{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:26:36Z","timestamp":1790778396761,"version":"4.1.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970470"],"award-info":[{"award-number":["81970470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic atrophic gastritis (CAG) can progress to gastric cancer (GC) thus requiring endoscopic surveillance. Here, we analyze various aspects of CAG progression, time, and mucosal background, to guide reasonable surveillance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CAG patients with three or more endoscopies from 2010\u20132021 were included. All cases were analyzed for rate and time of progression, and cases with operative link on gastritis assessment (OLGA) staging, operative link on gastric intestinal metaplasia assessment (OLGIM) staging, and Kimura-Takemoto classification were further analyzed. Additional investigation of guideline-defined low-risk patients by reviewing endoscopy in the short-term (1\u20132 years) after baseline identified several patients as high-risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety-seven (10.4%) of the 929 CAG patients progressed to low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), or GC, during the observation period of 36\u2013129 months (median 53, IQR=24), including 75 (8.1%) cases of LGIN, eight (0.9%) of HGIN, and 14 (1.5%) of GC. Among 170 patients with OLGA\/OLGIM at baseline, two (2\/2, 100%) GC cases occurred in patients with OLGA\/OLGIM III and IV. Of the 236 patients with Kimura-Takemoto classification at baseline, 5\/7 (71.4%) cases of GC occurred in patients with C3\u2013O3. Ten, 11, and 25 patients classified as low-risk on the European, British, and Chinese Guidelines, underwent additional endoscopy within 1\u20132 years, resulting in three (30.0%), four (36.4%), and eight (32.0%) patients being classified as high-risk on these guidelines, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A minority of CAG patients can progress to GC. OLGA\/OLGIM III and IV staging are closely associated with progression. Disease-associated risk may be underestimated in one-third of patients classified as low-risk by initial endoscopy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fonc.2022.942091","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T14:56:11Z","timestamp":1659365771000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Risk of progression in patients with chronic atrophic gastritis: A retrospective study"],"prefix":"10.3389","volume":"12","author":[{"given":"Lu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingtao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800790404","article-title":"Improving survival in gastric cancer: Review of 5-year survival rates in English language publications from 1970","volume":"79","author":"Akoh","year":"1992","journal-title":"Br J Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.071","article-title":"Gastric cancer risk in patients with premalignant gastric lesions: A nationwide cohort study in the Netherlands","volume":"134","author":"de Vries","year":"2008","journal-title":"Gastroenterology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314498","article-title":"Surveillance of premalignant gastric lesions: A multicentre prospective cohort study from low incidence regions","volume":"68","author":"den Hollander","year":"2019","journal-title":"Gut"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1010570","article-title":"Occurrence of gastric cancer and carcinoids in atrophic gastritis during prospective long-term follow up","volume":"50","author":"Lahner","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3867","article-title":"Incidence of gastric cancer among patients with gastric precancerous lesions: Observational cohort study in a low risk Western population","volume":"351","author":"Song","year":"2015","journal-title":"BMJ"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.03.791","article-title":"Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after helicobacter pylori eradication","volume":"84","author":"Shichijo","year":"2016","journal-title":"Gastrointest Endosc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314600","article-title":"Gastritis staging in the endoscopic follow-up for the secondary prevention of gastric cancer: A 5-year prospective study of 1755 patients","volume":"68","author":"Rugge","year":"2019","journal-title":"Gut"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001","article-title":"Classification and grading of gastritis. the updated Sydney system. 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