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Conversely, obvious pathological T-cell clones can be detected in blood, but there is uncertainty in how to categorize this clonal T cell population, thus, we adopt a multidisciplinary review of the clinical features, diagnostic material and radiology before making the diagnosis. In this review we shall discuss some of these challenges faced when diagnosing mature T-cell leukemias.<\/jats:p>","DOI":"10.3389\/fonc.2022.777066","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T08:36:00Z","timestamp":1646814960000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Mature T-Cell leukemias: Challenges in 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