{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:17:58Z","timestamp":1768832278962,"version":"3.49.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent pediatric cancer worldwide. Despite improvements in treatment regimens, approximately 20% of the cases cannot be cured, highlighting the necessity for identifying new biomarkers to improve the current clinical and molecular risk stratification schemes. We aimed to investigate whether <jats:italic>LINC00173<\/jats:italic> is a biomarker in ALL and to explore its expression level in other human cancer types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nested case\u2013control study including Mexican children with BCP-ALL was conducted. <jats:italic>LINC00173<\/jats:italic> expression was evaluated by qRT-PCR using hydrolysis probes. To validate our findings, RNA-seq expression data from BCP-ALL and normal tissues were retrieved from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Genotype-Tissue Expression (GTEx) repositories, respectively. <jats:italic>LINC00173<\/jats:italic> expression was also evaluated in solid tumors by downloading available data from The Cancer Genome Atlas (TCGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A lower expression of <jats:italic>LINC00173<\/jats:italic> in BCP-ALL cases compared to normal subjects was observed (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). ALL patients who carry the <jats:italic>TCF3\/PBX1<\/jats:italic> fusion gene displayed lower expression of <jats:italic>LINC00173<\/jats:italic> in contrast to other BCP-ALL molecular subtypes (<jats:italic>p<\/jats:italic> &amp;lt; 0.04). <jats:italic>LINC00173<\/jats:italic> underexpression was associated with a high risk to relapse (HR = 1.946, 95% CI = 1.213\u20133.120) and die (HR = 2.073, 95% CI = 1.211\u20133.547). Patients with <jats:italic>TCF3\/PBX1<\/jats:italic> and underexpression of <jats:italic>LINC00173<\/jats:italic> had the worst prognosis (DFS: HR = 12.24, 95% CI = 5.04\u201329.71; OS: HR = 11.19, 95% CI = 26\u201332). TCGA data analysis revealed that underexpression of <jats:italic>LINC00173<\/jats:italic> is also associated with poor clinical outcomes in six new reported tumor types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that <jats:italic>LINC00173<\/jats:italic> is a biomarker of poor prognosis in BCP-ALL and other types of cancer. We observed an association between the expression of <jats:italic>LINC00173<\/jats:italic> and <jats:italic>TCF3\/PBX1<\/jats:italic> and the risk to relapse and die in BCP-ALL, which is worse in <jats:italic>TCF3\/PBX1-<\/jats:italic>positive cases displaying underexpression of <jats:italic>LINC00173.<\/jats:italic> Experimental studies are needed to provide insight into the <jats:italic>LINC00173<\/jats:italic> and <jats:italic>TCF3\/PBX<\/jats:italic> relationship.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.887766","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T07:45:18Z","timestamp":1654155918000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Underexpression of LINC00173 in TCF3\/PBX1-Positive Cases Is Associated With Poor Prognosis in Children With B-Cell Precursor Acute Lymphoblastic Leukemia"],"prefix":"10.3389","volume":"12","author":[{"given":"Didier 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