{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T23:12:08Z","timestamp":1788649928312,"version":"build-2803163510"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901728, 82030125, 82074534"],"award-info":[{"award-number":["81901728, 82030125, 82074534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Although chemotherapy is the first-line treatment strategy for a variety of tumors, its side effects have limited its efficacy. This review summarizes the progress on the use of acupoint stimulation to combat chemotherapy-associated side effects, including chemotherapy-induced peripheral neuropathy (CIPN), cognitive impairment (CICI), and gastrointestinal toxicity (GI), as well as myelosuppression and immunosuppression. It was found that acupoint stimulation attenuated CIPN and GI by modulating the 5-hydroxytryptamine system in dorsal root ganglia, the dorsal horn of the spinal cord, and the duodenum by reducing oxidative stress and neuroinflammation. Acupoint stimulation also alleviated GI by activating vagal activity in the nucleus tractus solitarius and promoting the secretion of gastrointestinal neuropeptide hormones. Acupoint stimulation restored both bone marrow hematopoiesis and immune function to combat cancer. In addition, the combination of acupoint stimulation and chemotherapy could inhibit tumor growth by promoting tumor cell apoptosis and the enrichment of chemotherapeutic agents in tumor tissue and by modulating the tumor immune microenvironment and normalizing the vasculature. Multiple evidence also indicates that neuroimmune regulation may be involved in the effects of acupoint stimulation. In conclusion, the evidence suggests that acupoint stimulation can alleviate the side effects of chemotherapy and can also assist chemotherapeutic agents in inhibiting tumor growth, which expands the clinical application of acupoint stimulation in cancer treatment. However, more high-quality clinical studies are needed to confirm the clinical value of acupoint stimulation.<\/jats:p>","DOI":"10.3389\/fonc.2022.864046","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T10:33:01Z","timestamp":1650882781000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Efficacy and Potential Mechanisms of Acupoint Stimulation Combined With Chemotherapy in Combating Cancer: A Review and Prospects"],"prefix":"10.3389","volume":"12","author":[{"given":"Shanshan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenlie","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global Cancer Statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"B2","article-title":"NCCN Guidelines Insights: Breast Cancer, Version 32018","volume":"17","author":"Goetz","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.0059","article-title":"NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 1.2020","volume":"17","author":"Ettinger","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0021","article-title":"NCCN Guidelines Insights: Colon Cancer, Version 2.2018","volume":"16","author":"Benson","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.11.011","article-title":"Irradiation Enhances Abscopal Anti-tumor Effects of Antigen-Specific Immunotherapy Through Regulating Tumor Microenvironment","volume":"26","author":"Chang","year":"2018","journal-title":"Mol Ther"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S46327","article-title":"Expression of Folate Receptors in Nasopharyngeal and Laryngeal Carcinoma and Folate Receptor-Mediated Endocytosis by Molecular Targeted Nanomedicine","volume":"8","author":"Xie","year":"2013","journal-title":"Int J Nanomed"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0489","article-title":"Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial","volume":"25","author":"Lu","year":"2020","journal-title":"Oncologist"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2016.0155","article-title":"Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis","volume":"23","author":"Dimitrova","year":"2017","journal-title":"J Altern Complement Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X20500135","article-title":"Research Advances on Acupuncture Analgesia","volume":"48","author":"Qiao","year":"2020","journal-title":"Am J Chin Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.586900","article-title":"Acupuncture Point Stimulation Treatments Combined With Conventional Treatment in Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis","volume":"8","author":"Tsai","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i27.8304","article-title":"Acupuncture and Regulation of Gastrointestinal Function","volume":"21","author":"Li","year":"2015","journal-title":"World J Gastroenterol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1186\/1472-6882-13-362","article-title":"The Role of Acupoint Stimulation as an Adjunct Therapy for Lung Cancer: A Systematic Review and Meta-Analysis","volume":"13","author":"Chen","year":"2013","journal-title":"BMC Complement Altern Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.5233","article-title":"Clinical Evidence for Association of Acupuncture and Acupressure With Improved Cancer Pain: A Systematic Review and Meta-Analysis","volume":"6","author":"He","year":"2020","journal-title":"JAMA Oncol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/acu.2018.1316","article-title":"Effect of Electroacupuncture on Natural-Killer Cells and Tumor Size in Patients With Cervical Squamous-Cell Carcinoma: A Randomized Controlled Trial","volume":"31","author":"Saraswati","year":"2019","journal-title":"Med Acupunct"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1845-z","article-title":"Anti-Inflammatory Effect of Laser Acupuncture in ST36 (Zusanli) Acupoint in Mouse Paw Edema","volume":"31","author":"Erthal","year":"2016","journal-title":"Lasers Med Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-5374.2012.18.003","article-title":"The Cumulative Analgesic Effect of Repeated Electroacupuncture Involves Synaptic Remodeling in the Hippocampal CA3 Region","volume":"7","author":"Xu","year":"2012","journal-title":"Neural Regener Res"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S309082","article-title":"Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study","volume":"16","author":"iu","year":"2021","journal-title":"Clin Interv Aging"},{"key":"B18","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3892\/etm.2021.9615","article-title":"Effects of Transcutaneous Electrical Acupoint Stimulation on Perioperative Immune Function and Postoperative Analgesia in Patients Undergoing Radical Mastectomy: A Randomized Controlled Trial","volume":"21","author":"Ao","year":"2021","journal-title":"Exp Ther Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2014.04.004","article-title":"Chemotherapy-Induced Neuropathy: A Comprehensive Survey","volume":"40","author":"Miltenburg","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"B20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.bbi.2020.04.035","article-title":"Electroacupuncture Trigeminal Nerve Stimulation Plus Body Acupuncture for Chemotherapy-Induced Cognitive Impairment in Breast Cancer Patients: An Assessor-Participant Blinded, Randomized Controlled Trial","volume":"88","author":"Zhang","year":"2020","journal-title":"Brain Behav Immun"},{"key":"B21","doi-asserted-by":"publisher","first-page":"349653","DOI":"10.1155\/2013\/349653","article-title":"Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture","volume":"2013","author":"Rostock","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1097\/j.pain.0000000000001540","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Where are We Now","author":"Colvin","year":"2019","journal-title":"Pain"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.11.011","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Current Status and Progress","volume":"140","author":"Brewer","year":"2016","journal-title":"Gynecol Oncol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1136\/acupmed-2016-011112","article-title":"Laser Acupuncture Attenuates Oxaliplatin-Induced Peripheral Neuropathy in Patients With Gastrointestinal Cancer: A Pilot Prospective Cohort Study","volume":"34","author":"Hsieh","year":"2016","journal-title":"Acupunct Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1136\/bmjspcare-2018-001542","article-title":"Acupuncture for Chemotherapy-Induced Peripheral Neuropathy: A Randomised Controlled Pilot Study[J]","volume":"12","author":"D'Alessandro","year":"2022","journal-title":"BMJ Support Palliat Care"},{"key":"B26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12885-016-3037-z","article-title":"Acupuncture Combined With Methylcobalamin for the Treatment of Chemotherapy-Induced Peripheral Neuropathy in Patients With Multiple Myeloma","volume":"17","author":"Han","year":"2017","journal-title":"BMC Cancer"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3759-2","article-title":"Randomized Sham-Controlled Pilot Trial of Weekly Electro-Acupuncture for the Prevention of Taxane-Induced Peripheral Neuropathy in Women With Early Stage Breast Cancer","volume":"156","author":"Greenlee","year":"2016","journal-title":"Breast Cancer Res Treat"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.909712","article-title":"Efficacy of Acupuncture Therapy for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients","volume":"24","author":"Tong","year":"2018","journal-title":"Med Sci Monit"},{"key":"B29","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1186\/1472-6882-14-471","article-title":"Serotonergic Mechanism of the Relieving Effect of Bee Venom Acupuncture on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats","volume":"14","author":"Lee","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"737","DOI":"10.3390\/toxins12120737","article-title":"Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by Modulating Action Potential Threshold in A-Fiber Dorsal Root Ganglia Neurons","volume":"12","author":"Lee","year":"2020","journal-title":"Toxins (Basel)"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1132","article-title":"Electroacupuncture Alleviates Chemotherapy-Induced Pain Through Inhibiting Phosphorylation of Spinal CaMKII in Rats","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur J Pain"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5917","DOI":"10.3390\/ijms20235917","article-title":"Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Rats Via Suppressing Tlr4 Signaling and TRPV1 Upregulation in Sensory Neurons","volume":"20","author":"Li","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934084","article-title":"Electroacupuncture Enhances Antioxidative Signal Pathway and Attenuates Neuropathic Pain Induced by Chemotherapeutic Paclitaxel","volume":"68","author":"Zhao","year":"2019","journal-title":"Physiol Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"351z","DOI":"10.3390\/toxins9110351","article-title":"Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats: Mediation by Spinal \u03b12-Adrenergic Receptor","volume":"9","author":"Choi","year":"2017","journal-title":"Toxins (Basel)"},{"key":"B35","article-title":"Chemotherapy-Induced Nausea and Vomiting: Strategies for Prevention and Treatment","volume":"15","author":"Schwartzberg","year":"2017","journal-title":"Clin Adv Hematol Oncol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"860631","DOI":"10.1155\/2014\/860631","article-title":"Effects and Mechanisms of Transcutaneous Electroacupuncture on Chemotherapy-Induced Nausea and Vomiting","volume":"2014","author":"Zhang","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40880-016-0176-1","article-title":"Effect of Transcutaneous Electrical Acupoint Stimulation Combined With Palonosetron on Chemotherapy-Induced Nausea and Vomiting: A Single-Blind, Randomized, Controlled Trial","volume":"36","author":"Xie","year":"2017","journal-title":"Chin J Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ejphar.2013.09.073","article-title":"International Antiemetic Guidelines on Chemotherapy Induced Nausea and Vomiting (CINV): Content and Implementation in Daily Routine Practice","volume":"722","author":"Jordan","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13020-020-00333-x","article-title":"Efficacy of Acupuncture in the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting in Patients With Advanced Cancer: A Multi-Center, Single-Blind, Randomized, Sham-Controlled Clinical Research","volume":"15","author":"Li","year":"2020","journal-title":"Chin Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1177\/1043454218810140","article-title":"Laser Acupuncture for Relieving Nausea and Vomiting in Pediatric Patients Undergoing Chemotherapy: A Single-Blind Randomized Clinical Trial","volume":"36","author":"Varej\u00e3o","year":"2019","journal-title":"J Pediatr Oncol Nurs"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.10.025","article-title":"Efficacy of Acupuncture in Prevention of Delayed Chemotherapy Induced Nausea and Vomiting in Gynecologic Cancer Patients","volume":"136","author":"Rithirangsriroj","year":"2015","journal-title":"Gynecol Oncol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s11655-014-2009-x","article-title":"Wrist-Ankle Acupuncture and Ginger Moxibustion for Preventing Gastrointestinal Reactions to Chemotherapy: A Randomized Controlled Trial","volume":"21","author":"Liu","year":"2015","journal-title":"Chin J Integr Med"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13158","article-title":"Transcutaneous Electrical Acustimulation Improves Gastrointestinal Disturbances Induced by Transcatheter Arterial Chemoembolization in Patients With Liver Cancers","volume":"23","author":"Zhu","year":"2020","journal-title":"Neuromodulation"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.3747\/co.24.3296","article-title":"The Effect of Acupuncture on Chemotherapy-Associated Gastrointestinal Symptoms in Gastric Cancer","volume":"24","author":"Zhou","year":"2017","journal-title":"Curr Oncol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951514000248","article-title":"The Effect of Acupressure Application on Chemotherapy-Induced Nausea, Vomiting, and Anxiety in Patients With Breast Cancer","volume":"13","author":"Gen\u00e7","year":"2015","journal-title":"Palliat Support Care"},{"key":"B46","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3390\/biom9100624","article-title":"Electro-Acupuncture Alleviates Cisplatin-Induced Anorexia in Rats by Modulating Ghrelin and Monoamine Neurotransmitters","volume":"9","author":"Baek","year":"2019","journal-title":"Biomolecules"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7250","article-title":"Electroacupuncture for Chemotherapy-Induced Anorexia Through Humoral Appetite Regulation: A Preliminary Experimental Study","volume":"17","author":"Kang","year":"2019","journal-title":"Exp Ther Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2015-010833","article-title":"Electroacupuncture Alleviates Cisplatin-Induced Nausea in Rats","volume":"34","author":"Cui","year":"2016","journal-title":"Acupunct Med"},{"key":"B49","first-page":"990","article-title":"Propelling Immunotherapy Combinations Into the Clinic","volume":"29","author":"Tchekmedyian","year":"2015","journal-title":"Oncol (Williston Park)"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.03.12","article-title":"Transcutaneous Electrical Acupoint Stimulation (TEAS) Ameliorates Chemotherapy-Induced Bone Marrow Suppression in Lung Cancer Patients","volume":"9","author":"Hou","year":"2017","journal-title":"J Thorac Dis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"217397","DOI":"10.1155\/2014\/217397","article-title":"Effects of Acupuncture on Leucopenia, Neutropenia, NK, and B Cells in Cancer Patients: A Randomized Pilot Study","volume":"2014","author":"Pais","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"B52","article-title":"Study on Dynamic Effect of Acupuncture on Marrow Cell Cycle Regulatory Protein Cyclin D1 Expression and Cell Cycle in Mice With Cyclophosphamide Induced Myelosuppression","volume":"31","author":"Lu","year":"2011","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"B53","article-title":"Effects of Acupuncture and Moxibustion on DNA Excision Repair-Related Proteins of Bone Marrow Cell in Cyclophosphamide-Induced Mice","volume":"29","author":"Lu","year":"2009","journal-title":"Zhongguo Zhen Jiu"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/ni1509","article-title":"Catecholaminergic Neurotransmitters Regulate Migration and Repopulation of Immature Human CD34+ Cells Through Wnt Signaling","volume":"8","author":"Spiegel","year":"2007","journal-title":"Nat Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.07.001","article-title":"Modulation of Hematopoietic Progenitor Cell Fate In Vitro by Varying Collagen Oligomer Matrix Stiffness in the Presence or Absence of Osteoblasts","volume":"425","author":"Chitteti","year":"2015","journal-title":"J Immunol Methods"},{"key":"B56","doi-asserted-by":"publisher","first-page":"22373","DOI":"10.1038\/srep22373","article-title":"Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Contributes to the Proliferation of Hematopoietic Progenitor Cells in Murine Bone Marrow Via PACAP-specific Receptor","volume":"6","author":"Xu","year":"2016","journal-title":"Sci Rep"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.714244","article-title":"Pac1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-012-9397-1","article-title":"Bone Marrow Microenvironment in Cancer Patients: Immunological Aspects and Clinical Implications","volume":"32","author":"Stefanovic","year":"2013","journal-title":"Cancer Metastasis Rev"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2011.47","article-title":"Bone Marrow and the Control of Immunity","volume":"9","author":"Zhao","year":"2012","journal-title":"Cell Mol Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S249797","article-title":"Moxibustion Enhances Chemotherapy of Breast Cancer by Affecting Tumor Microenvironment","volume":"12","author":"Xue","year":"2020","journal-title":"Cancer Manag Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"3170803","DOI":"10.1155\/2020\/3170803","article-title":"The Combinatorial Effect of Cisplatin and Moxibustion on Tumor Growth Inhibition With Special Reference to Modulation of the Immune Microenvironment in Lewis Lung Cancer Mice","volume":"2020","author":"Wang","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00576","article-title":"Electro-Acupuncture Promotes Accumulation of Paclitaxel by Altering Tumor Microvasculature and Microenvironment in Breast Cancer of Mice","volume":"9","author":"Yang","year":"2019","journal-title":"Front Oncol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13020-020-00315-z","article-title":"The Effect of Acupuncture on Tumor Growth and Gut Microbiota in Mice Inoculated With Osteosarcoma Cells","volume":"15","author":"Xu","year":"2020","journal-title":"Chin Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"387169","DOI":"10.1155\/2013\/387169","article-title":"The Effect of Electroacupuncture on Osteosarcoma Tumor Growth and Metastasis: Analysis of Different Treatment Regimens","volume":"2013","author":"Smeester","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"B65","doi-asserted-by":"publisher","first-page":"12900","DOI":"10.1038\/s41598-017-11213-0","article-title":"Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles","volume":"7","author":"Lee","year":"2017","journal-title":"Sci Rep"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-03013-3","article-title":"Chemotherapy: A Double-Edged Sword in Cancer Treatment","volume":"71","author":"Behranvand","year":"2022","journal-title":"Cancer Immunol Immunother"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/35077241","article-title":"The Microenvironment of the Tumour-Host Interface","volume":"411","author":"Liotta","year":"2001","journal-title":"Nature"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00066","article-title":"Pathophysiological Basis for the Formation of the Tumor Microenvironment","volume":"6","author":"Horsman","year":"2016","journal-title":"Front Oncol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxy042","article-title":"Immune Suppression and Reversal of the Suppressive Tumor Microenvironment","volume":"30","author":"Shimizu","year":"2018","journal-title":"Int Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.271","article-title":"The Tumor Microenvironment and its Role in Promoting Tumor Growth","volume":"27","author":"Whiteside","year":"2008","journal-title":"Oncogene"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.38521","article-title":"Inhibition of Triple-Negative Breast Cancer Tumor Growth by Electroacupuncture With Encircled Needling and Its Mechanisms in a Mice Xenograft Model","volume":"16","author":"Jiang","year":"2019","journal-title":"Int J Med Sci"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S324193","article-title":"Acupuncture Relieves Opioid-Induced Constipation in Clinical Cancer Therapy - A Meta-Analysis and Systematic Review","volume":"13","author":"Han","year":"2021","journal-title":"Clin Epidemiol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"14843","DOI":"10.1038\/s41598-021-94466-0","article-title":"Yoga Versus Massage in the Treatment of Aromatase Inhibitor-Associated Knee Joint Pain in Breast Cancer Survivors: A Randomized Controlled Trial","volume":"11","author":"Tsai","year":"2021","journal-title":"Sci Rep"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.7150\/jca.55803","article-title":"The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects","volume":"12","author":"Han","year":"2021","journal-title":"J Cancer"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S292657","article-title":"Knowledge Mapping of Acupuncture for Cancer Pain: A Scientometric Analysis (2000-2019)","volume":"14","author":"Huang","year":"2021","journal-title":"J Pain Res"},{"key":"B76","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13020-021-00558-4","article-title":"Acupuncture for Cancer Pain: An Evidence-Based Clinical Practice Guideline","volume":"17","author":"Ge","year":"2022","journal-title":"Chin Med"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5572869","article-title":"Therapeutic Effect of Catgut Implantation at Acupoint in a Mouse Model of Hepatocellular Carcinoma by Suppressing Immune Escape","volume":"2022","author":"Xu","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1534735419886662","DOI":"10.1177\/1534735419886662","article-title":"The Efficacy of Acupuncture in Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Meta-Analysis","volume":"18","author":"Chien","year":"2019","journal-title":"Integr Cancer Ther"},{"key":"B79","doi-asserted-by":"publisher","first-page":"9854893","DOI":"10.1155\/2017\/9854893","article-title":"Moxibustion for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-Analysis","volume":"2017","author":"Huang","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"B80","doi-asserted-by":"publisher","first-page":"5691468","DOI":"10.1155\/2020\/5691468","article-title":"Efficacy and Safety of Acupuncture-Moxibustion Therapy on Chemotherapy-Induced Leukopenia: A Systematic Review and Meta-Analysis","volume":"2020","author":"Jin","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms","volume":"73","author":"Von Hehn","year":"2012","journal-title":"Neuron"},{"key":"B82","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13020-021-00466-7","article-title":"The Role of Macrophage Polarization and Associated Mechanisms in Regulating the Anti-Inflammatory Action of Acupuncture: A Literature Review and Perspectives","volume":"16","author":"Wang","year":"2021","journal-title":"Chin Med"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3155","article-title":"P2X4R+ Microglia Drive Neuropathic Pain","volume":"15","author":"Beggs","year":"2012","journal-title":"Nat Neurosci"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70134-5","article-title":"The Role of the Immune System in the Generation of Neuropathic Pain","volume":"11","author":"Calvo","year":"2012","journal-title":"Lancet Neurol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S341581","article-title":"The Anti-Inflammatory Actions and Mechanisms of Acupuncture From Acupoint to Target Organs Via Neuro-Immune Regulation","volume":"14","author":"Li","year":"2021","journal-title":"J Inflammation Res"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1397662","article-title":"Drugging DNA Repair to Target T-ALL Cells","volume":"59","author":"Dasgupta","year":"2018","journal-title":"Leuk Lymphoma"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25718","article-title":"Doxorubicin-Induced Elevated Oxidative Stress and Neurochemical Alterations in Brain and Cognitive Decline: Protection by MESNA and Insights Into Mechanisms of Chemotherapy-Induced Cognitive Impairment (\"Chemobrain\")","volume":"9","author":"Keeney","year":"2018","journal-title":"Oncotarget"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2015.1022","article-title":"The Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (Cici)-\"Chemobrain\"","volume":"7","author":"Gaman","year":"2016","journal-title":"Aging Dis"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.06.015","article-title":"Adriamycin-Related Anxiety-Like Behavior, Brain Oxidative Stress and Myelotoxicity in Male Wistar Rats","volume":"99","author":"Merzoug","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-1008-y","article-title":"Quercetin Mitigates Adriamycin-induced Anxiety- and Depression-Like Behaviors, Immune Dysfunction, and Brain Oxidative Stress in Rats","volume":"387","author":"Merzoug","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"9125601","DOI":"10.1155\/2018\/9125601","article-title":"Neuroprotective Effects of Dl-3-n-Butylphthalide Against Doxorubicin-Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes","volume":"2018","author":"Liao","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"B92","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10571-016-0344-5","article-title":"Sodium Phenylbutyrate and Edaravone Abrogate Chronic Restraint Stress-Induced Behavioral Deficits: Implication of Oxido-Nitrosative, Endoplasmic Reticulum Stress Cascade, and Neuroinflammation","volume":"37","author":"Jangra","year":"2017","journal-title":"Cell Mol Neurobiol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv206","article-title":"Association of Proinflammatory Cytokines and Chemotherapy-Associated Cognitive Impairment in Breast Cancer Patients: A Multi-Centered, Prospective, Cohort Study","volume":"26","author":"Cheung","year":"2015","journal-title":"Ann Oncol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.3390\/cancers13164177","article-title":"Memantine Protects Against Paclitaxel-Induced Cognitive Impairment Through Modulation of Neurogenesis and Inflammation in Mice","volume":"13","author":"Sung","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3390\/pharmaceutics13071021","article-title":"Nanoencapsulated Doxorubicin Prevents Mucositis Development in Mice","volume":"13","author":"Pinto","year":"2021","journal-title":"Pharmaceutics"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.3390\/cells10061386","article-title":"Inflammation, Aging and Hematopoiesis: A Complex Relationship","volume":"10","author":"Bousounis","year":"2021","journal-title":"Cells"},{"key":"B97","doi-asserted-by":"publisher","first-page":"102793","DOI":"10.1016\/j.autneu.2021.102793","article-title":"Acupuncture Modulates Immunity in Sepsis: Toward a Science-Based Protocol","volume":"232","author":"Pan","year":"2021","journal-title":"Auton Neurosci"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.647647","article-title":"Electroacupuncture Ameliorates Acute Pancreatitis: A Role for the Vagus Nerve-Mediated Cholinergic Anti-Inflammatory Pathway","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Mol Biosci"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3479","article-title":"Dopamine Mediates Vagal Modulation of the Immune System by Electroacupuncture","volume":"20","author":"Torres-Rosas","year":"2014","journal-title":"Nat Med"},{"key":"B100","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.neuron.2020.07.015","article-title":"Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture","volume":"108","author":"Liu","year":"2020","journal-title":"Neuron"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04001-4","article-title":"A Neuroanatomical Basis for Electroacupuncture to Drive the Vagal-Adrenal Axis","volume":"598","author":"Liu","year":"2021","journal-title":"Nature"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.61525","article-title":"Ferumoxytol-\u03b2-Glucan Inhibits Melanoma Growth Via Interacting With Dectin-1 to Polarize Macrophages Into M1 Phenotype","volume":"18","author":"Liu","year":"2021","journal-title":"Int J Med Sci"},{"key":"B103","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1038\/s41467-021-23164-2","article-title":"Targeting Monoamine Oxidase A-regulated Tumor-Associated Macrophage Polarization for Cancer Immunotherapy","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"B104","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/ncb3371","article-title":"Suppression of microRNA Activity Amplifies IFN-\u03b3-Induced Macrophage Activation and Promotes Anti-Tumour Immunity","volume":"18","author":"Baer","year":"2016","journal-title":"Nat Cell Biol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nature22311","article-title":"Tumour Ischaemia by Interferon-\u03b3 Resembles Physiological Blood Vessel Regression","volume":"545","author":"Kammertoens","year":"2017","journal-title":"Nature"},{"key":"B106","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nri.2017.145","article-title":"Improving Immune-Vascular Crosstalk for Cancer Immunotherapy","volume":"18","author":"Huang","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nature21724","article-title":"Mutual Regulation of Tumour Vessel Normalization and Immunostimulatory Reprogramming","volume":"544","author":"Tian","year":"2017","journal-title":"Nature"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.864046\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T10:33:12Z","timestamp":1650882792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.864046\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,25]]},"references-count":107,"alternative-id":["10.3389\/fonc.2022.864046"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2022.864046","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,25]]},"article-number":"864046"}}