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Myeloid sarcoma, which rarely happens in acute promyelocytic leukemias, is more common in recurrent patients after the advent of all-trans retinoic acid (ATRA) and are rare in untreated acute promyelocytic leukemia. We described a case of, to our knowledge, <jats:italic>de novo<\/jats:italic> myeloid sarcoma of the spine confirmed as acute promyelocytic leukemia. Myeloid sarcoma is diagnosed by spinal tumor biopsy, and microscopic examination of a bone marrow smear and cytogenetic analysis led to a confirmed diagnosis of acute promyelocytic leukemia.<\/jats:p>","DOI":"10.3389\/fonc.2022.851406","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T05:49:12Z","timestamp":1646372952000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review"],"prefix":"10.3389","volume":"12","author":[{"given":"Xuemei","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-347229","article-title":"How I Treat Extramedullary Acute Myeloid Leukemia","volume":"118","author":"Bakst","year":"2011","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1159\/000205595","article-title":"Motility of Leukaemic Cells in Acute Leukaemia Related to Tumour Mass, Maturation and FAB Classification","volume":"80","author":"van der Weide","year":"1988","journal-title":"Acta Haematol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02324.x","article-title":"Clinical Significance of Granulocytic Sarcoma in Adult Patients With Acute Myeloid Leukemia","volume":"103","author":"Shimizu","year":"2012","journal-title":"Cancer Sci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.4.690","article-title":"Granulocytic Sarcoma is Associated With the 8;21 Translocation in Acute Myeloid Leukemia","volume":"11","author":"Tallman","year":"1993","journal-title":"J Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050348","article-title":"Granulocytic Sarcoma (Chloroma) of the Sacrum: Initial Manifestation of Leukemia","volume":"27","author":"Novick","year":"1998","journal-title":"Skeletal Radiol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3086","article-title":"Granulocytic Sarcoma of the Spine: MRI and Clinical Review","volume":"194","author":"Seok","year":"2010","journal-title":"AJR Am J Roentgenol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/137608","article-title":"Promyelocytic Sarcoma of the Spine: A Case Report and Review of the Literature","volume":"2010","author":"Pacilli","year":"2010","journal-title":"Adv Hematol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1991","article-title":"Acute Promyelocytic Leukemia Presenting as Recurrent Spinal Myeloid Sarcomas 3 Years Before Developing Leukemia: A Case Report With Review of Literature","volume":"7","author":"Yamashita","year":"2019","journal-title":"Clin Case Rep"},{"key":"B9","article-title":"Extramedullary Relapse in Lumbar Spine of Patient With Acute Promyelocytic Leukemia After Remission for 16 Years: A Case Report and Literature Review","volume":"8","author":"He","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1990.tb01115.x","article-title":"Granulocytic Sarcoma of the Thymus in Acute Promyelocytic Leukaemia","volume":"12","author":"Ajarim","year":"1990","journal-title":"Clin Lab Haematol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.06.010","article-title":"Primary Myeloid Sarcoma of the Testicle With T (15,17)","volume":"157","author":"Gopal","year":"2005","journal-title":"Cancer Genet Cytogenet"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403645","article-title":"Molecular and Cytogenetic Characterization of a New Case of T (5,17)(Q35;Q21) Variant Acute Promyelocytic Leukemia","volume":"19","author":"Nicci","year":"2005","journal-title":"Leukemia"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.6.912","article-title":"Granulocytic Sarcoma: An Unusual Complication of Acute Promyelocytic Leukemia Causing Cerebellar Hemorrhage. 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