{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:27:22Z","timestamp":1782599242520,"version":"3.54.5"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009609","name":"Hospital Infantil de M\u00e9xico Federico G\u00f3mez","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>In Mexico, the main institution of social security is the \u201cInstituto Mexicano del Seguro Social\u201d (IMSS), with more than 60 million enrolled individuals. This study of childhood cancer survival is the first based on complete cohorts of incident cases for the population IMSS- affiliated in the central-south region, which represents 27% of all children IMSS affiliated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It is an observational cohort study from 2006 to 2012 to estimate the 5-year observed survival of the minors under 18 years old, identified in the Central-South Region Registry of Children with Cancer. The survival of cases was carried out through the active and passive search. Survival rates were estimated by the Kaplan\u2013Meier  (KM) method, the analysis of equality of survival functions was evaluated for some clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 2,357 minors; the 5-year observed survival was 56.1% with a time of survival median of 3.4 years, and the overall loss of follow-up was 18.4%. The 5-year survival in cases with a diagnosis of leukemia was 53.5%, while for solid tumors, it was 57.9%. The median time of death was 1 year. The types of cancer with a survival greater than 70% were group V-retinoblastoma (87.2%), IIa-Hodgkin\u2019s lymphoma (86.8%), Xc- gonadal tumors (83.3%), Iid-miscellaneous lymphomas (80%), IVa-nephroblastoma (79.5%), and IIc-Burkitt\u2019s lymphoma (75.4%). Meanwhile, the lowest survival rates were in group VIII-bone tumors (32.3%), III-CNS (central nervous system; 44.1%), and IX-soft tissues (46.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival results in the 2006\u20132012 cohorts show a significant gap in relation to the goal of 60% proposed by the World Health Organization for 2030.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.882501","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T06:21:37Z","timestamp":1656656497000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Childhood Cancer Survival, 2006-2012 Cohorts of Mexican Institute of Social Security Beneficiaries at the Central-South Region of Mexico"],"prefix":"10.3389","volume":"12","author":[{"given":"Ang\u00e9lica","family":"Castro-R\u00edos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mart\u00ednez-Valverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9","article-title":"International Incidence of Childhood Cancer, 2001\u201310: A Population-Based Registry Study","volume":"18","author":"Steliarova-Foucher","year":"2017","journal-title":"Lancet Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/jnci\/djaa069","article-title":"Scaling Up the Surveillance of Childhood Cancer: A Global Roadmap","volume":"113","author":"Pi\u00f1eros","year":"2021","journal-title":"J Natl Cancer Inst"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4892","article-title":"Science and Health for All Children With Cancer","volume":"363","author":"Lam","year":"2019","journal-title":"Science"},{"key":"B4","unstructured":"Global Initiative for Childhood Cancer: An Overview2020"},{"key":"B5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S1470-2045(13)70548-5","article-title":"Childhood Cancer Survival in Europe 1999-2007: Results of EUROCARE-5\u2013a Population-Based Study","volume":"15","author":"Gatta","year":"2014","journal-title":"Lancet Oncol"},{"key":"B6","unstructured":"10.17226\/25944Washington, DCThe National Academies PressChildhood Cancer and Functional Impacts Across the Care Continuum2021"},{"key":"B7","unstructured":"SEER Cancer Statistics. 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