{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:41:09Z","timestamp":1793029269272,"version":"4.5.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reconstruction of pelvis girdle stability after tumor-induced hemipelvectomy remains challenging. We surgically treated 13 patients with custom-made, three-dimensional printed hemipelvic prostheses. We aim to identify the preliminary outcomes for patients who have been managed with more mixed regions of prosthetic pelvic reconstruction and the feasibility of two reconstructive systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven male patients and 6 female patients treated at our center between January 2019 and May 2021 were included. There were 11 primary sarcomas and 2 solitary bone metastases. After en bloc tumor resection, two types of personalized, three-dimensional printed prostheses were fixed to restore the stability and rebuild the load transfer. The position of the reconstructed hemipelvis was evaluated on an anteroposterior plain radiograph. The complications and outcomes were traced. One amputation specimen was discovered through histological analysis of the porous\u00a0structure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The operative duration was 467 \u00b1 144 min, and the blood loss was 3,119 \u00b1 662 ml. During a follow-up of 22.4 \u00b1 8.5 months, two patients had delayed wound healing and one had a second-stage flap transfer. One patient with osteosarcoma died of pulmonary metastasis 27 months after surgery. Two patients with marginal resection suffered from local recurrence and had extra surgeries. One patient had traumatic hip dislocation 2 months after surgery and manipulative reduction was performed. The acetabular inclination of the affected side was 42.2 \u00b1 4.3\u00b0, compared with 42.1 \u00b1 3.9\u00b0 on the contralateral side. The horizontal distance between the center of the femoral head and the middle vertical line was 10.4 \u00b1 0.6 cm, while the reconstructed side was 9.8 \u00b1 0.8 cm. No significant difference in acetabular position after surgery was found (<jats:italic>p<\/jats:italic> &amp;gt; 0.05). The amputation specimen harvested from one patient with local recurrence demonstrated bone and soft tissue ingrowth within the three-dimensional printed trabecular structure. Walking ability was preserved in all patients who are still alive and no prosthesis-related complications occurred. The MSTS score was 22.0 \u00b1 3.7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both types of custom-made, three-dimensional printed prostheses manifested excellent precision, mechanical stability, and promising functional rehabilitation. The porous structure exhibited favorable histocompatibility to facilitate the ingrowth of bone and soft tissue.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.935059","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T09:49:58Z","timestamp":1656582598000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Reconstruction of Tumor-Induced Pelvic Defects With Customized, Three-Dimensional Printed Prostheses"],"prefix":"10.3389","volume":"12","author":[{"given":"Shenglin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiling","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukang","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8627023","article-title":"Biomechanical Analysis of a Novel Acetabulum Reconstruction Technique With Acetabulum Reconstruction Cage and Threaded Rods After Type Ii Pelvic Resections","volume":"2016","author":"Singh","year":"2016","journal-title":"Sarcoma"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.99B2.BJJ-2016-0654.R1","article-title":"Reconstruction With 3d-Printed Pelvic Endoprostheses After Resection of a Pelvic Tumour","author":"Liang","year":"2017","journal-title":"Bone Joint J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.19.01437","article-title":"3d-Printed Modular Hemipelvic Endoprosthetic Reconstruction Following Periacetabular Tumor Resection: Early Results of 80 Consecutive Cases","volume":"102","author":"Ji","year":"2020","journal-title":"J Bone Joint Surg Am"},{"key":"B4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00003086-200204000-00005","article-title":"Iliofemoral Arthrodesis and Pseudarthrosis: A Long-Term Functional Outcome Evaluation","author":"Fuchs","year":"2002","journal-title":"Clin Orthop Relat Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3109\/17453679609002326","article-title":"High Complication Rates With Pelvic Allografts. 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