{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:12:39Z","timestamp":1788588759113,"version":"build-2803163510"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Adenoid cystic carcinoma (ACC) of the breast (breast ACC) is a rare tumor, especially in men, with only 17 cases reported in the literature. Owing to this rarity, male breast ACC is susceptible to missed or incorrect diagnoses, and data on treatment options and prognosis is also scarce. Herein, we report a case of a male patient with primary breast ACC and performed a detailed clinicopathological analysis of the 17 cases reported in the literature. A 38-year-old Chinese man patient developed right-sided breast nipple retraction in 2013 and presented to our hospital in 2015 with a palpable mass in the right breast for four days. B-scan ultrasound indicated the presence of a solid space-occupying lesion in the right breast. Breast Imaging Reporting and Data System (BI-RADS) classified the lesion as category 4B, and mammography showed a right breast nodule classified as BI-RADS 4C. Modified radical mastectomy for breast cancer was performed on the right breast. Microscopic examination of the excised tissue revealed diffuse tumor invasion of the subcutaneous fibers and adipose tissue, with tumor cells arranged in cribriform, tubular, and microcystic patterns. Immunohistochemical staining indicated that the glandular epithelial cells were positive for CD117, CK7, and Ki67 (approximately 30%) and negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, while the myoepithelial\/basal cells were positive for P63, CK5\/6 and S-100. Moreover, basement membrane materials were positive for collagen type IV. Molecular pathology analysis by fluorescence <jats:italic>in situ<\/jats:italic> hybridization revealed that the tumor was negative for <jats:italic>MYB<\/jats:italic> rearrangements. The patient was followed up for 82 months with no tumor recurrence or metastasis. According to the current literature, mastectomies have a better prognosis than lumpectomy. Accurately identifying the diagnosis of male breast ACC and considering the surgery of mastectomy may be the key factors for patients to obtain a good prognosis based on the microscopic characteristics of the tumor.<\/jats:p>","DOI":"10.3389\/fonc.2022.905997","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T05:58:57Z","timestamp":1657173537000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Adenoid Cystic Carcinoma of the Breast in a Male Patient: A Case Report and Literature Review"],"prefix":"10.3389","volume":"12","author":[{"given":"Dan","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.732","article-title":"Adenoid Cystic Carcinoma of Breast: Recent Advances","volume":"2","author":"Miyai","year":"2014","journal-title":"World J Clin Cases"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.621012","article-title":"Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"R54","DOI":"10.1186\/bcr2613","article-title":"Adenoid Cystic Carcinoma of the Breast in the United States (1977 to 2006): A Population-Based Cohort Study","volume":"12","author":"Ghabach","year":"2010","journal-title":"Breast Cancer Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.annpat.2010.01.003","article-title":"Adenoid Cystic Carcinoma of the Breast: Clinical, Histological and Immunohistochemical Characterization","volume":"30","author":"Defaud-H\u00e9non","year":"2010","journal-title":"Ann Pathol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.07.013","article-title":"MYB-NFIB Gene Fusion in Adenoid Cystic Carcinoma of the Breast With Special Focus Paid to the Solid Variant With Basaloid Features","volume":"45","author":"D\u2019Alfonso","year":"2014","journal-title":"Hum Pathol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909114106","article-title":"Recurrent Fusion of MYB and NFIB Transcription Factor Genes in Carcinomas of the Breast and Head and Neck","volume":"106","author":"Persson","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10455","article-title":"Adenoid Cystic Carcinoma of the Breast: Molecular Markers, Treatment, and Clinical Outcome","volume":"94","author":"Arpino","year":"2002","journal-title":"Cancer"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24702","article-title":"Is Axillary Surgery Beneficial for Patients With Adenoid Cystic Carcinoma of the Breast","volume":"116","author":"Welsh","year":"2017","journal-title":"J Surg Oncol"},{"key":"B9","article-title":"Fine Structure of Mammary Adenoid Cystic Carcinoma","volume":"9","author":"Woyke","year":"1970","journal-title":"Pol Med J"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/59.5.653","article-title":"Mammary Adenoid Cystic Carcinoma With Unusual Features","volume":"59","author":"Verani","year":"1973","journal-title":"Am J Clin Pathol"},{"key":"B11","article-title":"Adenoid Cystic Carcinoma of the Male Breast: Report of a Case","volume":"40","author":"Ferlito","year":"1974","journal-title":"Am Surg"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nn1304","article-title":"Adenoid Cystic Carcinoma of the Breast. 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