2015","journal-title":"J Breast Cancer."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.110167","article-title":"Associations between first and second primary cancers: a population-based study","volume":"184","author":"Nielsen","year":"2012","journal-title":"CMAJ."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00089-8","article-title":"Lung cancer risks in women with previous breast cancer","volume":"38","author":"Prochazka","year":"2002","journal-title":"Eur J Cancer (Oxford Engl 1990)."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00316.x","article-title":"Women with a prior diagnosis of breast cancer are not at an increased risk for subsequent colorectal cancer","volume":"100","author":"Srinivasan","year":"2005","journal-title":"Am J gastroenterology."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/75.2.207","article-title":"Multiple cancer\u2013an epidemiologic exercise in Finland","volume":"75","author":"Teppo","year":"1985","journal-title":"J Natl Cancer Institute."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018487506546","article-title":"Second primary cancers in breast cancer patients in Slovenia","volume":"8","author":"Volk","year":"1997","journal-title":"Cancer causes control CCC."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1981.247","article-title":"Multiple primary cancers of the breast and ovary","volume":"44","author":"Prior","year":"1981","journal-title":"Br J cancer."},{"key":"B59","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/oxfordjournals.jjco.a039211","article-title":"Second primary cancers following female breast cancer in Osaka, Japan\u2013a population-based cohort study","volume":"17","author":"Murakami","year":"1987","journal-title":"Japanese J Clin Oncol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90013-6","article-title":"Second primary neoplasms following breast cancer in saarland, Germany, 1968-1987","author":"Brenner","year":"1993","journal-title":"Eur J Cancer (Oxford Engl 1990)"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006489918700","article-title":"Increased risk of second cancers following breast cancer: role of the initial treatment","volume":"61","author":"Rubino","year":"2000","journal-title":"Breast Cancer Res Treat"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1603","article-title":"Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England","volume":"84","author":"Evans","year":"2001","journal-title":"Br J cancer."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1349-7006.2001.tb01040.x","article-title":"Second primary cancers following breast cancer in the Japanese female population","volume":"92","author":"Tanaka","year":"2001","journal-title":"Japanese J Cancer Res Gann."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg028","article-title":"Cancer risk in women with previous breast cancer","volume":"14","author":"Levi","year":"2003","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023908509928","article-title":"Second primary breast and thyroid cancers (Israel)","volume":"14","author":"Sadetzki","year":"2003","journal-title":"Cancer Causes Control."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602505","article-title":"Second primary malignancies in patients with male breast cancer","volume":"92","author":"Hemminki","year":"2005","journal-title":"Br J cancer."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0109","article-title":"Increased risk for second primary malignancies in women with breast cancer diagnosed at young age: A population-based study in Taiwan","volume":"17","author":"Lee","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.9081","article-title":"Risk of new primary nonbreast cancers after breast cancer treatment: A Dutch population-based study","volume":"26","author":"Schaapveld","year":"2008","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181a12e8b","article-title":"Second primary gynecologic cancers after breast cancer in Turkish women","volume":"19","author":"Gulhan","year":"2009","journal-title":"Int J gynecological Cancer Off J Int Gynecological Cancer Society."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0099","article-title":"Nonendocrine cancers associated with benign and malignant parathyroid tumors","volume":"96","author":"Fallah","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0009","article-title":"Risk of primary non\u2013breast cancer after female breast cancer by age at DiagnosisCancer after breast cancer","volume":"20","author":"Mellemkj\u00e6r","year":"2011","journal-title":"Cancer epidemiology Biomarkers Prev"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0349-7","article-title":"Incidence of second sarcomas: a cancer registry-based study","volume":"25","author":"Levi","year":"2014","journal-title":"Cancer Causes Control."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12433","article-title":"Incidence of multiple primary cancers and interval between first and second primary cancers","volume":"105","author":"Utada","year":"2014","journal-title":"Cancer Science."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0561","article-title":"A possible association between thyroid cancer and breast cancer","volume":"25","author":"An","year":"2015","journal-title":"Thyroid Off J Am Thyroid Assoc"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e0148597","DOI":"10.1371\/journal.pone.0148597","article-title":"Risk of second non-breast primary cancer in Male and female breast cancer patients: A population-based cohort study","volume":"11","author":"Hung","year":"2016","journal-title":"PloS One"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2016.07.101","article-title":"Risks of second malignancies after breast cancer treatment: Long-term results","volume":"21","author":"Bazire","year":"2017","journal-title":"Cancer radiotherapie J la Societe francaise radiotherapie oncologique."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1473","article-title":"The bidirectional association among female hormone-related cancers: breast, ovary, and uterine corpus","volume":"7","author":"Chen","year":"2018","journal-title":"Cancer Med"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e187147","DOI":"10.1001\/jamanetworkopen.2018.7147","article-title":"Evaluation of the incidence of hematologic malignant neoplasms among breast cancer survivors in France","volume":"2","author":"Jabagi","year":"2019","journal-title":"JAMA network Open"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05879-w","article-title":"Risk of primary urological and genital cancers following incident breast cancer: a Danish population-based cohort study","volume":"184","author":"Sundboll","year":"2020","journal-title":"Breast Cancer Res Treat"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-04489-3_2","article-title":"Etiology of cancer","author":"Hill","year":"2019","journal-title":"Clin Ophthalmic Oncology: Springer;"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23130","article-title":"Association of first primary cancer with risk of subsequent primary cancer among survivors of adult-onset cancers in the united states","volume":"324","author":"Sung","year":"2020","journal-title":"Jama."},{"key":"B82","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcancer.2017.08.010","article-title":"Prognostic and predictive biomarkers in breast cancer: Past, present and future","volume-title":"In Seminars in cancer biology","author":"Nicolini","year":"2018"},{"key":"B83","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/cncr.32472","article-title":"Male Breast cancer in the united states: Treatment patterns and prognostic factors in the 21st century","volume":"126","author":"Yadav","year":"2020","journal-title":"Cancer."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01940-1","article-title":"Risk of developing a second primary cancer in male breast cancer survivors: A systematic review and meta-analysis","volume":"127","author":"Allen","year":"2022","journal-title":"Br J Cancer"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/73.5.1049","article-title":"Breast cancer as a risk factor for other primary malignant diseases. a nationwide cohort study","volume":"73","author":"Adami","year":"1984","journal-title":"J Natl Cancer Institute."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90013-6","article-title":"Second primary neoplasms following breast cancer in saarland, Germany, 1968\u20131987","volume":"29","author":"Brenner","year":"1993","journal-title":"Eur J Cancer."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/72.3.531","article-title":"Risk of leukemia associated with the first course of cancer treatment: an analysis of the surveillance, epidemiology, and end results program experience","volume":"72","author":"Curtis","year":"1984","journal-title":"J Natl Cancer Institute."},{"key":"B88","article-title":"Second cancer following cancer of the female breast in Denmark, 1943-80","volume":"68","author":"Ewertz","year":"1985","journal-title":"Natl Cancer Institute Monograph."},{"key":"B89","first-page":"99","article-title":"Second cancer following cancer of the breast in Connecticut, 1935-82","volume":"68","author":"Harvey","year":"1985","journal-title":"Natl Cancer Institute Monograph."},{"key":"B90","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/oxfordjournals.jjco.a039211","article-title":"Second primary cancers following female breast cancer in Osaka, Japan\u2013a population-based cohort study","volume":"17","author":"Murakami","year":"1987","journal-title":"Japanese J Clin Oncol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/75.2.207","article-title":"Multiple cancer\u2013an epidemiologic exercise in Finland","volume":"75","author":"Teppo","year":"1985","journal-title":"J Natl Cancer Institute."},{"key":"B92","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3857\/roj.2018.00290","article-title":"Radiation induced secondary malignancies: a review article","volume":"36","author":"Dracham","year":"2018","journal-title":"Radiat Oncol J"},{"key":"B93","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.7150\/jca.25482","article-title":"Multiple primary malignant tumors-a clinical analysis of 15,321 patients with malignancies at a single center in China","volume":"9","author":"Zhai","year":"2018","journal-title":"J cancer."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-0877","article-title":"A linkage between thyroid and breast cancer: A common etiology","volume":"28","author":"Bolf","year":"2019","journal-title":"Metachronous Thyroid Breast Cancer. Cancer Epidemiology Biomarkers Prev"},{"key":"B95","volume-title":"International rules for multiple primary cancers (ICD-O third edition)","year":"2004"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.08.014","article-title":"Distribution and risk of the second discordant primary cancers combined after a specific first primary cancer in German and Swedish cancer registries","volume":"369","author":"Chen","year":"2015","journal-title":"Cancer letters."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2407-14-94","article-title":"The effect of patient characteristics on second primary cancer risk in France","volume":"14","author":"J\u00e9gu","year":"2014","journal-title":"BMC cancer."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/bcr1643","article-title":"Risk of second primary cancer in men with breast cancer","volume":"9","author":"Satram-Hoang","year":"2007","journal-title":"Breast Cancer Res"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.1094136\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:33:05Z","timestamp":1673915585000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.1094136\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":98,"alternative-id":["10.3389\/fonc.2022.1094136"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2022.1094136","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]},"article-number":"1094136"}}