{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:20:14Z","timestamp":1792790414895,"version":"4.5.0"},"reference-count":227,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Skin cancers are among the most common cancers worldwide and are increasingly prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of melanocytes in the epidermis. Although CM shows lower incidence than other skin cancers, it is the most aggressive and responsible for the vast majority of skin cancer-related deaths. Indeed, 75% of patients present with invasive or metastatic tumors, even after surgical excision. In CM, the photoprotective pigment melanin, which is produced by melanocytes, plays a central role in the pathology of the disease. Melanin absorbs ultraviolet radiation and scavenges reactive oxygen\/nitrogen species (ROS\/RNS) resulting from the radiation exposure. However, the scavenged ROS\/RNS modify melanin and lead to the induction of signature DNA damage in CM cells, namely cyclobutane pyrimidine dimers, which are known to promote CM immortalization and carcinogenesis. Despite triggering the malignant transformation of melanocytes and promoting initial tumor growth, the presence of melanin inside CM cells is described to negatively regulate their invasiveness by increasing cell stiffness and reducing elasticity. Emerging evidence also indicates that melanin secreted from CM cells is required for the immunomodulation of tumor microenvironment. Indeed, melanin transforms dermal fibroblasts in cancer-associated fibroblasts, suppresses the immune system and promotes tumor angiogenesis, thus sustaining CM progression and metastasis. Here, we review the current knowledge on the role of melanin secretion in CM aggressiveness and the molecular machinery involved, as well as the impact in tumor microenvironment and immune responses. A better understanding of this role and the molecular players involved could enable the modulation of melanin secretion to become a therapeutic strategy to impair CM invasion and metastasis and, hence, reduce the burden of CM-associated deaths.<\/jats:p>","DOI":"10.3389\/fonc.2022.887366","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T13:51:49Z","timestamp":1652190709000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["The Dark Side of Melanin Secretion in Cutaneous Melanoma Aggressiveness"],"prefix":"10.3389","volume":"12","author":[{"given":"Lu\u00eds C.","family":"Caba\u00e7o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Tom\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duarte C.","family":"Barral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4046","article-title":"Global, Regional and National Incidence, Mortality and Disability-Adjusted Life-Years of Skin Cancers and Trend Analysis From 1990 to 2019: An Analysis of the Global Burden of Disease Study 2019","volume":"10","author":"Zhang","year":"2021","journal-title":"Cancer Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2018.4287","article-title":"Cutaneous Melanoma: From Pathogenesis to Therapy (Review)","volume":"52","author":"Leonardi","year":"2018","journal-title":"Int J Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nature05660","article-title":"Melanocyte Biology and Skin Pigmentation","volume":"445","author":"Lin","year":"2007","journal-title":"Nature"},{"key":"B4","unstructured":"ChristensenL SuggsA BaronE Ultraviolet Photobiology in Dermatology2017"},{"key":"B5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer Statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/583748","article-title":"From Melanocyte to Metastatic Malignant Melanoma","volume":"2010","author":"Bandarchi","year":"2010","journal-title":"Dermatol Res Pract"},{"key":"B7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s13045-021-01213-z","article-title":"Global, Regional, and National Cancer Incidence and Death for 29 Cancer Groups in 2019 and Trends Analysis of the Global Cancer Burden, 1990\u20132019","volume":"14","author":"Lin","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neo.2021.11.013","article-title":"Spatiotemporal Trends of the Global Burden of Melanoma in 204 Countries and Territories From 1990 to 2019: Results From the 2019 Global Burden of Disease Study","volume":"24","author":"Li","year":"2022","journal-title":"Neoplasia"},{"key":"B9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.14740\/wjon1349","article-title":"Cutaneous Malignant Melanoma: A Review of Early Diagnosis and Management","volume":"12","author":"Naik","year":"2021","journal-title":"World J Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2677","article-title":"The Landscape of Metastatic Progression Patterns Across Major Human Cancers","volume":"6","author":"Budczies","year":"2015","journal-title":"Oncotarget"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21409","article-title":"Melanoma Staging: Evidence-Based Changes in the American Joint Committee on Cancer Eighth Edition Cancer Staging Manual","volume":"67","author":"Gershenwald","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.737399\/full","article-title":"Prognosis for Cutaneous Melanoma by Clinical and Pathological Profile: A Population-Based Study","volume":"11","author":"Buja","year":"2021","journal-title":"Front Oncol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic Classification of Cutaneous Melanoma","volume":"161","year":"2015","journal-title":"Cell"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31345","article-title":"Melanoma: What do All the Mutations Mean","volume":"124","author":"Davis","year":"2018","journal-title":"Cancer"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23989","article-title":"Genetic Alterations in Main Candidate Genes During Melanoma Progression","volume":"9","author":"Sini","year":"2018","journal-title":"Oncotarget"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.43","article-title":"Targeted Agents and Immunotherapies: Optimizing Outcomes in Melanoma","volume":"14","author":"Luke","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112302","article-title":"Survival in BRAF V600\u2013Mutant Advanced Melanoma Treated With Vemurafenib","volume":"366","author":"Sosman","year":"2012","journal-title":"N Engl J Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2147\/ITT.S134842","article-title":"Melanoma Treatment in Review","volume":"7","author":"Domingues","year":"2018","journal-title":"ImmunoTargets Ther"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz411","article-title":"Cutaneous Melanoma: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up","volume":"30","author":"Michielin","year":"2019","journal-title":"Ann Oncol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0292-y","article-title":"MEK Inhibitors in the Treatment of Metastatic Melanoma and Solid Tumors","volume":"18","author":"Grimaldi","year":"2017","journal-title":"Am J Clin Dermatol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1177\/1758834015616934","article-title":"Combination Therapy With BRAF and MEK Inhibitors for Melanoma: Latest Evidence and Place in Therapy","volume":"8","author":"Eroglu","year":"2016","journal-title":"Ther Adv Med Oncol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22190","article-title":"Immune System and Melanoma Biology: A Balance Between Immunosurveillance and Immune Escape","volume":"8","author":"Passarelli","year":"2017","journal-title":"Oncotarget"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910836","article-title":"Five-Year Survival With Combined Nivolumab and Ipilimumab in Advanced Melanoma","volume":"381","author":"Larkin","year":"2019","journal-title":"N Engl J Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042020-042741","article-title":"Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance","volume":"16","author":"Bagchi","year":"2021","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00990\/full","article-title":"Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma","volume":"10","author":"Yu","year":"2019","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2267","article-title":"Primary and Acquired Resistance to Immune Checkpoint Inhibitors in Metastatic Melanoma","volume":"24","author":"Gide","year":"2018","journal-title":"Clin Cancer Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.15656","article-title":"Association of Sociodemographic Factors With Immunotherapy Receipt for Metastatic Melanoma in the US","volume":"3","author":"Moyers","year":"2020","journal-title":"JAMA Netw Open"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2491","article-title":"In Vivo Switching of Human Melanoma Cells Between Proliferative and Invasive States","volume":"68","author":"Hoek","year":"2008","journal-title":"Cancer Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2217\/fon.12.177","article-title":"MITF, the Janus Transcription Factor of Melanoma","volume":"9","author":"Koludrovic","year":"2013","journal-title":"Futur Oncol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/635203","article-title":"Melanoma: From Melanocyte to Genetic Alterations and Clinical Options","volume":"2013","author":"Bertolotto","year":"2013","journal-title":"Sci (Cairo)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.3390\/ijms19092668","article-title":"Clinical and Biological Characterization of Skin Pigmentation Diversity and Its Consequences on UV Impact","volume":"19","author":"Del Bino","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256022","article-title":"Chemiexcitation of Melanin Derivatives Induces DNA Photoproducts Long After UV Exposure","volume":"347","author":"Premi","year":"2015","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.1038\/s41598-019-45643-9","article-title":"Melanin Presence Inhibits Melanoma Cell Spread in Mice in a Unique Mechanical Fashion","volume":"9","author":"Sarna","year":"2019","journal-title":"Sci Rep"},{"key":"B35","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/ijms19020607","article-title":"Nanomechanical Phenotype of Melanoma Cells Depends Solely on the Amount of Endogenous Pigment in the Cells","volume":"19","author":"Sarna","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B36","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1083\/jcb.152.4.795","article-title":"Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes","volume":"152","author":"Hume","year":"2001","journal-title":"J Cell Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12840","article-title":"The Exocyst Is Required for Melanin Exocytosis From Melanocytes and Transfer to Keratinocytes","volume":"33","author":"Moreiras","year":"2020","journal-title":"Pigment Cell Melanoma Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.jid.2019.12.023","article-title":"RAB27A\/Melanophilin Blocker Inhibits Melanoma Cell Motility and Invasion","volume":"140","author":"Guo","year":"2020","journal-title":"J Invest Dermatol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"11958","DOI":"10.1038\/s41598-020-67465-w","article-title":"Coronin 1C Inhibits Melanoma Metastasis Through Regulation of MT1-MMP-Containing Extracellular Vesicle Secretion","volume":"10","author":"Tagliatela","year":"2020","journal-title":"Sci Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.04.073","article-title":"Oncogenic BRAF-Mediated Melanoma Cell Invasion","volume":"15","author":"Lu","year":"2016","journal-title":"Cell Rep"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00226.x","article-title":"The Protective Role of Melanin Against UV Damage in Human Skin","volume":"84","author":"Brenner","year":"2008","journal-title":"Photochem Photobiol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914628107","article-title":"Human Skin Pigmentation as an Adaptation to UV Radiation","volume":"107","author":"Jablonski","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00088.x","article-title":"Cutaneous Photobiology. The Melanocyte vs. The Sun: Who Will Win the Final Round","volume":"16","author":"Kadekaro","year":"2003","journal-title":"Pigment Cell Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1038\/ncomms1893","article-title":"Melanoma Induction by Ultraviolet A But Not Ultraviolet B Radiation Requires Melanin Pigment","volume":"3","author":"Noonan","year":"2012","journal-title":"Nat Commun"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-157","article-title":"Histological Review of Skin Cancers in African Albinos: A 10-Year Retrospective Review","volume":"14","author":"Kiprono","year":"2014","journal-title":"BMC Cancer"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15312","article-title":"Primary Cutaneous Malignancies in Nonalbino and Albino Africans","volume":"60","author":"Okafor","year":"2021","journal-title":"Int J Dermatol"},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.15586\/codon.cutaneousmelanoma.2017.ch2","article-title":"The Epidemiology of Cutaneous Melanoma in the White and Black African Population Groups in South Africa","volume-title":"Cutaneous Melanoma: Etiology and Therapy","author":"Norval","year":"2017"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12201","article-title":"Assessment of Ultraviolet-Radiation-Induced DNA Damage Within Melanocytes in Skin of Different Constitutive Pigmentation","volume":"168","author":"Del Bino","year":"2013","journal-title":"Br J Dermatol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12956","article-title":"Dark Cyclobutane Pyrimidine Dimers Are Formed in the Epidermis of Fitzpatrick Skin Types I\/II and VI In Vivo After Exposure to Solar-Simulated Radiation","volume":"34","author":"Fajuyigbe","year":"2021","journal-title":"Pigment Cell Melanoma Res"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0865fje","article-title":"UV-Induced DNA Damage and Melanin Content in Human Skin Differing in Racial\/Ethnic Origin","volume":"17","author":"Tadokoro","year":"2003","journal-title":"FASEB J"},{"key":"B51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1755-148X.2010.00755.x","article-title":"Human Hair Melanins: What We Have Learned and Have Not Learned From Mouse Coat Color Pigmentation","volume":"24","author":"Ito","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2003","article-title":"Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation","volume":"84","author":"Slominski","year":"2004","journal-title":"Physiol Rev"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12970","article-title":"Chemical and Biochemical Control of Skin Pigmentation With Special Emphasis on Mixed Melanogenesis","volume":"34","author":"Wakamatsu","year":"2021","journal-title":"Pigment Cell Melanoma Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00238.x","article-title":"Chemistry of Mixed Melanogenesis\u2014Pivotal Roles of Dopaquinone","volume":"84","author":"Ito","year":"2008","journal-title":"Photochem Photobiol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04278.x","article-title":"Diversity of Human Hair Pigmentation as Studied by Chemical Analysis of Eumelanin and Pheomelanin","volume":"25","author":"Ito","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41586-020-2937-x","article-title":"MFSD12 Mediates the Import of Cysteine Into Melanosomes and Lysosomes","volume":"588","author":"Adelmann","year":"2020","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1562\/2004-07-23-RC-245","article-title":"Oxidation Potentials of Human Eumelanosomes and Pheomelanosomes","volume":"81","author":"Samokhvalov","year":"2004","journal-title":"Photochem Photobiol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1562\/2004-08-03-RA-259.1","article-title":"Comparison of Structural and Chemical Properties of Black and Red Human Hair Melanosomes","volume":"81","author":"Liu","year":"2005","journal-title":"Photochem Photobiol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12262","article-title":"Pheomelanin-Induced Oxidative Stress: Bright and Dark Chemistry Bridging Red Hair Phenotype and Melanoma","volume":"27","author":"Napolitano","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.13.s8.25.x","article-title":"UVA, Pheomelanin and the Carcinogenesis of Melanoma","volume":"13","author":"Hill","year":"2000","journal-title":"Pigment Cell Res"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12393","article-title":"Melanins and Melanogenesis: From Pigment Cells to Human Health and Technological Applications","volume":"28","author":"D\u2019Ischia","year":"2015","journal-title":"Pigment Cell Melanoma Res"},{"key":"B62","doi-asserted-by":"publisher","first-page":"183318","DOI":"10.1016\/j.bbamem.2020.183318","article-title":"Membrane Transport Proteins in Melanosomes: Regulation of Ions for Pigmentation","volume":"1862","author":"Wiriyasermkul","year":"2020","journal-title":"Biochim Biophys Acta - Biomembr"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.3390\/cancers13061463","article-title":"Applications of Melanin and Melanin-Like Nanoparticles in Cancer Therapy: A Review of Recent Advances","volume":"13","author":"Cuzzubbo","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.10950","article-title":"Roles of Inflammation Factors in Melanogenesis (Review)","volume":"21","author":"Fu","year":"2020","journal-title":"Mol Med Rep"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-017-1953-7","article-title":"The Role of Macrophages in Skin Homeostasis","volume":"469","author":"Yanez","year":"2017","journal-title":"Pflugers Arch"},{"key":"B66","doi-asserted-by":"publisher","first-page":"4589","DOI":"10.3390\/ijms22094589","article-title":"Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation","volume":"22","author":"Voss","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B67","doi-asserted-by":"publisher","first-page":"3970","DOI":"10.3390\/ijms22083970","article-title":"Diversified Stimuli-Induced Inflammatory Pathways Cause Skin Pigmentation","volume":"22","author":"Hossain","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.08.024","article-title":"Cross-Talk Between Interferon-Gamma and Interleukin-18 in Melanogenesis","volume":"163","author":"Zhou","year":"2016","journal-title":"J Photochem Photobiol B"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.09.005","article-title":"Enhancement of the P38 MAPK and PKA Signaling Pathways Is Associated With the Pro-Melanogenic Activity of Interleukin 33 in Primary Melanocytes","volume":"73","author":"Zhou","year":"2014","journal-title":"J Dermatol Sci"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304988111","article-title":"IFN-\u03b3 Signaling Maintains Skin Pigmentation Homeostasis Through Regulation of Melanosome Maturation","volume":"111","author":"Natarajan","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.237","article-title":"IL-17 and TNF Synergistically Modulate Cytokine Expression While Suppressing Melanogenesis: Potential Relevance to Psoriasis","volume":"133","author":"Wang","year":"2013","journal-title":"J Invest Dermatol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.331","article-title":"IL-4 Inhibits the Melanogenesis of Normal Human Melanocytes Through the JAK2-STAT6 Signaling Pathway","volume":"133","author":"Choi","year":"2013","journal-title":"J Invest Dermatol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3399","article-title":"Melanoma miRNA Trafficking Controls Tumour Primary Niche Formation","volume":"18","author":"Dror","year":"2016","journal-title":"Nat Cell Biol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1006\/cimm.1999.1599","article-title":"Synthetic Melanin Suppresses Production of Proinflammatory Cytokines","volume":"199","author":"Mohagheghpour","year":"2000","journal-title":"Cell Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1999.tb00365.x","article-title":"What\u2019s the Use of Generating Melanin","volume":"8","author":"Wood","year":"1999","journal-title":"Exp Dermatol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.59.2.248","article-title":"\u03b1-MSH Production, Receptors, and Influence on Neopterin in a Human Monocyte\/Macrophage Cell Line","volume":"59","author":"Rajora","year":"1996","journal-title":"J Leukoc Biol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040868","article-title":"Modulation of Human T-Cell Functions by Reactive Nitrogen Species","volume":"41","author":"Kasic","year":"2011","journal-title":"Eur J Immunol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101956","article-title":"Chemokine Nitration Prevents Intratumoral Infiltration of Antigen-Specific T Cells","volume":"208","author":"Molon","year":"2011","journal-title":"J Exp Med"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2014.02.005","article-title":"Introduction to the Role of the Immune System in Melanoma","volume":"28","author":"Margolin","year":"2014","journal-title":"Hematol Oncol Clin North Am"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01148\/full","article-title":"Immune System Evasion as Hallmark of Melanoma Progression: The Role of Dendritic Cells","volume":"9","author":"Tucci","year":"2019","journal-title":"Front Oncol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/intimm\/13.5.695","article-title":"Skin Antigens in the Steady State Are Trafficked to Regional Lymph Nodes by Transforming Growth Factor-\u03b21-Dependent Cells","volume":"13","author":"Hemmi","year":"2001","journal-title":"Int Immunol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl087","article-title":"Constant Rate of Steady-State Self-Antigen Trafficking From Skin to Regional Lymph Nodes","volume":"18","author":"Yoshino","year":"2006","journal-title":"Int Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1586\/edm.10.70","article-title":"Update on the Regulation of Mammalian Melanocyte Function and Skin Pigmentation","volume":"6","author":"Kondo","year":"2011","journal-title":"Expert Rev Dermatol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/biof.29","article-title":"Physiological Factors That Regulate Skin Pigmentation","volume":"35","author":"Yamaguchi","year":"2009","journal-title":"BioFactors"},{"key":"B85","doi-asserted-by":"publisher","first-page":"R9","DOI":"10.1093\/hmg\/ddp003","article-title":"Molecular Genetics of Human Pigmentation Diversity","volume":"18","author":"Sturm","year":"2009","journal-title":"Hum Mol Genet"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.11.040","article-title":"Melanocortin MC1 Receptor in Human Genetics and Model Systems","volume":"660","author":"Beaumont","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq363","article-title":"Association of MC1R Variants and Host Phenotypes With Melanoma Risk in CDKN2A Mutation Carriers: A GenoMEL Study","volume":"102","author":"Demenais","year":"2010","journal-title":"JNCI J Natl Cancer Inst"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.3.121806.151541","article-title":"Molecular Pathogenesis of Cutaneous Melanocytic Neoplasms","volume":"4","author":"Ibrahim","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0217","article-title":"Signaling From the Human Melanocortin 1 Receptor to ERK1 and ERK2 Mitogen-Activated Protein Kinases Involves Transactivation of cKIT","volume":"25","author":"Herraiz","year":"2011","journal-title":"Mol Endocrinol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.334730","article-title":"Melanocortin 1 Receptor Regulates Melanoma Cell Migration by Controlling Syndecan-2 Expression","volume":"287","author":"Chung","year":"2012","journal-title":"J Biol Chem"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.14670\/HH-24.643","article-title":"C-KIT Signaling as the Driving Oncogenic Event in Sub-Groups of Melanomas","volume":"24","author":"Smalley","year":"2009","journal-title":"Histol Histopathol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.562","article-title":"The MAPK Pathway Functions as a Redundant Survival Signal That Reinforces the PI3K Cascade in C-Kit Mutant Melanoma","volume":"33","author":"Todd","year":"2014","journal-title":"Oncogene"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2020.61.7.562","article-title":"KIT and Melanoma: Biological Insights and Clinical Implications","volume":"61","author":"Pham","year":"2020","journal-title":"Yonsei Med J"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0213729","article-title":"UV-Induction of Keratinocyte Endothelin-1 Downregulates E-Cadherin in Melanocytes and Melanoma Cells","volume":"110","author":"Jamal","year":"2002","journal-title":"J Clin Invest"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2344","article-title":"Endothelin B Receptor Blockade Inhibits Dynamics of Cell Interactions and Communications in Melanoma Cell Progression","volume":"64","author":"Bagnato","year":"2004","journal-title":"Cancer Res"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01628-x","article-title":"Inhibition of Endothelin-B Receptor Signaling Synergizes With MAPK Pathway Inhibitors in BRAF Mutated Melanoma","volume":"40","author":"Sch\u00e4fer","year":"2021","journal-title":"Oncogene"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2606","article-title":"Endothelin-1 and Endothelin-3 Promote Invasive Behavior via Hypoxia-Inducible Factor-1\u03b1 in Human Melanoma Cells","volume":"67","author":"Spinella","year":"2007","journal-title":"Cancer Res"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11496","article-title":"An Endothelin Receptor B Antagonist Inhibits Growth and Induces Cell Death in Human Melanoma Cells In Vitro and In Vivo","volume":"96","author":"Lahav","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209409","article-title":"Pro-Metastatic Signaling by C-Met Through RAC-1 and Reactive Oxygen Species (ROS)","volume":"25","author":"Ferraro","year":"2006","journal-title":"Oncogene"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205150","article-title":"Hepatocyte Growth Factor\/Scatter Factor Activates Proliferation in Melanoma Cells Through P38 MAPK, ATF-2 and Cyclin D1","volume":"21","author":"Recio","year":"2002","journal-title":"Oncogene"},{"key":"B101","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1038\/s41467-020-15546-9","article-title":"Pre-Clinical Modeling of Cutaneous Melanoma","volume":"11","author":"Rebecca","year":"2020","journal-title":"Nat Commun"},{"key":"B102","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/s12885-019-5606-4","article-title":"A Novel Spheroid-Based Co-Culture Model Mimics Loss of Keratinocyte Differentiation, Melanoma Cell Invasion, and Drug-Induced Selection of ABCB5-Expressing Cells","volume":"19","author":"Klicks","year":"2019","journal-title":"BMC Cancer"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-14-1","article-title":"Melanoma Cells Influence the Differentiation Pattern of Human Epidermal Keratinocytes","volume":"14","author":"Kodet","year":"2015","journal-title":"Mol Cancer"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/s41598-020-80336-8","article-title":"Transcript Levels of Keratin 1\/5\/6\/14\/15\/16\/17 as Potential Prognostic Indicators in Melanoma Patients","volume":"11","author":"Han","year":"2021","journal-title":"Sci Rep"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1993.1142","article-title":"Melanocytes as \u201cSensory\u201d and Regulatory Cells in the Epidermis","volume":"164","author":"Slominski","year":"1993","journal-title":"J Theor Biol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.5.457","article-title":"Neuroendocrinology of the Skin","volume":"21","author":"Slominski","year":"2000","journal-title":"Endocr Rev"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00892.x","article-title":"Neuroendocrine Activity of the Melanocyte","volume":"18","author":"Slominski","year":"2009","journal-title":"Exp Dermatol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19617.x","article-title":"Expression of Hypothalamic-Pituitary-Thyroid Axis Related Genes in the Human Skin","volume":"119","author":"Slominski","year":"2002","journal-title":"J Invest Dermatol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700151","article-title":"Adrenergic and Cholinergic Control in the Biology of Epidermis: Physiological and Clinical Significance","volume":"126","author":"Grando","year":"2006","journal-title":"J Invest Dermatol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"8071","DOI":"10.3390\/ijms22158071","article-title":"Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication","volume":"22","author":"Enkhtaivan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1210\/en.2017-03230","article-title":"How UV Light Touches the Brain and Endocrine System Through Skin, and Why","volume":"159","author":"Slominski","year":"2018","journal-title":"Endocrinology"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.02.009","article-title":"Melanoma Resistance: A Bright Future for Academicians and a Challenge for Patient Advocates","volume":"89","author":"Slominski","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"B113","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1152\/physrev.2000.80.3.979","article-title":"Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress","volume":"80","author":"Slominski","year":"2000","journal-title":"Physiol Rev"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1092","article-title":"Key Role of CRF in the Skin Stress Response System","volume":"34","author":"Slominski","year":"2013","journal-title":"Endocr Rev"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(86)90125-2","article-title":"Increased Serum Alpha-Melanocyte Stimulating Hormone (Alpha-MSH) in Human Malignant Melanoma","volume":"22","author":"Ghanem","year":"1986","journal-title":"Eur J Cancer Clin Oncol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640192","article-title":"Expression of Proopiomelanocortin, Corticotropin-Releasing Hormone (CRH), and CRH Receptor in Melanoma Cells, Nevus Cells, and Normal Human Melanocytes","volume":"4","author":"Funasaka","year":"1999","journal-title":"J Investig Dermatol Symp Proc"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02263.x","article-title":"Immunoreactivity of Alpha-Melanocyte-Stimulating Hormone, Adrenocorticotrophic Hormone and Beta-Endorphin in Cutaneous Malignant Melanoma and Benign Melanocytic Naevi","volume":"138","author":"Nagahama","year":"1998","journal-title":"Br J Dermatol"},{"key":"B118","article-title":"Detection of Proopiomelanocortin-Derived Antigens in Normal and Pathologic Human Skin","volume":"122","author":"Slominski","year":"1993","journal-title":"J Lab Clin Med"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.598","article-title":"Mitf Is the Key Molecular Switch Between Mouse or Human Melanoma Initiating Cells and Their Differentiated Progeny","volume":"30","author":"Cheli","year":"2011","journal-title":"Oncogene"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.319","article-title":"Pro-Survival Role of MITF in Melanoma","volume":"135","author":"Hartman","year":"2015","journal-title":"J Invest Dermatol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/730170","article-title":"Molecular Network Associated With MITF in Skin Melanoma Development and Progression","volume":"2011","author":"Yajima","year":"2011","journal-title":"J Skin Cancer"},{"key":"B122","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1101\/gad.290940.116","article-title":"Translation Reprogramming Is an Evolutionarily Conserved Driver of Phenotypic Plasticity and Therapeutic Resistance in Melanoma","volume":"31","author":"Falletta","year":"2017","journal-title":"Genes Dev"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.425","article-title":"Hypoxia and MITF Control Metastatic Behaviour in Mouse and Human Melanoma Cells","volume":"31","author":"Cheli","year":"2012","journal-title":"Oncogene"},{"key":"B124","doi-asserted-by":"publisher","first-page":"5712","DOI":"10.1038\/ncomms6712","article-title":"Low MITF\/AXL Ratio Predicts Early Resistance to Multiple Targeted Drugs in Melanoma","volume":"5","author":"M\u00fcller","year":"2014","journal-title":"Nat Commun"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1101\/gad.329771.119","article-title":"Melanoma Plasticity and Phenotypic Diversity: Therapeutic Barriers and Opportunities","volume":"33","author":"Rambow","year":"2019","journal-title":"Genes Dev"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63093","article-title":"MITF Reprograms the Extracellular Matrix and Focal Adhesion in Melanoma","volume":"10","author":"Dilshat","year":"2021","journal-title":"Elife"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200505059","article-title":"Elevated Expression of MITF Counteracts B-RAF\u2013stimulated Melanocyte and Melanoma Cell Proliferation","volume":"170","author":"Wellbrock","year":"2005","journal-title":"J Cell Biol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200206000-00009","article-title":"Melanoma Progression and Serum L-Dopa\/L-Tyrosine Ratio: A Comparison With S100B","volume":"12","author":"Stoitchkov","year":"2002","journal-title":"Melanoma Res"},{"key":"B129","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1755-148X.2011.00898.x","article-title":"L-Tyrosine and L-Dihydroxyphenylalanine as Hormone-Like Regulators of Melanocyte Functions","volume":"25","author":"Slominski","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)81274-C","article-title":"POMC Gene Expression in Mouse and Hamster Melanoma Cells","volume":"291","author":"Slominski","year":"1991","journal-title":"FEBS Lett"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(92)90109-Z","article-title":"L-Dopa Binding Sites in Rodent Melanoma Cells","volume":"1139","author":"Slominski","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1007\/BF02633219","article-title":"L-Tyrosine-Binding Proteins on Melanoma Cells","author":"Slominski","year":"1991","journal-title":"Vitro Cell Dev Biol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-999-0093-6","article-title":"Modification of Melanogenesis in Cultured Human Melanoma Cells","volume":"35","author":"Slominski","year":"1999","journal-title":"Vitro Cell Dev Biol Anim"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1992.tb00569.x","article-title":"L-Dopa Inhibits In Vitro Phosphorylation of Melanoma Glycoproteins","volume":"5","author":"Slominski","year":"1992","journal-title":"Pigment Cell Res"},{"key":"B135","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.chembiol.2009.12.013","article-title":"Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones","volume":"17","author":"Wang","year":"2010","journal-title":"Chem Biol"},{"key":"B136","article-title":"Metabolic Characterization of Three Hamster Melanoma Variants","volume":"32","author":"Scis\u0142owski","year":"1985","journal-title":"Neoplasma"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711x(84)90107-1","article-title":"Biochemical Characterization of Three Hamster Melanoma Variants\u2013II. Glycolysis and Oxygen Consumption","volume":"16","author":"Scis\u0142owski","year":"1984","journal-title":"Int J Biochem"},{"key":"B138","article-title":"The Role of NADP-Dependent Dehydrogenases in Hydroxylation of Tyrosine in Hamster Melanoma","volume":"30","author":"Scis\u0142owski","year":"1983","journal-title":"Neoplasma"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70206-6","article-title":"Plasma 5-S-Cysteinyldopa Differentiates Patients With Primary and Metastatic Melanoma From Patients With Dysplastic Nevus Syndrome and Normal Subjects","volume":"19","author":"Peterson","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(77)90039-1","article-title":"5-S-Cysteinyldopa in Diagnosis and Treatment of Human Malignant Melanomas and Ultrastructural Observations","volume":"13","author":"Aubert","year":"1977","journal-title":"Eur J Cancer"},{"key":"B141","doi-asserted-by":"publisher","first-page":"432","DOI":"10.3390\/ijms21020432","article-title":"Significance of 5-S-Cysteinyldopa as a Marker for Melanoma","volume":"21","author":"Wakamatsu","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199504000-00007","article-title":"Tyrosinase Activity in the Serum of Patients With Malignant Melanoma","volume":"5","author":"Sonesson","year":"1995","journal-title":"Melanoma Res"},{"key":"B143","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/CMR.0b013e328054c667","article-title":"Prognostic Relevance of Baseline and Sequential Peripheral Blood Tyrosinase Expression in 200 Consecutive Advanced Metastatic Melanoma Patients","volume":"17","author":"Quaglino","year":"2007","journal-title":"Melanoma Res"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.04.045","article-title":"Tyrosinase-Related Proteins Suppress Tyrosinase-Mediated Cell Death of Melanocytes and Melanoma Cells","volume":"298","author":"Rad","year":"2004","journal-title":"Exp Cell Res"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12951","article-title":"Human TYRP1: Two Functions for a Single Gene","volume":"34","author":"Gautron","year":"2021","journal-title":"Pigment Cell Melanoma Res"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3623","article-title":"A Non-Coding Function of TYRP1 mRNA Promotes Melanoma Growth","volume":"19","author":"Gilot","year":"2017","journal-title":"Nat Cell Biol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3390\/dermatopathology8030040","article-title":"Aberrant Expression of Immunohistochemical Markers in Malignant Melanoma: A Review","volume":"8","author":"Saliba","year":"2021","journal-title":"Dermatopathology"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000428","article-title":"The P16-Ki-67-HMB45 Immunohistochemistry Scoring System Is Highly Concordant With the Fluorescent In Situ Hybridization Test to Differentiate Between Melanocytic Nevi and Melanomas","volume":"26","author":"Uguen","year":"2018","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.07.020","article-title":"Conjunctival Nevi and Melanoma: Multiparametric Immunohistochemical Analysis, Including P16, SOX10, HMB45, and Ki-67","volume":"103","author":"Milman","year":"2020","journal-title":"Hum Pathol"},{"key":"B150","article-title":"Beta1,6-Branched Oligosaccharides and Coarse Vesicles: A Common, Pervasive Phenotype in Melanoma and Other Human Cancers","volume":"63","author":"Handerson","year":"2003","journal-title":"Cancer Res"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01359.x","article-title":"Autophagy in Cutaneous Malignant Melanoma","volume":"37","author":"Lazova","year":"2010","journal-title":"J Cutan Pathol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00933.x","article-title":"Why do Melanomas Get So Dark","volume":"18","author":"Lazova","year":"2009","journal-title":"Exp Dermatol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00034.x","article-title":"The Seiji Memorial Lecture: The Melanosome: An Ideal Model to Study Cellular Differentiation","volume":"16","author":"Kushimoto","year":"2003","journal-title":"Pigment Cell Res"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(05)80292-9","article-title":"Are L-Tyrosine and L-Dopa Hormone-Like Bioregulators","volume":"143","author":"Slominski","year":"1990","journal-title":"J Theor Biol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1034\/j.1600-0749.13.s8.7.x","article-title":"The Melanosome: The Perfect Model for Cellular Responses to the Environment","author":"Hearing","year":"2000","journal-title":"Pigment Cell Res"},{"key":"B156","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1021\/pr025562r","article-title":"Proteomic Analysis of Early Melanosomes: Identification of Novel Melanosomal Proteins","volume":"2","author":"Basrur","year":"2003","journal-title":"J Proteome Res"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201845918","article-title":"Rab22A Recruits BLOC-1 and BLOC-2 to Promote the Biogenesis of Recycling Endosomes","volume":"19","author":"Shakya","year":"2018","journal-title":"EMBO Rep"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1593\/neo.04514","article-title":"Seven Novel and Stable Translocations Associated With Oncogenic Gene Expression in Malignant Melanoma","volume":"7","author":"Okamoto","year":"2005","journal-title":"Neoplasia"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12329","article-title":"RAB22A Overexpression Promotes the Tumor Growth of Melanoma","volume":"7","author":"Su","year":"2016","journal-title":"Oncotarget"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201898994","article-title":"KIF13A-Regulated RhoB Plasma Membrane Localization Governs Membrane Blebbing and Blebby Amoeboid Cell Migration","volume":"37","author":"Gong","year":"2018","journal-title":"EMBO J"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.351908","article-title":"BLOC-2, AP-3, and AP-1 Proteins Function in Concert With Rab38 and Rab32 Proteins to Mediate Protein Trafficking to Lysosome-Related Organelles","volume":"287","author":"Bultema","year":"2012","journal-title":"J Biol Chem"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3811","article-title":"A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases During Melanoma Metastasis","volume":"78","author":"Huang","year":"2018","journal-title":"Cancer Res"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.216226\/265555\/Rab4A-organizes-endosomal-domains-for-sorting","article-title":"Rab4A Organizes Endosomal Domains for Sorting Cargo to Lysosome\u2013Related Organelles","volume":"131","author":"Nag","year":"2018","journal-title":"J Cell Sci"},{"key":"B164","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1042\/BJ20110361","article-title":"Procathepsin L Secretion, Which Triggers Tumour Progression, Is Regulated by Rab4a in Human Melanoma Cells","volume":"437","author":"Barbarin","year":"2011","journal-title":"Biochem J"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12535","article-title":"Cell Elasticity is an Important Indicator of the Metastatic Phenotype of Melanoma Cells","volume":"23","author":"Sarna","year":"2014","journal-title":"Exp Dermatol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"8238","DOI":"10.1038\/srep08238","article-title":"Rab1A Regulates Anterograde Melanosome Transport by Recruiting Kinesin-1 to Melanosomes Through Interaction With SKIP","volume":"5","author":"Ishida","year":"2015","journal-title":"Sci Rep"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.010207","article-title":"Rab27a and MyoVa Are the Primary Mlph Interactors Regulating Melanosome Transport in Melanocytes","volume":"120","author":"Hume","year":"2007","journal-title":"J Cell Sci"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.432","article-title":"Rab11b Mediates Melanin Transfer Between Donor Melanocytes and Acceptor Keratinocytes via Coupled Exo\/Endocytosis","volume":"134","author":"Tarafder","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B169","doi-asserted-by":"publisher","first-page":"445450","DOI":"10.1101\/2021.05.24.445450","article-title":"Rab3a Regulates Melanin Exocytosis Induced by Keratinocyte-Conditioned Medium","author":"Caba\u00e7o","year":"2021","journal-title":"bioRxiv"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.04.005","article-title":"Toll-Like Receptor 2 Utilizes RAB11A for Melanosome Transfer From Melanocytes to Keratinocytes","volume":"94","author":"Koike","year":"2019","journal-title":"J Dermatol Sci"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2011.01172.x","article-title":"The Recycling Endosome Protein Rab17 Regulates Melanocytic Filopodia Formation and Melanosome Trafficking","volume":"12","author":"Beaumont","year":"2011","journal-title":"Traffic"},{"key":"B172","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jdermsci.2016.08.534","article-title":"The Effect of the NMDA Receptor-Dependent Signaling Pathway on Cell Morphology and Melanosome Transfer in Melanocytes","volume":"84","author":"Ni","year":"2016","journal-title":"J Dermatol Sci"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-159046","article-title":"Melanin Transfer in Human Skin Cells Is Mediated by Filopodia\u2014A Model for Homotypic and Heterotypic Lysosome-Related Organelle Transfer","volume":"24","author":"Singh","year":"2010","journal-title":"FASEB J"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.02.013","article-title":"PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion","volume":"29","author":"Halberg","year":"2016","journal-title":"Cancer Cell"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.218","article-title":"Myosin-Va Contributes to Manifestation of Malignant-Related Properties in Melanoma Cells","volume":"133","author":"Alves","year":"2013","journal-title":"J Invest Dermatol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29948","article-title":"Rab3 Proteins and Cancer: Exit Strategies","volume":"122","author":"Raffaniello","year":"2021","journal-title":"J Cell Biochem"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S249736","article-title":"Long Noncoding RNA CAR10 Contributes to Melanoma Progression By Suppressing miR-125b-5p to Induce RAB3D Expression","volume":"13","author":"Xie","year":"2020","journal-title":"Onco Targets Ther"},{"key":"B178","doi-asserted-by":"publisher","first-page":"REVIEWS3007","DOI":"10.1186\/gb-2001-2-5-reviews3007","article-title":"The Rab GTPase Family","volume":"2","author":"Stenmark","year":"2001","journal-title":"Genome Biol"},{"key":"B179","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1006\/jmbi.2001.5072","article-title":"Evolution of the Rab Family of Small GTP-Binding Proteins","volume":"313","author":"Pereira-Leal","year":"2001","journal-title":"J Mol Biol"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201511093","article-title":"A Rab3a-Dependent Complex Essential for Lysosome Positioning and Plasma Membrane Repair","volume":"213","author":"Encarna\u00e7\u00e3o","year":"2016","journal-title":"J Cell Biol"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2064","article-title":"Melanoma Growth and Progression After Ultraviolet A Irradiation: Impact of Lysosomal Exocytosis and Cathepsin Proteases","volume":"95","author":"Eding","year":"2014","journal-title":"Acta Derm Venereol"},{"key":"B182","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.devcel.2020.08.009","article-title":"The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis","volume":"55","author":"Funato","year":"2020","journal-title":"Dev Cell"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-207","article-title":"Cathepsin B Inhibition Interferes With Metastatic Potential of Human Melanoma: An In Vitro and In Vivo Study","volume":"9","author":"Matarrese","year":"2010","journal-title":"Mol Cancer"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.63","article-title":"Cathepsin K in Melanoma Invasion","volume":"128","author":"Quintanilla-Dieck","year":"2008","journal-title":"J Invest Dermatol"},{"key":"B185","doi-asserted-by":"publisher","first-page":"jcs246694","DOI":"10.1242\/jcs.246694","article-title":"Rab11 Is Required for Lysosome Exocytosis Through the Interaction With Rab3a, Sec15 and GRAB","volume":"134","author":"Escrevente","year":"2021","journal-title":"J Cell Sci"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207831","article-title":"Loss of E-Cadherin Leads to Upregulation of Nf\u03bab Activity in Malignant Melanoma","volume":"23","author":"Kuphal","year":"2004","journal-title":"Oncogene"},{"key":"B187","doi-asserted-by":"publisher","first-page":"109642","DOI":"10.1016\/j.cellsig.2020.109642","article-title":"Integrin Linked Kinase Regulates Endosomal Recycling of N-Cadherin in Melanoma Cells","volume":"72","author":"Gil","year":"2020","journal-title":"Cell Signal"},{"key":"B188","doi-asserted-by":"publisher","first-page":"10449","DOI":"10.1038\/s41598-018-28717-y","article-title":"Myosin X Is Required for Efficient Melanoblast Migration and Melanoma Initiation and Metastasis","volume":"8","author":"Tokuo","year":"2018","journal-title":"Sci Rep"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00333\/abstract","article-title":"Evidence That GRIN2A Mutations in Melanoma Correlate With Decreased Survival","volume":"3","author":"D\u2019mello","year":"2014","journal-title":"Front Oncol"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12048","article-title":"Blocking Glutamate-Mediated Signalling Inhibits Human Melanoma Growth and Migration","volume":"21","author":"Song","year":"2012","journal-title":"Exp Dermatol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.08.003","article-title":"Cultured Human Melanocytes Express Functional Toll-Like Receptors 2\u20134, 7 and 9","volume":"56","author":"Yu","year":"2009","journal-title":"J Dermatol Sci"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.02065.x","article-title":"Melanocytes Are Potential Immunocompetent Cells: Evidence From Recognition of Immunological Characteristics of Cultured Human Melanocytes","volume":"15","author":"Lu","year":"2002","journal-title":"Pigment Cell Res"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2011_2217","article-title":"Secretion of Proinflammatory Cytokines by Normal Human Melanocytes in Response to Lipopolysaccharide","volume":"58","author":"Tam","year":"2011","journal-title":"Acta Biochim Pol"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23664","article-title":"Inhibition of Melanogenesis as a Radiation Sensitizer for Melanoma Therapy","volume":"123","author":"Brozyna","year":"2008","journal-title":"Int J Cancer"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24005","article-title":"Inhibitors of Melanogenesis Increase Toxicity of Cyclophosphamide and Lymphocytes Against Melanoma Cells","volume":"124","author":"Slominski","year":"2009","journal-title":"Int J Cancer"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.02.022","article-title":"Melanogenesis Affects Overall and Disease-Free Survival in Patients With Stage III and IV Melanoma","volume":"44","author":"Bro\u017cyna","year":"2013","journal-title":"Hum Pathol"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget","article-title":"Melanin Content in Melanoma Metastases Affects the Outcome of Radiotherapy","volume":"7","author":"Bro\u017cyna","year":"2016","journal-title":"Oncotarget"},{"key":"B198","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.1038\/s41598-018-23889-z","article-title":"Structure-Function Analysis and Therapeutic Efficacy of Antibodies to Fungal Melanin for Melanoma Radioimmunotherapy","volume":"8","author":"Nosanchuk","year":"2018","journal-title":"Sci Rep"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.347","article-title":"Identification of the Immunodominant Peptides of the MART-1 Human Melanoma Antigen Recognized by the Majority of HLA-A2-Restricted Tumor Infiltrating Lymphocytes","volume":"180","author":"Kawakami","year":"1994","journal-title":"J Exp Med"},{"key":"B200","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/BF02602776","article-title":"A New Gene Coding for a Differentiation Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas","volume":"180","author":"Coulie","year":"1994","journal-title":"J Exp Med"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.489","article-title":"The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas","volume":"178","author":"Brichard","year":"1993","journal-title":"J Exp Med"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.4.989","article-title":"Melanoma Cells and Normal Melanocytes Share Antigens Recognized by HLA-A2-Restricted Cytotoxic T Cell Clones From Melanoma Patients","volume":"177","author":"Anichini","year":"1993","journal-title":"J Exp Med"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1637","article-title":"Melanocyte Destruction After Antigen-Specific Immunotherapy of Melanoma","volume":"192","author":"Yee","year":"2000","journal-title":"J Exp Med"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01605.x","article-title":"Direct Evidence to Support the Role of Antigen-Specific CD8+ T Cells in Melanoma-Associated Vitiligo","volume":"117","author":"Le Gal","year":"2001","journal-title":"J Invest Dermatol"},{"key":"B205","doi-asserted-by":"publisher","first-page":"5731","DOI":"10.3390\/ijms20225731","article-title":"Melanoma and Vitiligo: In Good Company","volume":"20","author":"Failla","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.4756","article-title":"Vitiligo-Like Depigmentation in Patients With Stage III-IV Melanoma Receiving Immunotherapy and Its Association With Survival: A Systematic Review and Meta-Analysis","volume":"33","author":"Teulings","year":"2015","journal-title":"J Clin Oncol"},{"key":"B207","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.161.6.2873","article-title":"Alpha-Melanocyte-Stimulating Hormone Inhibits the Nuclear Transcription Factor NF-Kappa B Activation Induced by Various Inflammatory Agents","volume":"161","author":"Manna","year":"1998","journal-title":"J Immunol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00583-9","article-title":"Effects of Melanocortin Peptides on Lipopolysaccharide\/Interferon-Gamma-Induced NF-kappaB DNA Binding and Nitric Oxide Production in Macrophage-Like RAW 264.7 Cells: Evidence for Dual Mechanisms of Action","volume":"61","author":"Mandrika","year":"2001","journal-title":"Biochem Pharmacol"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(96)00063-8","article-title":"Production and Release of Proopiomelanocortin (POMC) Derived Peptides by Human Melanocytes and Keratinocytes in Culture: Regulation by Ultraviolet B","volume":"1313","author":"Chakraborty","year":"1996","journal-title":"Biochim Biophys Acta - Mol Cell Res"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08676.x","article-title":"Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1r","volume":"885","author":"Becher","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05388.x","article-title":"The Role of \u03b1-MSH as a Modulator of Cutaneous Inflammation","volume":"917","author":"Luger","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B212","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/246856","article-title":"The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells Into Treg Cells","volume":"2011","author":"Taylor","year":"2011","journal-title":"J Transplant"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202382","article-title":"Interleukin-6 Dependent Induction of the Cyclin Dependent Kinase Inhibitor P21waf1\/CIP1 Is Lost During Progression of Human Malignant Melanoma","volume":"18","author":"Fl\u00f8renes","year":"1999","journal-title":"Oncogene"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3283550aa5","article-title":"Serum Interleukin-6 as a Prognostic Biomarker in Patients With Metastatic Melanoma","volume":"22","author":"Hoejberg","year":"2012","journal-title":"Melanoma Res"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000172","article-title":"Tocilizumab Unmasks a Stage-Dependent Interleukin-6 Component in Statin-Induced Apoptosis of Metastatic Melanoma Cells","volume":"25","author":"Minichsdorfer","year":"2015","journal-title":"Melanoma Res"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2413","article-title":"Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells","volume":"34","author":"Tuccitto","year":"2016","journal-title":"Stem Cells"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1159\/000097167","article-title":"Alpha-Melanocyte-Stimulating Hormone Suppresses Antigen-Stimulated T Cell Production of Gamma-Lnterferon","volume":"1","author":"Taylor","year":"1994","journal-title":"Neuroimmunomodulation"},{"key":"B218","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/ph14010045","article-title":"Antifibrotic and Anti-Inflammatory Actions of \u03b1-Melanocytic Hormone: New Roles for an Old Player","volume":"14","author":"Dinparastisaleh","year":"2021","journal-title":"Pharmaceuticals"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09577.x","article-title":"Cutaneous Immunomodulation and Coordination of Skin Stress Responses by \u03b1-Melanocyte-Stimulating Hormone","volume":"840","author":"Luger","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.17.8016","article-title":"Evidence of Autocrine Modulation of Macrophage Nitric Oxide Synthase by Alpha-Melanocyte-Stimulating Hormone","volume":"92","author":"Star","year":"1995","journal-title":"Proc Natl Acad Sci"},{"key":"B221","article-title":"Dopa Inhibits Induced Proliferative Activity of Murine and Human Lymphocytes","volume":"12","author":"Slominski","year":"1992","journal-title":"Anticancer Res"},{"key":"B222","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/apha.12476","article-title":"Dopamine and T Cells: Dopamine Receptors and Potent Effects on T Cells, Dopamine Production in T Cells, and Abnormalities in the Dopaminergic System in T Cells in Autoimmune, Neurological and Psychiatric Diseases","volume":"216","author":"Levite","year":"2016","journal-title":"Acta Physiol"},{"key":"B223","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.abb.2014.06.030","article-title":"The Role of Melanogenesis in Regulation of Melanoma Behavior: Melanogenesis Leads to Stimulation of HIF-1\u03b1 Expression and HIF-Dependent Attendant Pathways","volume":"563","author":"Slominski","year":"2014","journal-title":"Arch Biochem Biophys"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0781","article-title":"Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression During Metastatic Melanoma Dissemination","volume":"69","author":"Pinner","year":"2009","journal-title":"Cancer Res"},{"key":"B225","doi-asserted-by":"publisher","first-page":"5735","DOI":"10.3390\/ijms22115735","article-title":"Pigmentation Levels Affect Melanoma Responses to Coriolus Versicolor Extract and Play a Crucial Role in Melanoma-Mononuclear Cell Crosstalk","volume":"22","author":"Pawlikowska","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0003","article-title":"Interleukin-12-Deficient Mice Are at Greater Risk of UV Radiation\u2013Induced Skin Tumors and Malignant Transformation of Papillomas to Carcinomas","volume":"5","author":"Meeran","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"B227","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1089\/hum.2005.16.35","article-title":"Intratumoral Injection of DNA Encoding Human Interleukin 12 Into Patients With Metastatic Melanoma: Clinical Efficacy","volume":"16","author":"Heinzerling","year":"2005","journal-title":"Hum Gene Ther"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.887366\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T20:49:13Z","timestamp":1675543753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.887366\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":227,"alternative-id":["10.3389\/fonc.2022.887366"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2022.887366","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"article-number":"887366"}}