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We found that N-glycan biosynthesis pathway was activated in high-grade tumor, but TNF-related pathway was activated in cystitis glandularis. The tumor microenvironment (TME) of different samples showed great heterogeneity. Notably, cystitis glandularis was dominated by T cells, low-grade and high-grade tumors by macrophages, while TME in patient with high-grade relapse by stromal cells. Our research provides single-cell transcriptome profiles of cystitis glandularis and BLCA in different clinical states, and the biological program revealed by single-cell data can be used as biomarkers related to clinical prognosis in independent cohorts.<\/jats:p>","DOI":"10.3389\/fonc.2022.818147","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T06:14:29Z","timestamp":1645424069000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Single-Cell Transcriptome Comparison of Bladder Cancer Reveals Its 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