{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:01Z","timestamp":1787026981403,"version":"build-2736575974"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Lymphoma is a malignant disease that threatens human health and imposes a significant burden on the society burden; however, there are limited accurate mortality data on lymphoma in China. The present study aimed to analyse lymphoma-associated mortality at the national and provincial levels in mainland China. Mortality data of lymphoma was extracted from the disease surveillance system of the Chinese Center for Disease Control and Prevention. Mortality was represented by the number of deaths, crude mortality rate, and age-standardized mortality rate. Temporal trends in mortality rates were examined using the fitting joinpoint models. Lymphoma accounted for 31,225 deaths in 2020, of which 1,838 and 29,387 were due to Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), respectively. The age-standardized mortality rate per 100,000 population was 1.76 for lymphoma, 0.10 for HL, and 1.66 for NHL. The mortality rate increased with age, reaching a peak in the age group of 80\u201384 years for HL and over 85 years for NHL. Moreover, the death risk due to lymphoma was approximately 1.5\u20132 times greater in males than in females in all age groups. The mortality rate was higher in eastern China than in central and western China, indicating a heterogeneous distribution at the provincial level. During 2013\u20132020, the mortality rate of lymphoma decreased by 1.85% (\u221222.94% for HL and \u22120.14% for NHL). In conclusion, the mortality of lymphoma varied by sex, age, and regions, which highlighted the need of establish differentiated strategy for disease control and prevention.<\/jats:p>","DOI":"10.3389\/fonc.2022.902643","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:58:37Z","timestamp":1654563517000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Mortality Rate of Lymphoma in China, 2013\u20132020"],"prefix":"10.3389","volume":"12","author":[{"given":"Weiping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maigeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21357","article-title":"2016 US Lymphoid Malignancy Statistics by World Health Organization Subtypes","volume":"66","author":"Teras","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"B4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13045-019-0785-7","article-title":"Burden of Lymphoma in China, 2006-2016: An Analysis of the Global Burden of Disease Study 2016","volume":"12","author":"Liu","year":"2019","journal-title":"J Hematol Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13045-019-0706-9","article-title":"Mortality of Lymphoma and Myeloma in China, 2004-2017: An Observational Study","volume":"12","author":"Liu","year":"2019","journal-title":"J Hematol Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.2996","article-title":"Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study","volume":"5","author":"Fitzmaurice","year":"2019","journal-title":"JAMA Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338","article-title":"Cancer Statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"B8","volume-title":"Cancer Mortality for Selected Sites in 24 Countries (1950\u201357)","author":"Segi","year":"1960"},{"key":"B9","unstructured":"Communiqu\u00e9 on the Fourth National Economic Census (No. 7)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.2471\/BLT.15.153148","article-title":"An Integrated National Mortality Surveillance System for Death Registration and Mortality Surveillance, China","volume":"94","author":"Liu","year":"2016","journal-title":"Bull World Health Organ."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12025","article-title":"Cancer Burden of Major Cancers in China: A Need for Sustainable Actions","volume":"40","author":"Cao","year":"2020","journal-title":"Cancer Commun (Lond)."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21577","article-title":"Cancer Statistics for Adults Aged 85 Years and Older, 2019","volume":"69","author":"DeSantis","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103503","article-title":"Cancer Mortality in the Oldest Old: A Global Overview","volume":"12","author":"Hashim","year":"2020","journal-title":"Aging (Albany NY)."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz178","article-title":"Cancer Mortality in the Elderly in 11 Countries Worldwide, 1970-2015","volume":"30","author":"Carioli","year":"2019","journal-title":"Ann Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.94","article-title":"Lymphoma Incidence, Survival and Prevalence 2004-2014: Sub-Type Analyses From the UK\u2019s Haematological Malignancy Research Network","volume":"112","author":"Smith","year":"2015","journal-title":"Br J Cancer"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15532","article-title":"Incidence and Outcomes of Lymphoid Malignancies in Adolescent and Young Adult Patients in the United States","volume":"183","author":"Blum","year":"2018","journal-title":"Br J Haematol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30825","article-title":"Cancer Incidence and Mortality: A Cohort Study in China, 2008-2013","volume":"141","author":"Pan","year":"2017","journal-title":"Int J Cancer."},{"key":"B19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00038-018-1109-3","article-title":"Rural-Urban Inequities in Deaths and Cancer Mortality Amid Rapid Economic and Environmental Changes in China","volume":"64","author":"Liu","year":"2019","journal-title":"Int J Public Health"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21147\/j.issn.1000-9604.2018.01.01","article-title":"Cancer Incidence and Mortality in China, 2014","volume":"30","author":"Chen","year":"2018","journal-title":"Chin J Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s12913-016-1426-2","article-title":"Correlates of Unequal Access to Preventive Care in China: A Multilevel Analysis of National Data From the 2011 China Health and Nutrition Survey","volume":"16","author":"Huang","year":"2016","journal-title":"BMC Health Serv Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/1472-6963-14-305","article-title":"Financial Protection Effects of Modification of China\u2019s New Cooperative Medical Scheme on Rural Households With Chronic Diseases","volume":"14","author":"Wang","year":"2014","journal-title":"BMC Health Serv Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12939-017-0706-8","article-title":"Socioeconomic Inequalities of Outpatient and Inpatient Service Utilization in China: Personal and Regional Perspectives","volume":"16","author":"Zhu","year":"2017","journal-title":"Int J Equity Health"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29227","article-title":"Cancer Survival in China, 2003-2005: A Population-Based Study","volume":"136","author":"Zeng","year":"2015","journal-title":"Int J Cancer."},{"key":"B25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.21147\/j.issn.1000-9604.2021.03.01","article-title":"Chinese Society of Clinical Oncology (CSCO) Diagnosis and Treatment Guidelines for Malignant Lymphoma 2021 (English Version)","volume":"33","author":"Zhu","year":"2021","journal-title":"Chin J Cancer Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30127-X","article-title":"Changing Cancer Survival in China During 2003-15: A Pooled Analysis of 17 Population-Based Cancer Registries","volume":"6","author":"Zeng","year":"2018","journal-title":"Lancet Glob Health"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3037","article-title":"Improving Survival of 3760 Patients With Lymphoma: Experience of an Academic Center Over Two Decades","volume":"9","author":"Liu","year":"2020","journal-title":"Cancer Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237509","article-title":"Nationwide Claims Database Analysis of Treatment Patterns, Costs and Survival of Japanese Patients With Diffuse Large B-Cell Lymphoma","volume":"15","author":"Tsutsu\u00e9","year":"2020","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3557-1","article-title":"Survival in Advanced Diffuse Large B-Cell Lymphoma in Pre- and Post-Rituximab Eras in the United States","volume":"34","author":"Shah","year":"2014","journal-title":"Anticancer Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1186\/1471-2407-14-586","article-title":"Real World Costs and Cost-Effectiveness of Rituximab for Diffuse Large B-Cell Lymphoma Patients: A Population-Based Analysis","volume":"14","author":"Khor","year":"2014","journal-title":"BMC Cancer"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global Surveillance of Trends in Cancer Survival 2000-14 (CONCORD-3): Analysis of Individual Records for 37\u2008513\u2008025 Patients Diagnosed With One of 18 Cancers From 322 Population-Based Registries in 71 Countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.902643\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:58:40Z","timestamp":1654563520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.902643\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":31,"alternative-id":["10.3389\/fonc.2022.902643"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2022.902643","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,7]]},"article-number":"902643"}}