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This multifactorial syndrome is associated with changes in several metabolic pathways in adipose tissue which is affected early in the course of cachexia. Adipose depots are involved in energy storage and consumption as well as endocrine functions. In this mini review, we discuss the metabolic reprogramming in all three types of adipose tissues \u2013 white, brown, and beige \u2013 under the influence of the tumor macro-environment. Alterations in adipose tissue lipolysis, lipogenesis, inflammation and adaptive thermogenesis of beige\/brown adipocytes are highlighted. Energy-wasting circuits in adipose tissue impacts whole-body metabolism and particularly skeletal muscle. Targeting of key molecular players involved in the metabolic reprogramming may aid in the development of new treatment strategies for cancer cachexia.<\/jats:p>","DOI":"10.3389\/fonc.2022.848394","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T07:43:01Z","timestamp":1652341381000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["Metabolic Reprogramming in Adipose Tissue During Cancer Cachexia"],"prefix":"10.3389","volume":"12","author":[{"given":"Bahar Zehra Camurdanoglu","family":"Weber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilsad H.","family":"Arabaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Kir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829","article-title":"Cancer Cachexia: Understanding the Molecular Basis","volume":"14","author":"Argiles","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013","article-title":"Cachexia: A New Definition","volume":"27","author":"Evans","year":"2008","journal-title":"Clin Nutr"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(05)80001-3","article-title":"Prognostic Effect of Weight-Loss Prior to Chemotherapy in Cancer-Patients","volume":"69","author":"Dewys","year":"1980","journal-title":"Am J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2147\/cmar.s7101","article-title":"Optimal Management of Cancer Anorexia-Cachexia Syndrome","volume":"2010","author":"Argiles","year":"2010","journal-title":"Cancer Manag Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41574-018-0123-0","article-title":"Inter-Tissue Communication in Cancer Cachexia","volume":"15","author":"Argil\u00e9s","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00297.2015","article-title":"Revisiting the Adipocyte: A Model for Integration of Cytokine Signaling in the Regulation of Energy Metabolism","volume":"309","author":"Rodr\u00edguez","year":"2015","journal-title":"Am J Physiol Cell Physiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000321319","article-title":"Brown Versus White Adipose Tissue: A Mini-Review","volume":"58","author":"Saely","year":"2010","journal-title":"Gerontol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0","article-title":"Positional Cloning of the Mouse Obese Gene and Its Human Homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(79)80279-3","article-title":"Microcalorimetry of Isolated Mitochondria From Brown Adipose Tissue. 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