{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:07:21Z","timestamp":1782922041529,"version":"3.54.5"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aimed to summarize the morphological characteristics of low-grade gastric intraepithelial neoplasia (LGIN) and explore its outcomes and risk factors. Additionally, it aimed to screen the core different expression genes (DEGs) of high-grade gastric intraepithelial neoplasia (HGIN) using bioinformatics methods to identify biomarkers for early gastric cancer outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical and pathological data of 449 patients with LGIN in the endoscopy center of the Second Hospital of Hebei Medical University from June 2013 to September 2018 were collected for retrospective analysis. The GSE130823 and GSE55696 data sets were selected from the Gene Expression Omnibus database, and the GEO2R tool was used to screen DEGs in HGIN and chronic gastritis tissue types. A DEG functional enrichment analysis was conducted using the Database for Annotation, Visualization, and Integrated Discovery. The STRING database was utilized to create a protein\u2013protein interaction network, and the CytoHubba plug-in was used to screen the key genes of HGIN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of LGIN increased with age, and most of the patients were aged between 45\u201359 years (P = 0.048). Lesions were found mainly in the cardia, mostly in people aged 60 (P &amp;lt; 0.05). Progression occurred in 42 of 449 patients, with a 9.4% rate of cancer development. Foci larger than 10 mm, ulcerative lesions, and an Helicobacter pylori-positive result were factors affecting the outcome of LGIN (P &amp;lt; 0.05). Seven core genes of HGIN were screened, including MYC, SOX2, CDX2, TBX3, KRT7, CDKN2A, and MUC5AC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The patients with LGIN reflected the potential for developing cancer. A magnifying gastroscope can contribute to the detection of early gastric cancer. Additionally, the MYC, CDX2, and TBX3 genes may act as specific biomarkers of HGIN.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.899055","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T11:03:35Z","timestamp":1656587015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Single-Center Follow-Up Study of Low-Grade Gastric Intraepithelial Neoplasia and the Screening of Key Genes of Precancerous Lesions"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiao-Xu","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Ge","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Guang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Feng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Jie","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3978\/j.issn.1000-9604.2012.12.04","article-title":"Report of Incidence and Mortality in China Cancer Registries, 2009","volume":"25","author":"Chen","year":"2013","journal-title":"Chin J Cancer Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyp187","article-title":"Cancer Trends in China","volume":"40","author":"Zhao","year":"2010","journal-title":"Jpn J Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/s0140-6736(75)90498-5","article-title":"A Model for Gastric Cancer Epidemiology","volume":"2","author":"Correa","year":"1975","journal-title":"Lancet"},{"key":"B4","article-title":"Study on the Natural Evolution of Pre-Cancerous Mucosal Changes in the Stomach","volume":"21","author":"Yang","year":"2005","journal-title":"Zhong Guo Zong He Lin Chuang"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.9.977","article-title":"High Grade Dysplasia of the Gastric Mucosa: A Marker for Gastric Carcinoma","volume":"31","author":"Lansdown","year":"1990","journal-title":"Gut"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026849","article-title":"High Throughput Sequencing and Assessing Disease Risk","volume":"9","author":"Rego","year":"2019","journal-title":"Cold Spring Harb Perspect Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-5232.2019.06.001","article-title":"Major Projects of Beijing Science and Technology Commission: Expert Group of \u201cThe Early Gastric Cancer Treatment Specification Study\u201d. 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