{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:47:12Z","timestamp":1786387632738,"version":"build-2736575974"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Approximately 66% of head and neck cancers are diagnosed at an advanced stage. This prospective study aimed to detect newly diagnosed head and neck cancers using regular upper gastrointestinal (UGI) endoscopy with oral-pharynx-larynx examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 2,849 patients underwent UGI endoscopy with an additional oral-pharynx-larynx examination. Patients aged &amp;lt; 20 years, those who were pregnant, had a history of head and neck cancers, were undergoing emergency endoscopy, and had a poor laryngopharyngeal view were excluded. The symptoms, incidence, location, pathology, and stage of malignant neoplasms were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2,720 patients were enrolled. Endoscopically observable 23 abnormal findings (0.85%) included 18 (0.66%) benign lesions and 5 (0.18%) newly diagnosed malignant neoplasms. Notably, 4 (80%) of 5 patients with malignant neoplasms were diagnosed at an early stage (Stage 0, I, and II).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>UGI endoscopy with oral-pharynx-larynx examination can achieve opportunistic head neck cancer screening and is recommended for every patient in endoscopy units.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.793318","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T11:33:05Z","timestamp":1653651185000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Gastrointestinal Endoscopy Performed by Gastroenterologists: Opportunistic Screening Strategy for Newly Diagnosed Head and Neck Cancers"],"prefix":"10.3389","volume":"12","author":[{"given":"Chih-Wei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueng-Hsiang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Chien","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Kuo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global Cancer Statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer Statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23654","article-title":"Head and Neck Cancer: An Evolving Treatment Paradigm","volume":"113","author":"Cognetti","year":"2008","journal-title":"Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005456","article-title":"Detection of Subclinical Disorders of the Hypopharynx and Larynx by Gastrointestinal Endoscopy","volume":"28","author":"Watanabe","year":"1996","journal-title":"Endoscopy"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(82)73046-9","article-title":"Screening Examination of the Larynx and Pharynx During Upper Gastrointestinal Panendoscopy","volume":"28","author":"Lehman","year":"1982","journal-title":"Gastrointest Endosc"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.030130","article-title":"Controlled Prospective Evaluation of the Diagnostic Yield of a Laryngopharyngeal Screening Examination During Upper Gastrointestinal Endoscopy","volume":"53","author":"Mullhaupt","year":"2004","journal-title":"Gut"},{"key":"B7","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","article-title":"Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018","volume":"156","author":"Peery","year":"2019","journal-title":"Gastroenterology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2018.918","article-title":"Screening for Mouth Cancer: The Pros and Cons of a National Programme","volume":"225","author":"Brocklehurst","year":"2018","journal-title":"Br Dent J"},{"key":"B9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.oraloncology.2018.12.011","article-title":"Cost-Effectiveness Analysis of the Oral Cancer Screening Program in Taiwan","volume":"89","author":"Huang","year":"2019","journal-title":"Oral Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.12.007","article-title":"Finding an Oral Potentially Malignant Disorder in Screening Program Is Related to Early Diagnosis of Oral Cavity Cancer - 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