{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:09:34Z","timestamp":1753891774172,"version":"3.41.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Malignant tumors of the digestive system are common worldwide; however, it is extremely rare for more than two malignancies to occur simultaneously. Here, we report a case with a triple malignancy of the digestive system, including gastric, rectal, and hepatic tumors. The patient underwent surgical resection of three tumors followed by chemotherapy. Negative image-based screenings and the absence of serum tumor biomarkers elevation were found at 2.5 years after the surgery, indicating the absence of recurrence and metastasis of cancers.<\/jats:p>","DOI":"10.3389\/fonc.2022.945689","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T05:49:10Z","timestamp":1663652950000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: A rare occurrence of triple malignancy of the stomach, rectum and liver in a single patient"],"prefix":"10.3389","volume":"12","author":[{"given":"Cancan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangnan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirthikaa","family":"Balapattabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sizhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangbin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B2","article-title":"Multiple primary malignant tumors. a survey of the literature and a statistical study","volume":"16","author":"Warren","year":"1932","journal-title":"Am J Cancer"},{"key":"B3","article-title":"Detection of unexpected additional primary malignancies with PET\/CT","volume":"46","author":"Ishimori","year":"2005","journal-title":"J Nucl Med"},{"key":"B4","article-title":"Effectiveness of FDG-PET in screening of synchronous cancer of other organs in patients with esophageal cancer","volume":"34","author":"Miyazaki","year":"2014","journal-title":"Anticancer Res"},{"key":"B5","article-title":"Synchronous quadruple primary tumors of thyroid, breast, pancreas, and stomach: A case report","volume":"33","author":"Kim","year":"2013","journal-title":"Anticancer Res"},{"key":"B6","article-title":"Synchronous quadruple primary neoplasms: glioblastoma, neuroendocrine tumor, schwannoma and sessile serrated adenoma in a patient with history of prostate cancer","volume":"35","author":"Grace","year":"2015","journal-title":"Anticancer Res"},{"key":"B7","article-title":"Synchronous quadruple primary neoplasms: Colon adenocarcinoma, collision tumor of neuroendocrine tumor and schwann cell hamartoma and sessile serrated adenoma of the appendix","volume":"36","author":"Meeks","year":"2016","journal-title":"Anticancer Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2017.08.035","article-title":"Quadruple primary urogenital cancers - 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