{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:14:32Z","timestamp":1765808072175,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730003, 81870120, 82070187"],"award-info":[{"award-number":["81730003, 81870120, 82070187"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017ZX09304021, 2017YFA0104500, 2019YFC0840604"],"award-info":[{"award-number":["2017ZX09304021, 2017YFA0104500, 2019YFC0840604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Early T-cell precursor (ETP) lymphoblastic leukemia\/lymphoma is a high-risk T lymphoblastic leukemia\/lymphoma (T-ALL\/LBL) subgroup. We performed a real-world multicenter study to explore the clinical characteristics and prognosis of adolescent and young adults (AYA) and older adult ETP leukemia\/lymphoma. A total of 103 patients with ETP-ALL\/LBL in five centers in China between January 2016 and February 2021 were included in this study. The median age was 29 years (range, 15\u201370 years). Next-generation sequencing was performed in 94 patients and revealed that NOTCH1 (35.1%, 33 cases) was the most frequently mutated gene, followed by JAK3 (16.0%, 15 cases), PHF6 (13.80%, 13 cases) and EZH2 (11.70%, 11 cases). Complete remission (CR) was obtained in 74.2% (72\/97) of patients, and 6 relapsed\/refractory patients received a decitabine combined with AAG priming regimen as reinduction therapy with a CR rate of 50%. With a median follow-up of 18 months (0.5\u201360 months), the 2-year overall survival (OS) and relapse-free survival (RFS) rates for the entire cohort were 54% and 57.7%, respectively. Allogeneic stem cell transplantation (allo-SCT) was performed in 59.8% (58\/97) of patients. After landmark analysis at 6 months, the 2-year OS rates was 77% of patients with allo-SCT at CR1 and 25% of patients with chemotherapy alone (p &amp;lt; 0.001). A multivariate analysis suggested that allo-SCT and CR after the first course induction were independent prognostic factors for OS. Collectively, we reported the largest cohort study with AYA and older adult ETP-ALL\/LBL, and we found that ETP-ALL\/LBL was highly invasive and had a poor long-term prognosis. Allo-SCT could significantly improve ETP-ALL\/LBL patient survival.<\/jats:p>","DOI":"10.3389\/fonc.2022.846573","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T04:52:53Z","timestamp":1654491173000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Clinical Characteristics and Prognosis of AYA and Older Adult ETP-ALL\/LBL: A Real-World Multicenter Study in 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